Strain Name:
C57BL/6J-MtgxR5002Btlr/Mmmh
Stock Number:
042596-MU
Citation ID:
RRID:MMRRC_042596-MU
Other Names:
R5002 (G1), C57BL/6J-MtgxR5002Btlr
Major Collection:

Gene Information

Fn1
Name: fibronectin 1
Synonyms: Fn-1, Fn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14268
HGNC: HGNC:3778
Homologene: 1533
Wnk1
Name: WNK lysine deficient protein kinase 1
Synonyms: 6430573H23Rik, Prkwnk1, EG406236, Hsn2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232341
Homologene: 14253
Stk11ip
Name: serine/threonine kinase 11 interacting protein
Synonyms: LKB1IP, LIP1, 1200014D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71728
Homologene: 12406
Ltbp4
Name: latent transforming growth factor beta binding protein 4
Synonyms: 2310046A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 108075
HGNC: HGNC:6717
Homologene: 2645
Ociad1
Name: OCIA domain containing 1
Synonyms: expressed during mesenchymal induction 2, Emi2, B230209J16Rik, 6030432N09Rik, TPA018, Asrij, Imi2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68095
Homologene: 9866
Polk
Name: polymerase (DNA directed), kappa
Synonyms: Dinb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 27015
VEGA: 13
HGNC: HGNC:9183
Homologene: 32140
Apbb2
Name: amyloid beta (A4) precursor protein-binding, family B, member 2
Synonyms: TR2L, Rirl1, 2310007D03Rik, Zfra, FE65L1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11787
HGNC: HGNC:582
Homologene: 32079
Flnb
Name: filamin, beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 286940
HGNC: HGNC:3755
Homologene: 37480
Spast
Name: spastin
Synonyms: Spg4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 50850
VEGA: 17
Homologene: 8970
Cep128
Name: centrosomal protein 128
Synonyms: 5430424K18Rik, 4930534B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 75216
Homologene: 35315
Adgrl1
Name: adhesion G protein-coupled receptor L1
Synonyms: Lec2, lectomedin-2, 2900070I05Rik, Lphn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 330814
Homologene: 8951
Smarce1
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Synonyms: BAF57, 9030408N19Rik, 2810417B20Rik, 5830412H02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 57376
Homologene: 37727
Glud1
Name: glutamate dehydrogenase 1
Synonyms: Gdh-X, Glud
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14661
HGNC: HGNC:4335
Homologene: 55885
Ms4a14
Name: membrane-spanning 4-domains, subfamily A, member 14
Synonyms: LOC383435
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 383435
Homologene: 138453
Cenpe
Name: centromere protein E
Synonyms: N-7 kinesin, CENP-E, 312kDa, Kif10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229841
HGNC: HGNC:1856
Homologene: 20429
Slc12a7
Name: solute carrier family 12, member 7
Synonyms: Kcc4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20499
VEGA: 13
Homologene: 21312
Dna2
Name: DNA replication helicase/nuclease 2
Synonyms: E130315B21Rik, Dna2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 327762
HGNC: HGNC:2939
Homologene: 6124
Itga9
Name: integrin alpha 9
Synonyms: 2610002H11Rik, D9Ertd428e, 6720458D17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 104099
HGNC: HGNC:6145
Homologene: 1664
Tesk1
Name: testis specific protein kinase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21754
Homologene: 4577
Olfr457
Name: olfactory receptor 457
Synonyms: GA_x6K02T2P3E9-5088893-5089834, MOR257-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258989
Homologene: 133701
Casq1
Name: calsequestrin 1
Synonyms: CSQ-1, CSQ1, CSQ, sCSQ
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12372
HGNC: HGNC:1512
Homologene: 20329
Col6a6
Name: collagen, type VI, alpha 6
Synonyms: E330026B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 245026
Homologene: 18260
Ttc23l
Name: tetratricopeptide repeat domain 23-like
Synonyms: 4930401A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 75777
Homologene: 44907
Abca8b
Name: ATP-binding cassette, sub-family A (ABC1), member 8b
Synonyms: Abca8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 27404
HGNC: HGNC:38
Homologene: 56029
Vwc2l
Name: von Willebrand factor C domain-containing protein 2-like
Synonyms: brorin-like, Brl, A830006F12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 320460
Homologene: 27945
Nepn
Name: nephrocan
Synonyms: 5730521E12Rik, Npn, periolin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 66650
Homologene: 23549
Lrrk1
Name: leucine-rich repeat kinase 1
Synonyms: D130026O16Rik, C230002E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233328
Homologene: 23464
Slc29a4
Name: solute carrier family 29 (nucleoside transporters), member 4
Synonyms: ENT4, mPMAT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243328
Homologene: 71345
Tmpo
Name: thymopoietin
Synonyms: TP, 5630400D24Rik, LAP2, lamina-associated polypeptide 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 21917
VEGA: 10
Homologene: 31144
Nfil3
Name: nuclear factor, interleukin 3, regulated
Synonyms: E4BP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18030
HGNC: HGNC:7787
Homologene: 3928
Rbsn
Name: rabenosyn, RAB effector
Synonyms: 5330426D11Rik, Rabenosyn-5, Zfyve20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 78287
Homologene: 41477
Fcgbp
Name: Fc fragment of IgG binding protein
Synonyms: A430096B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 215384
Homologene: 68369
Gm10717
Name: predicted gene 10717
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Tas2r131
Name: taste receptor, type 2, member 131
Synonyms: mGR31, Tas2r31, mt2r61, T2R31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387356
Homologene: 52298
Ergic2
Name: ERGIC and golgi 2
Synonyms: 4930572C01Rik, 1200009B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67456
Homologene: 6574
Hhat
Name: hedgehog acyltransferase
Synonyms: Skn, 2810432O22Rik, AP-2CRE, Tg(TFAP2A-cre)1Will
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226861
Homologene: 41232
Zpld2
Name: zona pellucida like domain containing 2
Synonyms: Gm7534
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 665186
Homologene: 104039
Prss33
Name: protease, serine 33
Synonyms: tryptase-6, mT6, Eos
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 353130
Homologene: 77185
4930444G20Rik
Name: RIKEN cDNA 4930444G20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 114671
Homologene: 130042
Catsperb
Name: cation channel sperm associated auxiliary subunit beta
Synonyms: 4932415G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 271036
VEGA: 12
Homologene: 81904
Gpx6
Name: glutathione peroxidase 6
Synonyms: olfactory, 1700020G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 75512
HGNC: HGNC:4558
Homologene: 130008
Filip1l
Name: filamin A interacting protein 1-like
Synonyms: 4631422O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 78749
Homologene: 37121
Olfr1087
Name: olfactory receptor 1087
Synonyms: GA_x6K02T2Q125-48182406-48181465, MOR188-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258843
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 70,729,046 bp
  • T to A, chromosome 1 at 71,629,728 bp
  • C to A, chromosome 1 at 75,532,543 bp
  • T to A, chromosome 1 at 172,213,378 bp
  • A to T, chromosome 1 at 192,543,190 bp
  • C to A, chromosome 2 at 86,690,085 bp
  • A to T, chromosome 3 at 135,247,081 bp
  • T to C, chromosome 4 at 43,444,573 bp
  • T to A, chromosome 4 at 134,196,920 bp
  • A to G, chromosome 5 at 66,313,325 bp
  • T to C, chromosome 5 at 73,310,316 bp
  • A to T, chromosome 5 at 142,718,746 bp
  • C to A, chromosome 6 at 42,471,972 bp
  • C to T, chromosome 6 at 92,190,261 bp
  • G to A, chromosome 6 at 119,937,963 bp
  • T to C, chromosome 6 at 132,957,151 bp
  • A to G, chromosome 6 at 148,184,158 bp
  • GT to G, chromosome 7 at 27,327,685 bp
  • T to A, chromosome 7 at 28,086,103 bp
  • C to A, chromosome 7 at 66,332,363 bp
  • T to C, chromosome 8 at 83,933,587 bp
  • A to G, chromosome 9 at 3,025,532 bp
  • T to C, chromosome 9 at 105,786,093 bp
  • C to A, chromosome 9 at 118,663,898 bp
  • G to C, chromosome 10 at 22,067,817 bp
  • A to C, chromosome 10 at 52,391,754 bp
  • A to G, chromosome 10 at 62,950,842 bp
  • A to G, chromosome 10 at 91,164,114 bp
  • T to C, chromosome 11 at 99,225,063 bp
  • G to A, chromosome 11 at 109,961,797 bp
  • T to C, chromosome 12 at 91,255,723 bp
  • T to C, chromosome 12 at 101,520,554 bp
  • A to G, chromosome 13 at 21,313,688 bp
  • C to A, chromosome 13 at 52,968,676 bp
  • A to G, chromosome 13 at 73,763,777 bp
  • A to G, chromosome 13 at 96,489,244 bp
  • T to A, chromosome 14 at 7,945,882 bp
  • T to C, chromosome 14 at 34,335,388 bp
  • G to T, chromosome 15 at 10,551,550 bp
  • T to C, chromosome 16 at 57,571,103 bp
  • C to T, chromosome 17 at 23,835,358 bp
  • C to T, chromosome 17 at 74,369,226 bp
  • T to C, chromosome 19 at 11,304,289 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5002 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042596-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.