Strain Name:
C57BL/6J-MtgxR4846Btlr/Mmmh
Stock Number:
042459-MU
Citation ID:
RRID:MMRRC_042459-MU
Other Names:
R4846 (G1), C57BL/6J-MtgxR4846Btlr
Major Collection:

Gene Information

Met
Name: met proto-oncogene
Synonyms: HGF receptor, Par4, c-Met
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Mbd5
Name: methyl-CpG binding domain protein 5
Synonyms: C030040A15Rik, 9430004D19Rik, OTTMUSG00000012483
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 109241
Homologene: 81861
Sigmar1
Name: sigma non-opioid intracellular receptor 1
Synonyms: Sig1R, Oprs1, mSigmaR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18391
HGNC: HGNC:8157
Homologene: 39965
Denn2b
Name: DENN domain containing 2B
Synonyms: St5, 2610305K15Rik, 2010004M01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76954
Homologene: 3951
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, D230004K18Rik, b2b1625.2Clo, Gp330
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Socs3
Name: suppressor of cytokine signaling 3
Synonyms: STAT-induced STAT inhibitor 3, CIS3, cytokine-inducible SH2 protein 3, SSI-3, E2a-Pbx1 target gene in fibroblasts 10, EF-10, SOCS-3, Cish3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12702
Homologene: 2941
Btbd11
Name: BTB (POZ) domain containing 11
Synonyms: 6330404E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 74007
Homologene: 72536
Kansl1
Name: KAT8 regulatory NSL complex subunit 1
Synonyms: 1700081L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76719
Homologene: 9140
Trpm7
Name: transient receptor potential cation channel, subfamily M, member 7
Synonyms: 2310022G15Rik, 5033407O22Rik, CHAK1, TRP-PLIK, LTRPC7, 4833414K03Rik, Ltpr7, CHAK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 58800
Homologene: 9774
Mrpl20
Name: mitochondrial ribosomal protein L20
Synonyms: 2610008D01Rik, 4930425I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66448
Homologene: 9941
Suco
Name: SUN domain containing ossification factor
Synonyms: osteopotentia, AI848100, Opt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226551
HGNC: HGNC:1240
Homologene: 32212
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: MAP1C, Dnchc1, dynein heavy chain, retrograde transport, 9930018I23Rik, Dnec1, Loa, Swl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Axin2
Name: axin 2
Synonyms: Conductin, Axil
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12006
HGNC: HGNC:904
Homologene: 3420
Npas4
Name: neuronal PAS domain protein 4
Synonyms: Npas4, LE-PAS, Nxf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225872
VEGA: 19
Homologene: 15333
Ghsr
Name: growth hormone secretagogue receptor
Synonyms: C530020I22Rik, Ghsr1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 208188
HGNC: HGNC:4267
Homologene: 57161
Gprc5c
Name: G protein-coupled receptor, family C, group 5, member C
Synonyms: 1110028I06Rik, 3200002M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70355
Homologene: 11099
Pnkp
Name: polynucleotide kinase 3'- phosphatase
Synonyms: 1810009G08Rik, PNK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 59047
HGNC: HGNC:9154
Homologene: 5247
Galnt14
Name: polypeptide N-acetylgalactosaminyltransferase 14
Synonyms: 0610033M06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 71685
Homologene: 56997
Raf1
Name: v-raf-leukemia viral oncogene 1
Synonyms: v-Raf, Craf1, c-Raf, 6430402F14Rik, sarcoma 3611 oncogene, Raf-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 110157
HGNC: HGNC:9829
Homologene: 48145
Clk1
Name: CDC-like kinase 1
Synonyms: Clk1, STY
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12747
HGNC: HGNC:2068
Homologene: 101535
Hrob
Name: homologous recombination factor with OB-fold
Synonyms: BC030867
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217216
Homologene: 69368
Hoxb6
Name: homeobox B6
Synonyms: Hox-2.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15414
HGNC: HGNC:5117
Homologene: 7366
9930012K11Rik
Name: RIKEN cDNA 9930012K11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 268759
Homologene: 19540
Adam20
Name: a disintegrin and metallopeptidase domain 20
Synonyms: 4930529F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 384806
HGNC: HGNC:199
Homologene: 128364
Abcb4
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 4
Synonyms: Pgy2, Pgy-2, Mdr2, mdr-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18670
HGNC: HGNC:45
Homologene: 136368
Tet3
Name: tet methylcytosine dioxygenase 3
Synonyms: D230004J03Rik, B430006D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 194388
Homologene: 35360
Syde1
Name: synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
Synonyms: 1200008N06Rik, mSYD1A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71709
VEGA: 10
Homologene: 13195
Ephb6
Name: Eph receptor B6
Synonyms: Cekl, Mep
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13848
HGNC: HGNC:3396
Homologene: 20940
Hc
Name: hemolytic complement
Synonyms: C5a, He, Hfib2, C5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 15139
HGNC: HGNC:1331
Homologene: 20412
Ctss
Name: cathepsin S
Synonyms: Cat S
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13040
HGNC: HGNC:2545
Homologene: 20867
Mrgprx2
Name: MAS-related GPR, member X2
Synonyms: MrgB10, Mrgprb10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243978
Homologene: 24986
Wfdc6b
Name: WAP four-disulfide core domain 6B
Synonyms: Wfdc6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 433502
Homologene: 79014
Nek11
Name: NIMA (never in mitosis gene a)-related expressed kinase 11
Synonyms: 4932416N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208583
Homologene: 57008
Hykk
Name: hydroxylysine kinase 1
Synonyms: Agphd1, C630028N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235386
Homologene: 16057
Jade2
Name: jade family PHD finger 2
Synonyms: 1200017K05Rik, Phf15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76901
Homologene: 9082
Slc5a4b
Name: solute carrier family 5 (neutral amino acid transporters, system A), member 4b
Synonyms: pSGLT2, 2010104G07Rik, SGLT3b, SAAT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 64454
Homologene: 56968
Nostrin
Name: nitric oxide synthase trafficker
Synonyms: mDaIP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329416
Homologene: 43142
Vmn1r168
Name: vomeronasal 1 receptor 168
Synonyms: Gm10659
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100043101
Homologene: 122945
Psg18
Name: pregnancy specific glycoprotein 18
Synonyms: Cea3, Cea-3, mmCGM6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26438
Homologene: 110989
AI837181
Name: expressed sequence AI837181
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107242
Homologene: 12869
Dip2a
Name: disco interacting protein 2 homolog A
Synonyms: Kiaa0184-hp, 4931420H10Rik, Dip2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 64451
Homologene: 41012
Lrrc23
Name: leucine rich repeat containing 23
Synonyms: 4921537K05Rik, Lrpb7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16977
Homologene: 5082
Cd200
Name: CD200 antigen
Synonyms: Mox2, MRC OX-2, OX2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17470
HGNC: HGNC:7203
Homologene: 4344
BC051665
Name: cDNA sequence BC051665
Synonyms: cathepsin L-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218275
VEGA: 13
Homologene: 74298
Ankrd55
Name: ankyrin repeat domain 55
Synonyms: C030011J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 77318
VEGA: 13
Homologene: 12674
Fmo3
Name: flavin containing monooxygenase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14262
HGNC: HGNC:3771
Homologene: 128199
Csrnp2
Name: cysteine-serine-rich nuclear protein 2
Synonyms: CSRNP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 207785
VEGA: 15
Homologene: 32743
Stra6l
Name: STRA6-like
Synonyms: Rbpr2, 1300002K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74152
Homologene: 81924
1700014D04Rik
Name: RIKEN cDNA 1700014D04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 102638268
Homologene: 140986
Afg1l
Name: AFG1 like ATPase
Synonyms: Lace1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215951
Homologene: 5782
Gm17546
Name: predicted gene, 17546
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 102634389
VEGA: 15
Rps6-ps2
Name: ribosomal protein S6, pseudogene 2
Synonyms: Gm16406
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 675985
Anapc15
Name: anaphase promoting complex C subunit 15
Synonyms: 3200002M19Rik, 6330414C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 75430
Homologene: 87047
Dnase1l1
Name: deoxyribonuclease 1-like 1
Synonyms: 2310005K03Rik, Dnase1ll, G4.8, Dnl1ll
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 69537
HGNC: HGNC:2957
Homologene: 4896
Gm26515
Name: predicted gene, 26515
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 102639137
VEGA: 5
Ptges3l
Name: prostaglandin E synthase 3 like
Synonyms: 1700113I22Rik, 1110069E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 73635
Homologene: 101691
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 58,421,102 bp
  • G to A, chromosome 1 at 161,834,408 bp
  • T to C, chromosome 1 at 162,954,311 bp
  • A to G, chromosome 2 at 35,019,670 bp
  • T to A, chromosome 2 at 49,256,997 bp
  • T to C, chromosome 2 at 69,175,579 bp
  • T to A, chromosome 2 at 69,479,113 bp
  • G to A, chromosome 2 at 126,813,185 bp
  • A to G, chromosome 2 at 164,617,294 bp
  • T to C, chromosome 3 at 27,371,837 bp
  • C to T, chromosome 3 at 95,545,384 bp
  • A to G, chromosome 4 at 41,740,843 bp
  • G to A, chromosome 4 at 45,873,682 bp
  • A to G, chromosome 4 at 155,808,536 bp
  • C to T, chromosome 5 at 8,935,180 bp
  • T to C, chromosome 5 at 110,779,930 bp
  • A to T, chromosome 6 at 17,491,929 bp
  • G to A, chromosome 6 at 41,616,809 bp
  • A to T, chromosome 6 at 83,376,883 bp
  • T to A, chromosome 6 at 115,644,583 bp
  • G to A, chromosome 6 at 124,774,444 bp
  • A to T, chromosome 7 at 18,350,786 bp
  • A to T, chromosome 7 at 23,541,065 bp
  • C to T, chromosome 7 at 44,862,403 bp
  • A to T, chromosome 7 at 48,482,836 bp
  • T to A, chromosome 7 at 101,897,767 bp
  • C to A, chromosome 7 at 109,556,836 bp
  • A to G, chromosome 8 at 40,795,011 bp
  • T to G, chromosome 8 at 88,806,578 bp
  • A to G, chromosome 9 at 54,920,606 bp
  • T to A, chromosome 9 at 105,163,163 bp
  • G to A, chromosome 10 at 42,454,494 bp
  • A to G, chromosome 10 at 76,062,239 bp
  • A to G, chromosome 10 at 76,321,493 bp
  • A to T, chromosome 10 at 78,588,897 bp
  • A to G, chromosome 10 at 85,629,266 bp
  • T to C, chromosome 11 at 51,821,148 bp
  • G to A, chromosome 11 at 96,299,522 bp
  • A to T, chromosome 11 at 101,419,184 bp
  • A to G, chromosome 11 at 102,255,661 bp
  • A to T, chromosome 11 at 104,342,972 bp
  • A to G, chromosome 11 at 108,942,299 bp
  • G to T, chromosome 11 at 114,864,267 bp
  • A to G, chromosome 11 at 117,967,828 bp
  • C to A, chromosome 12 at 110,658,126 bp
  • T to C, chromosome 13 at 59,742,233 bp
  • T to C, chromosome 13 at 60,784,081 bp
  • A to C, chromosome 13 at 112,363,454 bp
  • T to A, chromosome 14 at 70,155,943 bp
  • C to A, chromosome 15 at 95,829,962 bp
  • A to T, chromosome 15 at 100,484,690 bp
  • C to T, chromosome 16 at 45,392,301 bp
  • A to T, chromosome 17 at 73,536,893 bp
  • C to A, chromosome 19 at 4,986,777 bp
  • A to G, chromosome 19 at 5,426,301 bp
  • C to T, chromosome X at 74,277,038 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4846 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042459-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.