Strain Name:
C57BL/6J-MtgxR4929Btlr/Mmmh
Stock Number:
042530-MU
Citation ID:
RRID:MMRRC_042530-MU
Other Names:
R4929 (G1), C57BL/6J-MtgxR4929Btlr
Major Collection:

Gene Information

Wasf2
Name: WAS protein family, member 2
Synonyms: WAVE2, D4Ertd13e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 242687
Homologene: 86743
Olr1
Name: oxidized low density lipoprotein (lectin-like) receptor 1
Synonyms: SR-EI, Scare1, LOX-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 108078
HGNC: HGNC:8133
Homologene: 1910
Jam2
Name: junction adhesion molecule 2
Synonyms: 2410030G21Rik, Jcam2, 2410167M24Rik, JAM-2, VE-JAM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 67374
Homologene: 10929
Itga5
Name: integrin alpha 5 (fibronectin receptor alpha)
Synonyms: Cd49e, Fnra
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 16402
VEGA: 15
HGNC: HGNC:6141
Homologene: 20508
Grhl2
Name: grainyhead like transcription factor 2
Synonyms: 0610015A08Rik, clft3, Tcfcp2l3, grainyheadlike, BOM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 252973
HGNC: HGNC:2799
Homologene: 32616
Thada
Name: thyroid adenoma associated
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 240174
VEGA: 17
Homologene: 75175
Aurka
Name: aurora kinase A
Synonyms: IAK1, aurora A, Ark1, Ayk1, Aurora-A, IAK, AIRK1, Stk6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20878
Homologene: 2670
Stx16
Name: syntaxin 16
Synonyms: 6330500A18Rik, SYN16, 5430410K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228960
Homologene: 2791
Tfcp2
Name: transcription factor CP2
Synonyms: LSF, UBP-1, CP-2, LBP-1c, LBP-1d, Tcfcp2, LBP1, D230015P20Rik, CP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 21422
VEGA: 15
Homologene: 4134
Ssr3
Name: signal sequence receptor, gamma
Synonyms: Trap-gamma, translocon-associated protein gamma, 0610038P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 67437
Homologene: 5154
Mycbp
Name: MYC binding protein
Synonyms: 5730488M09Rik, Amy-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 56309
HGNC: HGNC:7554
Homologene: 49312
Vamp2
Name: vesicle-associated membrane protein 2
Synonyms: sybII, synaptobrevin-2, synaptobrevin II, Syb-2, Syb2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 22318
Homologene: 7591
Trf
Name: transferrin
Synonyms: Tfn, HP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 22041
Homologene: 68153
Sox8
Name: SRY (sex determining region Y)-box 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 20681
Homologene: 7950
Lepr
Name: leptin receptor
Synonyms: Leprb, LEPROT, Modb1, OB-RGRP, leptin receptor gene-related protein, obl, obese-like, Obr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 16847
HGNC: HGNC:6554
Homologene: 1731
Abcd3
Name: ATP-binding cassette, sub-family D (ALD), member 3
Synonyms: Pxmp1, PMP70
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 19299
HGNC: HGNC:67
Homologene: 2140
Adamts12
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 239337
VEGA: 15
Homologene: 12808
Mxra8
Name: matrix-remodelling associated 8
Synonyms: 1200013A08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 74761
HGNC: HGNC:7542
Homologene: 11500
Pop4
Name: processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae)
Synonyms: Rpp29, 1110023P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 66161
Homologene: 31392
Fam135a
Name: family with sequence similarity 135, member A
Synonyms: 4921533L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 68187
Homologene: 32665
Lzic
Name: leucine zipper and CTNNBIP1 domain containing
Synonyms: 1810030J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 69151
Homologene: 12301
Ints2
Name: integrator complex subunit 2
Synonyms: 2810417D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 70422
Homologene: 10801
Naa40
Name: N(alpha)-acetyltransferase 40, NatD catalytic subunit
Synonyms: Nat11, 4931433E08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 70999
VEGA: 19
Homologene: 41588
Pgam5
Name: phosphoglycerate mutase family member 5
Synonyms: 2610528A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 72542
Homologene: 14597
Garnl3
Name: GTPase activating RANGAP domain-like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 99326
Homologene: 13003
Nbeal1
Name: neurobeachin like 1
Synonyms: ALS2CR17, 2310076G13Rik, A530083I02Rik, A530050O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 269198
Homologene: 16453
Ehbp1
Name: EH domain binding protein 1
Synonyms: Flj21950, KIAA0903-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216565
Homologene: 22880
Cep57l1
Name: centrosomal protein 57-like 1
Synonyms: 4930484D11Rik, 2410017P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 103268
Homologene: 12254
Ptgr1
Name: prostaglandin reductase 1
Synonyms: Zadh3, 2510002C21Rik, Ltb4dh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 67103
Homologene: 40820
4930432E11Rik
Name: RIKEN cDNA 4930432E11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 243900
Itga9
Name: integrin alpha 9
Synonyms: 6720458D17Rik, D9Ertd428e, 2610002H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 104099
HGNC: HGNC:6145
Homologene: 1664
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 545030
Homologene: 83473
Dym
Name: dymeclin
Synonyms: C030019K18Rik, 4933427L07Rik, 1810041M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 69190
VEGA: 18
Homologene: 69237
Olfr183
Name: olfactory receptor 183
Synonyms: GA_x54KRFPKG5P-55229158-55230087, MOR183-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 258478
Homologene: 27178
Slfn10-ps
Name: schlafen 10, pseudogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237887
Dpp6
Name: dipeptidylpeptidase 6
Synonyms: LOC384168, Rw, B930011P16Rik, Peplb, In(5)6H-p, Dpp-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 13483
HGNC: HGNC:3010
Homologene: 22560
Klhl32
Name: kelch-like 32
Synonyms: 6430524H05Rik, LOC384000, D4Ertd389e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 212390
Homologene: 14173
Shank2
Name: SH3 and multiple ankyrin repeat domains 2
Synonyms: ProSAP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 210274
Homologene: 105965
Cdh24
Name: cadherin-like 24
Synonyms: cadherin 14-like, ENSMUSG00000022188, EY-cadherin, 1700040A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 239096
VEGA: 14
Homologene: 56951
Vmn2r105
Name: vomeronasal 2, receptor 105
Synonyms: EG627743
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 627743
Homologene: 129680
Arfgef3
Name: ARFGEF family member 3
Synonyms: B930094H20Rik, D10Bwg1379e, BIG3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 215821
VEGA: 10
Homologene: 41366
Adamtsl4
Name: ADAMTS-like 4
Synonyms: Tsrc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229595
Homologene: 23141
Filip1
Name: filamin A interacting protein 1
Synonyms: FILIP, 5730485H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 70598
Homologene: 6700
Olfr686
Name: olfactory receptor 686
Synonyms: MOR35-1, GA_x6K02T2PBJ9-7832633-7831680
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 259072
Homologene: 17487
Cntn5
Name: contactin 5
Synonyms: A830025P08Rik, NB-2, 6720426O10Rik, LOC244683
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 244682
HGNC: HGNC:2175
Homologene: 28447
Zfp229
Name: zinc finger protein 229
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 381067
Homologene: 136287
Efcab5
Name: EF-hand calcium binding domain 5
Synonyms: 4930563A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 319634
Homologene: 63366
Ccdc144b
Name: coiled-coil domain containing 144B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 241943
Homologene: 87263
Epha1
Name: Eph receptor A1
Synonyms: 5730453L17Rik, Esk, Eph
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 13835
HGNC: HGNC:3385
Homologene: 3835
Lrrc3b
Name: leucine rich repeat containing 3B
Synonyms: LRP15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 218763
VEGA: 14
Homologene: 14190
Psg16
Name: pregnancy specific glycoprotein 16
Synonyms: bCEA, Cea11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 26436
Vmn2r12
Name: vomeronasal 2, receptor 12
Synonyms: Gm6769
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 627569
Homologene: 129606
Haus6
Name: HAUS augmin-like complex, subunit 6
Synonyms: 6230416J20Rik, D4Ertd27e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230376
Homologene: 9760
Prpf18
Name: pre-mRNA processing factor 18
Synonyms: 2810441A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 67229
Homologene: 2726
Col10a1
Name: collagen, type X, alpha 1
Synonyms: Col10, Col10a-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 12813
HGNC: HGNC:2185
Homologene: 55466
Zfp703
Name: zinc finger protein 703
Synonyms: Zeppo1, Csmn1, End2, 1110032O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 353310
Homologene: 81391
Olfr259
Name: olfactory receptor 259
Synonyms: GA_x6K02T2N869-1820-882, MOR172-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258766
Homologene: 106833
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 24,030,000 bp
  • C to T, chromosome 1 at 60,238,654 bp
  • A to T, chromosome 2 at 4,624,537 bp
  • G to A, chromosome 2 at 33,007,262 bp
  • A to G, chromosome 2 at 87,108,183 bp
  • A to T, chromosome 2 at 172,370,406 bp
  • T to C, chromosome 2 at 174,096,928 bp
  • G to A, chromosome 3 at 36,035,338 bp
  • A to G, chromosome 3 at 65,387,754 bp
  • A to G, chromosome 3 at 95,678,005 bp
  • A to T, chromosome 3 at 121,768,746 bp
  • T to A, chromosome 4 at 24,709,030 bp
  • C to A, chromosome 4 at 58,981,879 bp
  • T to C, chromosome 4 at 86,595,433 bp
  • A to G, chromosome 4 at 101,815,117 bp
  • A to G, chromosome 4 at 123,909,954 bp
  • C to A, chromosome 4 at 133,195,859 bp
  • T to A, chromosome 4 at 149,488,128 bp
  • T to A, chromosome 4 at 155,842,661 bp
  • G to A, chromosome 5 at 27,049,787 bp
  • A to T, chromosome 5 at 109,091,678 bp
  • A to T, chromosome 5 at 110,265,825 bp
  • C to A, chromosome 6 at 42,364,599 bp
  • T to C, chromosome 6 at 129,500,081 bp
  • G to A, chromosome 7 at 17,095,106 bp
  • A to G, chromosome 7 at 29,574,042 bp
  • A to G, chromosome 7 at 38,266,149 bp
  • A to G, chromosome 7 at 105,204,025 bp
  • A to G, chromosome 7 at 144,411,271 bp
  • T to A, chromosome 8 at 26,978,851 bp
  • T to A, chromosome 9 at 9,976,395 bp
  • T to C, chromosome 9 at 79,819,747 bp
  • G to T, chromosome 9 at 103,227,875 bp
  • C to A, chromosome 9 at 118,807,249 bp
  • T to A, chromosome 10 at 18,630,851 bp
  • T to C, chromosome 10 at 34,395,124 bp
  • T to C, chromosome 10 at 41,745,914 bp
  • T to G, chromosome 11 at 22,239,169 bp
  • T to A, chromosome 11 at 69,088,662 bp
  • T to G, chromosome 11 at 77,103,383 bp
  • A to G, chromosome 11 at 83,029,519 bp
  • G to T, chromosome 11 at 86,212,653 bp
  • C to A, chromosome 14 at 15,357,888 bp
  • T to C, chromosome 14 at 33,047,256 bp
  • C to T, chromosome 14 at 54,633,516 bp
  • C to T, chromosome 15 at 11,259,022 bp
  • A to G, chromosome 15 at 37,360,802 bp
  • A to T, chromosome 15 at 100,528,489 bp
  • A to G, chromosome 15 at 103,353,235 bp
  • A to C, chromosome 16 at 59,000,219 bp
  • G to A, chromosome 16 at 84,822,862 bp
  • A to T, chromosome 17 at 20,228,018 bp
  • T to A, chromosome 17 at 21,746,373 bp
  • G to A, chromosome 17 at 25,570,356 bp
  • T to C, chromosome 17 at 84,444,226 bp
  • T to A, chromosome 18 at 75,243,286 bp
  • A to G, chromosome 19 at 7,229,982 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4929 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042530-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.