Strain Name:
C57BL/6J-MtgxR5171Btlr/Mmmh
Stock Number:
042751-MU
Citation ID:
RRID:MMRRC_042751-MU
Other Names:
R5171 (G1), C57BL/6J-MtgxR5171Btlr
Major Collection:

Gene Information

Cdc25a
Name: cell division cycle 25A
Synonyms: D9Ertd393e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 12530
HGNC: HGNC:1725
Homologene: 1355
Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: WBE1, Flo, GENA 60, GENA 47, Whi, Mt, Gena 52, Edy, Dz, A730019I05Rik, Todo, Obt, Cyn, Cycn, Lda
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 320790
Homologene: 19067
Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Ranbp17
Name: RAN binding protein 17
Synonyms: 4932704E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 66011
Homologene: 36409
Mnx1
Name: motor neuron and pancreas homeobox 1
Synonyms: HB9, MNR2, Hlxb9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 15285
HGNC: HGNC:4979
Homologene: 21137
Itsn1
Name: intersectin 1 (SH3 domain protein 1A)
Synonyms: Eh domain, SH3 domain regulator of endocytosis 1, Intersectin-L, Ese1, Sh3p17, EHSH1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 16443
HGNC: HGNC:6183
Homologene: 2277
Kntc1
Name: kinetochore associated 1
Synonyms: jgl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 208628
Homologene: 32227
Zfp462
Name: zinc finger protein 462
Synonyms: 9430078C22Rik, Gt4-2, Zfpip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 242466
Homologene: 41430
Ube4b
Name: ubiquitination factor E4B
Synonyms: 4930551I19Rik, Ufd2p, D4Bwg0973e, UFD2a, UFD2, 4933406G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 63958
Homologene: 107623
Focad
Name: focadhesin
Synonyms: BC057079
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230393
Homologene: 9842
Hip1
Name: huntingtin interacting protein 1
Synonyms: A930014B11Rik, HIP-1, 2610109B09Rik, E130315I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 215114
HGNC: HGNC:4913
Homologene: 68463
Zfp26
Name: zinc finger protein 26
Synonyms: mkr-3, Zfp70, Zfp81-rs1, 5033428C05Rik, Zfp-26, KRAB15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 22688
Homologene: 52318
Tep1
Name: telomerase associated protein 1
Synonyms: Tp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 21745
VEGA: 14
Homologene: 5157
Rims2
Name: regulating synaptic membrane exocytosis 2
Synonyms: 2810036I15Rik, RIM2, Syt3-rs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 116838
VEGA: 15
Homologene: 81639
Gpsm1
Name: G-protein signalling modulator 1 (AGS3-like, C. elegans)
Synonyms: Ags3, 1810037C22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 67839
Homologene: 16987
Rasal1
Name: RAS protein activator like 1 (GAP1 like)
Synonyms: MRASAL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 19415
HGNC: HGNC:9873
Homologene: 3423
Gper1
Name: G protein-coupled estrogen receptor 1
Synonyms: Ceprl, Gper, Gpr30, GPCR-Br, FEG-1, CMKRL2, 6330420K13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 76854
HGNC: HGNC:4485
Homologene: 15855
Cpne6
Name: copine VI
Synonyms: neuronal copine
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 12891
HGNC: HGNC:2319
Homologene: 81815
Slc25a38
Name: solute carrier family 25, member 38
Synonyms: appoptosin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 208638
Homologene: 5553
Dmpk
Name: dystrophia myotonica-protein kinase
Synonyms: DM, Dm15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 13400
HGNC: HGNC:2933
Homologene: 3247
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 4632412F08Rik, 5330435L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237979
Homologene: 10406
Adtrp
Name: androgen dependent TFPI regulating protein
Synonyms: 9530008L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 109254
Homologene: 13107
Mbd3l1
Name: methyl-CpG binding domain protein 3-like 1
Synonyms: 1700070G05Rik, 1700095H13Rik, Mbd3l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 73503
VEGA: 9
Homologene: 12502
Unc13c
Name: unc-13 homolog C
Synonyms: Munc13-3, 1500037O19Rik, D9Ertd414e, Unc13h3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 208898
Homologene: 45443
Slc24a2
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
Synonyms: 6330417K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 76376
Homologene: 10669
Usp29
Name: ubiquitin specific peptidase 29
Synonyms: Ocat
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 57775
Homologene: 49641
Atp11b
Name: ATPase, class VI, type 11B
Synonyms: 1110019I14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 76295
Homologene: 32919
Ermp1
Name: endoplasmic reticulum metallopeptidase 1
Synonyms: D19Wsu12e, D19Ertd410e, b2b2633Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 226090
Homologene: 121891
Trim60
Name: tripartite motif-containing 60
Synonyms: Rnf33, 2czf45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234329
Homologene: 51876
Mroh3
Name: maestro heat-like repeat family member 3
Synonyms: 2310006M14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 76422
Acad9
Name: acyl-Coenzyme A dehydrogenase family, member 9
Synonyms: C630012L17Rik, 2600017P15Rik, NPD002
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229211
Homologene: 8539
Myom1
Name: myomesin 1
Synonyms: skelemin, D430047A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 17929
VEGA: 17
HGNC: HGNC:7613
Homologene: 31196
Spata22
Name: spermatogenesis associated 22
Synonyms: LOC380709
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 380709
Homologene: 13076
Slc5a7
Name: solute carrier family 5 (choline transporter), member 7
Synonyms: CHT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 63993
VEGA: 17
Homologene: 32516
AA986860
Name: expressed sequence AA986860
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 212439
Homologene: 49741
Gm8765
Name: predicted gene 8765
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 667693
Homologene: 134512
Rexo5
Name: RNA exonuclease 5
Synonyms: 2610020H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 434234
Homologene: 12803
Olfr411
Name: olfactory receptor 411
Synonyms: GA_x6K02T2P1NL-4481525-4480578, MOR255-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 258704
Homologene: 74999
Tmem151a
Name: transmembrane protein 151A
Synonyms: Tmem151, LOC381199
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 381199
Homologene: 17721
Olfr988
Name: olfactory receptor 988
Synonyms: GA_x6K02T2Q125-46830591-46829662, MOR203-5P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258166
Homologene: 103791
Donson
Name: downstream neighbor of SON
Synonyms: 1110025J21Rik, Donson, ORF60
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 60364
HGNC: HGNC:2993
Homologene: 32350
Btnl7-ps
Name: butyrophilin-like 7, pseudogene
Synonyms: Btnl7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 195349
Bcl2l12
Name: BCL2-like 12 (proline rich)
Synonyms: Bcl2-L12, 5430429M05Rik, Bcl-L12, 2810475P17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 75736
Homologene: 12619
Stac2
Name: SH3 and cysteine rich domain 2
Synonyms: 24b2/STAC2, 24b2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217154
Homologene: 17131
Ifi214
Name: interferon activated gene 214
Synonyms: BC094916, Pyhin-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 545384
HGNC: HGNC:5395
Homologene: 115929
Ddn
Name: dendrin
Synonyms: LOC328602
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 13199
VEGA: 15
Homologene: 12816
Coro2a
Name: coronin, actin binding protein 2A
Synonyms: coronin 4, 9030208C03Rik, IR10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 107684
HGNC: HGNC:2255
Homologene: 2546
Ccl12
Name: chemokine (C-C motif) ligand 12
Synonyms: Scya12, MCP-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 20293
Homologene: 2245
Gm3336
Name: predicted gene 3336
Synonyms: 2410018E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 100502950
Homologene: 136417
Igkv4-80
Name: immunoglobulin kappa variable 4-80
Synonyms: Gm16729
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 545848
Dnase1l1
Name: deoxyribonuclease 1-like 1
Synonyms: G4.8, Dnase1ll, Dnl1ll, 2310005K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 69537
HGNC: HGNC:2957
Homologene: 4896
Gm13741
Name: predicted gene 13741
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 130,742,847 bp
  • A to T, chromosome 1 at 136,191,656 bp
  • A to G, chromosome 1 at 173,526,634 bp
  • T to A, chromosome 2 at 26,327,464 bp
  • T to C, chromosome 2 at 85,353,770 bp
  • T to G, chromosome 2 at 87,656,544 bp
  • C to T, chromosome 3 at 35,832,937 bp
  • T to A, chromosome 3 at 36,074,398 bp
  • A to G, chromosome 4 at 8,753,100 bp
  • T to A, chromosome 4 at 46,542,372 bp
  • T to A, chromosome 4 at 55,016,986 bp
  • T to A, chromosome 4 at 86,996,634 bp
  • G to A, chromosome 4 at 88,309,856 bp
  • A to G, chromosome 4 at 149,350,738 bp
  • T to C, chromosome 5 at 29,474,853 bp
  • C to T, chromosome 5 at 120,663,764 bp
  • T to C, chromosome 5 at 123,799,844 bp
  • A to G, chromosome 5 at 135,440,302 bp
  • C to T, chromosome 5 at 139,426,658 bp
  • A to C, chromosome 6 at 69,016,665 bp
  • T to C, chromosome 7 at 6,962,075 bp
  • C to G, chromosome 7 at 19,088,019 bp
  • G to A, chromosome 7 at 44,991,394 bp
  • T to A, chromosome 7 at 119,823,779 bp
  • T to C, chromosome 8 at 65,000,524 bp
  • G to A, chromosome 8 at 70,721,875 bp
  • A to G, chromosome 9 at 18,485,134 bp
  • T to C, chromosome 9 at 20,444,907 bp
  • T to A, chromosome 9 at 73,757,954 bp
  • T to A, chromosome 9 at 109,877,161 bp
  • T to A, chromosome 9 at 120,122,115 bp
  • C to A, chromosome 11 at 21,997,037 bp
  • A to G, chromosome 11 at 33,217,419 bp
  • T to A, chromosome 11 at 73,336,208 bp
  • T to C, chromosome 11 at 74,346,814 bp
  • T to C, chromosome 11 at 82,102,634 bp
  • A to T, chromosome 11 at 98,043,498 bp
  • C to T, chromosome 11 at 113,850,982 bp
  • A to G, chromosome 13 at 41,777,563 bp
  • A to T, chromosome 13 at 50,700,378 bp
  • T to C, chromosome 14 at 50,824,802 bp
  • T to C, chromosome 14 at 55,512,148 bp
  • T to A, chromosome 15 at 39,437,103 bp
  • A to G, chromosome 15 at 98,806,326 bp
  • A to G, chromosome 16 at 91,681,293 bp
  • G to A, chromosome 16 at 91,785,298 bp
  • T to A, chromosome 17 at 34,533,529 bp
  • T to C, chromosome 17 at 54,276,676 bp
  • T to C, chromosome 17 at 71,099,972 bp
  • G to T, chromosome 19 at 5,082,033 bp
  • G to A, chromosome 19 at 29,631,428 bp
  • C to T, chromosome X at 74,277,038 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5171 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042751-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.