Strain Name:
C57BL/6J-MtgxR5170Btlr/Mmmh
Stock Number:
042750-MU
Citation ID:
RRID:MMRRC_042750-MU
Other Names:
R5170 (G1), C57BL/6J-MtgxR5170Btlr
Major Collection:

Strain Information

St8sia1
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
Synonyms: Siat8, alpha-2,8-sialyltransferase, 9330109E03Rik, Siat8a, ST8Sia I, GD3 synthase, GD3S
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20449
Homologene: 2282
Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Eif4g3
Name: eukaryotic translation initiation factor 4 gamma, 3
Synonyms: repro8, 1500002J22Rik, G1-419-52, 4930523M17Rik, eIF4GII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230861
HGNC: HGNC:3298
Homologene: 2789
Gtse1
Name: G two S phase expressed protein 1
Synonyms: Gtse-1, B99
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 29870
VEGA: 15
Homologene: 8489
Fry
Name: FRY microtubule binding protein
Synonyms: cg003, 9330186A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 320365
Homologene: 113770
Supt5
Name: suppressor of Ty 5, DSIF elongation factor subunit
Synonyms: Spt5, Supt5h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20924
Homologene: 2384
Psmb7
Name: proteasome (prosome, macropain) subunit, beta type 7
Synonyms: MC14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19177
HGNC: HGNC:9544
Homologene: 2093
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: 9330187F13Rik, Ten-m2, 2610040L17Rik, D3Bwg1534e, Odz2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 23964
Homologene: 22672
Clec16a
Name: C-type lectin domain family 16, member A
Synonyms: 4932416N17Rik, curt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74374
Homologene: 71019
Bdp1
Name: B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
Synonyms: TFC5, Tfnr, B130055N23Rik, G630013P12Rik, TFIIIB150, TFIIIB90, TAF3B1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 544971
Homologene: 34582
Psen1
Name: presenilin 1
Synonyms: presenilin-1, PS1, Ad3h, S182, PS-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 19164
VEGA: 12
HGNC: HGNC:9508
Homologene: 7186
Sumo2
Name: small ubiquitin-like modifier 2
Synonyms: Smt3h2, Smt3b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 170930
Homologene: 87858
Zfp740
Name: zinc finger protein 740
Synonyms: 1110034O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 68744
Homologene: 129530
C3
Name: complement component 3
Synonyms: Plp, complement factor 3, acylation stimulating protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12266
HGNC: HGNC:1318
Homologene: 68031
Lman1l
Name: lectin, mannose-binding 1 like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235416
HGNC: HGNC:6632
Homologene: 11047
Trmt1
Name: tRNA methyltransferase 1
Synonyms: 6720406L13Rik, D8Ertd812e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 212528
Homologene: 5632
Nup54
Name: nucleoporin 54
Synonyms: 54kDa, 3110079L04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269113
Homologene: 41169
Stxbp1
Name: syntaxin binding protein 1
Synonyms: Munc-18a, N-sec1, Unc18h, nsec1, Munc18-1, Sxtbp1, Rb-sec1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20910
Homologene: 2382
Trp73
Name: transformation related protein 73
Synonyms: deltaNp73, TAp73, p73
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 22062
Homologene: 3960
Dmpk
Name: dystrophia myotonica-protein kinase
Synonyms: Dm15, DM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13400
HGNC: HGNC:2933
Homologene: 3247
Ttn
Name: titin
Synonyms: L56, 1100001C23Rik, D330041I19Rik, 2310057K23Rik, D830007G01Rik, 2310074I15Rik, 2310036G12Rik, mdm, connectin, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Uggt2
Name: UDP-glucose glycoprotein glucosyltransferase 2
Synonyms: Ugcgl2, A230065J02Rik, 3110027P15Rik, 1810064L21Rik, 3110001A05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 66435
Homologene: 56875
Myo16
Name: myosin XVI
Synonyms: BM140241, C230040D10Rik, Nyap3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244281
Homologene: 34710
Arhgap30
Name: Rho GTPase activating protein 30
Synonyms: 6030405P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226652
Homologene: 18766
Cdh8
Name: cadherin 8
Synonyms: cad8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12564
HGNC: HGNC:1767
Homologene: 55604
Zfp941
Name: zinc finger protein 941
Synonyms: BC066028
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 407812
Slco1a1
Name: solute carrier organic anion transporter family, member 1a1
Synonyms: Oatp1, Oatp1a1, Slc21a1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 28248
Homologene: 137261
Ifi207
Name: interferon activated gene 207
Synonyms: AI607873, Pyhin-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226691
HGNC: HGNC:5395
Homologene: 115929
BC034090
Name: cDNA sequence BC034090
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 207792
Homologene: 19490
Fbxo47
Name: F-box protein 47
Synonyms: 2900052P03Rik, LOC380724
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72973
Homologene: 47677
Slc13a2
Name: solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
Synonyms: Nadc1, sodium/dicarboxylate co-transporter, mNaDC-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20500
Homologene: 2965
Gucy2e
Name: guanylate cyclase 2e
Synonyms: ROS-GC1, GC-E, GC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14919
HGNC: HGNC:4689
Homologene: 55442
Nwd2
Name: NACHT and WD repeat domain containing 2
Synonyms: 3110047P20Rik, B830017A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 319807
Homologene: 14974
Ccdc170
Name: coiled-coil domain containing 170
Synonyms: Gm221, LOC237250
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 100504234
Homologene: 69393
Erbb2
Name: erb-b2 receptor tyrosine kinase 2
Synonyms: c-erbB2, c-neu, HER2, HER-2, Neu oncogene, l11Jus8, ErbB-2, Neu
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13866
HGNC: HGNC:3430
Homologene: 3273
Evi5l
Name: ecotropic viral integration site 5 like
Synonyms: 1700084G18Rik, 3110007G05Rik, B130050I23Rik, 2310039H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 213027
Homologene: 134635
Parp14
Name: poly (ADP-ribose) polymerase family, member 14
Synonyms: CoaSt6, collaborator of Stat6, 1600029O10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 547253
Homologene: 19697
Zp1
Name: zona pellucida glycoprotein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 22786
Homologene: 33483
Ptx4
Name: pentraxin 4
Synonyms: 1110018H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 68509
VEGA: 17
Homologene: 19179
Zar1l
Name: zygote arrest 1-like
Synonyms: LOC545824
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 545824
Homologene: 85370
Defa41
Name: defensin, alpha, 41
Synonyms: Gm15293
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 100041759
Homologene: 113382
Fndc4
Name: fibronectin type III domain containing 4
Synonyms: 6330410H20Rik, 2810430J06Rik, FRCP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 64339
Homologene: 49716
Acox3
Name: acyl-Coenzyme A oxidase 3, pristanoyl
Synonyms: pristanoyl-CoA oxidase, EST-s59, PCOX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 80911
HGNC: HGNC:121
Homologene: 37792
Spmip10
Name: sperm microtubule inner protein 10
Synonyms: 1700065I17Rik, Tex43
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67343
Homologene: 77918
Tbc1d30
Name: TBC1 domain family, member 30
Synonyms: 4930505D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 74694
VEGA: 10
Homologene: 18930
Vmn2r-ps36
Name: vomeronasal 2, receptor, pseudogene 36
Synonyms: EG665442
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 665442
Igkv4-80
Name: immunoglobulin kappa variable 4-80
Synonyms: Gm16729
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 545848
Gm13441
Name: predicted gene 13441
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Airim
Name: AFG2 interacting ribosome maturation factor
Synonyms: 9930104L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 194268
Homologene: 23053
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 155,213,650 bp
  • A to G, chromosome 1 at 171,408,050 bp
  • T to C, chromosome 1 at 173,730,498 bp
  • A to T, chromosome 2 at 31,887,344 bp
  • T to C, chromosome 2 at 32,794,674 bp
  • A to G, chromosome 2 at 38,642,264 bp
  • A to G, chromosome 2 at 76,787,069 bp
  • C to T, chromosome 4 at 124,940,469 bp
  • A to T, chromosome 4 at 138,206,188 bp
  • C to T, chromosome 4 at 154,104,838 bp
  • T to C, chromosome 5 at 31,294,808 bp
  • A to G, chromosome 5 at 35,588,625 bp
  • A to T, chromosome 5 at 63,806,037 bp
  • A to G, chromosome 5 at 92,430,832 bp
  • G to A, chromosome 5 at 150,429,854 bp
  • A to G, chromosome 5 at 150,517,585 bp
  • A to C, chromosome 6 at 69,016,665 bp
  • T to C, chromosome 6 at 141,943,408 bp
  • T to C, chromosome 6 at 142,963,708 bp
  • A to G, chromosome 7 at 7,428,730 bp
  • C to G, chromosome 7 at 19,088,019 bp
  • G to A, chromosome 7 at 28,316,083 bp
  • G to A, chromosome 7 at 140,812,957 bp
  • A to G, chromosome 8 at 4,206,213 bp
  • A to G, chromosome 8 at 10,569,745 bp
  • A to T, chromosome 8 at 21,201,680 bp
  • T to C, chromosome 8 at 84,695,232 bp
  • G to A, chromosome 8 at 99,279,550 bp
  • G to A, chromosome 9 at 57,615,619 bp
  • G to A, chromosome 10 at 4,514,200 bp
  • T to C, chromosome 10 at 121,306,838 bp
  • C to A, chromosome 11 at 21,997,037 bp
  • T to A, chromosome 11 at 36,024,806 bp
  • A to T, chromosome 11 at 69,235,570 bp
  • T to C, chromosome 11 at 78,400,808 bp
  • A to G, chromosome 11 at 97,857,694 bp
  • A to G, chromosome 11 at 98,432,992 bp
  • G to A, chromosome 11 at 115,534,660 bp
  • T to A, chromosome 12 at 83,714,862 bp
  • A to T, chromosome 13 at 100,030,794 bp
  • T to A, chromosome 14 at 118,998,090 bp
  • T to C, chromosome 15 at 85,864,264 bp
  • T to C, chromosome 15 at 102,209,205 bp
  • A to G, chromosome 16 at 10,741,791 bp
  • T to C, chromosome 16 at 35,857,279 bp
  • G to A, chromosome 17 at 25,123,178 bp
  • C to T, chromosome 17 at 57,223,938 bp
  • A to T, chromosome 18 at 56,589,564 bp
  • C to A, chromosome 19 at 10,920,554 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5170 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042750-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.