Strain Name:
C57BL/6J-MtgxR5118Btlr/Mmmh
Stock Number:
042706-MU
Citation ID:
RRID:MMRRC_042706-MU
Other Names:
R5118 (G1), C57BL/6J-MtgxR5118Btlr
Major Collection:

Gene Information

Kdm1a
Name: lysine (K)-specific demethylase 1A
Synonyms: 1810043O07Rik, Aof2, Kdm1, LSD1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 99982
Homologene: 32240
Pcnt
Name: pericentrin (kendrin)
Synonyms: m275Asp, Pcnt2, m239Asp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18541
VEGA: 10
Ubr1
Name: ubiquitin protein ligase E3 component n-recognin 1
Synonyms: E3 alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22222
Homologene: 7582
Zfp462
Name: zinc finger protein 462
Synonyms: Gt4-2, 9430078C22Rik, Zfpip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242466
Homologene: 41430
Dop1a
Name: DOP1 leucine zipper like protein A
Synonyms: D9Ertd809e, B130005I07Rik, Dopey1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320615
Homologene: 26645
Tut4
Name: terminal uridylyl transferase 4
Synonyms: 6030404K05Rik, Tent3a, Zcchc11, 9230115F04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230594
Homologene: 35279
Tep1
Name: telomerase associated protein 1
Synonyms: Tp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21745
VEGA: 14
Homologene: 5157
Dmxl2
Name: Dmx-like 2
Synonyms: E130119P06Rik, 6430411K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Galnt5
Name: polypeptide N-acetylgalactosaminyltransferase 5
Synonyms: ppGaNTase-T5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241391
HGNC: HGNC:4127
Homologene: 8733
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: ELM2, Ten-m4, Doc4, l7Rn3, Odz4, l(7)-3Rn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 23966
Homologene: 8034
Erfe
Name: erythroferrone
Synonyms: Fam132b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227358
Homologene: 87245
Msh3
Name: mutS homolog 3
Synonyms: D13Em1, Rep3, Rep-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17686
HGNC: HGNC:7326
Homologene: 1829
2700049A03Rik
Name: RIKEN cDNA 2700049A03 gene
Synonyms: talpid3, Ta3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 76967
Homologene: 8839
Tmtc1
Name: transmembrane and tetratricopeptide repeat containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387314
Homologene: 65299
Rad54b
Name: RAD54 homolog B (S. cerevisiae)
Synonyms: E130016E03Rik, E130016E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 623474
Homologene: 8240
Irak2
Name: interleukin-1 receptor-associated kinase 2
Synonyms: 6330415L08Rik, IRAK-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 108960
HGNC: HGNC:6113
Homologene: 1207
Rtp1
Name: receptor transporter protein 1
Synonyms: LOC239766, LOC385871
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239766
VEGA: 16
Homologene: 17806
Kidins220
Name: kinase D-interacting substrate 220
Synonyms: 3110039L19Rik, C330002I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 77480
VEGA: 12
Homologene: 14254
Nuak1
Name: NUAK family, SNF1-like kinase, 1
Synonyms: B230104P22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 77976
Homologene: 8896
Rbm15b
Name: RNA binding motif protein 15B
Synonyms: 1810017N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 109095
Homologene: 8325
Reg3b
Name: regenerating islet-derived 3 beta
Synonyms: REG-III, Pap, PAP1, RegIII (beta)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 18489
HGNC: HGNC:8601
Homologene: 130506
Sfmbt1
Name: Scm-like with four mbt domains 1
Synonyms: 9330180L21Rik, Smr, 4930442N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 54650
Homologene: 9472
Adamts2
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2
Synonyms: procollagen N-proteinase, a disintegrin and metalloproteinase with thrombospondin repeats, hPCPNI, ADAM-TS2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216725
HGNC: HGNC:218
Homologene: 8597
Sorbs2
Name: sorbin and SH3 domain containing 2
Synonyms: 9430041O17Rik, 2010203O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234214
Homologene: 83295
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Gm7455, Col6a5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 665033
Homologene: 122792
Trp63
Name: transformation related protein 63
Synonyms: p63, p73L, KET protein, TAp63, p51/p63, Trp53rp1, deltaNp63
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 22061
Homologene: 31189
Rsl1
Name: regulator of sex limited protein 1
Synonyms: rslcan-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 380855
Homologene: 110878
Mul1
Name: mitochondrial ubiquitin ligase activator of NFKB 1
Synonyms: 0610009K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68350
Homologene: 11576
Wdr46
Name: WD repeat domain 46
Synonyms: Bing4, 2310007I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 57315
Homologene: 3981
Zfp954
Name: zinc finger protein 954
Synonyms: 5730403M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232853
Homologene: 129792
Arhgef40
Name: Rho guanine nucleotide exchange factor (GEF) 40
Synonyms: E130112L23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 268739
Homologene: 19560
Aldh1l2
Name: aldehyde dehydrogenase 1 family, member L2
Synonyms: D330038I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216188
Homologene: 51942
Alkbh6
Name: alkB homolog 6
Synonyms: Abh6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233065
Homologene: 15555
Epsti1
Name: epithelial stromal interaction 1 (breast)
Synonyms: 5033415K03Rik, 2310046K10Rik, BRESI1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 108670
VEGA: 14
Homologene: 12630
Psmb4
Name: proteasome (prosome, macropain) subunit, beta type 4
Synonyms: Pros-27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 19172
HGNC: HGNC:9541
Homologene: 2090
Tspan2
Name: tetraspanin 2
Synonyms: 6330415F13Rik, B230119D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 70747
Homologene: 21169
Pramel20
Name: PRAME like 20
Synonyms: BC080695
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329986
Homologene: 83161
Krt15
Name: keratin 15
Synonyms: K15, Krt1-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16665
HGNC: HGNC:6421
Homologene: 1712
Lgr5
Name: leucine rich repeat containing G protein coupled receptor 5
Synonyms: Gpr49
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14160
HGNC: HGNC:4504
Homologene: 20807
Cd44
Name: CD44 antigen
Synonyms: Ly-24, Pgp-1, HERMES
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12505
HGNC: HGNC:1681
Homologene: 508
Ankrd55
Name: ankyrin repeat domain 55
Synonyms: C030011J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 77318
VEGA: 13
Homologene: 12674
Mrap2
Name: melanocortin 2 receptor accessory protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244958
Homologene: 16307
Olfr1408
Name: olfactory receptor 1408
Synonyms: GA_x6K02T2R7CC-715776-716708, MOR267-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 258759
Homologene: 128062
Micall2
Name: MICAL-like 2
Synonyms: A930021H16Rik, Jrab, MICAL-L2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231830
Homologene: 85155
Zfp703
Name: zinc finger protein 703
Synonyms: End2, Csmn1, Zeppo1, 1110032O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 353310
Homologene: 81391
Usp17lc
Name: ubiquitin specific peptidase 17-like C
Synonyms: Dub-2, Dub2, Dub2b, Usp17l5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13532
Homologene: 131315
Pramel34
Name: PRAME like 34
Synonyms: C87414
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381654
Homologene: 133100
Gm1330
Name: predicted gene 1330
Synonyms: LOC383753
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Gm6181
Name: predicted pseudogene 6181
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 620782
Tmppe
Name: transmembrane protein with metallophosphoesterase domain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 100504715
VEGA: 9
Homologene: 62675
Gm4535
Name: predicted gene 4535
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100043585
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 91,370,716 bp
  • T to C, chromosome 1 at 173,130,917 bp
  • A to G, chromosome 2 at 58,015,003 bp
  • C to A, chromosome 2 at 102,865,370 bp
  • T to C, chromosome 2 at 120,882,264 bp
  • T to C, chromosome 2 at 149,002,986 bp
  • T to C, chromosome 3 at 94,884,942 bp
  • C to A, chromosome 3 at 102,749,835 bp
  • C to T, chromosome 4 at 11,595,677 bp
  • T to A, chromosome 4 at 55,010,667 bp
  • T to A, chromosome 4 at 108,520,292 bp
  • A to G, chromosome 4 at 136,557,358 bp
  • T to A, chromosome 4 at 138,439,349 bp
  • T to C, chromosome 4 at 143,571,127 bp
  • T to A, chromosome 5 at 93,637,797 bp
  • G to A, chromosome 5 at 139,716,447 bp
  • T to A, chromosome 6 at 78,372,128 bp
  • T to A, chromosome 6 at 113,665,811 bp
  • A to G, chromosome 6 at 148,269,987 bp
  • T to A, chromosome 7 at 7,115,715 bp
  • C to T, chromosome 7 at 30,311,939 bp
  • G to A, chromosome 7 at 52,755,616 bp
  • T to A, chromosome 7 at 96,893,086 bp
  • A to T, chromosome 7 at 103,418,661 bp
  • A to T, chromosome 7 at 141,406,806 bp
  • C to T, chromosome 8 at 26,979,205 bp
  • T to C, chromosome 8 at 45,795,785 bp
  • C to A, chromosome 9 at 54,460,987 bp
  • T to C, chromosome 9 at 86,506,259 bp
  • T to C, chromosome 9 at 87,182,703 bp
  • T to A, chromosome 9 at 105,937,005 bp
  • G to T, chromosome 9 at 106,886,102 bp
  • T to G, chromosome 9 at 114,405,481 bp
  • C to T, chromosome 10 at 76,412,168 bp
  • T to C, chromosome 10 at 83,508,113 bp
  • G to T, chromosome 10 at 84,374,984 bp
  • A to G, chromosome 10 at 115,452,339 bp
  • A to G, chromosome 11 at 50,781,869 bp
  • A to G, chromosome 11 at 100,133,128 bp
  • C to A, chromosome 12 at 24,992,297 bp
  • G to T, chromosome 12 at 71,164,546 bp
  • A to T, chromosome 12 at 71,164,547 bp
  • A to G, chromosome 13 at 67,181,981 bp
  • A to T, chromosome 13 at 92,309,434 bp
  • A to G, chromosome 13 at 112,355,939 bp
  • T to C, chromosome 14 at 30,790,770 bp
  • T to C, chromosome 14 at 50,855,587 bp
  • T to C, chromosome 14 at 51,991,883 bp
  • T to G, chromosome 14 at 77,986,682 bp
  • T to C, chromosome 16 at 23,431,535 bp
  • T to C, chromosome 16 at 25,889,010 bp
  • T to C, chromosome 17 at 33,948,837 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5118 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042706-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.