Strain Name:
C57BL/6J-MtgxR5207Btlr/Mmmh
Stock Number:
042782-MU
Citation ID:
RRID:MMRRC_042782-MU
Other Names:
R5207 (G1), C57BL/6J-MtgxR5207Btlr
Major Collection:

Strain Information

Derl2
Name: Der1-like domain family, member 2
Synonyms: CGI-101, F-lana, Flana, Derlin-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 116891
Homologene: 9356
Nes
Name: nestin
Synonyms: RC2, Marc2, ESTM46, Ifaprc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18008
HGNC: HGNC:7756
Homologene: 136487
Dock5
Name: dedicator of cytokinesis 5
Synonyms: lr2, 1110060D06Rik, rlc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 68813
VEGA: 14
Homologene: 57016
Senp2
Name: SUMO/sentrin specific peptidase 2
Synonyms: 4930538C18Rik, 2310007L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 75826
VEGA: 16
Homologene: 11005
Nf1
Name: neurofibromin 1
Synonyms: neurofibromin, Nf-1, Dsk9, Mhdadsk9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18015
HGNC: HGNC:7765
Homologene: 226
Sec24d
Name: Sec24 related gene family, member D (S. cerevisiae)
Synonyms: 2310020L09Rik, LOC383951
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69608
Homologene: 40986
Ahctf1
Name: AT hook containing transcription factor 1
Synonyms: 6230412P20Rik, Elys
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226747
Homologene: 9142
Ccar1
Name: cell division cycle and apoptosis regulator 1
Synonyms: Carp1, 2610511G16Rik, 9430036H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67500
VEGA: 10
Homologene: 10086
Tex2
Name: testis expressed gene 2
Synonyms: Taz4, Def-5, 4930568E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 21763
Homologene: 32414
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: D130015N03Rik, 2810449H11Rik, tbl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Chmp7
Name: charged multivesicular body protein 7
Synonyms: 4930596K11Rik, 6330407G04Rik, CHMP family, member 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105513
VEGA: 14
Homologene: 14613
Snx29
Name: sorting nexin 29
Synonyms: LOC381035, LOC385605, 4933437K13Rik, Gm11170, Rundc2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74478
Homologene: 32706
Tcf20
Name: transcription factor 20
Synonyms: SPBP, stromelysin 1 PDGF responsive element binding protein, 2810438H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 21411
VEGA: 15
Homologene: 4131
Lmo7
Name: LIM domain only 7
Synonyms: LOC380928, FBXO20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 380928
HGNC: HGNC:6646
Homologene: 83924
Csn2
Name: casein beta
Synonyms: CSN2, Csnb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12991
HGNC: HGNC:2447
Homologene: 1426
Med23
Name: mediator complex subunit 23
Synonyms: ESTM7, 3000002A17Rik, X83317, Crsp3, Sur2, sno
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70208
HGNC: HGNC:2372
Homologene: 3552
Plxna2
Name: plexin A2
Synonyms: OCT, Plxn2, 2810428A13Rik, PlexA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Tmem119
Name: transmembrane protein 119
Synonyms: obif
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231633
Homologene: 17145
Ddr2
Name: discoidin domain receptor family, member 2
Synonyms: Ntrkr3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18214
HGNC: HGNC:2731
Homologene: 68505
Rac2
Name: Rac family small GTPase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 19354
VEGA: 15
HGNC: HGNC:9802
Homologene: 55699
Mroh7
Name: maestro heat-like repeat family member 7
Synonyms: LOC381538, Gm1027, Heatr8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381538
Homologene: 19633
Nek3
Name: NIMA (never in mitosis gene a)-related expressed kinase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 23954
HGNC: HGNC:7746
Homologene: 1869
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244646
Homologene: 14627
Casc1
Name: cancer susceptibility candidate 1
Synonyms: Las1, A230084G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320662
Homologene: 41242
Garin3
Name: golgi associated RAB2 interactor 3
Synonyms: OTTMUSG00000005491, Fam71b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 432552
Homologene: 51067
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
Chdh
Name: choline dehydrogenase
Synonyms: D630034H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218865
Homologene: 41261
Ap3b2
Name: adaptor-related protein complex 3, beta 2 subunit
Synonyms: Naptb, beta3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11775
HGNC: HGNC:567
Homologene: 55837
Vmn2r25
Name: vomeronasal 2, receptor 25
Synonyms: EG545874
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 545874
Homologene: 135915
Mrps2
Name: mitochondrial ribosomal protein S2
Synonyms: 1500019M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 118451
Homologene: 99837
Whrn
Name: whirlin
Synonyms: 1110035G07Rik, wi, C430046P22Rik, Dfnb31, Ush2d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 73750
Homologene: 18739
Celsr3
Name: cadherin, EGF LAG seven-pass G-type receptor 3
Synonyms: Fmi1, flamingo, Adgrc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 107934
HGNC: HGNC:3230
Homologene: 1077
Lacc1
Name: laccase domain containing 1
Synonyms: 9030625A04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 210808
Homologene: 17712
Ficd
Name: FIC domain containing
Synonyms: D5Ertd40e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231630
Homologene: 5139
Or5b96
Name: olfactory receptor family 5 subfamily B member 96
Synonyms: GA_x6K02T2RE5P-3220047-3219130, MOR202-2, Olfr1446
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258699
HGNC: HGNC:8324
Homologene: 74233
Paqr8
Name: progestin and adipoQ receptor family member VIII
Synonyms: 3110001D06Rik, 1700019B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74229
Homologene: 32702
Pcdhb1
Name: protocadherin beta 1
Synonyms: PcdhbA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93872
HGNC: HGNC:8680
Homologene: 8348
Piwil2
Name: piwi-like RNA-mediated gene silencing 2
Synonyms: Miwi like, mili
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 57746
VEGA: 14
Homologene: 23071
Zfp558
Name: zinc finger protein 558
Synonyms: 1700007A21Rik, 4932704I17Rik, Zfp558-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72230
Homologene: 44903
Gbp10
Name: guanylate-binding protein 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 626578
Homologene: 128731
Fam161a
Name: family with sequence similarity 161, member A
Synonyms: 4930430E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 73873
Homologene: 19131
Or6c2
Name: olfactory receptor family 6 subfamily C member 2
Synonyms: GA_x6K02T2PULF-11205096-11206034, MOR114-1, Olfr791
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258932
Homologene: 71950
Ctrc
Name: chymotrypsin C (caldecrin)
Synonyms: 1810044E12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76701
HGNC: HGNC:2523
Homologene: 21422
Chmp2a
Name: charged multivesicular body protein 2A
Synonyms: 1500016L11Rik, chromatin modifying protein 2A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68953
Homologene: 6382
Ppp2r2b
Name: protein phosphatase 2, regulatory subunit B, beta
Synonyms: 6330404L05Rik, PP2A-PR55B, PR55-BETA, SCA12, 2900026H06Rik, E130009M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 72930
HGNC: HGNC:9305
Homologene: 55833
Gdf7
Name: growth differentiation factor 7
Synonyms: BMP12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238057
VEGA: 12
HGNC: HGNC:4222
Homologene: 32177
Mrgpra3
Name: MAS-related GPR, member A3
Synonyms: G protein-coupled receptor, MrgA3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233222
Homologene: 131159
Itpka
Name: inositol 1,4,5-trisphosphate 3-kinase A
Synonyms: IP3-kinase A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228550
HGNC: HGNC:6178
Homologene: 1671
Tlr12
Name: toll-like receptor 12
Synonyms: LOC384059, Tlr11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 384059
Homologene: 135964
Alg6
Name: asparagine-linked glycosylation 6 (alpha-1,3,-glucosyltransferase)
Synonyms: E230028F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320438
Homologene: 6920
Allc
Name: allantoicase
Synonyms: 1700012B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 94041
Homologene: 6202
Or6b2
Name: olfactory receptor family 6 subfamily B member 2
Synonyms: GA_x6K02T2R7CC-81277975-81278913, MOR103-3, Olfr1416
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 259040
Homologene: 17472
Cysltr2
Name: cysteinyl leukotriene receptor 2
Synonyms: CYSLT2R, Cyslt2, CysLT2, 2300001H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 70086
VEGA: 14
Homologene: 10688
Nagpa
Name: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
Synonyms: alpha-GlcNAcase, UCE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 27426
Homologene: 8466
Cldn23
Name: claudin 23
Synonyms: 2310014B08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 71908
Homologene: 12421
Pjvk
Name: pejvakin
Synonyms: LOC381375, pejvakin, Dfnb59
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 381375
Homologene: 19773
Gm17244
Name: predicted gene, 17244
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Emp3
Name: epithelial membrane protein 3
Synonyms: HNMP-1, H-4, H4, Ymp, MI-35
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13732
HGNC: HGNC:3335
Homologene: 1090
Borcs6
Name: BLOC-1 related complex subunit 6
Synonyms: 2310047M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71923
Homologene: 41183
Gm14486
Name: predicted gene 14486
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 665635
Mup20
Name: major urinary protein 20
Synonyms: darcin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381530
Homologene: 74304
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 20,935,258 bp
  • G to C, chromosome 1 at 90,801,531 bp
  • A to T, chromosome 1 at 92,479,872 bp
  • G to A, chromosome 1 at 169,984,961 bp
  • A to T, chromosome 1 at 179,793,594 bp
  • A to G, chromosome 1 at 194,788,899 bp
  • A to G, chromosome 2 at 28,469,751 bp
  • G to T, chromosome 2 at 30,658,560 bp
  • A to C, chromosome 2 at 76,650,390 bp
  • G to A, chromosome 2 at 119,750,493 bp
  • G to A, chromosome 3 at 87,978,628 bp
  • C to T, chromosome 3 at 123,353,646 bp
  • A to C, chromosome 4 at 62,051,586 bp
  • A to T, chromosome 4 at 63,432,714 bp
  • C to T, chromosome 4 at 99,719,194 bp
  • T to A, chromosome 4 at 106,721,386 bp
  • A to G, chromosome 4 at 123,115,921 bp
  • G to A, chromosome 4 at 128,616,709 bp
  • A to C, chromosome 4 at 141,840,384 bp
  • G to A, chromosome 5 at 87,694,962 bp
  • T to C, chromosome 5 at 105,224,709 bp
  • T to A, chromosome 5 at 113,737,011 bp
  • T to C, chromosome 5 at 113,795,228 bp
  • A to T, chromosome 6 at 123,840,103 bp
  • A to T, chromosome 6 at 145,179,068 bp
  • C to T, chromosome 7 at 13,036,322 bp
  • T to C, chromosome 7 at 45,919,949 bp
  • T to A, chromosome 7 at 47,590,161 bp
  • T to C, chromosome 7 at 81,476,769 bp
  • A to T, chromosome 8 at 22,132,227 bp
  • A to T, chromosome 8 at 35,826,028 bp
  • A to T, chromosome 8 at 109,633,191 bp
  • A to C, chromosome 9 at 18,457,000 bp
  • T to A, chromosome 9 at 66,399,869 bp
  • A to T, chromosome 9 at 108,832,759 bp
  • A to T, chromosome 10 at 24,895,836 bp
  • T to C, chromosome 10 at 62,753,281 bp
  • T to C, chromosome 10 at 129,526,904 bp
  • A to T, chromosome 11 at 23,020,583 bp
  • T to C, chromosome 11 at 46,405,163 bp
  • A to T, chromosome 11 at 69,060,848 bp
  • G to T, chromosome 11 at 71,019,247 bp
  • G to T, chromosome 11 at 79,454,189 bp
  • T to C, chromosome 11 at 106,546,840 bp
  • T to C, chromosome 11 at 116,006,539 bp
  • C to T, chromosome 12 at 8,298,371 bp
  • T to A, chromosome 12 at 28,555,326 bp
  • C to T, chromosome 14 at 30,031,361 bp
  • T to C, chromosome 14 at 67,776,284 bp
  • T to C, chromosome 14 at 69,732,306 bp
  • T to C, chromosome 14 at 70,392,517 bp
  • A to C, chromosome 14 at 73,029,511 bp
  • T to A, chromosome 14 at 77,034,154 bp
  • G to A, chromosome 14 at 101,900,464 bp
  • T to C, chromosome 15 at 78,565,454 bp
  • T to A, chromosome 15 at 82,856,185 bp
  • A to G, chromosome 16 at 5,199,614 bp
  • A to T, chromosome 16 at 11,738,363 bp
  • A to T, chromosome 16 at 22,041,380 bp
  • T to C, chromosome 18 at 37,266,462 bp
  • A to T, chromosome 18 at 42,688,352 bp
  • T to A, chromosome 19 at 12,890,437 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5207 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042782-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.