Strain Name:
C57BL/6J-MtgxR5125Btlr/Mmmh
Stock Number:
042713-MU
Citation ID:
RRID:MMRRC_042713-MU
Other Names:
R5125 (G1), C57BL/6J-MtgxR5125Btlr
Major Collection:

Gene Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: E330008K23Rik, HALR, Mll3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231051
Homologene: 46480
Znfx1
Name: zinc finger, NFX1-type containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 98999
Homologene: 10877
Denr
Name: density-regulated protein
Synonyms: 1500003K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 68184
HGNC: HGNC:2769
Homologene: 6275
Zfp729a
Name: zinc finger protein 729a
Synonyms: A530054K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 212281
Homologene: 133713
Adgrl2
Name: adhesion G protein-coupled receptor L2
Synonyms: Lphh1, Lec1, Lphn2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 99633
Homologene: 22712
Mcph1
Name: microcephaly, primary autosomal recessive 1
Synonyms: D030046N04Rik, 5430437K10Rik, BRIT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 244329
HGNC: HGNC:6954
Homologene: 32586
Ube4b
Name: ubiquitination factor E4B
Synonyms: 4930551I19Rik, Ufd2p, D4Bwg0973e, UFD2a, UFD2, 4933406G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 63958
Homologene: 107623
Rsf1
Name: remodeling and spacing factor 1
Synonyms: XAP8, p325, 4832420A03Rik, C030033M12Rik, Hbxap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233532
Homologene: 41142
Stim2
Name: stromal interaction molecule 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 116873
Homologene: 32490
Ei24
Name: etoposide induced 2.4 mRNA
Synonyms: PIG8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 13663
Homologene: 3588
Dcc
Name: deleted in colorectal carcinoma
Synonyms: Igdcc1, C030036D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 13176
HGNC: HGNC:2701
Homologene: 21081
Sp2
Name: Sp2 transcription factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 78912
Homologene: 2340
Rbm39
Name: RNA binding motif protein 39
Synonyms: Caper alpha, 2310040E03Rik, B330012G18Rik, 1500012C14Rik, Rnpc2, caper
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 170791
Homologene: 136465
Mcm4
Name: minichromosome maintenance complex component 4
Synonyms: Cdc21, mCdc21, 19G, Mcmd4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 17217
VEGA: 16
HGNC: HGNC:6947
Homologene: 40496
Abt1
Name: activator of basal transcription 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 30946
Homologene: 134288
Dhx29
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 29
Synonyms: E130202M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218629
VEGA: 13
Homologene: 10387
Ppwd1
Name: peptidylprolyl isomerase domain and WD repeat containing 1
Synonyms: A330090G21Rik, 4632422M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 238831
VEGA: 13
Homologene: 9099
Zfhx2
Name: zinc finger homeobox 2
Synonyms: zfh-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 239102
Homologene: 52657
Robo4
Name: roundabout guidance receptor 4
Synonyms: 1200012D01Rik, Magic roundabout
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 74144
Homologene: 10397
Sost
Name: sclerostin
Synonyms: 5430411E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 74499
Homologene: 11542
Pcdh15
Name: protocadherin 15
Synonyms: roda, nmf19, Ush1f, Gm9815
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 11994
Homologene: 23401
Reln
Name: reelin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Med12l
Name: mediator complex subunit 12-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 329650
Homologene: 43143
Tecta
Name: tectorin alpha
Synonyms: Tctna, [a]-tectorin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 21683
Homologene: 3955
Hephl1
Name: hephaestin-like 1
Synonyms: LOC244698, cw, thd, Zp, zyklopen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 244698
Homologene: 9112
Cyp2c66
Name: cytochrome P450, family 2, subfamily c, polypeptide 66
Synonyms: 2010301M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 69888
HGNC: HGNC:2623
Homologene: 133566
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
Slc22a26
Name: solute carrier family 22 (organic cation transporter), member 26
Synonyms: BC014805
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 236149
Grin2b
Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2)
Synonyms: Nmdar2b, GluN2B, NR2B, NMDAR2B, GluRepsilon2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 14812
HGNC: HGNC:4586
Homologene: 646
Dsg1b
Name: desmoglein 1 beta
Synonyms: Dsg5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225256
HGNC: HGNC:3048
Homologene: 1463
Ugt2b38
Name: UDP glucuronosyltransferase 2 family, polypeptide B38
Synonyms: 9430041C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100559
Homologene: 137225
Vmn1r87
Name: vomeronasal 1 receptor 87
Synonyms: V1rk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 171261
Homologene: 134023
Zfp976
Name: zinc finger protein 976
Synonyms: 9830147E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 208111
Homologene: 134004
Slc24a3
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
Synonyms: NCKX3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 94249
Homologene: 41390
Lmx1a
Name: LIM homeobox transcription factor 1 alpha
Synonyms: shaker short-tail, Lmx1.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 110648
HGNC: HGNC:6653
Homologene: 24921
Zc3h6
Name: zinc finger CCCH type containing 6
Synonyms: 4833425H18Rik, 4631426G04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 78751
Homologene: 35328
P2rx2
Name: purinergic receptor P2X, ligand-gated ion channel, 2
Synonyms: P2X2a, P2x2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231602
Homologene: 14251
Lair1
Name: leukocyte-associated Ig-like receptor 1
Synonyms: mLair-1, D7Bwg0421e, Lair-1, 5133400O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 52855
HGNC: HGNC:6477
Homologene: 48097
Exo5
Name: exonuclease 5
Synonyms: 3110037I16Rik, Dem1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 73172
Homologene: 41497
Olfr868
Name: olfactory receptor 868
Synonyms: MOR145-4, GA_x6K02T2PVTD-13841888-13842802
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258552
Homologene: 74168
Sh3rf3
Name: SH3 domain containing ring finger 3
Synonyms: Sh3md4, 4831416G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 237353
Homologene: 77551
Sp110
Name: Sp110 nuclear body protein
Synonyms: Ifi75, Ipr1, 5031415C07Rik, 5830484A20Rik, 52kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 109032
HGNC: HGNC:5401
Homologene: 82192
Carmil2
Name: capping protein regulator and myosin 1 linker 2
Synonyms: Rltpr, D130029J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234695
Homologene: 128439
Zhx1
Name: zinc fingers and homeoboxes 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 22770
Homologene: 5225
Ly6g6d
Name: lymphocyte antigen 6 complex, locus G6D
Synonyms: G6f, MEGT1, G6d, NG32, A930024F17Rik, NG25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 114654
Homologene: 76442
Olfr156
Name: olfactory receptor 156
Synonyms: OR37B, GA_x6K02T2N78B-16125144-16126100, mOR37b, Olfr37b, MOR262-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 29846
Homologene: 133652
Gm15922
Name: predicted gene 15922
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
Grin1os
Name: glutamate receptor, ionotropic, NMDA1 (zeta 1), opposite strand
Synonyms: E130003G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 320354
Tcrg-C4
Name: T cell receptor gamma, constant 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 107576
Gm7356
Name: predicted gene 7356
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 664821
Homologene: 133217
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 85,589,148 bp
  • C to T, chromosome 1 at 167,830,687 bp
  • T to C, chromosome 2 at 25,296,827 bp
  • A to G, chromosome 2 at 129,014,479 bp
  • T to C, chromosome 2 at 145,518,847 bp
  • A to T, chromosome 2 at 156,162,865 bp
  • A to T, chromosome 2 at 167,046,939 bp
  • G to A, chromosome 3 at 59,267,214 bp
  • T to A, chromosome 3 at 148,827,288 bp
  • T to A, chromosome 4 at 43,820,480 bp
  • A to T, chromosome 4 at 120,921,537 bp
  • T to C, chromosome 4 at 149,342,992 bp
  • A to G, chromosome 5 at 21,913,241 bp
  • A to G, chromosome 5 at 25,284,381 bp
  • T to C, chromosome 5 at 54,110,597 bp
  • A to G, chromosome 5 at 87,411,812 bp
  • G to A, chromosome 5 at 110,342,651 bp
  • A to T, chromosome 5 at 123,927,081 bp
  • C to T, chromosome 6 at 135,923,299 bp
  • T to A, chromosome 7 at 3,739,397 bp
  • G to A, chromosome 7 at 4,010,489 bp
  • G to T, chromosome 7 at 13,131,865 bp
  • A to G, chromosome 7 at 42,612,501 bp
  • A to G, chromosome 7 at 97,661,872 bp
  • T to A, chromosome 8 at 18,607,326 bp
  • G to T, chromosome 8 at 105,696,889 bp
  • T to A, chromosome 9 at 15,086,172 bp
  • T to A, chromosome 9 at 20,101,192 bp
  • T to A, chromosome 9 at 36,782,446 bp
  • T to C, chromosome 9 at 37,407,960 bp
  • T to C, chromosome 9 at 42,375,185 bp
  • C to G, chromosome 10 at 59,131,190 bp
  • A to G, chromosome 10 at 74,584,080 bp
  • A to G, chromosome 11 at 96,955,838 bp
  • C to T, chromosome 11 at 101,963,941 bp
  • C to T, chromosome 11 at 115,984,157 bp
  • A to G, chromosome 13 at 19,344,762 bp
  • G to T, chromosome 13 at 23,422,649 bp
  • A to G, chromosome 13 at 67,637,645 bp
  • A to T, chromosome 13 at 104,220,435 bp
  • T to G, chromosome 13 at 112,932,600 bp
  • A to T, chromosome 14 at 55,074,775 bp
  • C to G, chromosome 15 at 58,054,074 bp
  • T to A, chromosome 16 at 15,635,303 bp
  • T to C, chromosome 17 at 14,001,314 bp
  • A to G, chromosome 17 at 35,074,442 bp
  • G to A, chromosome 18 at 20,397,503 bp
  • A to G, chromosome 18 at 71,456,877 bp
  • T to C, chromosome 19 at 7,790,175 bp
  • A to G, chromosome 19 at 39,171,029 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5125 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042713-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.