Strain Name:
C57BL/6J-MtgxR5173Btlr/Mmmh
Stock Number:
042753-MU
Citation ID:
RRID:MMRRC_042753-MU
Other Names:
R5173 (G1), C57BL/6J-MtgxR5173Btlr
Major Collection:

Gene Information

Tlr9
Name: toll-like receptor 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 81897
Homologene: 68126
Rnf220
Name: ring finger protein 220
Synonyms: 5730503K05Rik, 4931406I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66743
Homologene: 10036
Osbpl1a
Name: oxysterol binding protein-like 1A
Synonyms: LOC328902, G430090F17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 64291
Homologene: 84746
Ubap2l
Name: ubiquitin-associated protein 2-like
Synonyms: 3110083O19Rik, NICE-4, 4932431F02Rik, A430103N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74383
Homologene: 136291
Rnmt
Name: RNA (guanine-7-) methyltransferase
Synonyms: 2610002P10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67897
Homologene: 2816
Cenpp
Name: centromere protein P
Synonyms: 4921518G09Rik, 1700022C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66336
VEGA: 13
Homologene: 23543
Cul3
Name: cullin 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 26554
HGNC: HGNC:2553
Homologene: 2661
Pi4ka
Name: phosphatidylinositol 4-kinase alpha
Synonyms: Pik4ca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224020
HGNC: HGNC:8983
Homologene: 11171
Zfp462
Name: zinc finger protein 462
Synonyms: Gt4-2, 9430078C22Rik, Zfpip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242466
Homologene: 41430
Eif2ak4
Name: eukaryotic translation initiation factor 2 alpha kinase 4
Synonyms: GCN2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 27103
Homologene: 40891
Dmtf1
Name: cyclin D binding myb like transcription factor 1
Synonyms: Dmp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 23857
Homologene: 8017
Lpar6
Name: lysophosphatidic acid receptor 6
Synonyms: 2610302I02Rik, P2y5, P2ry5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67168
Homologene: 55925
Ap1g1
Name: adaptor protein complex AP-1, gamma 1 subunit
Synonyms: gamma-adaptin, Adtg, D8Ertd374e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11765
HGNC: HGNC:555
Homologene: 47995
Dab1
Name: disabled 1
Synonyms: C630028C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13131
HGNC: HGNC:2661
Homologene: 32084
Cul5
Name: cullin 5
Synonyms: 4921514I20Rik, C330021I08Rik, C030032G03Rik, VACM-1, 8430423K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75717
HGNC: HGNC:2556
Homologene: 2597
Coch
Name: cochlin
Synonyms: Coch-5B2, D12H14S564E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 12810
VEGA: 12
HGNC: HGNC:2180
Homologene: 20868
Mobp
Name: myelin-associated oligodendrocytic basic protein
Synonyms: MOBP155
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17433
HGNC: HGNC:7189
Homologene: 32040
Apob
Name: apolipoprotein B
Synonyms: apob-100, apob-48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Gprc5c
Name: G protein-coupled receptor, family C, group 5, member C
Synonyms: 1110028I06Rik, 3200002M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70355
Homologene: 11099
Plod1
Name: procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
Synonyms: lysyl hydroxylase 1, LH1, 2410042F05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18822
HGNC: HGNC:9081
Homologene: 256
Psmd11
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
Synonyms: P44.5, S9, 1810019E17Rik, C78232, 2610024G20Rik, 2810055C24Rik, 1700089D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69077
HGNC: HGNC:9556
Homologene: 2108
Mis18bp1
Name: MIS18 binding protein 1
Synonyms: C79407
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217653
Homologene: 10147
Spryd3
Name: SPRY domain containing 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223918
Homologene: 13138
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268379
Homologene: 27991
Tex15
Name: testis expressed gene 15
Synonyms: 2210014E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 104271
Homologene: 12837
Chd3
Name: chromodomain helicase DNA binding protein 3
Synonyms: Mi-2 alpha, Prp9-1, Prp7, 2600010P09Rik, Chd7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216848
HGNC: HGNC:1918
Homologene: 62693
Or7c19
Name: olfactory receptor family 7 subfamily C member 19
Synonyms: GA_x6K02T2NUPS-13298842-13299780, MOR141-3, Olfr371
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 258858
Homologene: 65998
Taar6
Name: trace amine-associated receptor 6
Synonyms: LOC215855
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215855
Homologene: 27874
Psd3
Name: pleckstrin and Sec7 domain containing 3
Synonyms: 4931420C21Rik, EFA6D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234353
Homologene: 87257
Ptprt
Name: protein tyrosine phosphatase, receptor type, T
Synonyms: RPTPrho
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19281
HGNC: HGNC:9682
Homologene: 56924
Abca6
Name: ATP-binding cassette, sub-family A (ABC1), member 6
Synonyms: 6330565N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76184
HGNC: HGNC:36
Homologene: 71264
Grik5
Name: glutamate receptor, ionotropic, kainate 5 (gamma 2)
Synonyms: KA2, GluRgamma2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14809
HGNC: HGNC:4583
Homologene: 1578
Flnc
Name: filamin C, gamma
Synonyms: Fln2, 1110055E19Rik, actin binding protein 280
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Or4p18
Name: olfactory receptor family 4 subfamily P member 18
Synonyms: GA_x6K02T2Q125-49890854-49889931, MOR225-2, Olfr1179
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258919
Homologene: 74070
Mylk
Name: myosin, light polypeptide kinase
Synonyms: telokin, Mlck, MLCK210, MLCK108, 9530072E15Rik, A930019C19Rik, nmMlck
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 107589
HGNC: HGNC:7590
Homologene: 14202
A530032D15Rik
Name: RIKEN cDNA A530032D15Rik gene
Synonyms: LOC381287
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381287
Homologene: 131208
Rimbp2
Name: RIMS binding protein 2
Synonyms: A930033C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231760
Homologene: 14672
Rab39
Name: RAB39, member RAS oncogene family
Synonyms: C230094F14Rik, Rab39a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270160
Homologene: 56773
Slc10a1
Name: solute carrier family 10 (sodium/bile acid cotransporter family), member 1
Synonyms: sodium bile acid cotransporting polypeptide, Ntcp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20493
VEGA: 12
Homologene: 31126
Vmn2r60
Name: vomeronasal 2, receptor 60
Synonyms: Casr-rs3, EG637898, Gprc2a-rs3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 637898
Homologene: 129683
Muc21
Name: mucin 21
Synonyms: epiglycanin, Gm9573
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 672682
Tas2r144
Name: taste receptor, type 2, member 144
Synonyms: mt2r33, Tas2r44
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387515
Homologene: 47977
Mical1
Name: microtubule associated monooxygenase, calponin and LIM domain containing 1
Synonyms: Nical
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 171580
Homologene: 11246
Dpp4
Name: dipeptidylpeptidase 4
Synonyms: THAM, Cd26, Dpp-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13482
HGNC: HGNC:3009
Homologene: 3279
Tmem53
Name: transmembrane protein 53
Synonyms: 1700012A05Rik, 1500001P22Rik, 1110038M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68777
Homologene: 41573
Or2y16
Name: olfactory receptor family 2 subfamily Y member 16
Synonyms: GA_x6K02T2QP88-5991012-5990077, MOR256-28, Olfr1388
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258459
Homologene: 74258
Epn3
Name: epsin 3
Synonyms: 2310022G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71889
Homologene: 56791
Gm5799
Name: predicted gene 5799
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 108168155
Pcdha7
Name: protocadherin alpha 7
Synonyms: Cnr4, Crnr4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12939
Homologene: 117962
Lrg1
Name: leucine-rich alpha-2-glycoprotein 1
Synonyms: 2310031E04Rik, Lrhg, 1300008B03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 76905
VEGA: 17
Homologene: 36468
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 80,281,416 bp
  • G to A, chromosome 1 at 85,100,567 bp
  • T to C, chromosome 2 at 62,387,130 bp
  • G to A, chromosome 2 at 88,402,922 bp
  • A to G, chromosome 2 at 118,408,360 bp
  • A to T, chromosome 2 at 161,927,756 bp
  • T to C, chromosome 3 at 90,021,030 bp
  • T to C, chromosome 4 at 55,011,115 bp
  • T to C, chromosome 4 at 104,688,448 bp
  • T to A, chromosome 4 at 117,265,711 bp
  • T to C, chromosome 4 at 117,289,274 bp
  • A to G, chromosome 4 at 147,916,301 bp
  • A to G, chromosome 5 at 9,140,356 bp
  • T to C, chromosome 5 at 128,797,648 bp
  • A to G, chromosome 6 at 29,455,538 bp
  • T to A, chromosome 6 at 42,216,114 bp
  • T to C, chromosome 7 at 25,062,894 bp
  • T to C, chromosome 7 at 42,195,511 bp
  • T to A, chromosome 8 at 33,571,740 bp
  • T to C, chromosome 8 at 67,696,989 bp
  • T to C, chromosome 8 at 85,230,576 bp
  • T to A, chromosome 8 at 109,851,132 bp
  • T to C, chromosome 9 at 53,642,734 bp
  • T to C, chromosome 9 at 53,686,500 bp
  • T to A, chromosome 9 at 106,225,952 bp
  • A to G, chromosome 9 at 120,168,245 bp
  • A to G, chromosome 10 at 23,985,352 bp
  • T to C, chromosome 10 at 41,484,989 bp
  • AC to A, chromosome 11 at 9,682,032 bp
  • T to C, chromosome 11 at 49,443,886 bp
  • A to G, chromosome 11 at 69,369,243 bp
  • C to T, chromosome 11 at 80,460,740 bp
  • T to C, chromosome 11 at 94,496,097 bp
  • A to T, chromosome 11 at 110,191,720 bp
  • G to T, chromosome 11 at 114,864,267 bp
  • T to C, chromosome 12 at 8,008,238 bp
  • C to A, chromosome 12 at 51,596,507 bp
  • T to C, chromosome 12 at 65,149,375 bp
  • T to A, chromosome 12 at 80,956,028 bp
  • CAAACCTGAAAA to CAAA, chromosome 13 at 49,464,782 bp
  • A to G, chromosome 14 at 43,544,659 bp
  • A to T, chromosome 14 at 73,239,097 bp
  • C to T, chromosome 15 at 102,119,397 bp
  • A to T, chromosome 16 at 17,350,906 bp
  • A to G, chromosome 16 at 34,977,013 bp
  • G to T, chromosome 17 at 35,620,741 bp
  • T to G, chromosome 17 at 56,115,548 bp
  • C to T, chromosome 18 at 12,762,640 bp
  • C to A, chromosome 18 at 36,974,652 bp
  • C to T, chromosome 18 at 68,321,359 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5173 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042753-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.