Strain Name:
C57BL/6J-MtgxR4988Btlr/Mmmh
Stock Number:
042582-MU
Citation ID:
RRID:MMRRC_042582-MU
Other Names:
R4988 (G1), C57BL/6J-MtgxR4988Btlr
Major Collection:

Gene Information

Ctnnal1
Name: catenin (cadherin associated protein), alpha-like 1
Synonyms: Catnal1, ACRP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 54366
HGNC: HGNC:2512
Homologene: 2815
Mta1
Name: metastasis associated 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 116870
HGNC: HGNC:7410
Homologene: 3442
Proser1
Name: proline and serine rich 1
Synonyms: 2810046L04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 212127
Homologene: 13463
Akap13
Name: A kinase (PRKA) anchor protein 13
Synonyms: 1700026G02Rik, 5830460E08Rik, 5730522G15Rik, AKAP-Lbc, PROTO-LBC, PROTO-LB, Ht31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 75547
HGNC: HGNC:371
Homologene: 4903
Myo18a
Name: myosin XVIIIA
Synonyms: MyoPDZ
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 360013
Homologene: 7977
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: Dnec1, dynein heavy chain, retrograde transport, MAP1C, 9930018I23Rik, Swl, Loa, Dnchc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Cdc27
Name: cell division cycle 27
Synonyms: APC3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217232
HGNC: HGNC:1728
Homologene: 960
St7
Name: suppression of tumorigenicity 7
Synonyms: Fam4a2, TSG7, SEN4, HELG, 9430001H04Rik, RAY1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 64213
Homologene: 10185
Acaca
Name: acetyl-Coenzyme A carboxylase alpha
Synonyms: acetyl-CoA carboxylase, LOC327983, Acac, A530025K05Rik, Acc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 107476
HGNC: HGNC:84
Homologene: 31015
Clec3a
Name: C-type lectin domain family 3, member a
Synonyms: 1110019O10Rik, Clecsf1, LOC330844
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 403395
HGNC: HGNC:2052
Homologene: 4205
Mtus1
Name: mitochondrial tumor suppressor 1
Synonyms: Atip1, MTSG1, B430305I03Rik, MD44
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 102103
Homologene: 100292
Nepro
Name: nucleolus and neural progenitor protein
Synonyms: BC027231
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 212547
Homologene: 9127
Nbas
Name: neuroblastoma amplified sequence
Synonyms: 4933425L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 71169
VEGA: 12
Homologene: 41073
Nutm2
Name: NUT family member 2
Synonyms: Gm806, LOC328250
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 328250
Homologene: 128615
Dhx57
Name: DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 106794
VEGA: 17
Homologene: 56267
Abcb11
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 11
Synonyms: sister of P-glycoprotein, Lith1, Bsep, PFIC2, ABC16, PGY4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 27413
HGNC: HGNC:42
Homologene: 74509
Farp1
Name: FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)
Synonyms: Cdep
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 223254
HGNC: HGNC:3591
Homologene: 38098
Vwa8
Name: von Willebrand factor A domain containing 8
Synonyms: 4932416F07Rik, 1300010F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 219189
VEGA: 14
Homologene: 44881
Cpd
Name: carboxypeptidase D
Synonyms: D830034L15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 12874
HGNC: HGNC:2301
Homologene: 999
Zfp14
Name: zinc finger protein 14
Synonyms: 4732429I09Rik, Krox-9, Zfp-14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 243906
Homologene: 45619
Skint10
Name: selection and upkeep of intraepithelial T cells 10
Synonyms: A030001H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230613
Homologene: 136292
Col9a1
Name: collagen, type IX, alpha 1
Synonyms: Col9a-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12839
HGNC: HGNC:2217
Homologene: 1393
Olfr347
Name: olfactory receptor 347
Synonyms: MOR136-9, GA_x6K02T2NLDC-33428755-33429693
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258945
Homologene: 51790
Map1a
Name: microtubule-associated protein 1 A
Synonyms: Mtap1, 6330416M19Rik, Mtap-1, Mtap1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17754
HGNC: HGNC:6835
Homologene: 1778
Ccdc7b
Name: coiled-coil domain containing 7B
Synonyms: 1700008F21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 75453
Homologene: 49919
Slc6a19
Name: solute carrier family 6 (neurotransmitter transporter), member 19
Synonyms: B0AT1, 4632401C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 74338
Homologene: 52819
Ces1c
Name: carboxylesterase 1C
Synonyms: Es-1, Es-N, Es1, Es-4, Ces-N, Ee-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 13884
HGNC: HGNC:1863
Homologene: 117484
Rassf8
Name: Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
Synonyms: mHoj-1, 5133400D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 71323
Homologene: 5219
Pon3
Name: paraoxonase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 269823
HGNC: HGNC:9206
Homologene: 37371
Pcdhb15
Name: protocadherin beta 15
Synonyms: Pcdhb7, PcdhbO
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 93886
HGNC: HGNC:8692
Homologene: 32429
Efcab5
Name: EF-hand calcium binding domain 5
Synonyms: 4930563A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 319634
Homologene: 63366
Gm10717
Name: predicted gene 10717
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
Olfr982
Name: olfactory receptor 982
Synonyms: GA_x6K02T2PVTD-33772307-33773260, MOR223-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258853
VEGA: 9
Homologene: 17415
AA986860
Name: expressed sequence AA986860
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 212439
Homologene: 49741
Hint2
Name: histidine triad nucleotide binding protein 2
Synonyms: 1190005L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 68917
Homologene: 13072
St8sia4
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
Synonyms: PST, ST8SiaIV, Siat8d, PST-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 20452
Homologene: 4147
Elp5
Name: elongator acetyltransferase complex subunit 5
Synonyms: Clone 13u, Rai12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 54351
Homologene: 10291
Hhat
Name: hedgehog acyltransferase
Synonyms: Skn, 2810432O22Rik, AP-2CRE, Tg(TFAP2A-cre)1Will
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226861
Homologene: 41232
Asgr2
Name: asialoglycoprotein receptor 2
Synonyms: Asgr-2, Asgr, ASGPR2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 11890
HGNC: HGNC:743
Homologene: 912
Polm
Name: polymerase (DNA directed), mu
Synonyms: Tdt-N, B230309I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 54125
HGNC: HGNC:9185
Homologene: 41170
Ndst1
Name: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
Synonyms: Hsst, b2b2230Clo, 1200015G06Rik, Ndst-1, glucosaminyl N-deacetylase/N-sulfotransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 15531
VEGA: 18
HGNC: HGNC:7680
Homologene: 20386
Gpr156
Name: G protein-coupled receptor 156
Synonyms: Gababl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 239845
VEGA: 16
Homologene: 17683
Klrc2
Name: killer cell lectin-like receptor subfamily C, member 2
Synonyms: NKG2C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 16642
HGNC: HGNC:6375
Homologene: 130643
Olfr798
Name: olfactory receptor 798
Synonyms: MOR108-1, GA_x6K02T2PULF-11304679-11303744
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 258549
Homologene: 133881
Amy2b
Name: amylase 2b
Synonyms: mAmy2-1, Amy2-2, Amy-X
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 545562
Olfr165
Name: olfactory receptor 165
Synonyms: MOR279-1, GA_x54KRFPKG5P-15855164-15854223
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 258458
Homologene: 128262
H2-Ke6
Name: H2-K region expressed gene 6
Synonyms: Ring2, H-2Ke6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 14979
HGNC: HGNC:3554
Homologene: 56588
Fam210a
Name: family with sequence similarity 210, member A
Synonyms: 4933403F05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 108654
Homologene: 34981
Gm1758
Name: predicted gene 1758
Synonyms: LOC385737
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
Hps4
Name: HPS4, biogenesis of lysosomal organelles complex 3 subunit 2
Synonyms: BLOC-3, C130020P05Rik, 2010205O06Rik, Hermansky-Pudlak syndrome 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 192232
Homologene: 11123
Fmc1
Name: formation of mitochondrial complex V assembly factor 1
Synonyms: 1110001J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 66117
Homologene: 41627
Trav16
Name: T cell receptor alpha variable 16
Synonyms: Gm13896
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 195297
AC107766.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 24,185,192 bp
  • A to T, chromosome 1 at 34,723,454 bp
  • T to A, chromosome 1 at 95,591,797 bp
  • G to A, chromosome 1 at 130,742,710 bp
  • A to T, chromosome 1 at 192,657,294 bp
  • T to C, chromosome 2 at 36,734,984 bp
  • T to C, chromosome 2 at 69,323,892 bp
  • C to T, chromosome 2 at 121,303,050 bp
  • T to C, chromosome 3 at 53,479,625 bp
  • T to C, chromosome 3 at 113,151,234 bp
  • T to C, chromosome 4 at 43,654,953 bp
  • A to T, chromosome 4 at 56,847,854 bp
  • A to T, chromosome 4 at 112,728,872 bp
  • C to T, chromosome 5 at 112,378,153 bp
  • G to A, chromosome 6 at 5,254,582 bp
  • T to C, chromosome 6 at 17,934,226 bp
  • A to T, chromosome 6 at 38,534,982 bp
  • A to T, chromosome 6 at 129,656,463 bp
  • A to G, chromosome 6 at 145,817,144 bp
  • G to A, chromosome 7 at 30,038,057 bp
  • T to C, chromosome 7 at 75,730,528 bp
  • T to C, chromosome 8 at 41,084,541 bp
  • T to C, chromosome 8 at 93,100,708 bp
  • T to A, chromosome 8 at 114,418,087 bp
  • T to A, chromosome 8 at 129,145,532 bp
  • T to A, chromosome 9 at 3,026,368 bp
  • G to A, chromosome 9 at 40,074,665 bp
  • T to C, chromosome 10 at 129,626,061 bp
  • C to A, chromosome 11 at 5,837,618 bp
  • T to C, chromosome 11 at 69,979,842 bp
  • A to G, chromosome 11 at 70,097,839 bp
  • A to G, chromosome 11 at 76,814,830 bp
  • A to G, chromosome 11 at 77,137,252 bp
  • T to C, chromosome 11 at 77,845,521 bp
  • T to A, chromosome 11 at 84,263,295 bp
  • A to G, chromosome 11 at 104,526,124 bp
  • T to C, chromosome 12 at 13,408,265 bp
  • C to A, chromosome 12 at 110,658,126 bp
  • T to C, chromosome 12 at 113,130,978 bp
  • C to T, chromosome 13 at 50,472,343 bp
  • C to T, chromosome 13 at 73,685,840 bp
  • A to T, chromosome 14 at 53,738,357 bp
  • A to T, chromosome 14 at 79,198,283 bp
  • A to G, chromosome 14 at 121,275,607 bp
  • A to T, chromosome 16 at 14,502,203 bp
  • A to T, chromosome 16 at 19,407,110 bp
  • A to G, chromosome 16 at 37,948,215 bp
  • A to G, chromosome 16 at 44,734,542 bp
  • A to G, chromosome 17 at 34,027,288 bp
  • T to C, chromosome 17 at 80,251,398 bp
  • G to A, chromosome 18 at 37,475,802 bp
  • C to T, chromosome 18 at 60,702,933 bp
  • G to A, chromosome 18 at 68,276,147 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4988 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042582-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.