Strain Name:
C57BL/6J-MtgxR5038Btlr/Mmmh
Stock Number:
042628-MU
Citation ID:
RRID:MMRRC_042628-MU
Other Names:
R5038 (G1), C57BL/6J-MtgxR5038Btlr
Major Collection:

Gene Information

Map4k5
Name: mitogen-activated protein kinase kinase kinase kinase 5
Synonyms: MAPKKKK5, GCKR, KHS, 4432415E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 399510
HGNC: HGNC:6867
Homologene: 38199
Pik3r1
Name: phosphoinositide-3-kinase regulatory subunit 1
Synonyms: p85alpha, p50alpha, p55alpha, PI3K
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18708
HGNC: HGNC:8979
Homologene: 7889
Scd1
Name: stearoyl-Coenzyme A desaturase 1
Synonyms: stearoyl-CoA desaturase, Scd-1, SCD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20249
VEGA: 19
Homologene: 74538
Nos2
Name: nitric oxide synthase 2, inducible
Synonyms: iNOS, Nos-2, NOS-II, Nos2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18126
HGNC: HGNC:7873
Homologene: 55473
Slco1a5
Name: solute carrier organic anion transporter family, member 1a5
Synonyms: Oatp3, Slc21a7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 108096
Homologene: 56603
Ptpn14
Name: protein tyrosine phosphatase, non-receptor type 14
Synonyms: PTP36, C130080N23Rik, OTTMUSG00000022087
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19250
HGNC: HGNC:9647
Homologene: 3941
Epb41l1
Name: erythrocyte membrane protein band 4.1 like 1
Synonyms: 4.1N, Epb4.1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13821
HGNC: HGNC:3378
Homologene: 8126
B230219D22Rik
Name: RIKEN cDNA B230219D22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 78521
VEGA: 13
Homologene: 17572
Nup188
Name: nucleoporin 188
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227699
Homologene: 45683
Zfp7
Name: zinc finger protein 7
Synonyms: Krox-2, Zfp-7, KRAB7, Zfp65, mszf73-2, Zfp80, KRAB20, Zfp86-rs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223669
VEGA: 15
Homologene: 20729
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, C130061D10Rik, Phr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105689
Homologene: 9005
Tdh
Name: L-threonine dehydrogenase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 58865
Homologene: 10987
Cpne1
Name: copine I
Synonyms: 1810028N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 266692
HGNC: HGNC:2314
Homologene: 36501
Stat1
Name: signal transducer and activator of transcription 1
Synonyms: 2010005J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20846
Homologene: 21428
Zmym2
Name: zinc finger, MYM-type 2
Synonyms: SCLL, RAMP, MYM, FIM, Zfp198
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 76007
VEGA: 14
Homologene: 12631
Nr2c2
Name: nuclear receptor subfamily 2, group C, member 2
Synonyms: TAK1, Tr4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22026
HGNC: HGNC:7972
Homologene: 2475
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: D130015N03Rik, 2810449H11Rik, tbl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Cyb5r4
Name: cytochrome b5 reductase 4
Synonyms: B5+B5R, b5/b5r, 2810034J18Rik, Ncb5or
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 266690
Homologene: 69207
Otof
Name: otoferlin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 83762
HGNC: HGNC:8515
Homologene: 12892
Camta1
Name: calmodulin binding transcription activator 1
Synonyms: 2310058O09Rik, 1810059M14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100072
Homologene: 18942
Zfp335
Name: zinc finger protein 335
Synonyms: 1810045J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329559
Homologene: 11129
Gigyf2
Name: GRB10 interacting GYF protein 2
Synonyms: A830080H02Rik, 2610016F01Rik, Tnrc15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227331
Homologene: 41048
Rps3a1
Name: ribosomal protein S3A1
Synonyms: Rps3a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20091
Homologene: 68112
Jak3
Name: Janus kinase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16453
HGNC: HGNC:6193
Homologene: 181
Raf1
Name: v-raf-leukemia viral oncogene 1
Synonyms: Raf-1, sarcoma 3611 oncogene, 6430402F14Rik, v-Raf, c-Raf, Craf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 110157
HGNC: HGNC:9829
Homologene: 48145
Snx9
Name: sorting nexin 9
Synonyms: SH3PX1, SDP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66616
VEGA: 17
Homologene: 49454
Pold3
Name: polymerase (DNA-directed), delta 3, accessory subunit
Synonyms: P68, P66, 2410142G14Rik, C85233, GC12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67967
Homologene: 38202
Shq1
Name: SHQ1 homolog (S. cerevisiae)
Synonyms: 2810403P18Rik, Grim-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 72171
Homologene: 31683
Zfc3h1
Name: zinc finger, C3H1-type containing
Synonyms: Psrc2, Ccdc131
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216345
Homologene: 17017
Zfp984
Name: zinc finger protein 984
Synonyms: Gm13157
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100041677
Homologene: 133076
Trpa1
Name: transient receptor potential cation channel, subfamily A, member 1
Synonyms: ANKTM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 277328
HGNC: HGNC:497
Homologene: 7189
Sv2b
Name: synaptic vesicle glycoprotein 2 b
Synonyms: A830038F04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 64176
Homologene: 32236
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Slc4a8
Name: solute carrier family 4 (anion exchanger), member 8
Synonyms: sodium bicarbonate cotransporter isoform 3 kNBC-3, KNBC-3, NDCBE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 59033
Homologene: 68419
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 229003
Homologene: 14118
Atp7b
Name: ATPase, Cu++ transporting, beta polypeptide
Synonyms: WND, Wilson protein, Atp7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11979
HGNC: HGNC:870
Homologene: 20063
Ifna11
Name: interferon alpha 11
Synonyms: IFN-[a]11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15964
HGNC: HGNC:5425
Homologene: 68536
Bnc1
Name: basonuclin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12173
HGNC: HGNC:1081
Homologene: 31048
Olfr1461
Name: olfactory receptor 1461
Synonyms: GA_x6K02T2RE5P-3491834-3492772, MOR202-35
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258299
Homologene: 128112
Adprs
Name: ADP-ribosylserine hydrolase
Synonyms: Arh3, Adprhl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100206
Homologene: 9863
Dsg1c
Name: desmoglein 1 gamma
Synonyms: Dsg6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 211924
HGNC: HGNC:3048
Olfr1505
Name: olfactory receptor 1505
Synonyms: GA_x6K02T2RE5P-4250267-4251217, MOR211-4P, MOR211-10_i
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258151
Homologene: 17394
Abtb2
Name: ankyrin repeat and BTB (POZ) domain containing 2
Synonyms: BPOZ-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99382
Homologene: 15904
Olfr1446
Name: olfactory receptor 1446
Synonyms: GA_x6K02T2RE5P-3220047-3219130, MOR202-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258699
Homologene: 74233
Pkn3
Name: protein kinase N3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 263803
Homologene: 50980
Vmn1r113
Name: vomeronasal 1 receptor 113
Synonyms: Gm5748
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 436135
Homologene: 104166
Ckmt2
Name: creatine kinase, mitochondrial 2
Synonyms: 2300008A19Rik, ScCKmit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76722
HGNC: HGNC:1996
Homologene: 68206
Agbl5
Name: ATP/GTP binding protein-like 5
Synonyms: 9430057O19Rik, Ccp5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231093
Homologene: 11053
4930512M02Rik
Name: RIKEN cDNA 4930512M02 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 102631730
Vmn1r171
Name: vomeronasal 1 receptor 171
Synonyms: V3R7, V1rd7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 81012
Homologene: 128341
Car1
Name: carbonic anhydrase 1
Synonyms: CA I, Car-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12346
HGNC: HGNC:1368
Homologene: 20414
Acsm5
Name: acyl-CoA synthetase medium-chain family member 5
Synonyms: C730027J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 272428
Homologene: 69242
Dhrs13
Name: dehydrogenase/reductase (SDR family) member 13
Synonyms: 2610209N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70451
Homologene: 64807
Cdh22
Name: cadherin 22
Synonyms: PB-cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 104010
Homologene: 23148
Tmc7
Name: transmembrane channel-like gene family 7
Synonyms: C630024K23Rik, 1700030H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 209760
Homologene: 36424
Fam114a1
Name: family with sequence similarity 114, member A1
Synonyms: 1190001N04Rik, 9130005N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68303
Homologene: 12259
Gm7742
Name: predicted gene 7742
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 665669
Imp4
Name: IMP4, U3 small nucleolar ribonucleoprotein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 27993
Homologene: 68891
Ifna15
Name: interferon alpha 15
Synonyms: Ifnaa, Gm12597
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242517
HGNC: HGNC:5425
Homologene: 68536
Nxph2
Name: neurexophilin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18232
HGNC: HGNC:8076
Homologene: 7454
Gm15455
Name: predicted gene 15455
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 433287
Krtap19-2
Name: keratin associated protein 19-2
Synonyms: Krtap16-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 170651
VEGA: 16
Trmt61b
Name: tRNA methyltransferase 61B
Synonyms: 1110039F03Rik, Gm6431
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 68789
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 14,910,866 bp
  • T to C, chromosome 1 at 33,838,176 bp
  • A to T, chromosome 1 at 34,442,935 bp
  • A to T, chromosome 1 at 52,123,209 bp
  • G to A, chromosome 1 at 87,440,546 bp
  • T to C, chromosome 1 at 189,786,886 bp
  • G to A, chromosome 2 at 23,321,544 bp
  • T to C, chromosome 2 at 30,085,281 bp
  • T to C, chromosome 2 at 30,309,220 bp
  • G to A, chromosome 2 at 76,848,640 bp
  • G to T, chromosome 2 at 103,567,063 bp
  • G to A, chromosome 2 at 156,077,657 bp
  • T to C, chromosome 2 at 156,521,410 bp
  • G to T, chromosome 2 at 164,910,644 bp
  • T to C, chromosome 2 at 165,142,277 bp
  • C to A, chromosome 2 at 181,240,591 bp
  • A to G, chromosome 3 at 14,770,873 bp
  • C to A, chromosome 3 at 86,138,031 bp
  • T to C, chromosome 4 at 88,558,029 bp
  • T to C, chromosome 4 at 88,820,077 bp
  • C to T, chromosome 4 at 126,317,309 bp
  • T to A, chromosome 4 at 147,755,446 bp
  • T to C, chromosome 4 at 151,145,469 bp
  • C to T, chromosome 5 at 30,384,439 bp
  • G to A, chromosome 5 at 30,903,059 bp
  • A to G, chromosome 5 at 65,009,045 bp
  • A to G, chromosome 6 at 92,139,822 bp
  • A to G, chromosome 6 at 100,630,993 bp
  • G to A, chromosome 6 at 115,620,235 bp
  • T to C, chromosome 6 at 142,262,637 bp
  • C to T, chromosome 6 at 142,266,364 bp
  • A to G, chromosome 7 at 20,787,494 bp
  • A to G, chromosome 7 at 23,632,763 bp
  • A to T, chromosome 7 at 75,157,425 bp
  • A to G, chromosome 7 at 81,968,714 bp
  • A to G, chromosome 7 at 100,121,383 bp
  • A to G, chromosome 7 at 118,543,365 bp
  • A to G, chromosome 7 at 119,534,811 bp
  • A to C, chromosome 8 at 22,028,456 bp
  • G to A, chromosome 8 at 71,686,058 bp
  • T to G, chromosome 9 at 66,476,460 bp
  • T to G, chromosome 9 at 87,059,077 bp
  • G to A, chromosome 10 at 115,404,211 bp
  • A to T, chromosome 11 at 11,589,375 bp
  • A to G, chromosome 11 at 78,032,430 bp
  • G to A, chromosome 11 at 78,922,314 bp
  • A to T, chromosome 12 at 69,824,614 bp
  • T to C, chromosome 13 at 55,699,475 bp
  • T to C, chromosome 13 at 91,861,163 bp
  • C to T, chromosome 13 at 101,689,444 bp
  • T to A, chromosome 14 at 56,956,180 bp
  • A to T, chromosome 14 at 63,496,126 bp
  • C to T, chromosome 14 at 103,296,939 bp
  • T to C, chromosome 15 at 76,891,810 bp
  • T to C, chromosome 15 at 100,795,821 bp
  • A to T, chromosome 16 at 88,874,028 bp
  • T to C, chromosome 17 at 5,887,073 bp
  • A to T, chromosome 17 at 21,200,315 bp
  • T to C, chromosome 17 at 71,588,566 bp
  • G to A, chromosome 18 at 20,264,844 bp
  • T to A, chromosome 19 at 12,890,406 bp
  • T to A, chromosome 19 at 13,165,591 bp
  • T to A, chromosome 19 at 13,919,458 bp
  • C to T, chromosome 19 at 44,401,709 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5038 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042628-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.