Strain Name:
C57BL/6J-MtgxR5168Btlr/Mmmh
Stock Number:
042748-MU
Citation ID:
RRID:MMRRC_042748-MU
Other Names:
R5168 (G1), C57BL/6J-MtgxR5168Btlr
Major Collection:

Gene Information

Dock1
Name: dedicator of cytokinesis 1
Synonyms: 9130006G06Rik, D630004B07Rik, Dock180, b2b3190Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330662
HGNC: HGNC:2987
Homologene: 55575
Tacr3
Name: tachykinin receptor 3
Synonyms: neuromedin K receptor, Nk3r, Tac3r
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 21338
Homologene: 824
Polr1c
Name: polymerase (RNA) I polypeptide C
Synonyms: Rpo1-1, RPA40, 40kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20016
Homologene: 3586
Vcl
Name: vinculin
Synonyms: metavinculin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 22330
VEGA: 14
Homologene: 7594
Ddx54
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
Synonyms: DP97, APR-5, 2410015A15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71990
Homologene: 5590
Tanc2
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
Synonyms: 5730590C14Rik, 3526402J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 77097
Homologene: 64680
Abca1
Name: ATP-binding cassette, sub-family A (ABC1), member 1
Synonyms: ABC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11303
HGNC: HGNC:29
Homologene: 21130
Cntrob
Name: centrobin, centrosomal BRCA2 interacting protein
Synonyms: 9830165K03Rik, Lip8, Nip2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216846
Homologene: 14205
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: Garnl1, Tulip1, 4930400K19Rik, 2310003F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Vps8
Name: VPS8 CORVET complex subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 209018
Homologene: 44592
Calcr
Name: calcitonin receptor
Synonyms: Clr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12311
HGNC: HGNC:1440
Homologene: 1320
Srp68
Name: signal recognition particle 68
Synonyms: 2610024I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217337
Homologene: 7056
Cntrl
Name: centriolin
Synonyms: Cep1, b2b1468Clo, IB3/5, Ma2a8, 6720467O09Rik, Cep110
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 26920
HGNC: HGNC:1858
Homologene: 38260
Zfp746
Name: zinc finger protein 746
Synonyms: 2810407L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 69228
Homologene: 19783
Gle1
Name: GLE1 RNA export mediator (yeast)
Synonyms: 4933405K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74412
HGNC: HGNC:4315
Homologene: 20379
Trim33
Name: tripartite motif-containing 33
Synonyms: 8030451N04Rik, Ecto, ectodermin, Tif1g
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 94093
Homologene: 9296
Nrbp1
Name: nuclear receptor binding protein 1
Synonyms: Nrbp, B230344L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 192292
HGNC: HGNC:7993
Homologene: 8373
Lig1
Name: ligase I, DNA, ATP-dependent
Synonyms: LigI, mLigI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16881
HGNC: HGNC:6598
Homologene: 197
Mccc1
Name: methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)
Synonyms: MCCA, MCCalpha, 2310058B18Rik, 1810045E08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72039
HGNC: HGNC:6936
Homologene: 10603
Katnal1
Name: katanin p60 subunit A-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231912
Homologene: 12942
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Gm1966
Name: predicted gene 1966
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434223
Homologene: 32708
Acsl1
Name: acyl-CoA synthetase long-chain family member 1
Synonyms: Acas1, Facl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14081
HGNC: HGNC:3569
Homologene: 37561
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Tmem62
Name: transmembrane protein 62
Synonyms: B830009D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 96957
Homologene: 11801
Pard3b
Name: par-3 family cell polarity regulator beta
Synonyms: 2010002N16Rik, 2810455B10Rik, PAR3beta, PAR3B, 1810008K04Rik, PAR3L, Als2cr19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 72823
Homologene: 35389
Haus5
Name: HAUS augmin-like complex, subunit 5
Synonyms: 2310022K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71909
Homologene: 18969
Aox1
Name: aldehyde oxidase 1
Synonyms: Aox-1, Aox2, retinal oxidase, Aox-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11761
HGNC: HGNC:553
Homologene: 68165
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: bl, E130113P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231470
Homologene: 23516
Hecw2
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
Synonyms: A730039N16Rik, Nedl2, D030049F17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329152
Homologene: 66192
Nt5dc1
Name: 5'-nucleotidase domain containing 1
Synonyms: 6030401B09Rik, Nt5c2l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 319638
Homologene: 16281
Pkn1
Name: protein kinase N1
Synonyms: Stk3, Pkn, PRK1, F730027O18Rik, PAK1, Prkcl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 320795
HGNC: HGNC:9405
Homologene: 48130
Dab2
Name: disabled 2, mitogen-responsive phosphoprotein
Synonyms: D630005B22Rik, p96, D15Wsu122e, 5730435J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13132
HGNC: HGNC:2662
Homologene: 1026
Tmem236
Name: transmembrane protein 236
Synonyms: Fam23a, 2010003H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 625286
Homologene: 46598
Bag6
Name: BCL2-associated athanogene 6
Synonyms: D17H6S52E, 2410045D21Rik, G3, Bat3, Scythe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224727
Homologene: 3409
Atp8a1
Name: ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
Synonyms: Atp3a2, B230107D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11980
Homologene: 48402
Gm13103
Name: predicted gene 13103
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 194225
Homologene: 129883
Tmem79
Name: transmembrane protein 79
Synonyms: 2310074C17Rik, 2310042N02Rik, ma, Matt, mattrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71913
Homologene: 11492
Fam205a1
Name: family with sequence similarity 205, member A1
Synonyms: Gm12429
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 433698
Homologene: 79022
Slc26a3
Name: solute carrier family 26, member 3
Synonyms: Dra, 9030623B18Rik, 9130013M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13487
HGNC: HGNC:3018
Homologene: 55435
Olfr378
Name: olfactory receptor 378
Synonyms: GA_x6K02T2P1NL-3586282-3585338, MOR135-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 259026
Homologene: 74110
Cxcl15
Name: chemokine (C-X-C motif) ligand 15
Synonyms: Scyb15, lungkine, weche, Il8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20309
Ugt1a10
Name: UDP glycosyltransferase 1 family, polypeptide A10
Synonyms: A13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 394430
Homologene: 133281
Olfr564
Name: olfactory receptor 564
Synonyms: GA_x6K02T2PBJ9-5513635-5514627, MOR14-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258356
Homologene: 121507
Trav6-5
Name: T cell receptor alpha variable 6-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 100126464
Gpr31b
Name: G protein-coupled receptor 31, D17Leh66b region
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 436440
VEGA: 17
HGNC: HGNC:4486
Homologene: 48337
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 53,913,300 bp
  • T to A, chromosome 1 at 58,049,402 bp
  • A to G, chromosome 1 at 62,010,363 bp
  • A to G, chromosome 1 at 88,055,809 bp
  • C to T, chromosome 1 at 90,773,639 bp
  • T to C, chromosome 2 at 14,192,328 bp
  • T to C, chromosome 2 at 29,936,117 bp
  • T to A, chromosome 2 at 35,157,655 bp
  • T to A, chromosome 2 at 120,993,607 bp
  • C to T, chromosome 3 at 35,990,780 bp
  • A to T, chromosome 3 at 88,333,344 bp
  • C to T, chromosome 3 at 103,341,681 bp
  • T to C, chromosome 3 at 134,829,559 bp
  • C to T, chromosome 4 at 42,851,488 bp
  • T to C, chromosome 4 at 53,086,070 bp
  • T to C, chromosome 4 at 143,853,198 bp
  • T to A, chromosome 5 at 31,250,137 bp
  • A to G, chromosome 5 at 67,813,191 bp
  • T to A, chromosome 5 at 90,795,283 bp
  • A to C, chromosome 5 at 96,708,757 bp
  • A to G, chromosome 5 at 120,617,032 bp
  • A to G, chromosome 5 at 148,921,322 bp
  • T to C, chromosome 6 at 3,708,610 bp
  • G to C, chromosome 6 at 48,064,395 bp
  • T to A, chromosome 7 at 13,307,629 bp
  • T to C, chromosome 7 at 30,657,711 bp
  • C to T, chromosome 7 at 102,804,321 bp
  • T to C, chromosome 7 at 106,596,847 bp
  • T to C, chromosome 7 at 135,118,908 bp
  • G to A, chromosome 7 at 141,639,559 bp
  • T to A, chromosome 8 at 46,513,266 bp
  • G to A, chromosome 8 at 83,670,177 bp
  • T to A, chromosome 10 at 34,397,240 bp
  • T to A, chromosome 11 at 69,299,990 bp
  • T to A, chromosome 11 at 73,425,843 bp
  • A to G, chromosome 11 at 105,909,062 bp
  • C to A, chromosome 11 at 116,265,474 bp
  • G to A, chromosome 12 at 31,468,554 bp
  • A to G, chromosome 12 at 55,758,032 bp
  • T to C, chromosome 13 at 11,752,321 bp
  • C to T, chromosome 14 at 21,010,102 bp
  • A to T, chromosome 14 at 53,491,516 bp
  • T to C, chromosome 15 at 6,336,443 bp
  • A to T, chromosome 16 at 21,457,445 bp
  • A to C, chromosome 16 at 21,533,099 bp
  • A to T, chromosome 17 at 13,051,439 bp
  • T to C, chromosome 17 at 35,144,695 bp
  • G to T, chromosome 17 at 46,247,709 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5168 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042748-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.