Strain Name:
C57BL/6J-MtgxR5081Btlr/Mmmh
Stock Number:
042670-MU
Citation ID:
RRID:MMRRC_042670-MU
Other Names:
R5081 (G1), C57BL/6J-MtgxR5081Btlr
Major Collection:

Gene Information

Col1a1
Name: collagen, type I, alpha 1
Synonyms: Cola1, Cola-1, Col1a-1, Mov-13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12842
HGNC: HGNC:2197
Homologene: 73874
Myo10
Name: myosin X
Synonyms: D15Ertd600e, myosin-X
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 17909
HGNC: HGNC:7593
Homologene: 36328
Ntrk3
Name: neurotrophic tyrosine kinase, receptor, type 3
Synonyms: TrkC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18213
HGNC: HGNC:8033
Homologene: 49183
Nrcam
Name: neuronal cell adhesion molecule
Synonyms: C130076O07Rik, Bravo, C030017F07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319504
VEGA: 12
HGNC: HGNC:7994
Homologene: 21041
Ulk2
Name: unc-51 like kinase 2
Synonyms: A830085I22Rik, Unc51.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 29869
Homologene: 5891
Arpp21
Name: cyclic AMP-regulated phosphoprotein, 21
Synonyms: ARPP-21, Tarpp, R3hdm3, D9Bwg1012e, 0710001E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74100
Homologene: 32306
Cyp39a1
Name: cytochrome P450, family 39, subfamily a, polypeptide 1
Synonyms: oxysterol 7-alpha-hydroxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56050
VEGA: 17
Homologene: 9580
Asah2
Name: N-acylsphingosine amidohydrolase 2
Synonyms: neutral/alkaline ceramidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 54447
VEGA: 19
Homologene: 10310
Arhgap35
Name: Rho GTPase activating protein 35
Synonyms: p190RhoGAP, p190A, 6430596G11Rik, P190 RhoGAP, Grlf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232906
HGNC: HGNC:4591
Homologene: 35136
Sf3a2
Name: splicing factor 3a, subunit 2
Synonyms: PRP11, Sap62, 66kDa, SFA66
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 20222
Homologene: 133823
Kpna3
Name: karyopherin (importin) alpha 3
Synonyms: importin alpha 4, IPOA4, importin alpha 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16648
VEGA: 14
HGNC: HGNC:6396
Homologene: 20520
Cep68
Name: centrosomal protein 68
Synonyms: 6030463E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216543
Homologene: 65235
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: Odz2, D3Bwg1534e, 9330187F13Rik, Ten-m2, 2610040L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 23964
Homologene: 22672
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: A330049M09Rik, SYNE-1, nesprin-1, C130039F11Rik, enaptin165
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Ash1l
Name: ASH1 like histone lysine methyltransferase
Synonyms: KMT2H, chromatin remodeling factor, E430018P19Rik, 8030453L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 192195
Homologene: 10225
Ass1
Name: argininosuccinate synthetase 1
Synonyms: Ass-1, fold, ASS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11898
HGNC: HGNC:758
Homologene: 6899
Cspp1
Name: centrosome and spindle pole associated protein 1
Synonyms: 2310020J12Rik, 4930413O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 211660
Homologene: 23487
Tia1
Name: cytotoxic granule-associated RNA binding protein 1
Synonyms: 2310050N03Rik, mTIA-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 21841
Homologene: 20692
Psmd2
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
Synonyms: Tex190, TEG-190, 9430095H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 21762
HGNC: HGNC:9559
Homologene: 2101
Cdc23
Name: CDC23 cell division cycle 23
Synonyms: D18Ertd243e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 52563
HGNC: HGNC:1724
Homologene: 3426
Morc1
Name: microrchidia 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17450
VEGA: 16
HGNC: HGNC:7198
Homologene: 7843
Rbm14
Name: RNA binding motif protein 14
Synonyms: PSP2, 1300007E16Rik, p16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 56275
Homologene: 4614
Ap3s1
Name: adaptor-related protein complex 3, sigma 1 subunit
Synonyms: [s]3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 11777
VEGA: 18
HGNC: HGNC:2013
Homologene: 4254
Scn4a
Name: sodium channel, voltage-gated, type IV, alpha
Synonyms: Nav1.4, SkM1, mH2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 110880
Homologene: 283
Cdh23
Name: cadherin 23 (otocadherin)
Synonyms: sals, nmf112, nmf181, nmf252, 4930542A03Rik, ahl, USH1D, mdfw, bob
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22295
Homologene: 11142
Itga11
Name: integrin alpha 11
Synonyms: 4732459H24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319480
HGNC: HGNC:6136
Homologene: 8151
Ttc16
Name: tetratricopeptide repeat domain 16
Synonyms: 1200002K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 338348
Homologene: 17011
Rbm15b
Name: RNA binding motif protein 15B
Synonyms: 1810017N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 109095
Homologene: 8325
Cnga4
Name: cyclic nucleotide gated channel alpha 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233649
HGNC: HGNC:2152
Homologene: 13579
Dock3
Name: dedicator of cyto-kinesis 3
Synonyms: Moca, PBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208869
HGNC: HGNC:2989
Homologene: 21030
Mink1
Name: misshapen-like kinase 1 (zebrafish)
Synonyms: Map4k6, MINK, Misshapen/NIKs-related kinase, Ysk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 50932
Homologene: 56762
Serpinb6d
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6d
Synonyms: SPI3D, Gm11390
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238568
HGNC: HGNC:8950
Pgm2l1
Name: phosphoglucomutase 2-like 1
Synonyms: BM32A, 4931406N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70974
Homologene: 12374
Cd101
Name: CD101 antigen
Synonyms: Igsf2, LOC381460
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 630146
HGNC: HGNC:5949
Homologene: 3142
Ctsj
Name: cathepsin J
Synonyms: CATP, Cat P, Ctsp, rat gene/Cathepsin L-related protein, CatRLP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 26898
VEGA: 13
Homologene: 137246
Olfr346
Name: olfactory receptor 346
Synonyms: GA_x6K02T2NLDC-33382467-33383396, MOR136-11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258940
Homologene: 133616
Ces1c
Name: carboxylesterase 1C
Synonyms: Ces-N, Es-1, Es1, Es-4, Ee-1, Es-N
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13884
HGNC: HGNC:1863
Homologene: 117484
Nnt
Name: nicotinamide nucleotide transhydrogenase
Synonyms: 4930423F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18115
HGNC: HGNC:7863
Olfr851
Name: olfactory receptor 851
Synonyms: GA_x6K02T2PVTD-13234278-13235216, MOR155-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258907
Homologene: 74178
Sart1
Name: squamous cell carcinoma antigen recognized by T cells 1
Synonyms: U5-110K
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20227
VEGA: 19
Homologene: 133770
Gtf3a
Name: general transcription factor III A
Synonyms: 2010015D03Rik, 2610111I01Rik, 5330403M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66596
HGNC: HGNC:4662
Homologene: 55630
Alox12
Name: arachidonate 12-lipoxygenase
Synonyms: P-12LO, Alox12p, 9930022G08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11684
HGNC: HGNC:429
Homologene: 560
Gtpbp3
Name: GTP binding protein 3
Synonyms: 2410009F13Rik, Gtpbp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 70359
Homologene: 6600
Obsl1
Name: obscurin-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98733
Idi1
Name: isopentenyl-diphosphate delta isomerase
Synonyms: 4832416K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 319554
HGNC: HGNC:5387
Homologene: 3315
Agbl5
Name: ATP/GTP binding protein-like 5
Synonyms: 9430057O19Rik, Ccp5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231093
Homologene: 11053
Vmn1r66
Name: vomeronasal 1 receptor 66
Synonyms: V1re11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 171264
Pank1
Name: pantothenate kinase 1
Synonyms: Pank1a, Pank1b, Pank1, 4632412I06Rik, 5430426F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 75735
VEGA: 19
HGNC: HGNC:8598
Homologene: 56979
Gpcpd1
Name: glycerophosphocholine phosphodiesterase 1
Synonyms: 2310004G06Rik, Prei4, 2310032D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74182
Homologene: 10478
Zfp512b
Name: zinc finger protein 512B
Synonyms: LOC269401, Znf512b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269401
Homologene: 69314
Vwa2
Name: von Willebrand factor A domain containing 2
Synonyms: Amaco
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 240675
Homologene: 18238
Nkx3-1
Name: NK3 homeobox 1
Synonyms: Bax, NKX3.1, Nkx-3.1, NKX3A, bagpipe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18095
HGNC: HGNC:7838
Homologene: 4494
Ccpg1
Name: cell cycle progression 1
Synonyms: 1700030B06Rik, D9Ertd392e, 1810073J13Rik, 9430028F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72278
Homologene: 3487
Aig1
Name: androgen-induced 1
Synonyms: CGI-103, 1500031O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 66253
Homologene: 32297
AI593442
Name: expressed sequence AI593442
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 330941
VEGA: 9
Homologene: 52281
H2-Ke6
Name: H2-K region expressed gene 6
Synonyms: Ring2, H-2Ke6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14979
HGNC: HGNC:3554
Homologene: 56588
Rhbdd2
Name: rhomboid domain containing 2
Synonyms: 0610011L13Rik, Usmg1, Rhbdl7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 215160
Homologene: 32481
H2-Oa
Name: histocompatibility 2, O region alpha locus
Synonyms: H-2Oa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 15001
HGNC: HGNC:4936
Homologene: 1601
Qsox1
Name: quiescin Q6 sulfhydryl oxidase 1
Synonyms: QSOX, Qscn6, 1300003H02Rik, b2b2673Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 104009
HGNC: HGNC:9756
Homologene: 37690
2310068J16Rik
Name: RIKEN cDNA 2310068J16 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 70281
Ttc9c
Name: tetratricopeptide repeat domain 9C
Synonyms: 6330408J23Rik, 2210019E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 70387
Homologene: 18361
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 10,047,466 bp
  • T to C, chromosome 1 at 75,487,963 bp
  • G to T, chromosome 1 at 155,812,835 bp
  • G to A, chromosome 2 at 31,488,653 bp
  • A to T, chromosome 2 at 32,767,976 bp
  • A to G, chromosome 2 at 36,688,643 bp
  • A to T, chromosome 2 at 132,547,702 bp
  • A to G, chromosome 2 at 181,589,173 bp
  • T to G, chromosome 3 at 88,984,717 bp
  • T to A, chromosome 3 at 101,003,705 bp
  • G to A, chromosome 5 at 30,903,059 bp
  • T to A, chromosome 5 at 135,636,022 bp
  • T to A, chromosome 5 at 146,951,282 bp
  • A to T, chromosome 6 at 86,425,737 bp
  • A to G, chromosome 7 at 10,274,795 bp
  • A to G, chromosome 7 at 16,565,134 bp
  • A to G, chromosome 7 at 78,577,774 bp
  • A to G, chromosome 7 at 100,268,265 bp
  • T to C, chromosome 7 at 105,407,025 bp
  • A to T, chromosome 8 at 71,490,382 bp
  • A to G, chromosome 8 at 93,127,569 bp
  • A to G, chromosome 9 at 19,497,261 bp
  • TGAGGAGGAGGAGGAGGA to TGAGGAGGAGGAGGA, chromosome 9 at 52,677,814 bp
  • A to G, chromosome 9 at 62,755,196 bp
  • A to G, chromosome 9 at 72,999,078 bp
  • G to A, chromosome 9 at 106,884,921 bp
  • A to T, chromosome 9 at 106,991,093 bp
  • T to C, chromosome 9 at 112,143,514 bp
  • T to C, chromosome 10 at 5,047,767 bp
  • A to G, chromosome 10 at 13,801,900 bp
  • T to C, chromosome 10 at 60,436,807 bp
  • C to A, chromosome 10 at 80,804,441 bp
  • G to T, chromosome 11 at 20,238,477 bp
  • T to C, chromosome 11 at 36,024,633 bp
  • G to A, chromosome 11 at 61,803,662 bp
  • A to T, chromosome 11 at 70,255,314 bp
  • T to C, chromosome 11 at 70,605,144 bp
  • A to G, chromosome 11 at 94,951,576 bp
  • G to A, chromosome 11 at 106,348,727 bp
  • A to T, chromosome 12 at 44,570,353 bp
  • T to A, chromosome 13 at 8,887,927 bp
  • A to T, chromosome 13 at 33,671,247 bp
  • T to A, chromosome 13 at 61,003,850 bp
  • T to C, chromosome 13 at 119,366,400 bp
  • C to T, chromosome 14 at 61,391,245 bp
  • T to C, chromosome 14 at 69,191,947 bp
  • A to G, chromosome 15 at 25,785,940 bp
  • G to A, chromosome 15 at 99,973,017 bp
  • A to G, chromosome 16 at 20,661,655 bp
  • T to G, chromosome 16 at 48,502,352 bp
  • G to A, chromosome 17 at 34,027,578 bp
  • A to T, chromosome 17 at 34,094,370 bp
  • C to A, chromosome 17 at 43,746,597 bp
  • C to A, chromosome 18 at 34,651,689 bp
  • T to A, chromosome 18 at 46,754,430 bp
  • A to G, chromosome 19 at 4,802,795 bp
  • T to C, chromosome 19 at 5,388,548 bp
  • A to T, chromosome 19 at 8,816,032 bp
  • T to A, chromosome 19 at 32,014,308 bp
  • T to C, chromosome 19 at 34,878,916 bp
  • C to T, chromosome 19 at 56,909,320 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5081 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042670-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.