Strain Name:
C57BL/6J-MtgxR5129Btlr/Mmmh
Stock Number:
042717-MU
Citation ID:
RRID:MMRRC_042717-MU
Other Names:
R5129 (G1), C57BL/6J-MtgxR5129Btlr
Major Collection:

Gene Information

Tyrp1
Name: tyrosinase-related protein 1
Synonyms: Tyrp, isa, TRP-1, TRP1, Oca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 22178
Homologene: 464
Vcan
Name: versican
Synonyms: PG-M, hdf, heart defect, 5430420N07Rik, DPEAAE, Cspg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Epb41l1
Name: erythrocyte membrane protein band 4.1 like 1
Synonyms: 4.1N, Epb4.1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13821
HGNC: HGNC:3378
Homologene: 8126
Triobp
Name: TRIO and F-actin binding protein
Synonyms: Mus EST 478828, Tara, EST478828
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 110253
Homologene: 5104
Kdm5a
Name: lysine (K)-specific demethylase 5A
Synonyms: RBP2, Rbbp2, Jarid1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 214899
HGNC: HGNC:9886
Homologene: 3419
G3bp1
Name: GTPase activating protein (SH3 domain) binding protein 1
Synonyms: GAP SH3 binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 27041
Homologene: 38096
Eef1b2
Name: eukaryotic translation elongation factor 1 beta 2
Synonyms: 2810017J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 55949
HGNC: HGNC:3208
Homologene: 1480
Prrc2a
Name: proline-rich coiled-coil 2A
Synonyms: G2, Bat-2, D17H6S51E, Wbp12, 3110039B05Rik, Bat2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 53761
Homologene: 10567
Uhrf2
Name: ubiquitin-like, containing PHD and RING finger domains 2
Synonyms: 2310065A22Rik, Nirf, D130071B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 109113
Homologene: 17001
Nf2
Name: neurofibromin 2
Synonyms: schwannomin, merlin, moesin-ezrin-radixin-like protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18016
HGNC: HGNC:7773
Homologene: 2180
Zfp866
Name: zinc finger protein 866
Synonyms: 9830167H18Rik, D330038O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 330788
Pirb
Name: paired Ig-like receptor B
Synonyms: Gp91, Lilrb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18733
HGNC: HGNC:6607
Homologene: 134028
Zfp740
Name: zinc finger protein 740
Synonyms: 1110034O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 68744
Homologene: 129530
Uty
Name: ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
Synonyms: Hydb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 22290
Gm3604
Name: predicted gene 3604
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 100041979
Homologene: 136271
Zfp74
Name: zinc finger protein 74
Synonyms: Zfp66, KRAB8, 2810054M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72723
Homologene: 51861
Zfp457
Name: zinc finger protein 457
Synonyms: Rslcan-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 431706
Homologene: 75311
Zfp451
Name: zinc finger protein 451
Synonyms: Kiaa0576-hp, 4933435G09Rik, 4930515K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98403
Homologene: 9188
Hsd17b14
Name: hydroxysteroid (17-beta) dehydrogenase 14
Synonyms: retSDR3, 0610039E24Rik, Dhrs10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66065
Homologene: 133800
Zfp874a
Name: zinc finger protein 874a
Synonyms: Rslcan15, C330011K17Rik, Zfp874
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238692
Homologene: 135597
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269700
Homologene: 28297
Tlr3
Name: toll-like receptor 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 142980
Homologene: 20696
Nbas
Name: neuroblastoma amplified sequence
Synonyms: 4933425L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 71169
VEGA: 12
Homologene: 41073
Aldh3b1
Name: aldehyde dehydrogenase 3 family, member B1
Synonyms: ALDH7, ALDH4, 1700001N19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67689
VEGA: 19
HGNC: HGNC:410
Homologene: 73890
Ppil3
Name: peptidylprolyl isomerase (cyclophilin)-like 3
Synonyms: 2510026K04Rik, Cyp10l, 2310076N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70225
HGNC: HGNC:9262
Homologene: 41717
4930432E11Rik
Name: RIKEN cDNA 4930432E11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243900
Cdh13
Name: cadherin 13
Synonyms: T-cadherin, Tcad, 4932416G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12554
HGNC: HGNC:1753
Homologene: 20335
Hivep2
Name: human immunodeficiency virus type I enhancer binding protein 2
Synonyms: MIBP1, Schnurri-2, Shn-2, Gm20114
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15273
HGNC: HGNC:4921
Homologene: 4900
Capn7
Name: calpain 7
Synonyms: PalBH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12339
HGNC: HGNC:1484
Homologene: 7651
Daw1
Name: dynein assembly factor with WDR repeat domains 1
Synonyms: 4933429D11Rik, 4930563E19Rik, Wdr69, b2b1116Clo, b2b1584Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71227
Fbxw14
Name: F-box and WD-40 domain protein 14
Synonyms: Fbx12, E330009N23Rik, Fbxo12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 50757
Homologene: 110776
Spata16
Name: spermatogenesis associated 16
Synonyms: spermatogenesis-related protein, Nyd-sp12, 4930503K02Rik, 4921511F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 70862
Homologene: 49974
Krt78
Name: keratin 78
Synonyms: 2310030B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 332131
VEGA: 15
Homologene: 65261
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: EG235580, 1110001D15Rik, Dvwa, Vwa6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68553
Homologene: 130754
Semp2l1
Name: SUMO/sentrin specific peptidase 2-like 1
Synonyms: Gm5415
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 408191
Homologene: 130042
Klhdc7b
Name: kelch domain containing 7B
Synonyms: EG546648
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 546648
Homologene: 34707
Atp1a2
Name: ATPase, Na+/K+ transporting, alpha 2 polypeptide
Synonyms: Atpa-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98660
HGNC: HGNC:800
Homologene: 47947
Cntnap5b
Name: contactin associated protein-like 5B
Synonyms: Caspr5-2, C230078M14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241175
Homologene: 104295
Hlf
Name: hepatic leukemia factor
Synonyms: E230015K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217082
HGNC: HGNC:4977
Homologene: 31074
Olfr961
Name: olfactory receptor 961
Synonyms: GA_x6K02T2PVTD-33343617-33344561, MOR224-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258497
VEGA: 9
Homologene: 74020
Fstl4
Name: follistatin-like 4
Synonyms: B230374F23Rik, SPIG1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 320027
Homologene: 18543
Dvl3
Name: dishevelled segment polarity protein 3
Synonyms: b2b2866Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13544
HGNC: HGNC:3087
Homologene: 20928
Hsd3b7
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101502
Homologene: 41617
Vmn1r225
Name: vomeronasal 1 receptor 225
Synonyms: V1re5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 171228
Adamts14
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14
Synonyms: TS14, Adamts-14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237360
Homologene: 16383
Tmem72
Name: transmembrane protein 72
Synonyms: C230095G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 319776
Homologene: 18704
Fam43b
Name: family with sequence similarity 43, member B
Synonyms: OTTMUSG00000009974
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 625638
Homologene: 45810
Mroh9
Name: maestro heat-like repeat family member 9
Synonyms: 4921528O07Rik, Armc11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 78258
Homologene: 123521
Gm5900
Name: predicted pseudogene 5900
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 545987
Mir877
Name: microRNA 877
Synonyms: mmu-mir-877, Mirn877
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100124459
VEGA: 17
CR974439.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 32,545,479 bp
  • T to A, chromosome 1 at 32,545,480 bp
  • C to T, chromosome 1 at 33,802,933 bp
  • A to G, chromosome 1 at 58,440,833 bp
  • T to G, chromosome 1 at 63,179,580 bp
  • T to C, chromosome 1 at 83,205,903 bp
  • G to A, chromosome 1 at 100,379,090 bp
  • C to G, chromosome 1 at 163,060,760 bp
  • A to T, chromosome 1 at 172,275,955 bp
  • A to T, chromosome 2 at 156,509,281 bp
  • A to G, chromosome 3 at 26,667,564 bp
  • T to A, chromosome 4 at 80,846,607 bp
  • A to T, chromosome 4 at 138,395,472 bp
  • G to A, chromosome 5 at 121,343,510 bp
  • A to G, chromosome 6 at 116,702,013 bp
  • T to C, chromosome 6 at 120,405,022 bp
  • T to C, chromosome 7 at 3,714,223 bp
  • A to G, chromosome 7 at 29,561,361 bp
  • C to T, chromosome 7 at 29,932,455 bp
  • C to T, chromosome 7 at 45,557,664 bp
  • A to G, chromosome 7 at 104,950,016 bp
  • C to A, chromosome 7 at 127,801,134 bp
  • A to T, chromosome 8 at 45,402,981 bp
  • A to T, chromosome 8 at 69,767,709 bp
  • A to G, chromosome 8 at 119,095,215 bp
  • T to A, chromosome 9 at 39,647,494 bp
  • T to C, chromosome 9 at 106,013,377 bp
  • A to G, chromosome 9 at 109,326,603 bp
  • A to G, chromosome 10 at 14,130,864 bp
  • T to A, chromosome 10 at 61,249,618 bp
  • A to C, chromosome 11 at 4,816,145 bp
  • C to A, chromosome 11 at 53,186,439 bp
  • T to C, chromosome 11 at 55,489,116 bp
  • T to C, chromosome 11 at 90,390,252 bp
  • T to C, chromosome 12 at 13,390,960 bp
  • A to T, chromosome 13 at 62,369,774 bp
  • T to C, chromosome 13 at 67,293,356 bp
  • A to T, chromosome 13 at 67,442,981 bp
  • T to C, chromosome 13 at 89,690,240 bp
  • T to C, chromosome 14 at 31,344,511 bp
  • A to G, chromosome 15 at 78,961,096 bp
  • A to G, chromosome 15 at 89,388,548 bp
  • C to A, chromosome 15 at 101,947,580 bp
  • A to G, chromosome 15 at 102,208,376 bp
  • T to A, chromosome 16 at 20,517,340 bp
  • T to A, chromosome 17 at 20,503,116 bp
  • T to C, chromosome 17 at 35,160,178 bp
  • C to T, chromosome 17 at 35,960,795 bp
  • T to C, chromosome 17 at 37,575,180 bp
  • A to G, chromosome 19 at 3,915,336 bp
  • A to G, chromosome 19 at 30,075,221 bp
  • T to C, chromosome Y at 1,158,592 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5129 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042717-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.