Strain Name:
C57BL/6J-MtgxR4920Btlr/Mmmh
Stock Number:
042522-MU
Citation ID:
RRID:MMRRC_042522-MU
Other Names:
R4920 (G1), C57BL/6J-MtgxR4920Btlr
Major Collection:

Strain Information

Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Glrx3
Name: glutaredoxin 3
Synonyms: PKC interacting cousin of thioredoxin, PICOT, Txnl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 30926
Homologene: 4769
Tbc1d22a
Name: TBC1 domain family, member 22a
Synonyms: D15Ertd781e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223754
VEGA: 15
HGNC: HGNC:1309
Homologene: 105406
Rfc1
Name: replication factor C (activator 1) 1
Synonyms: RFC140, Alp145, 140kDa, Recc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19687
HGNC: HGNC:9969
Homologene: 2187
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: Lba, D3Ertd775e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Psmd1
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
Synonyms: P112, S1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70247
HGNC: HGNC:9554
Homologene: 2100
Brca1
Name: breast cancer 1, early onset
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12189
HGNC: HGNC:1100
Homologene: 5276
Bmal1
Name: basic helix-loop-helix ARNT like 1
Synonyms: Arnt3, MOP3, bHLHe5, Arntl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11865
HGNC: HGNC:701
Homologene: 910
Ccdc141
Name: coiled-coil domain containing 141
Synonyms: ENSMUSG00000075261, CAMDI, 2610301F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 545428
Homologene: 52149
Fam171b
Name: family with sequence similarity 171, member B
Synonyms: D430039N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241520
Homologene: 18462
Adcy4
Name: adenylate cyclase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 104110
VEGA: 14
HGNC: HGNC:235
Homologene: 23149
Polr2b
Name: polymerase (RNA) II (DNA directed) polypeptide B
Synonyms: RPB2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231329
HGNC: HGNC:9188
Homologene: 722
Tent2
Name: terminal nucleotidyltransferase 2
Synonyms: 8030446C20Rik, Papd4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 100715
VEGA: 13
Homologene: 44022
Rrn3
Name: RRN3 RNA polymerase I transcription factor homolog (yeast)
Synonyms: E130302O19Rik, TIF-1A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 106298
VEGA: 16
Homologene: 39531
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: 4833421P10Rik, A130030D10Rik, 1110059H15Rik, Zfp650
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68795
Homologene: 52092
Cpa4
Name: carboxypeptidase A4
Synonyms: 1110019K20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 71791
Homologene: 56753
Fcrl5
Name: Fc receptor-like 5
Synonyms: BXMAS1-like protein 2, Fcrh3, mBXMH2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329693
Homologene: 137404
Grhl3
Name: grainyhead like transcription factor 3
Synonyms: Som, Get1, ct
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230824
Homologene: 18864
Dync1i2
Name: dynein cytoplasmic 1 intermediate chain 2
Synonyms: 3110079H08Rik, Dncic2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13427
HGNC: HGNC:2964
Homologene: 37921
Slc9a2
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 2
Synonyms: NHE2, 4932415O19Rik, 2210416H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226999
Homologene: 20661
Nek10
Name: NIMA (never in mitosis gene a)- related kinase 10
Synonyms: LOC238944
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 674895
Homologene: 130947
Mfsd13a
Name: major facilitator superfamily domain containing 13a
Synonyms: 4930449A08Rik, 4930538D17Rik, Tmem180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 75146
Homologene: 12592
Ces2b
Name: carboxyesterase 2B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234669
HGNC: HGNC:1864
Homologene: 135851
Gm973
Name: predicted gene 973
Synonyms: LOC381260
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381260
Homologene: 124277
Fam83b
Name: family with sequence similarity 83, member B
Synonyms: C530008M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208994
Homologene: 19478
Dennd3
Name: DENN domain containing 3
Synonyms: E030003N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105841
Homologene: 28254
Pramel23
Name: PRAME like 23
Synonyms: Gm13089
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 277667
Ofcc1
Name: orofacial cleft 1 candidate 1
Synonyms: ojoplano, Opo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218165
VEGA: 13
Homologene: 125376
Dpy19l3
Name: dpy-19-like 3 (C. elegans)
Synonyms: 9330164H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233115
Homologene: 18692
Ccr9
Name: chemokine (C-C motif) receptor 9
Synonyms: GPR-9-6, Cmkbr10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12769
HGNC: HGNC:1610
Homologene: 22546
Vmn2r96
Name: vomeronasal 2, receptor 96
Synonyms: EG433070
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 433070
Ear2
Name: eosinophil-associated, ribonuclease A family, member 2
Synonyms: eosinophil-derived neurotoxin, liver, Rnase2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 13587
Homologene: 40596
Pgm1
Name: phosphoglucomutase 1
Synonyms: Pgm-2, 2610020G18Rik, Pgm1a, Pgm2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72157
HGNC: HGNC:8905
Homologene: 1979
Apbb1ip
Name: amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
Synonyms: proline-rich protein 48, Prp48, 9930118P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 54519
Homologene: 32434
Lca5l
Name: Leber congenital amaurosis 5-like
Synonyms: 4921526F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 385668
HGNC: HGNC:1255
Homologene: 47978
Arhgef16
Name: Rho guanine nucleotide exchange factor (GEF) 16
Synonyms: Neuroblastoma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230972
Homologene: 82484
Smo
Name: smoothened, frizzled class receptor
Synonyms: E130215L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 319757
Homologene: 4115
Dtwd2
Name: DTW domain containing 2
Synonyms: 8030470C17Rik, 1190002H09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 68857
Homologene: 79701
Galntl6
Name: UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
Synonyms: 1700021K10Rik, 4930431L04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 270049
Homologene: 65137
Gsdmd
Name: gasdermin D
Synonyms: M2-4, DF5L, 1810036L03Rik, Dfna5l, Gsdmdc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 69146
VEGA: 15
Homologene: 12299
Sap25
Name: sin3 associated polypeptide
Synonyms: 25 kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 751865
Homologene: 104044
Zfp189
Name: zinc finger protein 189
Synonyms: C430015I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230162
Homologene: 20737
1700092K14Rik
Name: RIKEN cDNA 1700092K14 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 73536
Ighv14-3
Name: immunoglobulin heavy variable V14-3
Synonyms: Gm16840
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238418
Gm14488
Name: predicted gene 14488
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 100038700
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 40,755,718 bp
  • T to C, chromosome 1 at 59,627,566 bp
  • T to C, chromosome 1 at 86,132,749 bp
  • A to G, chromosome 2 at 22,819,684 bp
  • A to T, chromosome 2 at 30,715,032 bp
  • A to G, chromosome 2 at 69,952,868 bp
  • G to A, chromosome 2 at 71,247,324 bp
  • T to C, chromosome 2 at 77,168,563 bp
  • A to G, chromosome 2 at 83,880,359 bp
  • T to A, chromosome 3 at 86,664,458 bp
  • T to G, chromosome 3 at 87,444,173 bp
  • G to A, chromosome 4 at 49,529,302 bp
  • C to T, chromosome 4 at 99,986,733 bp
  • T to A, chromosome 4 at 135,559,104 bp
  • T to C, chromosome 4 at 143,699,283 bp
  • T to C, chromosome 4 at 154,279,735 bp
  • C to A, chromosome 5 at 65,287,928 bp
  • T to C, chromosome 5 at 77,306,487 bp
  • T to A, chromosome 5 at 137,642,245 bp
  • T to C, chromosome 6 at 29,759,594 bp
  • T to C, chromosome 6 at 30,568,463 bp
  • A to T, chromosome 7 at 35,708,042 bp
  • A to G, chromosome 7 at 113,285,114 bp
  • A to G, chromosome 7 at 137,464,130 bp
  • T to C, chromosome 8 at 58,427,773 bp
  • T to C, chromosome 8 at 104,836,906 bp
  • G to A, chromosome 9 at 76,491,868 bp
  • G to T, chromosome 9 at 123,779,439 bp
  • A to T, chromosome 11 at 101,524,959 bp
  • A to T, chromosome 11 at 114,199,045 bp
  • A to G, chromosome 12 at 114,060,257 bp
  • T to C, chromosome 13 at 13,647,060 bp
  • G to A, chromosome 13 at 40,015,388 bp
  • G to A, chromosome 13 at 93,186,325 bp
  • T to A, chromosome 14 at 14,860,986 bp
  • G to A, chromosome 14 at 44,103,125 bp
  • C to T, chromosome 14 at 55,779,029 bp
  • A to G, chromosome 15 at 73,540,725 bp
  • T to C, chromosome 15 at 75,864,357 bp
  • A to C, chromosome 15 at 86,311,748 bp
  • A to G, chromosome 16 at 13,790,639 bp
  • T to A, chromosome 16 at 96,178,835 bp
  • A to G, chromosome 17 at 18,582,656 bp
  • G to T, chromosome 18 at 49,698,440 bp
  • T to G, chromosome 19 at 46,367,216 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4920 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042522-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.