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Strain Name:
C57BL/6J-MtgxR5125Btlr/Mmmh
Stock Number:
042713-MU
Citation ID:
RRID:MMRRC_042713-MU
Other Names:
R5125 (G1), C57BL/6J-MtgxR5125Btlr
Major Collection:

Strain Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: E330008K23Rik, HALR, Mll3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231051
Homologene: 46480
Znfx1
Name: zinc finger, NFX1-type containing 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98999
Homologene: 10877
Denr
Name: density-regulated protein
Synonyms: 1500003K04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68184
HGNC: HGNC:2769
Homologene: 6275
Adgrl2
Name: adhesion G protein-coupled receptor L2
Synonyms: Lphh1, Lec1, Lphn2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99633
Homologene: 22712
Mcph1
Name: microcephaly, primary autosomal recessive 1
Synonyms: 5430437K10Rik, BRIT1, D030046N04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244329
HGNC: HGNC:6954
Homologene: 32586
Ube4b
Name: ubiquitination factor E4B
Synonyms: UFD2, 4933406G05Rik, 4930551I19Rik, UFD2a, D4Bwg0973e, Ufd2p
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 63958
Homologene: 107623
Rsf1
Name: remodeling and spacing factor 1
Synonyms: p325, XAP8, Hbxap, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Stim2
Name: stromal interaction molecule 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 116873
Homologene: 32490
Ei24
Name: etoposide induced 2.4 mRNA
Synonyms: PIG8
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13663
Homologene: 3588
Dcc
Name: DCC netrin 1 receptor
Synonyms: C030036D22Rik, Igdcc1, deleted in colorectal carcinoma
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13176
HGNC: HGNC:2701
Homologene: 21081
Sp2
Name: Sp2 transcription factor
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78912
Homologene: 2340
Rbm39
Name: RNA binding motif protein 39
Synonyms: caper, 2310040E03Rik, 1500012C14Rik, Rnpc2, B330012G18Rik, Caper alpha
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 170791
Homologene: 136465
Mcm4
Name: minichromosome maintenance complex component 4
Synonyms: mCdc21, Cdc21, Mcmd4, 19G
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17217
VEGA: 16
HGNC: HGNC:6947
Homologene: 40496
Abt1
Name: activator of basal transcription 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 30946
Homologene: 134288
Dhx29
Name: DExH-box helicase 29
Synonyms: E130202M19Rik, DEAH (Asp-Glu-Ala-His) box polypeptide 29
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218629
VEGA: 13
Homologene: 10387
Ppwd1
Name: peptidylprolyl isomerase domain and WD repeat containing 1
Synonyms: A330090G21Rik, 4632422M10Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238831
VEGA: 13
Homologene: 9099
Zfhx2
Name: zinc finger homeobox 2
Synonyms: zfh-5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239102
Homologene: 52657
Robo4
Name: roundabout guidance receptor 4
Synonyms: 1200012D01Rik, Magic roundabout
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74144
Homologene: 10397
Sost
Name: sclerostin
Synonyms: 5430411E23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74499
Homologene: 11542
Med12l
Name: mediator complex subunit 12-like
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329650
Homologene: 43143
Tecta
Name: tectorin alpha
Synonyms: [a]-tectorin, Tctna
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21683
Homologene: 3955
Hephl1
Name: hephaestin-like 1
Synonyms: LOC244698, Zp, zyklopen, thd, cw
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244698
Homologene: 9112
Cyp2c66
Name: cytochrome P450, family 2, subfamily c, polypeptide 66
Synonyms: 2010301M18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 69888
Homologene: 133566
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
Slc22a26
Name: solute carrier family 22 (organic cation transporter), member 26
Synonyms: BC014805
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 236149
Grin2b
Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2)
Synonyms: NMDAR2B, NR2B, Nmdar2b, GluRepsilon2, GluN2B
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14812
HGNC: HGNC:4586
Homologene: 646
Dsg1b
Name: desmoglein 1 beta
Synonyms: Dsg5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225256
HGNC: HGNC:3048
Homologene: 1463
Ugt2b38
Name: UDP glucuronosyltransferase 2 family, polypeptide B38
Synonyms: 9430041C03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100559
Homologene: 137225
Vmn1r87
Name: vomeronasal 1 receptor 87
Synonyms: V1rk1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171261
Homologene: 134023
Slc24a3
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
Synonyms: NCKX3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94249
Homologene: 41390
Lmx1a
Name: LIM homeobox transcription factor 1 alpha
Synonyms: Lmx1.1, shaker short-tail
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 110648
HGNC: HGNC:6653
Homologene: 24921
Zc3h6
Name: zinc finger CCCH type containing 6
Synonyms: 4631426G04Rik, 4833425H18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78751
Homologene: 35328
P2rx2
Name: purinergic receptor P2X, ligand-gated ion channel, 2
Synonyms: P2X2a, P2x2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231602
Homologene: 14251
Lair1
Name: leukocyte-associated Ig-like receptor 1
Synonyms: 5133400O11Rik, mLair-1, Lair-1, D7Bwg0421e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 52855
Homologene: 48097
Exo5
Name: exonuclease 5
Synonyms: 3110037I16Rik, Dem1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73172
Homologene: 41497
Or7e174
Name: olfactory receptor family 7 subfamily E member 174
Synonyms: GA_x6K02T2PVTD-13841888-13842802, MOR145-4, Olfr868
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258552
HGNC: HGNC:8396
Homologene: 74168
Sh3rf3
Name: SH3 domain containing ring finger 3
Synonyms: 4831416G18Rik, Sh3md4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237353
Homologene: 77551
Sp110
Name: Sp110 nuclear body protein
Synonyms: 52kDa, Ipr1, 5031415C07Rik, 5830484A20Rik, Ifi75
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109032
HGNC: HGNC:5401
Homologene: 82192
Carmil2
Name: capping protein regulator and myosin 1 linker 2
Synonyms: D130029J02Rik, Rltpr
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234695
Homologene: 128439
Zhx1
Name: zinc fingers and homeoboxes 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22770
Homologene: 5225
Ly6g6d
Name: lymphocyte antigen 6 family member G6D
Synonyms: NG32, G6f, NG25, G6d, MEGT1, A930024F17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 114654
Homologene: 76442
Or13c7b
Name: olfactory receptor family 13 subfamily C member 7B
Synonyms: OR37B, mOR37b, Olfr37b, GA_x6K02T2N78B-16125144-16126100, MOR262-6, Olfr156
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 29846
Homologene: 133652
Gm15922
Name: predicted gene 15922
Type: Gene
Species: Mouse
Chromosome: 7
Grin1os
Name: glutamate receptor, ionotropic, NMDA1 (zeta 1), opposite strand
Synonyms: E130003G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320354
Trgc4
Name: T cell receptor gamma, constant 4
Synonyms: Tcrg-C4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 107576
Gm7356
Name: predicted gene 7356
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 664821
Homologene: 133217
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 85,589,148 bp
  • C to T, chromosome 1 at 167,830,687 bp
  • T to C, chromosome 2 at 25,296,827 bp
  • A to G, chromosome 2 at 129,014,479 bp
  • T to C, chromosome 2 at 145,518,847 bp
  • A to T, chromosome 2 at 156,162,865 bp
  • A to T, chromosome 2 at 167,046,939 bp
  • G to A, chromosome 3 at 59,267,214 bp
  • T to A, chromosome 3 at 148,827,288 bp
  • T to A, chromosome 4 at 43,820,480 bp
  • A to T, chromosome 4 at 120,921,537 bp
  • T to C, chromosome 4 at 149,342,992 bp
  • A to G, chromosome 5 at 21,913,241 bp
  • A to G, chromosome 5 at 25,284,381 bp
  • T to C, chromosome 5 at 54,110,597 bp
  • A to G, chromosome 5 at 87,411,812 bp
  • G to A, chromosome 5 at 110,342,651 bp
  • A to T, chromosome 5 at 123,927,081 bp
  • C to T, chromosome 6 at 135,923,299 bp
  • T to A, chromosome 7 at 3,739,397 bp
  • G to A, chromosome 7 at 4,010,489 bp
  • G to T, chromosome 7 at 13,131,865 bp
  • A to G, chromosome 7 at 42,612,501 bp
  • A to G, chromosome 7 at 97,661,872 bp
  • T to A, chromosome 8 at 18,607,326 bp
  • G to T, chromosome 8 at 105,696,889 bp
  • T to A, chromosome 9 at 15,086,172 bp
  • T to A, chromosome 9 at 20,101,192 bp
  • T to A, chromosome 9 at 36,782,446 bp
  • T to C, chromosome 9 at 37,407,960 bp
  • T to C, chromosome 9 at 42,375,185 bp
  • C to G, chromosome 10 at 59,131,190 bp
  • A to G, chromosome 10 at 74,584,080 bp
  • A to G, chromosome 11 at 96,955,838 bp
  • C to T, chromosome 11 at 101,963,941 bp
  • C to T, chromosome 11 at 115,984,157 bp
  • A to G, chromosome 13 at 19,344,762 bp
  • G to T, chromosome 13 at 23,422,649 bp
  • A to G, chromosome 13 at 67,637,645 bp
  • A to T, chromosome 13 at 104,220,435 bp
  • T to G, chromosome 13 at 112,932,600 bp
  • A to T, chromosome 14 at 55,074,775 bp
  • C to G, chromosome 15 at 58,054,074 bp
  • T to A, chromosome 16 at 15,635,303 bp
  • T to C, chromosome 17 at 14,001,314 bp
  • A to G, chromosome 17 at 35,074,442 bp
  • G to A, chromosome 18 at 20,397,503 bp
  • A to G, chromosome 18 at 71,456,877 bp
  • T to C, chromosome 19 at 7,790,175 bp
  • A to G, chromosome 19 at 39,171,029 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5125 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042713-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.