Strain Name:
C57BL/6J-MtgxR5075Btlr/Mmmh
Stock Number:
042664-MU
Citation ID:
RRID:MMRRC_042664-MU
Other Names:
R5075 (G1), C57BL/6J-MtgxR5075Btlr
Major Collection:

Strain Information

Ep400
Name: E1A binding protein p400
Synonyms: p400, mDomino, 1700020J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75560
Homologene: 38779
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Dnajc21
Name: DnaJ heat shock protein family (Hsp40) member C21
Synonyms: 9930116P15Rik, 4930461P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 78244
Homologene: 6752
Zfat
Name: zinc finger and AT hook domain containing
Synonyms: LOC380993, Zfp406, Zfat1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 380993
Homologene: 16829
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: Lba, D3Ertd775e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Sacm1l
Name: SAC1 suppressor of actin mutations 1-like (yeast)
Synonyms: Sac1p, SAC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 83493
VEGA: 9
Homologene: 6320
Recql4
Name: RecQ protein-like 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 79456
VEGA: 15
HGNC: HGNC:9949
Homologene: 3144
Hdac4
Name: histone deacetylase 4
Synonyms: 4932408F19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208727
Homologene: 55946
Atf7ip
Name: activating transcription factor 7 interacting protein
Synonyms: ATFa-associated Modulator, AM, 2610204M12Rik, Mcaf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 54343
Homologene: 10051
Stat1
Name: signal transducer and activator of transcription 1
Synonyms: 2010005J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20846
Homologene: 21428
Mier1
Name: MEIR1 treanscription regulator
Synonyms: 5830411K19Rik, 4933425I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 71148
Homologene: 136176
Kpna1
Name: karyopherin (importin) alpha 1
Synonyms: mSRP1, m-importin-alpha-S1, Rch2, NPI1, importin alpha 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 16646
HGNC: HGNC:6394
Homologene: 55642
Tet2
Name: tet methylcytosine dioxygenase 2
Synonyms: E130014J05Rik, Ayu17-449
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 214133
Homologene: 49498
Fkbp15
Name: FK506 binding protein 15
Synonyms: FKBP133, C430014M02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 338355
Homologene: 28743
Cep85
Name: centrosomal protein 85
Synonyms: 2410030J07Rik, Ccdc21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 70012
Homologene: 11254
Ctnnd1
Name: catenin (cadherin associated protein), delta 1
Synonyms: P120, Ctnnd, p120-catenin, Catns
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12388
HGNC: HGNC:2515
Homologene: 1017
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 195018
Homologene: 9027
Peg3
Name: paternally expressed 3
Synonyms: Pw1, Zfp102, End4, Gcap4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18616
HGNC: HGNC:8826
Homologene: 31363
Snrnp40
Name: small nuclear ribonucleoprotein 40 (U5)
Synonyms: 0610009C03Rik, Wdr57
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66585
Homologene: 3538
Rex2
Name: reduced expression 2
Synonyms: Gm13138
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100043034
Homologene: 133076
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, P1-Loop, Dnahc8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Nup160
Name: nucleoporin 160
Synonyms: 2810011M03Rik, Gtl1-13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 59015
Homologene: 32509
Ttyh1
Name: tweety family member 1
Synonyms: tty, 6330408P11Rik, 4930459B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57776
Homologene: 10779
Foxp2
Name: forkhead box P2
Synonyms: 2810043D05Rik, D0Kist7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 114142
Homologene: 134404
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Slc4a3
Name: solute carrier family 4 (anion exchanger), member 3
Synonyms: Ae3, A930038D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20536
Homologene: 129474
Agl
Name: amylo-1,6-glucosidase, 4-alpha-glucanotransferase
Synonyms: 9430004C13Rik, 9630046L06Rik, 1110061O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 77559
HGNC: HGNC:321
Homologene: 536
Ust
Name: uronyl-2-sulfotransferase
Synonyms: D930010O20Rik, UA2OST
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 338362
VEGA: 10
Homologene: 4174
4931408C20Rik
Name: RIKEN cDNA 4931408C20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 210940
Homologene: 86827
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217843
Homologene: 41397
Megf8
Name: multiple EGF-like-domains 8
Synonyms: Egfl4, b2b288Clo, b2b1702Clo, m687Ddg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269878
HGNC: HGNC:3233
Homologene: 15988
Zmynd15
Name: zinc finger, MYND-type containing 15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 574428
Homologene: 12995
Sun1
Name: Sad1 and UNC84 domain containing 1
Synonyms: 4632417G13Rik, 5730434D03Rik, Unc84a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 77053
Homologene: 11544
Esm1
Name: endothelial cell-specific molecule 1
Synonyms: 0610042H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 71690
HGNC: HGNC:3466
Homologene: 5107
Gm10722
Name: predicted gene 10722
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Selplg
Name: selectin, platelet (p-selectin) ligand
Synonyms: Psgl-1, Psgl1, CD162
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20345
Homologene: 2261
Gm2128
Name: predicted gene 2128
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100039269
Homologene: 45597
Cntn6
Name: contactin 6
Synonyms: NB-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 53870
HGNC: HGNC:2176
Homologene: 8702
Or5b121
Name: olfactory receptor family 5 subfamily B member 121
Synonyms: GA_x6K02T2RE5P-3862389-3863336, MOR202-44, Olfr1480
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 404339
Homologene: 110492
Sgsh
Name: N-sulfoglucosamine sulfohydrolase (sulfamidase)
Synonyms: sulphamidase, 4632406A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 27029
Homologene: 167
Tmc7
Name: transmembrane channel-like gene family 7
Synonyms: C630024K23Rik, 1700030H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 209760
Homologene: 36424
Wdr81
Name: WD repeat domain 81
Synonyms: shakey 5, MGC32441, nur5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192652
Homologene: 13983
Mettl7b
Name: methyltransferase like 7B
Synonyms: 0610006F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71664
VEGA: 10
Homologene: 12400
Rnf25
Name: ring finger protein 25
Synonyms: AO7, 0610009H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 57751
Homologene: 11193
Hypk
Name: huntingtin interacting protein K
Synonyms: 2310003F16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67693
Homologene: 9498
Stk16
Name: serine/threonine kinase 16
Synonyms: Embryo-Derived Protein Kinase, EDPK, Krct, PKL12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20872
Homologene: 2739
Gm10766
Name: predicted gene 10766
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Igkv4-60
Name: immunoglobulin kappa variable 4-60
Synonyms: Gm10455
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 385277
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 26,683,052 bp
  • A to T, chromosome 1 at 52,122,712 bp
  • A to G, chromosome 1 at 74,595,644 bp
  • A to G, chromosome 1 at 75,212,216 bp
  • A to T, chromosome 1 at 75,557,368 bp
  • A to G, chromosome 1 at 91,996,120 bp
  • A to G, chromosome 2 at 69,465,758 bp
  • G to A, chromosome 2 at 84,624,459 bp
  • A to G, chromosome 2 at 90,700,174 bp
  • A to G, chromosome 2 at 121,455,630 bp
  • A to T, chromosome 2 at 127,269,959 bp
  • A to T, chromosome 3 at 86,351,338 bp
  • A to G, chromosome 3 at 116,793,807 bp
  • T to A, chromosome 3 at 133,486,906 bp
  • T to C, chromosome 4 at 62,321,029 bp
  • A to G, chromosome 4 at 103,139,473 bp
  • T to C, chromosome 4 at 130,388,582 bp
  • C to A, chromosome 4 at 134,132,367 bp
  • A to T, chromosome 4 at 147,057,694 bp
  • T to C, chromosome 5 at 110,685,485 bp
  • T to C, chromosome 5 at 113,819,984 bp
  • T to C, chromosome 5 at 139,226,891 bp
  • G to A, chromosome 6 at 15,378,007 bp
  • T to C, chromosome 6 at 69,463,721 bp
  • T to A, chromosome 6 at 104,833,030 bp
  • A to G, chromosome 6 at 136,560,234 bp
  • C to T, chromosome 7 at 4,133,393 bp
  • A to T, chromosome 7 at 6,708,420 bp
  • C to A, chromosome 7 at 25,348,295 bp
  • A to G, chromosome 7 at 41,158,963 bp
  • A to T, chromosome 7 at 118,552,696 bp
  • A to C, chromosome 9 at 3,001,041 bp
  • A to G, chromosome 9 at 123,582,262 bp
  • A to G, chromosome 10 at 8,518,224 bp
  • A to G, chromosome 10 at 128,960,680 bp
  • G to C, chromosome 11 at 70,462,120 bp
  • A to G, chromosome 11 at 72,858,344 bp
  • A to T, chromosome 11 at 75,452,481 bp
  • G to A, chromosome 11 at 119,346,768 bp
  • A to T, chromosome 12 at 103,074,954 bp
  • A to G, chromosome 13 at 113,213,358 bp
  • G to T, chromosome 15 at 10,461,877 bp
  • A to G, chromosome 15 at 68,180,230 bp
  • G to A, chromosome 15 at 76,709,544 bp
  • T to C, chromosome 16 at 32,754,794 bp
  • T to A, chromosome 16 at 36,009,352 bp
  • T to C, chromosome 17 at 30,739,757 bp
  • G to A, chromosome 17 at 30,748,568 bp
  • T to A, chromosome 17 at 30,800,531 bp
  • T to A, chromosome 19 at 13,530,273 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5075 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042664-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.