Strain Name:
C57BL/6J-MtgxR5189Btlr/Mmmh
Stock Number:
042767-MU
Citation ID:
RRID:MMRRC_042767-MU
Other Names:
R5189 (G1), C57BL/6J-MtgxR5189Btlr
Major Collection:

Gene Information

Plin2
Name: perilipin 2
Synonyms: Adrp, Adfp, ADPH, adipophilin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11520
HGNC: HGNC:248
Homologene: 872
Trip10
Name: thyroid hormone receptor interactor 10
Synonyms: Cip4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106628
VEGA: 17
Homologene: 99728
Rbm6
Name: RNA binding motif protein 6
Synonyms: Def-3, NY-LU-12, g16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 19654
HGNC: HGNC:9903
Homologene: 31336
Tbc1d8
Name: TBC1 domain family, member 8
Synonyms: AD3, BUB2-like protein 1, GRAM domain, HBLP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 54610
Homologene: 31421
Smg6
Name: Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103677
Homologene: 23024
Hip1
Name: huntingtin interacting protein 1
Synonyms: 2610109B09Rik, HIP-1, A930014B11Rik, E130315I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 215114
HGNC: HGNC:4913
Homologene: 68463
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: LOC381562, A930005E13Rik, 1810009A16Rik, p600, D930005K06Rik, Zubr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69116
Homologene: 10804
Kank1
Name: KN motif and ankyrin repeat domains 1
Synonyms: Ankrd15, A930031B09Rik, D330024H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107351
Homologene: 17706
Mpzl3
Name: myelin protein zero-like 3
Synonyms: 5430427F17Rik, rc, A530065I17Rik, ruf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319742
Homologene: 18867
Pkd2
Name: polycystin 2, transient receptor potential cation channel
Synonyms: PC2, C030034P18Rik, polycystin-2, TRPP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18764
HGNC: HGNC:9009
Homologene: 20104
Sass6
Name: SAS-6 centriolar assembly protein
Synonyms: 2810453L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72776
Homologene: 45668
2700049A03Rik
Name: RIKEN cDNA 2700049A03 gene
Synonyms: talpid3, Ta3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 76967
Homologene: 8839
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930543C13Rik, 4930516E05Rik, D330038K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hy3, hy-3, 4930545D19Rik, hyrh, 1700034M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244653
Homologene: 52118
Ttn
Name: titin
Synonyms: D830007G01Rik, L56, 1100001C23Rik, mdm, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, shru, connectin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Il12rb1
Name: interleukin 12 receptor, beta 1
Synonyms: IL-12R[b], CD212
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16161
HGNC: HGNC:5971
Homologene: 4042
Myh15
Name: myosin, heavy chain 15
Synonyms: EG667772
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 667772
VEGA: 16
Homologene: 18929
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: fibrocystin L, D86 mRNA, PKHDL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 192190
Homologene: 16332
Ankar
Name: ankyrin and armadillo repeat containing
Synonyms: 4932422E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 319695
Homologene: 85163
Igsf3
Name: immunoglobulin superfamily, member 3
Synonyms: 2810035F16Rik, 1700016K10Rik, 4833439O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 78908
HGNC: HGNC:5950
Homologene: 1182
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 435626
Homologene: 52359
Cacnb2
Name: calcium channel, voltage-dependent, beta 2 subunit
Synonyms: Cavbeta2, Cchb2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12296
HGNC: HGNC:1402
Homologene: 75191
Hsf4
Name: heat shock transcription factor 4
Synonyms: ldis1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 26386
HGNC: HGNC:5227
Homologene: 100128
Megf6
Name: multiple EGF-like-domains 6
Synonyms: Egfl3, 2600001P17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230971
HGNC: HGNC:3232
Homologene: 45412
Tmem260
Name: transmembrane protein 260
Synonyms: 6720456H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218989
Homologene: 49506
Map7d1
Name: MAP7 domain containing 1
Synonyms: Mtap7d1, Rprc1, Parcc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 245877
Homologene: 17009
Mex3b
Name: mex3 RNA binding family member B
Synonyms: 4931439A04Rik, Rkhd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 108797
Homologene: 13570
Slc41a2
Name: solute carrier family 41, member 2
Synonyms: A230035L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 338365
Homologene: 9870
Nacad
Name: NAC alpha domain containing
Synonyms: mKIAA0363
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192950
Homologene: 135717
Vmn1r84
Name: vomeronasal 1 receptor 84
Synonyms: V1rg11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 171267
Homologene: 74328
4930505A04Rik
Name: RIKEN cDNA 4930505A04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75087
Homologene: 18988
Gpcpd1
Name: glycerophosphocholine phosphodiesterase 1
Synonyms: 2310004G06Rik, 2310032D16Rik, Prei4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74182
Homologene: 10478
Olfr522
Name: olfactory receptor 522
Synonyms: MOR103-5, GA_x6K02T2PBJ9-42315125-42314187
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258954
Homologene: 62435
Nkx2-6
Name: NK2 homeobox 6
Synonyms: tinman, Nkx2.6, Tix, Nkx-2.6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18092
Homologene: 22604
Kap
Name: kidney androgen regulated protein
Synonyms: kidney androgen-regulated protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16483
Homologene: 49244
Ly96
Name: lymphocyte antigen 96
Synonyms: myeloid differentiation factor-2, ESOP-1, MD-2, MD2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17087
Homologene: 9109
Nkx2-3
Name: NK2 homeobox 3
Synonyms: tinman, Nkx-2.3, Nkx2.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18089
HGNC: HGNC:7836
Homologene: 17061
Pcdha6
Name: protocadherin alpha 6
Synonyms: Crnr2, Cnr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12937
HGNC: HGNC:8672
Homologene: 75098
Gatb
Name: glutamyl-tRNA(Gln) amidotransferase, subunit B
Synonyms: Pet112l, Pet112, 9430026F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229487
HGNC: HGNC:8849
Homologene: 3357
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 16,700,867 bp
  • T to C, chromosome 1 at 39,385,132 bp
  • T to C, chromosome 1 at 72,658,414 bp
  • T to C, chromosome 1 at 74,147,663 bp
  • G to T, chromosome 2 at 14,986,038 bp
  • A to T, chromosome 2 at 76,811,243 bp
  • T to C, chromosome 2 at 132,553,972 bp
  • T to C, chromosome 3 at 85,636,931 bp
  • A to T, chromosome 3 at 101,431,527 bp
  • T to C, chromosome 3 at 116,618,589 bp
  • A to G, chromosome 4 at 86,657,146 bp
  • G to T, chromosome 4 at 126,242,304 bp
  • A to G, chromosome 4 at 139,410,649 bp
  • G to T, chromosome 4 at 154,252,523 bp
  • G to A, chromosome 5 at 104,459,919 bp
  • A to G, chromosome 5 at 135,434,293 bp
  • A to G, chromosome 6 at 133,851,916 bp
  • A to T, chromosome 7 at 12,362,458 bp
  • A to G, chromosome 7 at 82,869,251 bp
  • A to G, chromosome 7 at 140,162,719 bp
  • A to G, chromosome 8 at 70,811,058 bp
  • GCAGCACCGGGTCA to G, chromosome 8 at 105,271,428 bp
  • A to T, chromosome 8 at 110,413,211 bp
  • T to C, chromosome 9 at 45,062,110 bp
  • C to T, chromosome 9 at 107,779,673 bp
  • T to C, chromosome 10 at 83,313,411 bp
  • A to G, chromosome 11 at 6,601,611 bp
  • T to C, chromosome 11 at 30,426,169 bp
  • A to G, chromosome 11 at 75,041,996 bp
  • G to T, chromosome 12 at 71,164,546 bp
  • A to T, chromosome 12 at 71,164,547 bp
  • C to T, chromosome 12 at 71,193,349 bp
  • T to A, chromosome 14 at 48,509,116 bp
  • A to T, chromosome 14 at 69,171,893 bp
  • A to G, chromosome 15 at 44,547,148 bp
  • C to A, chromosome 16 at 49,101,507 bp
  • A to T, chromosome 17 at 57,261,288 bp
  • A to T, chromosome 18 at 36,968,791 bp
  • G to T, chromosome 19 at 16,685,315 bp
  • T to C, chromosome 19 at 25,424,181 bp
  • T to G, chromosome 19 at 43,612,708 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5189 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042767-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.