Strain Name:
C57BL/6J-MtgxR5196Btlr/Mmmh
Stock Number:
042772-MU
Citation ID:
RRID:MMRRC_042772-MU
Other Names:
R5196 (G1), C57BL/6J-MtgxR5196Btlr
Major Collection:

Gene Information

Septin4
Name: septin 4
Synonyms: cell division control-related protein 2b, Pnutl2, Bh5, septin H5, ARTS, Sept4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18952
HGNC: HGNC:9165
Homologene: 6107
Chrna5
Name: cholinergic receptor, nicotinic, alpha polypeptide 5
Synonyms: Acra-5, Acra5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 110835
VEGA: 9
HGNC: HGNC:1959
Homologene: 55485
Fgd4
Name: FYVE, RhoGEF and PH domain containing 4
Synonyms: Frabin-gamma, Frabin-beta, Frabin-alpha, Frabin, 9330209B17Rik, ZFYVE6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224014
Homologene: 26727
Hdlbp
Name: high density lipoprotein (HDL) binding protein
Synonyms: D1Ertd101e, 1110005P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 110611
HGNC: HGNC:4857
Homologene: 38035
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: apollon, Bruce, A430032G04Rik, D630005A10Rik, A430040A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12211
Homologene: 7248
Mtdh
Name: metadherin
Synonyms: D8Bwg1112e, 3D3/Lyric, Lyric, 2610103J23Rik, AEG-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67154
Homologene: 12089
Uhrf1bp1
Name: UHRF1 (ICBP90) binding protein 1
Synonyms: 1110020K19Rik, F830021D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224648
Homologene: 9816
Evi5
Name: ecotropic viral integration site 5
Synonyms: NB4S
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14020
HGNC: HGNC:3501
Homologene: 121902
Ccm2
Name: cerebral cavernous malformation 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216527
Homologene: 12868
Wdr12
Name: WD repeat domain 12
Synonyms: Ytm1, Ytm1p, 4933402C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 57750
Homologene: 10098
Pten
Name: phosphatase and tensin homolog
Synonyms: MMAC1, TEP1, 2310035O07Rik, A130070J02Rik, B430203M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 19211
HGNC: HGNC:9588
Homologene: 265
Tfcp2
Name: transcription factor CP2
Synonyms: LBP-1d, LBP-1c, LSF, UBP-1, CP-2, D230015P20Rik, LBP1, CP2, Tcfcp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 21422
VEGA: 15
Homologene: 4134
Afg3l2
Name: AFG3-like AAA ATPase 2
Synonyms: 2310036I02Rik, par, Emv66
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 69597
VEGA: 18
HGNC: HGNC:315
Homologene: 4947
Lrrfip1
Name: leucine rich repeat (in FLII) interacting protein 1
Synonyms: FLAP (FLI LRR associated protein), Fliiap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16978
HGNC: HGNC:6702
Homologene: 48301
Kctd4
Name: potassium channel tetramerisation domain containing 4
Synonyms: 2210017A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67516
VEGA: 14
Homologene: 36441
Arcn1
Name: archain 1
Synonyms: 4632432M07Rik, pale coat neuro, nur17, delta-COP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 213827
HGNC: HGNC:649
Homologene: 1250
Gm9847
Name: predicted pseudogene 9847
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 100043256
VEGA: 12
Klrb1c
Name: killer cell lectin-like receptor subfamily B member 1C
Synonyms: Nkrp1-c, NK-RP1, Nk1.1, CD161, NK-1.1, Ly-59, Nk-1, Ly55c, Nk-1.2, NKR-P1, Nk1, Ly59, NKR-P1C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17059
HGNC: HGNC:6373
Homologene: 84369
Lgr6
Name: leucine-rich repeat-containing G protein-coupled receptor 6
Synonyms: A530037C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329252
Homologene: 49680
Ntng1
Name: netrin G1
Synonyms: Lmnt1, A930010C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80883
Homologene: 8949
Clk1
Name: CDC-like kinase 1
Synonyms: STY, Clk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12747
HGNC: HGNC:2068
Homologene: 101535
Asph
Name: aspartate-beta-hydroxylase
Synonyms: cI-37, 2310005F16Rik, aspartyl beta-hydroxylase, calsequestrin-binding protein, Junctin, jumbug, BAH, 3110001L23Rik, junctate
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 65973
HGNC: HGNC:757
Homologene: 20910
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72205
Homologene: 8125
Prmt9
Name: protein arginine methyltransferase 9
Synonyms: Prmt10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102182
Homologene: 16298
Pask
Name: PAS domain containing serine/threonine kinase
Synonyms: Paskin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269224
Homologene: 9038
Kat6a
Name: K(lysine) acetyltransferase 6A
Synonyms: MOZ, Zfp220, 9930021N24Rik, Myst3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244349
Homologene: 4924
Amigo2
Name: adhesion molecule with Ig like domain 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105827
VEGA: 15
Homologene: 18649
H2-T23
Name: histocompatibility 2, T region locus 23
Synonyms: H-2T23, T18c(37), T18c, 37c, 37b, T23d, T23b, Qed-1, Qa1, Qa-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 15040
HGNC: HGNC:4962
Homologene: 134018
Chrm5
Name: cholinergic receptor, muscarinic 5
Synonyms: muscarinic acetylcholine receptor 5, M5R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 213788
HGNC: HGNC:1954
Homologene: 22697
Cdc42bpa
Name: CDC42 binding protein kinase alpha
Synonyms: DMPK-like, A930014J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226751
HGNC: HGNC:1737
Homologene: 55765
Rb1cc1
Name: RB1-inducible coiled-coil 1
Synonyms: LaXp180, 2900055E04Rik, Cc1, 5930404L04Rik, Fip200
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12421
Homologene: 7659
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Arhgef25
Name: Rho guanine nucleotide exchange factor (GEF) 25
Synonyms: 2410008H17Rik, GEFT, D10Ertd610e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 52666
VEGA: 10
Homologene: 32691
Cdh7
Name: cadherin 7, type 2
Synonyms: CDH7L1, 9330156F07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241201
HGNC: HGNC:1766
Homologene: 68391
Mast3
Name: microtubule associated serine/threonine kinase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 546071
Homologene: 66191
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 435626
Homologene: 52359
Mybpc1
Name: myosin binding protein C, slow-type
Synonyms: Slow-type C-protein, 8030451F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 109272
HGNC: HGNC:7549
Homologene: 1846
Tcaf3
Name: TRPM8 channel-associated factor 3
Synonyms: Eapa2, Fam115e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 403088
Homologene: 74374
4930503B20Rik
Name: RIKEN cDNA 4930503B20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 75015
Homologene: 41344
Zfp536
Name: zinc finger protein 536
Synonyms: 9630010P11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243937
Homologene: 8813
Cfap43
Name: cilia and flagella associated protein 43
Synonyms: 4930428C11Rik, 4632415N18Rik, 4930463G05Rik, D19Ertd652e, Wdr96
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 100048534
Homologene: 36425
Slc5a7
Name: solute carrier family 5 (choline transporter), member 7
Synonyms: CHT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 63993
VEGA: 17
Homologene: 32516
Reg2
Name: regenerating islet-derived 2
Synonyms: pancreatic thread protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19693
Homologene: 68517
Odr4
Name: odr4 GPCR localization factor homolog
Synonyms: 1810053E15Rik, BC003331
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226499
Homologene: 41202
Fbxw19
Name: F-box and WD-40 domain protein 19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235612
Homologene: 110776
Pif1
Name: PIF1 5'-to-3' DNA helicase
Synonyms: AI449441
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208084
Homologene: 99775
Ak8
Name: adenylate kinase 8
Synonyms: 1190002A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68870
Homologene: 17622
Zfp647
Name: zinc finger protein 647
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239546
VEGA: 15
Homologene: 27805
Mfap3
Name: microfibrillar-associated protein 3
Synonyms: 2700079M14Rik, 2610509F16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216760
HGNC: HGNC:7034
Homologene: 4333
Gask1a
Name: golgi associated kinase 1A
Synonyms: C730027P07Rik, Fam198a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 245050
VEGA: 9
Homologene: 18620
Plppr2
Name: phospholipid phosphatase related 2
Synonyms: PRG-4, BC018242, Lppr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235044
Homologene: 11229
Atp10d
Name: ATPase, class V, type 10D
Synonyms: IMAGE:1069176, D5Buc24e, 9830145H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231287
1700001O22Rik
Name: RIKEN cDNA 1700001O22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 73598
Homologene: 18859
6330409D20Rik
Name: RIKEN cDNA 6330409D20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70730
Olfr812
Name: olfactory receptor 812
Synonyms: GA_x6K02T2PULF-11521598-11520666, MOR110-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258791
Homologene: 73931
Olfr1176
Name: olfactory receptor 1176
Synonyms: GA_x6K02T2Q125-49824309-49825256, MOR174-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258767
4930589L23Rik
Name: RIKEN cDNA 4930589L23 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 75879
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 6,234,230 bp
  • T to A, chromosome 1 at 58,414,613 bp
  • T to C, chromosome 1 at 60,087,084 bp
  • T to C, chromosome 1 at 74,147,663 bp
  • G to T, chromosome 1 at 90,816,538 bp
  • A to G, chromosome 1 at 91,114,608 bp
  • A to G, chromosome 1 at 93,310,083 bp
  • T to C, chromosome 1 at 93,420,193 bp
  • T to A, chromosome 1 at 110,138,000 bp
  • C to T, chromosome 1 at 134,994,010 bp
  • T to A, chromosome 1 at 150,382,389 bp
  • T to C, chromosome 1 at 180,072,413 bp
  • A to G, chromosome 2 at 28,700,247 bp
  • T to C, chromosome 2 at 30,796,438 bp
  • T to A, chromosome 2 at 32,740,540 bp
  • A to G, chromosome 2 at 88,339,748 bp
  • T to C, chromosome 2 at 112,480,384 bp
  • T to C, chromosome 3 at 79,572,538 bp
  • T to C, chromosome 3 at 109,934,983 bp
  • A to G, chromosome 3 at 146,646,263 bp
  • A to T, chromosome 4 at 9,607,830 bp
  • C to T, chromosome 5 at 72,227,758 bp
  • A to G, chromosome 5 at 107,799,135 bp
  • G to T, chromosome 6 at 42,593,715 bp
  • T to A, chromosome 6 at 78,405,547 bp
  • T to A, chromosome 6 at 128,780,299 bp
  • G to A, chromosome 7 at 19,201,163 bp
  • G to A, chromosome 7 at 37,480,760 bp
  • G to A, chromosome 8 at 22,911,713 bp
  • A to T, chromosome 8 at 70,788,245 bp
  • G to A, chromosome 8 at 77,564,997 bp
  • T to C, chromosome 9 at 21,941,132 bp
  • A to T, chromosome 9 at 44,760,027 bp
  • A to G, chromosome 9 at 55,006,519 bp
  • G to T, chromosome 9 at 65,588,092 bp
  • T to C, chromosome 9 at 109,484,428 bp
  • T to G, chromosome 9 at 121,965,661 bp
  • A to G, chromosome 10 at 88,536,351 bp
  • A to G, chromosome 10 at 127,185,109 bp
  • T to A, chromosome 10 at 129,842,781 bp
  • G to A, chromosome 11 at 6,561,181 bp
  • A to G, chromosome 11 at 57,529,813 bp
  • A to G, chromosome 11 at 87,583,404 bp
  • T to A, chromosome 12 at 14,495,015 bp
  • A to G, chromosome 14 at 75,962,687 bp
  • G to T, chromosome 15 at 34,118,004 bp
  • G to A, chromosome 15 at 76,912,085 bp
  • A to G, chromosome 15 at 97,246,061 bp
  • A to G, chromosome 15 at 100,520,714 bp
  • T to A, chromosome 16 at 16,484,142 bp
  • A to G, chromosome 17 at 27,856,763 bp
  • A to G, chromosome 17 at 36,032,607 bp
  • C to A, chromosome 17 at 54,281,722 bp
  • T to C, chromosome 17 at 74,606,141 bp
  • G to T, chromosome 18 at 67,421,259 bp
  • A to T, chromosome 19 at 32,815,497 bp
  • A to T, chromosome 19 at 47,825,925 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5196 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042772-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.