Strain Name:
C57BL/6J-MtgxR5199Btlr/Mmmh
Stock Number:
042775-MU
Citation ID:
RRID:MMRRC_042775-MU
Other Names:
R5199 (G1), C57BL/6J-MtgxR5199Btlr
Major Collection:

Strain Information

Cds2
Name: CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
Synonyms: 5730460C18Rik, D2Wsu127e, 5730450N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 110911
HGNC: HGNC:1801
Homologene: 37854
Rptor
Name: regulatory associated protein of MTOR, complex 1
Synonyms: raptor, 4932417H02Rik, Rap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74370
Homologene: 80210
Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Vsx2
Name: visual system homeobox 2
Synonyms: Hox-10, Hox10, Chx10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 12677
HGNC: HGNC:1975
Homologene: 7266
Inpp5a
Name: inositol polyphosphate-5-phosphatase A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 212111
HGNC: HGNC:6076
Homologene: 4045
Cxcr4
Name: chemokine (C-X-C motif) receptor 4
Synonyms: PB-CKR, fusin, CD184, Cmkar4, Sdf1r, b2b220Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12767
HGNC: HGNC:2561
Homologene: 20739
Dapp1
Name: dual adaptor for phosphotyrosine and 3-phosphoinositides 1
Synonyms: Bam32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 26377
Homologene: 32138
Dlgap4
Name: DLG associated protein 4
Synonyms: WBP16, SAP90/PSD-95-associated protein 4, PSD-95/SAP90 binding protein 4, DAP4, Sapap4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228836
Homologene: 8935
Carmil1
Name: capping protein regulator and myosin 1 linker 1
Synonyms: 1110037D04Rik, Lrrc16, Carmil, Lrrc16a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68732
Homologene: 9757
Psme4
Name: proteasome (prosome, macropain) activator subunit 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103554
Homologene: 113742
Ezh2
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
Synonyms: Enx-1, Enx1h, KMT6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14056
HGNC: HGNC:3527
Homologene: 37926
Cnot8
Name: CCR4-NOT transcription complex, subunit 8
Synonyms: 1810022F04Rik, 1500015I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69125
HGNC: HGNC:9207
Homologene: 48304
Pcnt
Name: pericentrin (kendrin)
Synonyms: Pcnt2, m275Asp, m239Asp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18541
VEGA: 10
Etl4
Name: enhancer trap locus 4
Synonyms: Etl-4, E330027G05Rik, 6620402G01Rik, 9430077C05Rik, Skt, Sickle tail
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 208618
Homologene: 10477
Gpat4
Name: glycerol-3-phosphate acyltransferase 4
Synonyms: Agpat6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102247
Homologene: 32425
Ranbp2
Name: RAN binding protein 2
Synonyms: A430087B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19386
VEGA: 10
Homologene: 87808
Urb1
Name: URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
Synonyms: 5730405K23Rik, 4921511H13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 207932
Homologene: 45941
Topbp1
Name: topoisomerase (DNA) II binding protein 1
Synonyms: D430026L04Rik, 2810429C13Rik, 1110031N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235559
Homologene: 38262
Tmem245
Name: transmembrane protein 245
Synonyms: A630051L19Rik, D730040F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242474
HGNC: HGNC:1363
Homologene: 41841
Dsp
Name: desmoplakin
Synonyms: DP, 2300002E22Rik, 5730453H04Rik, rul
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Oas1d
Name: 2'-5' oligoadenylate synthetase 1D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100535
HGNC: HGNC:8086
Homologene: 110815
Kansl2-ps
Name: KAT8 regulatory NSL complex subunit 2, pseudogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233391
Qtrt2
Name: queuine tRNA-ribosyltransferase accessory subunit 2
Synonyms: 3110012M05Rik, 4930470H18Rik, Qrtr2, Qtrtd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 106248
Homologene: 41576
Phlpp1
Name: PH domain and leucine rich repeat protein phosphatase 1
Synonyms: Plekhe1, Phlpp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98432
Homologene: 11015
Cep170b
Name: centrosomal protein 170B
Synonyms: AW555464
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217882
VEGA: 12
Homologene: 46165
AW554918
Name: expressed sequence AW554918
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225289
Homologene: 52652
Dhps
Name: deoxyhypusine synthase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 330817
HGNC: HGNC:2869
Homologene: 1453
Adar
Name: adenosine deaminase, RNA-specific
Synonyms: ADAR1, mZaADAR, Adar1p150, Adar1p110
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56417
HGNC: HGNC:225
Homologene: 9281
St3gal1
Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Synonyms: CMP-N-acetylneuraminate: [beta-galactosidase alpha-2,3] sialytransferase, Siat4, ST3GalI, Siat4a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20442
VEGA: 15
Homologene: 7540
Amdhd1
Name: amidohydrolase domain containing 1
Synonyms: 1300019J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71761
Homologene: 14730
Cabp1
Name: calcium binding protein 1
Synonyms: caldendrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 29867
HGNC: HGNC:1384
Homologene: 99790
Cpne8
Name: copine VIII
Synonyms: 1200003E11Rik, 1500031E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66871
Homologene: 12049
Zfp804b
Name: zinc finger protein 804B
Synonyms: LOC207618
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 207618
Homologene: 52304
Vmn2r82
Name: vomeronasal 2, receptor 82
Synonyms: EG624845
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 624845
Homologene: 83483
Aadacl2fm1
Name: AADACL2 family member 1
Synonyms: C130079G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229333
Vmn1r178
Name: vomeronasal 1 receptor 178
Synonyms: LOC232959, V1rd13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232959
Homologene: 104166
Mug2
Name: murinoglobulin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17837
Homologene: 136663
Per3
Name: period circadian clock 3
Synonyms: mPer3, 2810049O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18628
HGNC: HGNC:8847
Homologene: 7886
Hinfp
Name: histone H4 transcription factor
Synonyms: DKFZp434F162, Mizf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 102423
VEGA: 9
Homologene: 9174
Hip1r
Name: huntingtin interacting protein 1 related
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 29816
Homologene: 78348
Crygn
Name: crystallin, gamma N
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 214301
Homologene: 16986
Mcmdc2
Name: minichromosome maintenance domain containing 2
Synonyms: 6030422M02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240697
Homologene: 18309
Cnnm1
Name: cyclin M1
Synonyms: Acdp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 83674
VEGA: 19
HGNC: HGNC:102
Homologene: 10673
Or9g3
Name: olfactory receptor family 9 subfamily G member 3
Synonyms: GA_x6K02T2Q125-47239120-47238185, MOR213-6, Olfr1012
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258561
Homologene: 64889
Gbp9
Name: guanylate-binding protein 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 236573
Homologene: 128731
Haus6
Name: HAUS augmin-like complex, subunit 6
Synonyms: D4Ertd27e, 6230416J20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230376
Homologene: 9760
Saxo1
Name: stabilizer of axonemal microtubules 1
Synonyms: 4930500O09Rik, Fam154a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 75811
Homologene: 27548
Or5ac21
Name: olfactory receptor family 5 subfamily AC member 21
Synonyms: GA_x54KRFPKG5P-55517445-55518365, MOR182-5, Olfr203
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 258479
Homologene: 122781
Klrh1
Name: killer cell lectin-like receptor subfamily H, member 1
Synonyms: LOC232415, Gm156
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232415
Homologene: 16395
Adam1a
Name: a disintegrin and metallopeptidase domain 1a
Synonyms: Ftna, PH-30 alpha, fertilin alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 280668
HGNC: HGNC:187
Homologene: 73803
Cyp4f15
Name: cytochrome P450, family 4, subfamily f, polypeptide 15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106648
Homologene: 80199
Gm11444
Name: predicted gene 11444
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Or4c110
Name: olfactory receptor family 4 subfamily C member 110
Synonyms: GA_x6K02T2Q125-50482823-50481885, MOR233-13, Olfr1215
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258451
Homologene: 74071
Ifna14
Name: interferon alpha 14
Synonyms: OTTMUSG00000007662
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 404549
Homologene: 68536
Igkv3-3
Name: immunoglobulin kappa variable 3-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 667946
Ndufb3
Name: NADH:ubiquinone oxidoreductase subunit B3
Synonyms: 2700033I16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66495
HGNC: HGNC:7698
Homologene: 37630
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 9,920,435 bp
  • C to G, chromosome 1 at 58,591,122 bp
  • T to A, chromosome 1 at 106,173,394 bp
  • A to G, chromosome 1 at 128,589,546 bp
  • G to T, chromosome 2 at 20,744,042 bp
  • A to G, chromosome 2 at 85,760,214 bp
  • T to A, chromosome 2 at 89,001,763 bp
  • T to A, chromosome 2 at 132,298,483 bp
  • A to T, chromosome 2 at 156,749,028 bp
  • T to C, chromosome 3 at 59,936,485 bp
  • T to A, chromosome 3 at 89,745,944 bp
  • C to T, chromosome 3 at 137,981,385 bp
  • G to A, chromosome 4 at 56,925,149 bp
  • T to A, chromosome 4 at 86,487,782 bp
  • T to C, chromosome 4 at 86,582,985 bp
  • T to A, chromosome 4 at 88,571,362 bp
  • G to T, chromosome 4 at 151,012,895 bp
  • A to T, chromosome 5 at 6,770,013 bp
  • A to G, chromosome 5 at 24,756,158 bp
  • T to C, chromosome 5 at 105,083,812 bp
  • A to G, chromosome 5 at 115,186,043 bp
  • G to T, chromosome 5 at 120,919,145 bp
  • T to C, chromosome 5 at 121,521,152 bp
  • C to T, chromosome 5 at 124,001,433 bp
  • C to T, chromosome 6 at 47,551,725 bp
  • A to T, chromosome 6 at 70,687,504 bp
  • T to A, chromosome 6 at 122,040,660 bp
  • T to A, chromosome 6 at 129,775,818 bp
  • A to T, chromosome 7 at 23,894,389 bp
  • A to G, chromosome 7 at 72,673,194 bp
  • C to T, chromosome 7 at 139,481,650 bp
  • A to G, chromosome 8 at 23,182,696 bp
  • G to A, chromosome 8 at 85,073,406 bp
  • T to C, chromosome 9 at 44,296,392 bp
  • A to G, chromosome 9 at 103,346,672 bp
  • G to A, chromosome 10 at 58,464,443 bp
  • T to A, chromosome 10 at 76,418,544 bp
  • G to A, chromosome 10 at 79,396,087 bp
  • A to T, chromosome 10 at 93,525,985 bp
  • C to A, chromosome 11 at 21,997,037 bp
  • A to G, chromosome 11 at 30,853,272 bp
  • C to T, chromosome 11 at 58,115,274 bp
  • A to C, chromosome 11 at 85,848,019 bp
  • T to A, chromosome 11 at 119,603,816 bp
  • A to G, chromosome 12 at 84,593,210 bp
  • T to A, chromosome 12 at 112,744,147 bp
  • A to G, chromosome 13 at 24,111,870 bp
  • T to G, chromosome 13 at 38,192,902 bp
  • A to G, chromosome 15 at 67,113,715 bp
  • G to A, chromosome 15 at 90,648,609 bp
  • T to C, chromosome 16 at 43,867,425 bp
  • T to A, chromosome 16 at 59,303,740 bp
  • T to C, chromosome 16 at 90,792,748 bp
  • A to G, chromosome 17 at 32,702,372 bp
  • C to A, chromosome 18 at 25,340,299 bp
  • A to G, chromosome 19 at 43,494,986 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5199 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042775-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.