Strain Name:
C57BL/6J-MtgxR5115Btlr/Mmmh
Stock Number:
042703-MU
Citation ID:
RRID:MMRRC_042703-MU
Other Names:
R5115 (G1), C57BL/6J-MtgxR5115Btlr
Major Collection:

Gene Information

Atic
Name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Synonyms: 2610509C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 108147
HGNC: HGNC:794
Homologene: 2983
Slc17a5
Name: solute carrier family 17 (anion/sugar transporter), member 5
Synonyms: 4631416G20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235504
Homologene: 56571
Mfn1
Name: mitofusin 1
Synonyms: 6330416C07Rik, 2310002F04Rik, HR2, D3Ertd265e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 67414
Homologene: 11481
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: slip, DNA-PK, DNAPDcs, dxnph, DOXNPH, DNA-PKcs, XRCC7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Cep83
Name: centrosomal protein 83
Synonyms: 5730513H21Rik, 4921537D05Rik, Ccdc41, 2600001G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 77048
VEGA: 10
Homologene: 9396
Cyp11b2
Name: cytochrome P450, family 11, subfamily b, polypeptide 2
Synonyms: steroid-11-beta-hydroxylase, Cyp11b-2, aldosterone synthase, Cyp11b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 13072
Homologene: 128035
Mllt6
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6
Synonyms: Af17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 246198
HGNC: HGNC:7138
Homologene: 31347
Papola
Name: poly (A) polymerase alpha
Synonyms: Plap, PapIII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 18789
Homologene: 23389
Pikfyve
Name: phosphoinositide kinase, FYVE type zinc finger containing
Synonyms: Pip5k3, 5230400C17Rik, PipkIII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 18711
Homologene: 32115
Pyroxd1
Name: pyridine nucleotide-disulphide oxidoreductase domain 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232491
Homologene: 11758
Serpina3c
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3C
Synonyms: Klkbp, 1A1, Kalbp, alpha-1 antiproteinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 16625
HGNC: HGNC:16
Homologene: 111129
Nrbp1
Name: nuclear receptor binding protein 1
Synonyms: Nrbp, B230344L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 192292
HGNC: HGNC:7993
Homologene: 8373
Kdm4a
Name: lysine (K)-specific demethylase 4A
Synonyms: D4Ertd222e, Jmjd2a, Jmjd2, JHDM3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230674
Homologene: 27780
Plxna2
Name: plexin A2
Synonyms: 2810428A13Rik, PlexA2, Plxn2, OCT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Ttyh1
Name: tweety family member 1
Synonyms: 6330408P11Rik, 4930459B04Rik, tty
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 57776
Homologene: 10779
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Fat2
Name: FAT atypical cadherin 2
Synonyms: Fath2, mKIAA0811, LOC245827, EMI2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Nlrc5
Name: NLR family, CARD domain containing 5
Synonyms: AI451557
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 434341
Homologene: 88935
Gsdmc2
Name: gasdermin C2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 331063
HGNC: HGNC:7151
Homologene: 69487
Ttll9
Name: tubulin tyrosine ligase-like family, member 9
Synonyms: 1700016F23Rik, 4930509O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 74711
Homologene: 41769
Zfp276
Name: zinc finger protein (C2H2 type) 276
Synonyms: D8Ertd370e, D8Ertd377e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 57247
Homologene: 10731
Asic1
Name: acid-sensing (proton-gated) ion channel 1
Synonyms: ASICalpha, ASIC1 beta, ASIC1a, B530003N02Rik, BNaC2, ASIC, Accn2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 11419
VEGA: 15
HGNC: HGNC:100
Homologene: 121755
Tmc6
Name: transmembrane channel-like gene family 6
Synonyms: EVER1, D11Ertd204e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217353
Homologene: 5258
Atp1b2
Name: ATPase, Na+/K+ transporting, beta 2 polypeptide
Synonyms: Atpb-2, Amog
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 11932
HGNC: HGNC:805
Homologene: 36075
Stk36
Name: serine/threonine kinase 36
Synonyms: Fused, 1700112N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 269209
Homologene: 49432
Vmn1r71
Name: vomeronasal 1 receptor 71
Synonyms: V1re13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 252910
Homologene: 74352
Plin1
Name: perilipin 1
Synonyms: perilipin A, Plin, Peri, perilipin B, 6030432J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 103968
HGNC: HGNC:9076
Homologene: 2001
Kng1
Name: kininogen 1
Synonyms: H-kininigen, L-kininogen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 16644
HGNC: HGNC:6383
Homologene: 88343
Rbfox1
Name: RNA binding protein, fox-1 homolog (C. elegans) 1
Synonyms: FOX1, HRNBP1, A2bp, A2bp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 268859
VEGA: 16
Homologene: 69339
Cwc15
Name: CWC15 spliceosome-associated protein
Synonyms: 0610040D20Rik, 2900052N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 66070
Homologene: 9499
C2cd6
Name: C2 calcium dependent domain containing 6
Synonyms: C2cd6b, Gm33589, Als2cr11, 4930408G06Rik, Als2cr11b, 1700052H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 102636554
Homologene: 134310
Tvp23a
Name: trans-golgi network vesicle protein 23A
Synonyms: Fam18a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 383103
Homologene: 19919
Golga7
Name: golgi autoantigen, golgin subfamily a, 7
Synonyms: GOLGA3AP1, HSPC041, C130038N16Rik, GCP16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 57437
Homologene: 9385
2600006K01Rik
Name: RIKEN cDNA 2600006K01 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
Sprr2b
Name: small proline-rich protein 2B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 20756
Gm12224
Name: predicted gene 12224
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 108167900
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 59,051,261 bp
  • T to C, chromosome 1 at 65,224,117 bp
  • G to A, chromosome 1 at 71,557,275 bp
  • T to C, chromosome 1 at 74,635,827 bp
  • G to A, chromosome 1 at 194,810,959 bp
  • A to G, chromosome 2 at 29,869,618 bp
  • T to C, chromosome 2 at 125,332,383 bp
  • C to A, chromosome 2 at 152,989,590 bp
  • T to C, chromosome 3 at 32,564,307 bp
  • G to T, chromosome 3 at 92,317,555 bp
  • G to T, chromosome 4 at 118,162,581 bp
  • T to G, chromosome 5 at 31,243,715 bp
  • T to C, chromosome 6 at 142,358,559 bp
  • C to T, chromosome 7 at 4,133,393 bp
  • T to A, chromosome 7 at 10,747,958 bp
  • AGGCCACCAGGGGGTGGGC to AGGC, chromosome 7 at 79,729,944 bp
  • A to T, chromosome 8 at 23,245,970 bp
  • G to A, chromosome 8 at 94,476,819 bp
  • A to G, chromosome 8 at 123,264,977 bp
  • A to G, chromosome 9 at 14,507,896 bp
  • A to G, chromosome 9 at 78,577,112 bp
  • A to G, chromosome 10 at 94,768,889 bp
  • C to T, chromosome 11 at 54,340,498 bp
  • A to G, chromosome 11 at 55,296,333 bp
  • T to C, chromosome 11 at 69,603,473 bp
  • G to A, chromosome 11 at 97,669,500 bp
  • G to A, chromosome 11 at 117,775,188 bp
  • T to C, chromosome 12 at 104,147,392 bp
  • T to C, chromosome 12 at 105,826,960 bp
  • A to T, chromosome 15 at 63,827,768 bp
  • A to T, chromosome 15 at 74,855,428 bp
  • C to T, chromosome 15 at 99,672,052 bp
  • A to G, chromosome 16 at 7,409,772 bp
  • T to A, chromosome 16 at 10,427,461 bp
  • A to G, chromosome 16 at 15,790,580 bp
  • G to A, chromosome 16 at 23,069,282 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5115 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042703-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.