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Strain Name:
C57BL/6J-MtgxR5117Btlr/Mmmh
Stock Number:
042705-MU
Citation ID:
RRID:MMRRC_042705-MU
Other Names:
R5117 (G1), C57BL/6J-MtgxR5117Btlr
Major Collection:

Strain Information

Pik3r1
Name: phosphoinositide-3-kinase regulatory subunit 1
Synonyms: p85alpha, p50alpha, p55alpha, PI3K
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18708
HGNC: HGNC:8979
Homologene: 7889
Ptch2
Name: patched 2
Synonyms: ptc2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19207
HGNC: HGNC:9586
Homologene: 37842
Cacna1g
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms: a1G, Cav3.1d
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12291
HGNC: HGNC:1394
Homologene: 22544
Wwp2
Name: WW domain containing E3 ubiquitin protein ligase 2
Synonyms: 1300010O06Rik, AIP2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66894
Homologene: 48490
Hsp90aa1
Name: heat shock protein 90, alpha (cytosolic), class A member 1
Synonyms: hsp4, Hsp90, Hsp86-1, Hsp89, Hspca
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 15519
HGNC: HGNC:5253
Homologene: 68464
Zfand5
Name: zinc finger, AN1-type domain 5
Synonyms: 2310057A04Rik, Zfp216, 5830475F03Rik, Za20d2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22682
Homologene: 21215
Senp6
Name: SUMO/sentrin specific peptidase 6
Synonyms: E130319N12Rik, 2810017C20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 215351
Homologene: 9196
Tm9sf2
Name: transmembrane 9 superfamily member 2
Synonyms: P76, 1500001N15Rik, D14Ertd64e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 68059
Homologene: 21004
Agrn
Name: agrin
Synonyms: NMF380, Agrin, nmf380
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11603
HGNC: HGNC:329
Homologene: 27907
Ints9
Name: integrator complex subunit 9
Synonyms: D14Ertd231e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 210925
VEGA: 14
Homologene: 10096
Supt16
Name: SPT16, facilitates chromatin remodeling subunit
Synonyms: Cdc68, Fact140, Spt16, Supt16h
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 114741
VEGA: 14
Homologene: 5207
Cep135
Name: centrosomal protein 135
Synonyms: LOC381644, Cep4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381644
Homologene: 45709
Adam11
Name: a disintegrin and metallopeptidase domain 11
Synonyms: Mdc
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11488
HGNC: HGNC:189
Homologene: 7614
Ube3b
Name: ubiquitin protein ligase E3B
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 117146
Homologene: 13775
Mapk6
Name: mitogen-activated protein kinase 6
Synonyms: Prkm6, ERK3, Prkm4, Erk3, Mapk63, Mapk4, D130053K17Rik, 2610021I23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 50772
HGNC: HGNC:6879
Homologene: 55683
Wdr4
Name: WD repeat domain 4
Synonyms: D530049K22Rik, Wh
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57773
Homologene: 32422
Myo19
Name: myosin XIX
Synonyms: 1110055A02Rik, Myohd1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66196
Homologene: 49819
Zfp599
Name: zinc finger protein 599
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235048
Homologene: 138456
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: LOC224126, Hapip, 2210407G14Rik, E530005C20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Ppara
Name: peroxisome proliferator activated receptor alpha
Synonyms: Nr1c1, PPAR-alpha, PPARalpha, Ppar, 4933429D07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19013
HGNC: HGNC:9232
Homologene: 21047
Pcdh7
Name: protocadherin 7
Synonyms: BH-protocadherin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54216
HGNC: HGNC:8659
Homologene: 36101
Or55b3
Name: olfactory receptor family 55 subfamily B member 3
Synonyms: GA_x6K02T2PBJ9-5199377-5198367, MOR42-2, Olfr543
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257947
Homologene: 81631
Tamalin
Name: trafficking regulator and scaffold protein tamalin
Synonyms: tamalin, Grasp
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 56149
VEGA: 15
Homologene: 32442
Or13n4
Name: olfactory receptor family 13 subfamily N member 4
Synonyms: GA_x6K02T2PBJ9-9202245-9201289, MOR260-4, Olfr702
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258590
Homologene: 121512
Serpina12
Name: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
Synonyms: vaspin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68054
Homologene: 23588
Klkb1
Name: kallikrein B, plasma 1
Synonyms: Kal-3, Kal3, Klk3, PSA
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16621
HGNC: HGNC:6371
Homologene: 68097
Ttc21a
Name: tetratricopeptide repeat domain 21A
Synonyms: 4921538N17Rik, Thm2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74052
Homologene: 14728
Abca8b
Name: ATP-binding cassette, sub-family A member 8b
Synonyms: Abca8
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 27404
HGNC: HGNC:38
Homologene: 56029
Cacna1b
Name: calcium channel, voltage-dependent, N type, alpha 1B subunit
Synonyms: Cchn1a, alpha(1B), Cav2.2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12287
HGNC: HGNC:1389
Homologene: 20184
Snx15
Name: sorting nexin 15
Synonyms: E130013C21Rik, 1500032B08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 69024
Homologene: 12294
Erich6
Name: glutamate rich 6
Synonyms: 4932431H17Rik, Fam194a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 545527
Homologene: 65043
Il18
Name: interleukin 18
Synonyms: Il-18, Igif
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16173
VEGA: 9
HGNC: HGNC:5986
Homologene: 1200
Serpinf2
Name: serine (or cysteine) peptidase inhibitor, clade F, member 2
Synonyms: alpha 2 antiplasmin, Pli
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18816
HGNC: HGNC:9075
Homologene: 719
Lipo3
Name: lipase, member O3
Synonyms: Lipo1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 381236
Homologene: 103863
Grid2
Name: glutamate receptor, ionotropic, delta 2
Synonyms: GluRdelta2, tpr, B230104L07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14804
HGNC: HGNC:4576
Homologene: 74399
Card14
Name: caspase recruitment domain family, member 14
Synonyms: CARMA2, Bimp2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 170720
Homologene: 11469
Fam234a
Name: family with sequence similarity 234, member A
Synonyms: Itfg3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106581
Homologene: 12932
Gm10717
Name: predicted gene 10717
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Nphp4
Name: nephronophthisis 4 (juvenile) homolog (human)
Synonyms: 4930564O18Rik, nmf192
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 260305
Homologene: 9024
Srrm4
Name: serine/arginine repetitive matrix 4
Synonyms: fp, flopsy, B230202K19Rik, nSR100, 1500001A10Rik, bv
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68955
Homologene: 49869
Myrf
Name: myelin regulatory factor
Synonyms: LOC225908, LOC386531, Gm98
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225908
HGNC: HGNC:1181
Homologene: 32167
Vmn2r14
Name: vomeronasal 2, receptor 14
Synonyms: EG231591
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231591
Homologene: 129606
Thoc2l
Name: THO complex subunit 2-like
Synonyms: Gm3179, BC005561
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100042165
4921509C19Rik
Name: RIKEN cDNA 4921509C19 gene
Synonyms: LOC381389
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381393
Homologene: 72396
Zfyve16
Name: zinc finger, FYVE domain containing 16
Synonyms: B130024H06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218441
Homologene: 8826
Ces1b
Name: carboxylesterase 1B
Synonyms: Gm5158
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382044
HGNC: HGNC:1863
Homologene: 117484
Slc7a11
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
Synonyms: System xc, xc, xCT, sut, 9930009M05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 26570
Homologene: 22684
Naga
Name: N-acetyl galactosaminidase, alpha
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17939
VEGA: 15
HGNC: HGNC:7631
Homologene: 221
Fbxl9
Name: F-box and leucine-rich repeat protein 9
Synonyms: FBL9, A630024J02Rik, Lrrc29
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234684
Homologene: 133339
Nr1h4
Name: nuclear receptor subfamily 1, group H, member 4
Synonyms: RIP14, FXR, HRR1, Rxrip14, Fxr
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20186
HGNC: HGNC:7967
Homologene: 3760
Fads3
Name: fatty acid desaturase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 60527
VEGA: 19
HGNC: HGNC:3576
Homologene: 11025
Trim56
Name: tripartite motif-containing 56
Synonyms: LOC384309, RNF109, A130009K11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384309
Homologene: 12812
Sh3d21
Name: SH3 domain containing 21
Synonyms: 1700029G01Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66938
Homologene: 12057
Or10j27
Name: olfactory receptor family 10 subfamily J member 27
Synonyms: GA_x6K02T2R7CC-715776-716708, MOR267-4, Olfr1408
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258759
Homologene: 128062
Gm5519
Name: predicted pseudogene 5519
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 433241
VEGA: 19
Gm11787
Name: predicted gene 11787
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 666513
Zfp703
Name: zinc finger protein 703
Synonyms: 1110032O19Rik, Csmn1, End2, Zeppo1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 353310
Homologene: 81391
Triqk
Name: triple QxxK/R motif containing
Synonyms: Triqk, Gm11818
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 208820
Homologene: 90150
Gm26672
Name: predicted gene, 26672
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
2010315B03Rik
Name: RIKEN cDNA 2010315B03 gene
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 630836
Homologene: 136499
Gm6654
Name: predicted pseudogene 6654
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 626175
Gm22953
Name: predicted gene, 22953
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Gm15564
Name: predicted gene 15564
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 102639045
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 173,130,917 bp
  • A to G, chromosome 2 at 24,732,328 bp
  • T to G, chromosome 2 at 31,458,049 bp
  • C to T, chromosome 2 at 121,450,703 bp
  • T to C, chromosome 2 at 151,472,540 bp
  • T to C, chromosome 3 at 50,379,150 bp
  • T to G, chromosome 3 at 58,623,205 bp
  • G to T, chromosome 4 at 3,509,524 bp
  • T to A, chromosome 4 at 12,980,390 bp
  • T to A, chromosome 4 at 117,105,949 bp
  • T to C, chromosome 4 at 126,151,872 bp
  • T to G, chromosome 4 at 152,524,232 bp
  • T to C, chromosome 4 at 156,185,553 bp
  • A to G, chromosome 5 at 57,721,748 bp
  • A to G, chromosome 5 at 76,631,429 bp
  • A to G, chromosome 5 at 104,520,255 bp
  • T to C, chromosome 5 at 109,216,095 bp
  • T to G, chromosome 5 at 114,419,631 bp
  • A to G, chromosome 5 at 116,449,447 bp
  • A to T, chromosome 5 at 137,113,978 bp
  • T to C, chromosome 6 at 28,446,279 bp
  • T to C, chromosome 6 at 63,256,933 bp
  • T to A, chromosome 6 at 146,647,283 bp
  • T to C, chromosome 7 at 102,477,502 bp
  • A to T, chromosome 7 at 106,823,662 bp
  • C to T, chromosome 8 at 26,979,205 bp
  • A to T, chromosome 8 at 45,289,112 bp
  • A to G, chromosome 8 at 93,073,209 bp
  • T to A, chromosome 8 at 105,312,860 bp
  • T to C, chromosome 8 at 107,554,062 bp
  • T to C, chromosome 9 at 3,025,625 bp
  • A to T, chromosome 9 at 22,250,100 bp
  • A to T, chromosome 9 at 50,581,509 bp
  • C to A, chromosome 9 at 75,397,735 bp
  • G to A, chromosome 9 at 80,130,746 bp
  • T to A, chromosome 9 at 119,966,565 bp
  • G to A, chromosome 9 at 124,293,085 bp
  • T to C, chromosome 10 at 89,478,422 bp
  • T to C, chromosome 11 at 75,432,500 bp
  • C to A, chromosome 11 at 84,909,467 bp
  • T to A, chromosome 11 at 94,432,503 bp
  • T to A, chromosome 11 at 102,776,079 bp
  • T to C, chromosome 11 at 109,966,803 bp
  • T to A, chromosome 11 at 119,338,250 bp
  • T to C, chromosome 12 at 104,037,750 bp
  • T to C, chromosome 12 at 110,695,264 bp
  • T to A, chromosome 13 at 92,505,689 bp
  • G to A, chromosome 13 at 101,692,236 bp
  • A to G, chromosome 14 at 52,183,092 bp
  • G to T, chromosome 14 at 64,993,091 bp
  • C to A, chromosome 14 at 122,143,501 bp
  • A to C, chromosome 15 at 82,337,456 bp
  • A to G, chromosome 15 at 85,777,761 bp
  • A to G, chromosome 15 at 101,230,537 bp
  • T to C, chromosome 16 at 34,033,601 bp
  • C to A, chromosome 16 at 35,971,832 bp
  • A to G, chromosome 17 at 26,213,538 bp
  • A to G, chromosome 17 at 31,499,824 bp
  • C to T, chromosome 18 at 37,752,886 bp
  • A to G, chromosome 19 at 6,124,151 bp
  • T to G, chromosome 19 at 10,041,958 bp
  • T to A, chromosome 19 at 10,212,493 bp
  • T to A, chromosome 19 at 21,279,645 bp
  • A to T, chromosome 19 at 33,559,552 bp
  • A to G, chromosome 19 at 33,825,071 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5117 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042705-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.