Strain Name:
C57BL/6J-MtgxR5193Btlr/Mmmh
Stock Number:
042769-MU
Citation ID:
RRID:MMRRC_042769-MU
Other Names:
R5193 (G1), C57BL/6J-MtgxR5193Btlr
Major Collection:

Strain Information

Suz12
Name: SUZ12 polycomb repressive complex 2 subunit
Synonyms: 2610028O16Rik, D11Ertd530e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52615
Homologene: 32256
Pzp
Name: PZP, alpha-2-macroglobulin like
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11287
Homologene: 104112
Cfl1
Name: cofilin 1, non-muscle
Synonyms: cofilin, Cof, n-cofilin
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12631
HGNC: HGNC:1874
Homologene: 99735
Tet1
Name: tet methylcytosine dioxygenase 1
Synonyms: 2510010B09Rik, D10Ertd17e, Cxxc6, BB001228
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52463
Homologene: 12735
Efnb2
Name: ephrin B2
Synonyms: Epl5, NLERK-1, LERK-5, ELF-2, Htk-L, Eplg5, Lerk5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13642
HGNC: HGNC:3227
Homologene: 3019
Hars1
Name: histidyl-tRNA synthetase 1
Synonyms: MMHRS, Hars
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 15115
VEGA: 18
HGNC: HGNC:4816
Homologene: 1592
Kifbp
Name: kinesin family binding protein
Synonyms: 2510003E04Rik, Kif1bp
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72320
Homologene: 9223
Rnps1
Name: RNA binding protein with serine rich domain 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19826
VEGA: 17
Homologene: 40648
Fnta
Name: farnesyltransferase, CAAX box, alpha
Synonyms: FTA
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14272
HGNC: HGNC:3782
Homologene: 1534
Scaf8
Name: SR-related CTD-associated factor 8
Synonyms: A930036P18Rik, A630086M08Rik, Rbm16
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106583
VEGA: 17
Homologene: 8928
Cc2d2a
Name: coiled-coil and C2 domain containing 2A
Synonyms: 5730509K17Rik, b2b1035Clo
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231214
Homologene: 18159
Afg3l2
Name: AFG3-like AAA ATPase 2
Synonyms: 2310036I02Rik, par, Emv66
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 69597
VEGA: 18
HGNC: HGNC:315
Homologene: 4947
Wdr62
Name: WD repeat domain 62
Synonyms: 2310038K02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233064
Homologene: 15927
Mafa
Name: MAF bZIP transcription factor A
Synonyms: RIPE3b1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 378435
VEGA: 15
Homologene: 65867
Scn10a
Name: sodium channel, voltage-gated, type X, alpha
Synonyms: Nav1.8
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20264
VEGA: 9
Homologene: 21300
Uba6
Name: ubiquitin-like modifier activating enzyme 6
Synonyms: 5730469D23Rik, Ube1l2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231380
Homologene: 10080
Arfgap3
Name: ADP-ribosylation factor GTPase activating protein 3
Synonyms: 1810004P07Rik, 1810035F16Rik, 0610009H19Rik, 9130416J18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66251
VEGA: 15
HGNC: HGNC:661
Homologene: 134103
Mcm9
Name: minichromosome maintenance 9 homologous recombination repair factor
Synonyms: 9030408O17Rik, Mcmdc1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71567
VEGA: 10
Homologene: 13546
Clec14a
Name: C-type lectin domain family 14, member a
Synonyms: 1200003C23Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66864
VEGA: 12
Homologene: 12047
Il31ra
Name: interleukin 31 receptor A
Synonyms: GLM-R, GPL
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218624
VEGA: 13
Homologene: 51395
Wdtc1
Name: WD and tetratricopeptide repeats 1
Synonyms: LOC230796, adp, adipose
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230796
Homologene: 8997
Trpa1
Name: transient receptor potential cation channel, subfamily A, member 1
Synonyms: ANKTM1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 277328
HGNC: HGNC:497
Homologene: 7189
Cenpl
Name: centromere protein L
Synonyms: 2610300B10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70454
Homologene: 19618
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, syne-2, D12Ertd777e, 6820443O06Rik, Nesp2g, Cpfl8, diminished cone electroretinogram, dice
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Pcsk5
Name: proprotein convertase subtilisin/kexin type 5
Synonyms: PC6, SPC6, PC5A, PC5/6A, b2b585Clo, b2b1549Clo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18552
VEGA: 19
HGNC: HGNC:8747
Homologene: 21244
Magi2
Name: membrane associated guanylate kinase, WW and PDZ domain containing 2
Synonyms: S-SCAM, Acvrinp1, Magi-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50791
Homologene: 8189
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Tyro3
Name: TYRO3 protein tyrosine kinase 3
Synonyms: Sky, Dtk, Etk-2, Tif, Brt, Rse, Sky
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22174
Homologene: 4585
Slc22a30
Name: solute carrier family 22, member 30
Synonyms: C730048C13Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 319800
Homologene: 77136
Tctn2
Name: tectonic family member 2
Synonyms: Tect2, 4432405B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67978
Homologene: 11729
Tbc1d16
Name: TBC1 domain family, member 16
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207592
Homologene: 10380
Hipk3
Name: homeodomain interacting protein kinase 3
Synonyms: DYRK6, FIST3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15259
HGNC: HGNC:4915
Homologene: 55923
Xkr6
Name: X-linked Kx blood group related 6
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219149
Homologene: 18287
Or10g1b
Name: olfactory receptor family 10 subfamily G member 1B
Synonyms: GA_x6K02T2RJGY-608749-609705, MOR223-9, Olfr1511
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258268
HGNC: HGNC:8170
Homologene: 87788
Pigc
Name: phosphatidylinositol glycan anchor biosynthesis, class C
Synonyms: 3110030E07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67292
HGNC: HGNC:8960
Homologene: 7109
Pou6f2
Name: POU domain, class 6, transcription factor 2
Synonyms: RPF-1, D130006K24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218030
Mrgprh
Name: MAS-related GPR, member H
Synonyms: MrgH, Gpr90
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 80978
VEGA: 17
Homologene: 12758
Cd151
Name: CD151 antigen
Synonyms: SFA-1, PETA-3, Tspan24
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12476
HGNC: HGNC:1630
Homologene: 20916
Det1
Name: DET1 partner of COP1 E3 ubiquitin ligase
Synonyms: 2610034H20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76375
Homologene: 9952
Abhd12
Name: abhydrolase domain containing 12
Synonyms: 6330583M11Rik, 1500011G07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76192
Homologene: 22910
Krt1
Name: keratin 1
Synonyms: Krt2-1, Krt-2.1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16678
VEGA: 15
HGNC: HGNC:6412
Homologene: 38146
Ccdc7a
Name: coiled-coil domain containing 7A
Synonyms: 4930540C21Rik, 4930517G15Rik, Ccdc7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74703
Homologene: 134760
Lancl1
Name: LanC (bacterial lantibiotic synthetase component C)-like 1
Synonyms: p40, LanC-like protein 1, Gpr69a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14768
HGNC: HGNC:6508
Homologene: 4417
Or5w17
Name: olfactory receptor family 5 subfamily W member 17
Synonyms: GA_x6K02T2Q125-49257818-49256883, MOR177-10, Olfr1141
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258630
Homologene: 74080
Slc17a2
Name: solute carrier family 17 (sodium phosphate), member 2
Synonyms: NPT3, C730032N17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218103
Homologene: 4260
Pou5f2
Name: POU domain class 5, transcription factor 2
Synonyms: 1700013G10Rik, Sprm1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75507
Homologene: 83454
Kctd15
Name: potassium channel tetramerisation domain containing 15
Synonyms: MGC25497
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233107
Homologene: 11450
Gm340
Name: predicted gene 340
Synonyms: LOC381224
Type: Gene
Species: Mouse
Chromosome: 19
Bpifc
Name: BPI fold containing family C
Synonyms: Bpil2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 270757
Homologene: 18383
Cst13
Name: cystatin 13
Synonyms: cystatin T, Cymg1, 1700006C19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69294
Homologene: 41707
Or1e16
Name: olfactory receptor family 1 subfamily E member 16
Synonyms: MOR135-13, GA_x6K02T2P1NL-3556334-3555390, I54, Olfr1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258923
Homologene: 115482
Fbxo10
Name: F-box protein 10
Synonyms: FBX10, LOC269529
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269529
Homologene: 19544
Cnn1
Name: calponin 1
Synonyms: CnnI, calponin h1, CN
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12797
VEGA: 9
HGNC: HGNC:2155
Homologene: 995
Prl3d2
Name: prolactin family 3, subfamily d, member 1
Synonyms: PL-Ib, Plib
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 215028
Homologene: 137215
Gprin2
Name: G protein regulated inducer of neurite outgrowth 2
Synonyms: C130040D06Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 432839
VEGA: 14
Homologene: 40975
Or51a7
Name: olfactory receptor family 51 subfamily A member 7
Synonyms: GA_x6K02T2PBJ9-5676385-5677371, MOR8-5, Olfr576
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258248
Homologene: 45856
Vgll2
Name: vestigial like family member 2
Synonyms: VITO-1, C130057C21Rik, Vito1, Vgl-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215031
Homologene: 35066
Spr-ps1
Name: sepiapterin reductase pseudogene 1
Synonyms: Sprp, EG665089
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 665089
Gm5117
Name: predicted gene 5117
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 330731
Cep112os1
Name: centrosomal protein 112, opposite strand 1
Synonyms: Gm11666
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 108167933
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 14,875,917 bp
  • T to A, chromosome 1 at 67,021,014 bp
  • C to A, chromosome 1 at 161,083,467 bp
  • T to C, chromosome 1 at 161,970,896 bp
  • A to T, chromosome 2 at 82,982,994 bp
  • A to T, chromosome 2 at 87,753,104 bp
  • A to G, chromosome 2 at 104,430,000 bp
  • T to C, chromosome 2 at 119,810,517 bp
  • C to A, chromosome 2 at 148,828,223 bp
  • A to T, chromosome 2 at 150,835,306 bp
  • T to A, chromosome 4 at 45,051,573 bp
  • G to A, chromosome 4 at 133,294,367 bp
  • G to A, chromosome 5 at 20,358,972 bp
  • A to G, chromosome 5 at 43,710,544 bp
  • G to T, chromosome 5 at 86,124,422 bp
  • T to C, chromosome 5 at 124,615,247 bp
  • T to C, chromosome 6 at 85,156,013 bp
  • T to C, chromosome 6 at 128,502,334 bp
  • A to T, chromosome 7 at 30,265,167 bp
  • A to G, chromosome 7 at 34,644,857 bp
  • A to G, chromosome 7 at 78,843,554 bp
  • T to A, chromosome 7 at 102,965,936 bp
  • A to G, chromosome 7 at 141,470,693 bp
  • A to G, chromosome 8 at 8,623,162 bp
  • A to T, chromosome 8 at 26,011,218 bp
  • A to T, chromosome 8 at 31,739,323 bp
  • T to A, chromosome 8 at 128,988,797 bp
  • A to T, chromosome 9 at 22,107,836 bp
  • T to C, chromosome 9 at 119,609,655 bp
  • T to A, chromosome 10 at 52,027,992 bp
  • T to A, chromosome 10 at 53,616,038 bp
  • T to C, chromosome 10 at 62,559,396 bp
  • T to C, chromosome 10 at 62,838,247 bp
  • T to C, chromosome 10 at 86,000,633 bp
  • TAGCGGTCGTA to T, chromosome 11 at 73,395,653 bp
  • AGCGGTCGTAGGC to AGC, chromosome 11 at 73,395,654 bp
  • A to G, chromosome 11 at 79,999,108 bp
  • T to A, chromosome 11 at 108,531,496 bp
  • A to T, chromosome 11 at 119,158,820 bp
  • A to G, chromosome 12 at 58,268,614 bp
  • A to G, chromosome 12 at 76,094,420 bp
  • T to C, chromosome 13 at 18,125,544 bp
  • A to G, chromosome 13 at 23,819,862 bp
  • T to A, chromosome 13 at 27,122,329 bp
  • C to A, chromosome 13 at 78,024,964 bp
  • T to C, chromosome 13 at 112,524,330 bp
  • C to T, chromosome 14 at 34,194,875 bp
  • A to G, chromosome 14 at 52,390,612 bp
  • A to G, chromosome 14 at 63,818,907 bp
  • G to T, chromosome 15 at 75,747,817 bp
  • C to T, chromosome 15 at 83,332,697 bp
  • C to A, chromosome 15 at 101,845,922 bp
  • C to G, chromosome 17 at 3,190,165 bp
  • T to C, chromosome 17 at 12,877,055 bp
  • G to A, chromosome 17 at 24,418,543 bp
  • A to G, chromosome 18 at 36,767,305 bp
  • G to T, chromosome 18 at 67,421,259 bp
  • T to A, chromosome 19 at 5,492,552 bp
  • G to A, chromosome 19 at 8,344,393 bp
  • T to A, chromosome 19 at 17,564,810 bp
  • A to G, chromosome 19 at 41,582,530 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5193 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042769-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.