Strain Name:
C57BL/6J-MtgxR4861Btlr/Mmmh
Stock Number:
042472-MU
Citation ID:
RRID:MMRRC_042472-MU
Other Names:
R4861 (G1), C57BL/6J-MtgxR4861Btlr
Major Collection:

Gene Information

Hapln1
Name: hyaluronan and proteoglycan link protein 1
Synonyms: link protein, CLP, LP-1, Crtl1, Crtl1l, cartilage linking protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 12950
VEGA: 13
HGNC: HGNC:2380
Homologene: 1420
Sp4
Name: trans-acting transcription factor 4
Synonyms: 5730497N03Rik, HF1-b, HF-1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20688
VEGA: 12
Homologene: 2341
Plg
Name: plasminogen
Synonyms: Pg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18815
VEGA: 17
HGNC: HGNC:9071
Homologene: 55452
Ncoa7
Name: nuclear receptor coactivator 7
Synonyms: 9030406N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 211329
VEGA: 10
Homologene: 65245
Rapgef2
Name: Rap guanine nucleotide exchange factor (GEF) 2
Synonyms: RA-GEF-1, Pdzgef1, 5830453M24Rik, nRapGEP, CNRasGEF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76089
Homologene: 35477
Smc2
Name: structural maintenance of chromosomes 2
Synonyms: Smc2l1, CAP-E, Fin16, 5730502P04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14211
Homologene: 4705
Nr5a2
Name: nuclear receptor subfamily 5, group A, member 2
Synonyms: D1Ertd308e, UF2-H3B, LRH-1, Ftf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 26424
HGNC: HGNC:7984
Homologene: 20827
Cdk13
Name: cyclin-dependent kinase 13
Synonyms: Cdc2l5, 2310015O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69562
VEGA: 13
HGNC: HGNC:1733
Homologene: 135707
Tbcd
Name: tubulin-specific chaperone d
Synonyms: 2310057L06Rik, A030005L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 108903
Homologene: 4368
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: Loa, 9930018I23Rik, MAP1C, Dnec1, Swl, Dnchc1, dynein heavy chain, retrograde transport
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Ice2
Name: interactor of little elongation complex ELL subunit 2
Synonyms: B230343B06Rik, Narg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 93697
Homologene: 11618
Pnkp
Name: polynucleotide kinase 3'- phosphatase
Synonyms: 1810009G08Rik, PNK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 59047
HGNC: HGNC:9154
Homologene: 5247
Mvk
Name: mevalonate kinase
Synonyms: 2310010A05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17855
HGNC: HGNC:7530
Homologene: 372
Lctl
Name: lactase-like
Synonyms: KLPH, E130104I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235435
Homologene: 70710
Mzt1
Name: mitotic spindle organizing protein 1
Synonyms: 2410129H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 76789
VEGA: 14
Homologene: 45495
Frmd6
Name: FERM domain containing 6
Synonyms: 2610019M19Rik, 4930488L10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319710
VEGA: 12
Homologene: 12449
Uncx
Name: UNC homeobox
Synonyms: Chx4, Uncx4.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22255
Homologene: 56598
Car3
Name: carbonic anhydrase 3
Synonyms: Car-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12350
HGNC: HGNC:1374
Homologene: 31298
Npy4r
Name: neuropeptide Y receptor Y4
Synonyms: Y4, NYYR-D, Ppyr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19065
VEGA: 14
HGNC: HGNC:9329
Homologene: 38119
Dbt
Name: dihydrolipoamide branched chain transacylase E2
Synonyms: dihydrolipoyl transacylase, D3Wsu60e, dihydrolipoyllysine-residue (2-methylpropanoyl)transferase, BCKAD E2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13171
HGNC: HGNC:2698
Homologene: 1444
Abcb11
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 11
Synonyms: Bsep, sister of P-glycoprotein, PFIC2, ABC16, PGY4, Lith1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 27413
HGNC: HGNC:42
Homologene: 74509
Gm5800
Name: predicted gene 5800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 545047
Homologene: 128452
Farp2
Name: FERM, RhoGEF and pleckstrin domain protein 2
Synonyms: D030026M03Rik, Fir
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227377
Homologene: 8877
Slc47a2
Name: solute carrier family 47, member 2
Synonyms: 4933429E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380701
Homologene: 134426
Alpi
Name: alkaline phosphatase, intestinal
Synonyms: 2010001C14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 76768
Homologene: 122414
Vars2
Name: valyl-tRNA synthetase 2, mitochondrial
Synonyms: 1190004I24Rik, Vars2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 68915
Homologene: 57502
Arfgef3
Name: ARFGEF family member 3
Synonyms: D10Bwg1379e, B930094H20Rik, BIG3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215821
VEGA: 10
Homologene: 41366
Slco1b2
Name: solute carrier organic anion transporter family, member 1b2
Synonyms: Oatp1b2, mlst-1, Slc21a6, Slc21a10, 7330442B20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 28253
Homologene: 75119
Slc41a2
Name: solute carrier family 41, member 2
Synonyms: A230035L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 338365
Homologene: 9870
Tas2r117
Name: taste receptor, type 2, member 117
Synonyms: Tas2r17, T2R17, mt2r54, mGR17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 353166
Homologene: 130073
Odad1
Name: outer dynein arm docking complex subunit 1
Synonyms: Ccdc114
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 211535
Homologene: 128610
Ahcy
Name: S-adenosylhomocysteine hydrolase
Synonyms: CuBP, SAHH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269378
HGNC: HGNC:343
Homologene: 554
Thumpd2
Name: THUMP domain containing 2
Synonyms: 2810025A12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72167
VEGA: 17
Homologene: 11898
Cept1
Name: choline/ethanolaminephosphotransferase 1
Synonyms: 9930118K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99712
Homologene: 81624
Dnase1l1
Name: deoxyribonuclease 1-like 1
Synonyms: G4.8, Dnase1ll, 2310005K03Rik, Dnl1ll
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 69537
HGNC: HGNC:2957
Homologene: 4896
Gm26727
Name: predicted gene, 26727
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 87,100,469 bp
  • T to C, chromosome 1 at 93,605,419 bp
  • A to G, chromosome 1 at 136,948,720 bp
  • T to C, chromosome 2 at 67,432,945 bp
  • C to T, chromosome 2 at 69,245,905 bp
  • T to C, chromosome 2 at 155,060,516 bp
  • T to C, chromosome 3 at 14,866,896 bp
  • T to C, chromosome 3 at 79,074,436 bp
  • A to C, chromosome 3 at 106,505,732 bp
  • A to T, chromosome 3 at 116,548,078 bp
  • G to A, chromosome 4 at 52,461,090 bp
  • C to T, chromosome 5 at 114,460,197 bp
  • C to T, chromosome 5 at 139,544,567 bp
  • T to C, chromosome 6 at 132,803,129 bp
  • A to T, chromosome 6 at 141,671,222 bp
  • C to T, chromosome 7 at 44,862,403 bp
  • A to G, chromosome 7 at 45,942,873 bp
  • T to C, chromosome 9 at 64,119,763 bp
  • T to A, chromosome 9 at 69,415,448 bp
  • G to A, chromosome 10 at 18,607,731 bp
  • T to A, chromosome 10 at 30,704,612 bp
  • T to C, chromosome 10 at 83,316,458 bp
  • A to T, chromosome 11 at 61,336,233 bp
  • C to T, chromosome 11 at 121,601,961 bp
  • T to G, chromosome 12 at 70,893,726 bp
  • C to A, chromosome 12 at 110,658,126 bp
  • G to T, chromosome 12 at 118,300,811 bp
  • A to T, chromosome 13 at 17,766,586 bp
  • G to A, chromosome 13 at 89,601,452 bp
  • C to T, chromosome 14 at 34,146,883 bp
  • T to A, chromosome 14 at 51,716,047 bp
  • T to C, chromosome 14 at 99,047,474 bp
  • G to A, chromosome 17 at 12,395,735 bp
  • G to T, chromosome 17 at 35,661,933 bp
  • A to G, chromosome 17 at 81,026,801 bp
  • C to T, chromosome X at 74,277,038 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4861 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042472-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.