Strain Name:
C57BL/6J-MtgxR5047Btlr/Mmmh
Stock Number:
042637-MU
Citation ID:
RRID:MMRRC_042637-MU
Other Names:
R5047 (G1), C57BL/6J-MtgxR5047Btlr
Major Collection:

Gene Information

Cdon
Name: cell adhesion molecule-related/down-regulated by oncogenes
Synonyms: CDO, CAM-related/down-regulated by oncogenes
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 57810
Homologene: 22996
Lmf1
Name: lipase maturation factor 1
Synonyms: 2400010G15Rik, Tmem112
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 76483
Homologene: 23384
Herc3
Name: hect domain and RLD 3
Synonyms: 5730409F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 73998
HGNC: HGNC:4876
Homologene: 57095
Lpp
Name: LIM domain containing preferred translocation partner in lipoma
Synonyms: B130055L10Rik, 9430020K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 210126
VEGA: 16
HGNC: HGNC:6679
Homologene: 4075
Yeats2
Name: YEATS domain containing 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 208146
VEGA: 16
Homologene: 9967
Top3b
Name: topoisomerase (DNA) III beta
Synonyms: Topo III beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 21976
Homologene: 2923
Mdc1
Name: mediator of DNA damage checkpoint 1
Synonyms: NFBD1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240087
Homologene: 67092
Evi5
Name: ecotropic viral integration site 5
Synonyms: NB4S
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14020
HGNC: HGNC:3501
Homologene: 121902
Tcof1
Name: treacle ribosome biogenesis factor 1
Synonyms: treacle
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 21453
Homologene: 68049
Rad50
Name: RAD50 double strand break repair protein
Synonyms: Rad50l, Mrell
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19360
HGNC: HGNC:9816
Homologene: 38092
Fchsd1
Name: FCH and double SH3 domains 1
Synonyms: A030002D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 319262
Homologene: 14127
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Kif13a
Name: kinesin family member 13A
Synonyms: 4930505I07Rik, N-3 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 16553
VEGA: 13
Homologene: 22589
Armh4
Name: armadillo-like helical domain containing 4
Synonyms: 3632451O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67419
Homologene: 12127
Blzf1
Name: basic leucine zipper nuclear factor 1
Synonyms: Golgin-45, 1700030G05Rik, Blzf1l, Jem-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66352
HGNC: HGNC:1065
Homologene: 31187
Tatdn3
Name: TatD DNase domain containing 3
Synonyms: 1500010M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68972
Homologene: 45949
Adamts13
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13
Synonyms: vWF-CP mRNA for von Willebrand factor-cleaving, LOC279028
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 279028
HGNC: HGNC:1366
Homologene: 16372
Gpr63
Name: G protein-coupled receptor 63
Synonyms: PSP24beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 81006
Homologene: 12759
Ltbp1
Name: latent transforming growth factor beta binding protein 1
Synonyms: Ltbp1L, LTBP-1, 9430031G15Rik, b2b1000Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268977
HGNC: HGNC:6714
Homologene: 522
Scn9a
Name: sodium channel, voltage-gated, type IX, alpha
Synonyms: PN1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20274
Homologene: 2237
Cyp2d40
Name: cytochrome P450, family 2, subfamily d, polypeptide 40
Synonyms: 1300013D18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71754
VEGA: 15
Homologene: 135470
Pcdhb22
Name: protocadherin beta 22
Synonyms: Pcdhb15, PcdhbV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93893
HGNC: HGNC:8686
Homologene: 113752
Phlpp2
Name: PH domain and leucine rich repeat protein phosphatase 2
Synonyms: C130044A18Rik, Phlppl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244650
Homologene: 71015
Scgb1b20
Name: secretoglobin, family 1B, member 20
Synonyms: Abpa20, Gm5895, Gm7147
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 545948
Homologene: 114479
Zfp976
Name: zinc finger protein 976
Synonyms: 9830147E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 208111
Homologene: 134004
Olfr398
Name: olfactory receptor 398
Synonyms: GA_x6K02T2P1NL-4141430-4140486, MOR157-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258705
Homologene: 17355
Jmy
Name: junction-mediating and regulatory protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 57748
VEGA: 13
Homologene: 10955
Gm10142
Name: predicted gene 10142
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 100502921
VEGA: 10
Homologene: 135713
Plscr3
Name: phospholipid scramblase 3
Synonyms: 2610037N06Rik, 2210403O21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70310
Homologene: 23219
Mst1
Name: macrophage stimulating 1 (hepatocyte growth factor-like)
Synonyms: D9H3F15S2, D3F15S2h, Hgfl, DNF15S2h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 15235
HGNC: HGNC:7380
Homologene: 7360
Fcgr1
Name: Fc receptor, IgG, high affinity I
Synonyms: CD64, FcgammaRI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14129
HGNC: HGNC:3613
Homologene: 475
Ttc4
Name: tetratricopeptide repeat domain 4
Synonyms: 2810002P21Rik, L62
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72354
Homologene: 31249
Olfr1238
Name: olfactory receptor 1238
Synonyms: GA_x6K02T2Q125-50849945-50848998, MOR231-11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258786
Homologene: 128093
Olfr739
Name: olfactory receptor 739
Synonyms: GA_x6K02T2PMLR-6121675-6122604, MOR106-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258663
Homologene: 121549
Fam186b
Name: family with sequence similarity 186, member B
Synonyms: EG545136
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 545136
VEGA: 15
Homologene: 69502
Clvs1
Name: clavesin 1
Synonyms: Rlbp1l1, 4933402J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74438
Homologene: 65267
Atg3
Name: autophagy related 3
Synonyms: APG3, PC3-96, 2610016C12Rik, Apg3l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 67841
Homologene: 6836
Olfr26
Name: olfactory receptor 26
Synonyms: MTPCR09, MOR171-9, GA_x6K02T2PVTD-32550930-32551856
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18324
VEGA: 9
HGNC: HGNC:8481
Homologene: 79676
Maml3
Name: mastermind like transcriptional coactivator 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 433586
Homologene: 41284
Spag1
Name: sperm associated antigen 1
Synonyms: TPR-containing protein involved in spermatogenesis, tpis
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 26942
VEGA: 15
Homologene: 8081
Tstd3
Name: thiosulfate sulfurtransferase (rhodanese)-like domain containing 3
Synonyms: 2610029I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 77032
Homologene: 123813
Vmn2r130
Name: vomeronasal 2, receptor 130
Synonyms: Vmn2r-ps130
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100042225
Gm5577
Name: predicted gene 5577
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 434064
4930503E14Rik
Name: RIKEN cDNA 4930503E14 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 74954
Homologene: 115686
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 164,306,468 bp
  • T to A, chromosome 1 at 191,046,278 bp
  • G to A, chromosome 2 at 26,996,910 bp
  • A to C, chromosome 2 at 66,562,480 bp
  • A to G, chromosome 2 at 89,406,713 bp
  • G to T, chromosome 3 at 51,690,841 bp
  • A to T, chromosome 3 at 96,285,884 bp
  • A to G, chromosome 4 at 9,281,941 bp
  • A to G, chromosome 4 at 21,759,621 bp
  • A to G, chromosome 4 at 25,008,202 bp
  • A to T, chromosome 4 at 106,668,238 bp
  • T to C, chromosome 5 at 107,821,874 bp
  • C to T, chromosome 6 at 58,855,760 bp
  • A to T, chromosome 6 at 88,005,223 bp
  • A to G, chromosome 7 at 33,373,312 bp
  • A to T, chromosome 7 at 42,613,419 bp
  • A to T, chromosome 8 at 109,913,619 bp
  • G to A, chromosome 9 at 35,478,639 bp
  • G to A, chromosome 9 at 38,855,289 bp
  • C to A, chromosome 9 at 108,084,309 bp
  • G to T, chromosome 10 at 77,716,162 bp
  • A to G, chromosome 11 at 53,674,696 bp
  • A to G, chromosome 11 at 69,850,091 bp
  • T to C, chromosome 11 at 73,984,378 bp
  • T to C, chromosome 13 at 46,788,085 bp
  • T to A, chromosome 13 at 93,441,572 bp
  • A to T, chromosome 14 at 44,169,241 bp
  • G to T, chromosome 14 at 49,770,438 bp
  • T to C, chromosome 14 at 50,425,239 bp
  • G to T, chromosome 15 at 36,195,442 bp
  • C to T, chromosome 15 at 82,760,259 bp
  • T to C, chromosome 15 at 99,280,686 bp
  • A to G, chromosome 16 at 16,891,418 bp
  • A to T, chromosome 16 at 20,208,465 bp
  • T to C, chromosome 16 at 24,971,846 bp
  • C to A, chromosome 16 at 45,178,232 bp
  • T to A, chromosome 17 at 23,063,820 bp
  • C to T, chromosome 17 at 25,631,838 bp
  • T to A, chromosome 17 at 35,847,844 bp
  • C to T, chromosome 17 at 67,743,281 bp
  • T to C, chromosome 17 at 75,292,886 bp
  • G to T, chromosome 18 at 37,519,126 bp
  • C to T, chromosome 18 at 37,959,873 bp
  • A to G, chromosome 18 at 60,831,914 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5047 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042637-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.