Strain Name:
C57BL/6J-MtgxR5008Btlr/Mmmh
Stock Number:
042599-MU
Citation ID:
RRID:MMRRC_042599-MU
Other Names:
R5008 (G1), C57BL/6J-MtgxR5008Btlr
Major Collection:

Gene Information

Col2a1
Name: collagen, type II, alpha 1
Synonyms: Col2, Col2a-1, Col2a, Rgsc856, M100856, Rgsc413, Lpk, M100413, Del1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12824
HGNC: HGNC:2200
Homologene: 55607
Dspp
Name: dentin sialophosphoprotein
Synonyms: Dmp3, Dsp, Dpp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 666279
HGNC: HGNC:3054
Rpa1
Name: replication protein A1
Synonyms: RP-A, Rpa, 70kDa, RF-A, 5031405K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68275
Homologene: 2208
Tbcel
Name: tubulin folding cofactor E-like
Synonyms: Lrrc35, E130107N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 272589
Homologene: 16120
Frmd5
Name: FERM domain containing 5
Synonyms: A930004K21Rik, 1500032A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228564
Homologene: 18206
Psme4
Name: proteasome (prosome, macropain) activator subunit 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103554
Homologene: 113742
Msh2
Name: mutS homolog 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17685
HGNC: HGNC:7325
Homologene: 210
Tnip1
Name: TNFAIP3 interacting protein 1
Synonyms: Nef, A20-binding inhibitor of NF-kappa B activation, ABIN1, VAN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 57783
Homologene: 31355
Tanc2
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
Synonyms: 5730590C14Rik, 3526402J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 77097
Homologene: 64680
Nckap5l
Name: NCK-associated protein 5-like
Synonyms: C230021P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 380969
Homologene: 18924
Polg
Name: polymerase (DNA directed), gamma
Synonyms: polymerase gamma, mitochondrial DNA polymerase-gamma, Pol gamma, Polga, mitochondrial DNA polymerase gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18975
HGNC: HGNC:9179
Homologene: 2016
Cntnap1
Name: contactin associated protein-like 1
Synonyms: shm, paranodin, p190, Nrxn4, Caspr, NCP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 53321
HGNC: HGNC:8011
Homologene: 2693
Npnt
Name: nephronectin
Synonyms: POEM, 1110009H02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 114249
Homologene: 14138
Rph3a
Name: rabphilin 3A
Synonyms: 2900002P20Rik, Doc2 family
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19894
Homologene: 7921
Zfp980
Name: zinc finger protein 980
Synonyms: Gm13242
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100041379
Homologene: 133076
Klhl28
Name: kelch-like 28
Synonyms: 4122402F11Rik, 2810440N09Rik, Btbd5, 4931401E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 66689
VEGA: 12
Homologene: 23036
Rasa3
Name: RAS p21 protein activator 3
Synonyms: Ras GTPase-activating protein III, GAPIII activator 3, GAPIII, hlb381, scat, R-Ras gap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 19414
Homologene: 7217
Pros1
Name: protein S (alpha)
Synonyms: protein S
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19128
HGNC: HGNC:9456
Homologene: 264
Pmm1
Name: phosphomannomutase 1
Synonyms: Secp53 (yeast) homolog
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 29858
HGNC: HGNC:9114
Homologene: 90898
2310022A10Rik
Name: RIKEN cDNA 2310022A10 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66367
Homologene: 35272
Chd1l
Name: chromodomain helicase DNA binding protein 1-like
Synonyms: 4432404A22Rik, Snf2p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68058
HGNC: HGNC:1916
Homologene: 11590
Wdr34
Name: WD repeat domain 34
Synonyms: 3200002I06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71820
Homologene: 14156
Galnt3
Name: polypeptide N-acetylgalactosaminyltransferase 3
Synonyms: ppGaNTase-T3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14425
HGNC: HGNC:4125
Homologene: 55827
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Tecta
Name: tectorin alpha
Synonyms: Tctna, [a]-tectorin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21683
Homologene: 3955
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: Dnahc17, LOC382552, Dnahcl1, 2810003K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Lrp12
Name: low density lipoprotein-related protein 12
Synonyms: C820005L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239393
Homologene: 8385
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Cst11
Name: cystatin 11
Synonyms: cystatin E1, CRES2, 9230101F08Rik, mCST E1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 78240
Homologene: 15634
Zc3h12c
Name: zinc finger CCCH type containing 12C
Synonyms: C230027N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244871
VEGA: 9
Homologene: 35462
Ltbp2
Name: latent transforming growth factor beta binding protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 16997
HGNC: HGNC:6715
Homologene: 369
Pld4
Name: phospholipase D family, member 4
Synonyms: thss
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104759
VEGA: 12
Homologene: 16350
Slc5a3
Name: solute carrier family 5 (inositol transporters), member 3
Synonyms: Smit1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 53881
Homologene: 31412
Skint6
Name: selection and upkeep of intraepithelial T cells 6
Synonyms: OTTMUSG00000008519
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230622
Homologene: 135888
Myo3b
Name: myosin IIIB
Synonyms: A430065P19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329421
Homologene: 51393
Myh4
Name: myosin, heavy polypeptide 4, skeletal muscle
Synonyms: Minmus, MM, Myhsf, MHC2B, MyHC-IIb, Minimsc, MYH-2B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17884
HGNC: HGNC:7574
Homologene: 123880
Igsf3
Name: immunoglobulin superfamily, member 3
Synonyms: 2810035F16Rik, 1700016K10Rik, 4833439O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 78908
HGNC: HGNC:5950
Homologene: 1182
Pramel30
Name: PRAME like 30
Synonyms: Gm13128
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 626995
Homologene: 129642
Ikzf4
Name: IKAROS family zinc finger 4
Synonyms: Zfpn1a4, A630026H08Rik, Eos
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22781
Homologene: 69103
Slc5a1
Name: solute carrier family 5 (sodium/glucose cotransporter), member 1
Synonyms: Sglt1, sodium glucose cotransporter 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20537
Homologene: 55456
Zbbx
Name: zinc finger, B-box domain containing
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213234
Homologene: 11661
Dctd
Name: dCMP deaminase
Synonyms: 6030466N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 320685
HGNC: HGNC:2710
Homologene: 55618
Stat5b
Name: signal transducer and activator of transcription 5B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20851
Homologene: 55718
Hivep3
Name: human immunodeficiency virus type I enhancer binding protein 3
Synonyms: Krc, 2900056N03Rik, E030045D18Rik, Shn3, Schnurri-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16656
Homologene: 7803
Catsperg1
Name: cation channel sperm associated auxiliary subunit gamma 1
Synonyms: A230107C01Rik, Catsperg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 320225
Homologene: 10915
Olfr434
Name: olfactory receptor 434
Synonyms: MOR261-10, GA_x6K02T2P3E9-4341246-4340281
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258366
Homologene: 133700
Slc23a2
Name: solute carrier family 23 (nucleobase transporters), member 2
Synonyms: SVCT2, YSPL3, Slc23a1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 54338
Homologene: 68440
Krt83
Name: keratin 83
Synonyms: 5430421N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 100126226
HGNC: HGNC:6460
Homologene: 68248
Mdp1
Name: magnesium-dependent phosphatase 1
Synonyms: 1810034K20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67881
VEGA: 14
Homologene: 5846
Pfkm
Name: phosphofructokinase, muscle
Synonyms: PFK-M, Pfk-4, Pfkx, Pfk4, PFK-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18642
VEGA: 15
HGNC: HGNC:8877
Homologene: 20101
Repin1
Name: replication initiator 1
Synonyms: E430037F08Rik, AP4, Zfp464
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 58887
Homologene: 22810
Slc34a3
Name: solute carrier family 34 (sodium phosphate), member 3
Synonyms: NPTIIc, Npt2c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 142681
Homologene: 15444
2310057N15Rik
Name: RIKEN cDNA 2310057N15 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 69696
Homologene: 114409
Pigq
Name: phosphatidylinositol glycan anchor biosynthesis, class Q
Synonyms: Gpih, Gpi1, Gpi1p, Gpi1h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14755
Homologene: 31228
Lat2
Name: linker for activation of T cells family, member 2
Synonyms: Wbscr15, Wbscr5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56743
Homologene: 11297
Scgn
Name: secretagogin, EF-hand calcium binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 214189
Homologene: 5088
Ppp1r42
Name: protein phosphatase 1, regulatory subunit 42
Synonyms: 4930418G15Rik, 1700011J18Rik, Lrrc67
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 69312
Homologene: 27077
Olfr8
Name: olfactory receptor 8
Synonyms: GA_x6K02T2QGN0-2857086-2856154, MOR139-5P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18372
Homologene: 136441
Rps18
Name: ribosomal protein S18
Synonyms: H-2Ke3, H2-Ke3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20084
Homologene: 88764
Olfr715b
Name: olfactory receptor 715B
Synonyms: EG384732, Gm10081
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384732
HGNC: HGNC:8244
Homologene: 81541
Rnf186
Name: ring finger protein 186
Synonyms: 9130020G10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66825
Homologene: 10404
Gm20997
Name: predicted gene, 20997
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Chchd5
Name: coiled-coil-helix-coiled-coil-helix domain containing 5
Synonyms: 1110027L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66170
Homologene: 11929
Gm37710
Name: predicted gene, 37710
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 9,985,695 bp
  • C to T, chromosome 2 at 25,230,842 bp
  • C to A, chromosome 2 at 30,032,769 bp
  • C to A, chromosome 2 at 66,085,241 bp
  • T to A, chromosome 2 at 70,258,068 bp
  • C to A, chromosome 2 at 121,548,860 bp
  • A to T, chromosome 2 at 129,130,399 bp
  • T to C, chromosome 2 at 132,101,494 bp
  • A to G, chromosome 2 at 148,770,405 bp
  • A to C, chromosome 3 at 75,151,448 bp
  • T to C, chromosome 3 at 97,583,908 bp
  • C to T, chromosome 3 at 101,450,917 bp
  • C to T, chromosome 3 at 132,906,457 bp
  • A to T, chromosome 4 at 112,991,255 bp
  • A to G, chromosome 4 at 120,098,917 bp
  • A to T, chromosome 4 at 138,967,229 bp
  • A to G, chromosome 4 at 144,331,266 bp
  • G to A, chromosome 4 at 145,702,083 bp
  • A to G, chromosome 5 at 33,152,573 bp
  • A to T, chromosome 5 at 104,175,573 bp
  • G to T, chromosome 5 at 120,945,391 bp
  • A to G, chromosome 5 at 134,603,137 bp
  • T to A, chromosome 6 at 43,217,057 bp
  • T to C, chromosome 6 at 48,596,608 bp
  • T to A, chromosome 6 at 130,484,617 bp
  • T to A, chromosome 6 at 130,485,020 bp
  • C to G, chromosome 7 at 27,578,767 bp
  • A to T, chromosome 7 at 29,195,434 bp
  • G to T, chromosome 7 at 79,460,074 bp
  • A to T, chromosome 7 at 107,106,081 bp
  • G to A, chromosome 7 at 141,639,559 bp
  • A to T, chromosome 8 at 13,584,959 bp
  • C to T, chromosome 8 at 48,137,414 bp
  • C to A, chromosome 9 at 42,373,062 bp
  • C to T, chromosome 9 at 42,416,123 bp
  • T to C, chromosome 9 at 52,116,700 bp
  • T to C, chromosome 9 at 72,972,318 bp
  • T to A, chromosome 10 at 78,956,071 bp
  • T to G, chromosome 10 at 128,641,250 bp
  • T to A, chromosome 11 at 30,856,896 bp
  • A to T, chromosome 11 at 54,937,984 bp
  • T to A, chromosome 11 at 67,253,532 bp
  • A to G, chromosome 11 at 75,313,299 bp
  • G to C, chromosome 11 at 100,802,483 bp
  • G to A, chromosome 11 at 101,188,741 bp
  • G to A, chromosome 11 at 105,625,060 bp
  • A to G, chromosome 11 at 118,110,577 bp
  • C to T, chromosome 12 at 64,957,227 bp
  • A to G, chromosome 12 at 84,809,673 bp
  • A to T, chromosome 12 at 112,768,050 bp
  • A to G, chromosome 13 at 23,990,975 bp
  • C to T, chromosome 14 at 55,659,226 bp
  • C to T, chromosome 15 at 39,878,456 bp
  • A to T, chromosome 15 at 81,957,894 bp
  • G to A, chromosome 15 at 97,979,669 bp
  • G to A, chromosome 15 at 98,122,689 bp
  • T to C, chromosome 15 at 99,425,850 bp
  • T to A, chromosome 15 at 101,491,224 bp
  • A to T, chromosome 16 at 37,062,387 bp
  • A to G, chromosome 16 at 62,928,185 bp
  • A to G, chromosome 16 at 88,773,775 bp
  • T to A, chromosome 16 at 92,077,281 bp
  • A to G, chromosome 17 at 25,934,203 bp
  • A to T, chromosome 17 at 33,952,284 bp
  • C to A, chromosome 17 at 87,723,413 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5008 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042599-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.