Strain Name:
C57BL/6J-MtgxR5194Btlr/Mmmh
Stock Number:
042770-MU
Citation ID:
RRID:MMRRC_042770-MU
Other Names:
R5194 (G1), C57BL/6J-MtgxR5194Btlr
Major Collection:

Gene Information

Myo5a
Name: myosin VA
Synonyms: 9630007J19Rik, MVa, Dbv, MyoVA, Myo5, flail
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17918
HGNC: HGNC:7602
Homologene: 20100
Acadm
Name: acyl-Coenzyme A dehydrogenase, medium chain
Synonyms: MCAD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11364
HGNC: HGNC:89
Homologene: 3
P2rx7
Name: purinergic receptor P2X, ligand-gated ion channel, 7
Synonyms: P2X(7), P2X7R, P2X7 receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18439
HGNC: HGNC:8537
Homologene: 1925
Ewsr1
Name: Ewing sarcoma breakpoint region 1
Synonyms: Ews
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14030
HGNC: HGNC:3508
Homologene: 134632
Acly
Name: ATP citrate lyase
Synonyms: A730098H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 104112
HGNC: HGNC:115
Homologene: 854
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: D3Ertd775e, Lba
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Schip1
Name: schwannomin interacting protein 1
Synonyms: SCHIP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 30953
Homologene: 130673
Arfgef1
Name: ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)
Synonyms: ARFGEP1, P200, BIG1, D730028O18Rik, D130059B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 211673
Homologene: 4687
Phip
Name: pleckstrin homology domain interacting protein
Synonyms: Wdr11, Ndrp, 2810004D21Rik, 4632404O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 83946
Homologene: 41209
Zfp407
Name: zinc finger protein 407
Synonyms: LOC240469, 6430585N13Rik, LOC381139
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240476
Homologene: 86402
Myo9b
Name: myosin IXb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17925
HGNC: HGNC:7609
Homologene: 3058
Ubqln1
Name: ubiquilin 1
Synonyms: DA41, 1110046H03Rik, 1810030E05Rik, D13Ertd372e, Dsk2, XDRP1, Plic-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56085
VEGA: 13
Homologene: 137258
Dtna
Name: dystrobrevin alpha
Synonyms: Dtn, 2210407P21Rik, a-DB-1, alpha-dystrobrevin, A0, 87K protein, adbn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13527
VEGA: 18
HGNC: HGNC:3057
Homologene: 20362
Cep135
Name: centrosomal protein 135
Synonyms: Cep4, LOC381644
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381644
Homologene: 45709
Pgr
Name: progesterone receptor
Synonyms: NR3C3, ENSMUSG00000074510, 9930019P03Rik, PR-A, PR-B, PR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18667
HGNC: HGNC:8910
Homologene: 713
Fam120a
Name: family with sequence similarity 120, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218236
VEGA: 13
Homologene: 8752
Lgr6
Name: leucine-rich repeat-containing G protein-coupled receptor 6
Synonyms: A530037C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329252
Homologene: 49680
Arhgef2
Name: rho/rac guanine nucleotide exchange factor (GEF) 2
Synonyms: Lbcl1, Lfc, GEF-H1, LFP40, GEFH1, P40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 16800
HGNC: HGNC:682
Homologene: 3468
D11Wsu47e
Name: DNA segment, Chr 11, Wayne State University 47, expressed
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 276852
Homologene: 9928
Eif2ak3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
Synonyms: PERK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13666
HGNC: HGNC:3255
Homologene: 3557
Rab2a
Name: RAB2A, member RAS oncogene family
Synonyms: Rab2, 9330148M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 59021
HGNC: HGNC:9763
Homologene: 20628
Agtpbp1
Name: ATP/GTP binding protein 1
Synonyms: 5730402G09Rik, 1700020N17Rik, 4930445M19Rik, atms, 2310001G17Rik, Nna1, 2900054O13Rik, Ccp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67269
Homologene: 9067
Ngfr
Name: nerve growth factor receptor (TNFR superfamily, member 16)
Synonyms: LNGFR, p75, p75 neurotrophin receptor, Tnfrsf16, p75NTR, p75NGFR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18053
HGNC: HGNC:7809
Homologene: 1877
Irak2
Name: interleukin-1 receptor-associated kinase 2
Synonyms: IRAK-2, 6330415L08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 108960
HGNC: HGNC:6113
Homologene: 1207
Egfem1
Name: EGF-like and EMI domain containing 1
Synonyms: 6130401L20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 75740
Homologene: 135950
Mylk3
Name: myosin light chain kinase 3
Synonyms: D830007F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 213435
Homologene: 35278
Wdr17
Name: WD repeat domain 17
Synonyms: B230207L18Rik, 3010002I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244484
Homologene: 12460
Ptpdc1
Name: protein tyrosine phosphatase domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218232
VEGA: 13
Homologene: 17576
Drc7
Name: dynein regulatory complex subunit 7
Synonyms: Ccdc135, SRG-L, LOC330830
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 330830
Homologene: 12996
Slc22a21
Name: solute carrier family 22 (organic cation transporter), member 21
Synonyms: Octn3, Slc22a9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 56517
Homologene: 137336
Ankrd7
Name: ankyrin repeat domain 7
Synonyms: 4930532L20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 75196
Homologene: 35506
Acnat2
Name: acyl-coenzyme A amino acid N-acyltransferase 2
Synonyms: C730036D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 209186
Homologene: 28287
Dennd5a
Name: DENN/MADD domain containing 5A
Synonyms: Rab6ip1, ORF37, 1500012B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19347
Homologene: 14584
Myt1l
Name: myelin transcription factor 1-like
Synonyms: Pmng1, C630034G21Rik, 2900093J19Rik, 2900046C06Rik, Nztf1, Png-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 17933
VEGA: 12
HGNC: HGNC:7623
Homologene: 7435
F13a1
Name: coagulation factor XIII, A1 subunit
Synonyms: Factor XIIIA, 1200014I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 74145
VEGA: 13
HGNC: HGNC:3531
Homologene: 20077
Aadacl4fm2
Name: AADACL4 family member 2
Synonyms: Gm13124
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 627085
Homologene: 135767
Trim34a
Name: tripartite motif-containing 34A
Synonyms: Trim34, Trim34-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 94094
Homologene: 128238
Sntb1
Name: syntrophin, basic 1
Synonyms: beta1-Syntrophin, 59-1 DAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20649
Homologene: 9618
Gpaa1
Name: GPI anchor attachment protein 1
Synonyms: mGAA1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 14731
HGNC: HGNC:4446
Homologene: 37852
Tll2
Name: tolloid-like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 24087
VEGA: 19
Homologene: 56545
Sipa1l2
Name: signal-induced proliferation-associated 1 like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244668
Homologene: 18956
Wiz
Name: widely-interspaced zinc finger motifs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22404
Homologene: 7997
Smco1
Name: single-pass membrane protein with coiled-coil domains 1
Synonyms: 2310010M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 69576
Homologene: 18842
Olfr698
Name: olfactory receptor 698
Synonyms: MOR283-3, GA_x6K02T2PBJ9-9130754-9129519
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258595
Homologene: 133598
Sh3bp1
Name: SH3-domain binding protein 1
Synonyms: 3BP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20401
Homologene: 7534
Olfr1347
Name: olfactory receptor 1347
Synonyms: MOR103-19_i, GA_x6K02T2QGBW-3218686-3217748, MOR103-11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258383
Homologene: 128065
Olfr814
Name: olfactory receptor 814
Synonyms: GA_x6K02T2PULF-11553313-11552381, MOR113-8, MOR113-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 259165
Homologene: 133585
Cbs
Name: cystathionine beta-synthase
Synonyms: HIP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12411
Homologene: 37258
Sdr16c5
Name: short chain dehydrogenase/reductase family 16C, member 5
Synonyms: Scdr9, Rdhe2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242285
Homologene: 15039
Vstm2b
Name: V-set and transmembrane domain containing 2B
Synonyms: 2900093B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 58188
Homologene: 10970
H2-Ab1
Name: histocompatibility 2, class II antigen A, beta 1
Synonyms: I-Ab, A beta, Ia-2, I-Abeta, Rmcs1, H2-Ab, Ia2, H-2Ab, IAb, Abeta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14961
HGNC: HGNC:4944
Homologene: 1603
Gm17490
Name: predicted gene, 17490
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Hoxd12
Name: homeobox D12
Synonyms: Hox-5.6, Hox-4.7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 15432
HGNC: HGNC:5135
Homologene: 7369
Ifi204
Name: interferon activated gene 204
Synonyms: p204
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 15951
HGNC: HGNC:5395
Homologene: 115929
Olfr576
Name: olfactory receptor 576
Synonyms: MOR8-5, GA_x6K02T2PBJ9-5676385-5677371
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258248
Homologene: 45856
Olfr1264
Name: olfactory receptor 1264
Synonyms: GA_x6K02T2Q125-51454183-51453257, MOR236-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258206
Homologene: 66365
Pcdhga4
Name: protocadherin gamma subfamily A, 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93712
HGNC: HGNC:8702
Homologene: 81866
Gm8587
Name: predicted pseudogene 8587
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 667350
Homologene: 133537
AC120402.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
1700122O11Rik
Name: RIKEN cDNA 1700122O11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 76651
Rps2-ps10
Name: ribosomal protein S2, pseudogene 10
Synonyms: Gm8553
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 667279
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 10,204,907 bp
  • C to T, chromosome 1 at 134,994,010 bp
  • C to T, chromosome 1 at 173,749,344 bp
  • T to C, chromosome 2 at 11,626,251 bp
  • T to C, chromosome 2 at 74,675,103 bp
  • T to A, chromosome 2 at 90,021,526 bp
  • G to A, chromosome 3 at 29,357,196 bp
  • T to C, chromosome 3 at 68,494,872 bp
  • A to C, chromosome 3 at 86,328,219 bp
  • A to T, chromosome 3 at 88,635,649 bp
  • C to T, chromosome 3 at 153,933,118 bp
  • C to A, chromosome 4 at 4,006,663 bp
  • T to A, chromosome 4 at 8,604,381 bp
  • G to T, chromosome 4 at 49,380,452 bp
  • A to G, chromosome 4 at 144,555,082 bp
  • T to C, chromosome 5 at 76,615,777 bp
  • T to C, chromosome 5 at 122,673,795 bp
  • A to G, chromosome 6 at 18,868,077 bp
  • T to C, chromosome 6 at 70,858,478 bp
  • T to C, chromosome 6 at 113,690,790 bp
  • A to G, chromosome 7 at 6,488,520 bp
  • T to A, chromosome 7 at 40,902,488 bp
  • A to G, chromosome 7 at 102,965,864 bp
  • A to G, chromosome 7 at 104,260,993 bp
  • A to T, chromosome 7 at 106,753,219 bp
  • T to C, chromosome 7 at 109,933,729 bp
  • A to G, chromosome 8 at 54,687,604 bp
  • C to T, chromosome 8 at 71,349,089 bp
  • T to C, chromosome 8 at 85,352,866 bp
  • T to C, chromosome 8 at 95,061,717 bp
  • T to C, chromosome 8 at 125,439,273 bp
  • G to C, chromosome 9 at 8,901,946 bp
  • T to C, chromosome 9 at 75,212,943 bp
  • G to A, chromosome 9 at 82,908,862 bp
  • C to T, chromosome 10 at 129,874,098 bp
  • T to C, chromosome 11 at 5,082,355 bp
  • T to C, chromosome 11 at 53,979,847 bp
  • T to C, chromosome 11 at 95,580,982 bp
  • T to A, chromosome 11 at 100,523,546 bp
  • T to C, chromosome 11 at 113,688,828 bp
  • A to C, chromosome 12 at 29,811,648 bp
  • T to A, chromosome 12 at 84,417,337 bp
  • C to T, chromosome 12 at 88,089,786 bp
  • T to G, chromosome 13 at 36,972,063 bp
  • C to A, chromosome 13 at 48,586,789 bp
  • A to G, chromosome 13 at 48,880,935 bp
  • A to G, chromosome 13 at 58,199,033 bp
  • T to C, chromosome 13 at 59,500,639 bp
  • G to A, chromosome 15 at 55,906,301 bp
  • C to A, chromosome 15 at 76,333,866 bp
  • A to G, chromosome 15 at 78,903,101 bp
  • C to T, chromosome 16 at 32,273,774 bp
  • C to T, chromosome 17 at 31,624,224 bp
  • T to C, chromosome 17 at 32,377,848 bp
  • C to T, chromosome 17 at 34,269,378 bp
  • T to C, chromosome 17 at 48,037,250 bp
  • C to T, chromosome 18 at 23,590,245 bp
  • A to C, chromosome 18 at 37,687,741 bp
  • T to A, chromosome 18 at 61,259,908 bp
  • T to C, chromosome 18 at 84,561,309 bp
  • T to C, chromosome 19 at 41,095,897 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5194 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042770-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.