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Strain Name:
C57BL/6J-MtgxR5100Btlr/Mmmh
Stock Number:
042689-MU
Citation ID:
RRID:MMRRC_042689-MU
Other Names:
R5100 (G1), C57BL/6J-MtgxR5100Btlr
Major Collection:

Strain Information

Wnt5b
Name: wingless-type MMTV integration site family, member 5B
Synonyms: Wnt-5b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22419
Homologene: 22530
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Ncoa3
Name: nuclear receptor coactivator 3
Synonyms: pCIP, TRAM-1, AIB1, RAC3, TRAM1, Src3, 2010305B15Rik, KAT13B, bHLHe42
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17979
HGNC: HGNC:7670
Homologene: 4764
Plcd3
Name: phospholipase C, delta 3
Synonyms: 2610205J15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72469
HGNC: HGNC:9061
Homologene: 14858
Spred2
Name: sprouty-related EVH1 domain containing 2
Synonyms: Spred-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 114716
Homologene: 24918
Kif15
Name: kinesin family member 15
Synonyms: N-10 kinesin, HKLP2, 3930402I10Rik, 3110023M17Rik, Knsl7
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 209737
VEGA: 9
Homologene: 23210
Asxl1
Name: ASXL transcriptional regulator 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228790
Homologene: 9098
Apaf1
Name: apoptotic peptidase activating factor 1
Synonyms: Apaf1l, 6230400I06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11783
HGNC: HGNC:576
Homologene: 7626
Lpin2
Name: lipin 2
Synonyms: 2610511G02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 64898
Homologene: 8769
Pms2
Name: PMS1 homolog2, mismatch repair system component
Synonyms: mismatch repair, DNA mismatch repair
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18861
Homologene: 133560
Arhgef17
Name: Rho guanine nucleotide exchange factor 17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207212
Homologene: 129601
Flrt3
Name: fibronectin leucine rich transmembrane protein 3
Synonyms: 5530600M07Rik, C430047I10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71436
HGNC: HGNC:3762
Homologene: 8322
Grhl3
Name: grainyhead like transcription factor 3
Synonyms: Som, Get1, ct
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230824
Homologene: 18864
Mesd
Name: mesoderm development LRP chaperone
Synonyms: 2210015O11Rik, msd, Mesdc2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67943
Homologene: 11347
Mfge8
Name: milk fat globule EGF and factor V/VIII domain containing
Synonyms: Mfgm, SED1, MFG-E8, lactadherin, EGF/factor VIII
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17304
HGNC: HGNC:7036
Homologene: 4334
Elac2
Name: elaC ribonuclease Z 2
Synonyms: 1110017O07Rik, D11Wsu80e, tRNase Z(L)
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68626
Homologene: 6403
Ppp1r12c
Name: protein phosphatase 1, regulatory subunit 12C
Synonyms: 2410197A17Rik, Mbs85
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232807
Homologene: 75071
Zfyve26
Name: zinc finger, FYVE domain containing 26
Synonyms: 9330197E15Rik, LOC380767, A630028O16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 211978
VEGA: 12
Homologene: 9102
Pla2g7
Name: phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Synonyms: PAF acetylhydrolase, PAF-AH
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27226
HGNC: HGNC:9040
Homologene: 3725
Gm11992
Name: predicted gene 11992
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 626870
Homologene: 77951
Depdc1a
Name: DEP domain containing 1a
Synonyms: 5830484J08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76131
Homologene: 9834
Trpm3
Name: transient receptor potential cation channel, subfamily M, member 3
Synonyms: B930001P07Rik, 6330504P12Rik, MLSN2, melastatin 2, LTRPC3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226025
VEGA: 19
Homologene: 62287
Pcsk5
Name: proprotein convertase subtilisin/kexin type 5
Synonyms: PC6, SPC6, PC5A, PC5/6A, b2b585Clo, b2b1549Clo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18552
VEGA: 19
HGNC: HGNC:8747
Homologene: 21244
Ptchd4
Name: patched domain containing 4
Synonyms: 3110082D06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627626
VEGA: 17
Homologene: 78322
Scn9a
Name: sodium channel, voltage-gated, type IX, alpha
Synonyms: PN1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20274
Homologene: 2237
Adamts3
Name: ADAM metallopeptidase with thrombospondin type 1 motif 3
Synonyms: 6330442E02Rik, 1100001H14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330119
HGNC: HGNC:219
Homologene: 8596
Tnxb
Name: tenascin XB
Synonyms: Tnx, TN-MHC
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 81877
Homologene: 49589
Gm4787
Name: predicted gene 4787
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 214321
Homologene: 86950
4933427D14Rik
Name: RIKEN cDNA 4933427D14 gene
Synonyms: Gm43951
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74477
Homologene: 8874
Zfp820
Name: zinc finger protein 820
Synonyms: 2610036F08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 75424
VEGA: 17
Lrit1
Name: leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
Synonyms: Lrrc21
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239037
Homologene: 9215
Ngp
Name: neutrophilic granule protein
Synonyms: clone B6, myeloid granule protein, bectenecin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18054
Homologene: 49180
Arhgap31
Name: Rho GTPase activating protein 31
Synonyms: CdGAP
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12549
Homologene: 10644
Cobll1
Name: Cobl-like 1
Synonyms: Coblr1, D430044D16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 319876
Homologene: 8933
Ncoa5
Name: nuclear receptor coactivator 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228869
Homologene: 32496
Gsdmcl1
Name: gasdermin C-like 1
Synonyms: 1700022L20Rik, Gsdmdc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 74236
H2-Q6
Name: histocompatibility 2, Q region locus 6
Synonyms: Qa6, Qa-6, H-2Q6, 0610037M15Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 110557
Homologene: 128352
Tgm2
Name: transglutaminase 2, C polypeptide
Synonyms: tissue transglutaminase, protein-glutamine gamma-glutamyltransferase, G[a]h, TG C, tTGas, tTG, TG2, TGase2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21817
Homologene: 3391
Ap3m2
Name: adaptor-related protein complex 3, mu 2 subunit
Synonyms: 5830445E16Rik, AP-3B
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 64933
HGNC: HGNC:570
Homologene: 4950
Terb1
Name: telomere repeat binding bouquet formation protein 1
Synonyms: 4930532D21Rik, Ccdc79
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320022
Homologene: 18330
Nhlrc1
Name: NHL repeat containing 1
Synonyms: B230309E09Rik, EPM2B, Malin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105193
VEGA: 13
Homologene: 18439
Ptf1aos
Name: pancreas specific transcription factor 1a, opposite strand
Synonyms: Gm13336
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 102637107
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 92,644,385 bp
  • T to A, chromosome 2 at 19,446,595 bp
  • T to A, chromosome 2 at 65,125,901 bp
  • T to C, chromosome 2 at 66,534,119 bp
  • T to A, chromosome 2 at 140,671,384 bp
  • C to G, chromosome 2 at 153,397,931 bp
  • A to T, chromosome 2 at 158,127,164 bp
  • A to G, chromosome 2 at 165,009,389 bp
  • G to A, chromosome 2 at 166,050,097 bp
  • C to T, chromosome 2 at 177,315,115 bp
  • A to T, chromosome 3 at 159,515,520 bp
  • A to C, chromosome 4 at 123,474,468 bp
  • A to G, chromosome 4 at 135,542,675 bp
  • G to A, chromosome 5 at 89,708,643 bp
  • A to T, chromosome 5 at 114,256,759 bp
  • A to G, chromosome 5 at 143,928,188 bp
  • A to C, chromosome 6 at 119,440,488 bp
  • T to C, chromosome 7 at 4,483,664 bp
  • G to A, chromosome 7 at 30,178,651 bp
  • A to T, chromosome 7 at 79,143,300 bp
  • C to T, chromosome 7 at 83,897,769 bp
  • A to T, chromosome 7 at 100,881,756 bp
  • T to A, chromosome 8 at 22,789,388 bp
  • A to T, chromosome 8 at 104,495,173 bp
  • T to C, chromosome 9 at 110,420,001 bp
  • A to G, chromosome 9 at 122,991,994 bp
  • A to T, chromosome 10 at 90,997,287 bp
  • T to C, chromosome 11 at 9,061,290 bp
  • T to A, chromosome 11 at 20,021,291 bp
  • G to A, chromosome 11 at 65,001,871 bp
  • A to T, chromosome 11 at 72,166,651 bp
  • C to A, chromosome 11 at 103,078,349 bp
  • T to A, chromosome 12 at 79,280,058 bp
  • G to C, chromosome 12 at 81,377,830 bp
  • T to C, chromosome 13 at 47,014,421 bp
  • T to C, chromosome 13 at 55,009,030 bp
  • T to A, chromosome 14 at 37,062,214 bp
  • T to C, chromosome 15 at 63,850,549 bp
  • A to T, chromosome 16 at 38,601,459 bp
  • C to A, chromosome 17 at 21,821,073 bp
  • A to T, chromosome 17 at 34,710,928 bp
  • G to C, chromosome 17 at 35,425,320 bp
  • A to T, chromosome 17 at 42,503,676 bp
  • T to C, chromosome 17 at 43,611,376 bp
  • G to A, chromosome 17 at 71,243,970 bp
  • C to T, chromosome 19 at 17,515,135 bp
  • T to G, chromosome 19 at 22,918,766 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5100 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042689-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.