Strain Name:
C57BL/6J-MtgxR5209Btlr/Mmmh
Stock Number:
042784-MU
Citation ID:
RRID:MMRRC_042784-MU
Other Names:
R5209 (G1), C57BL/6J-MtgxR5209Btlr
Major Collection:

Gene Information

Npr3
Name: natriuretic peptide receptor 3
Synonyms: Nppc receptor, lgj, longjohn, NPR-C, B430320C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18162
VEGA: 15
HGNC: HGNC:7945
Homologene: 699
Rgs9
Name: regulator of G-protein signaling 9
Synonyms: Rgs9-2, RGS9-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19739
Homologene: 2845
Satb1
Name: special AT-rich sequence binding protein 1
Synonyms: 2610306G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20230
Homologene: 2232
Trmo
Name: tRNA methyltransferase O
Synonyms: 5830415F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74753
Homologene: 32316
Dusp1
Name: dual specificity phosphatase 1
Synonyms: mkp-1, erp, 3CH134, Ptpn16, MKP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 19252
HGNC: HGNC:3064
Homologene: 3254
Tesk2
Name: testis-specific kinase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230661
Homologene: 5188
Mtmr14
Name: myotubularin related protein 14
Synonyms: 1110061O04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 97287
Homologene: 11203
Hmgcr
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
Synonyms: HMG-CoAR, 3-hydroxy-3-methylglutaryl-CoA reductase, Red
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 15357
HGNC: HGNC:5006
Homologene: 30994
Rps6ka1
Name: ribosomal protein S6 kinase polypeptide 1
Synonyms: Rsk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 20111
Homologene: 55703
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: apollon, Bruce, A430032G04Rik, D630005A10Rik, A430040A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12211
Homologene: 7248
Stam
Name: signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Synonyms: STAM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20844
Homologene: 37788
Trappc12
Name: trafficking protein particle complex 12
Synonyms: CGI-87, D930014A20Rik, Ttc15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217449
VEGA: 12
Homologene: 34805
Vdac1
Name: voltage-dependent anion channel 1
Synonyms: Vdac5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22333
Homologene: 107244
Cinp
Name: cyclin-dependent kinase 2 interacting protein
Synonyms: 1810047K05Rik, 2810452K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 67236
VEGA: 12
Homologene: 12103
Mettl1
Name: methyltransferase like 1
Synonyms: 2810012D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17299
HGNC: HGNC:7030
Homologene: 3918
Rag1
Name: recombination activating 1
Synonyms: Rag-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19373
HGNC: HGNC:9831
Homologene: 387
Gnaz
Name: guanine nucleotide binding protein, alpha z subunit
Synonyms: Gz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14687
HGNC: HGNC:4395
Homologene: 22574
Fam81a
Name: family with sequence similarity 81, member A
Synonyms: 6430514L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 76886
Homologene: 17584
Slit2
Name: slit guidance ligand 2
Synonyms: Slil3, Drad-1, E130320P19Rik, E030015M03Rik, b2b1200.1Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20563
Homologene: 3516
Epg5
Name: ectopic P-granules autophagy protein 5 homolog (C. elegans)
Synonyms: 5430411K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 100502841
VEGA: 18
Homologene: 14575
Ms4a4c
Name: membrane-spanning 4-domains, subfamily A, member 4C
Synonyms: 5830413L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 64380
Homologene: 113790
Msh3
Name: mutS homolog 3
Synonyms: D13Em1, Rep-3, Rep3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17686
HGNC: HGNC:7326
Homologene: 1829
Ubr2
Name: ubiquitin protein ligase E3 component n-recognin 2
Synonyms: 9930021A08Rik, E130209G04Rik, ENSMUSG00000043296
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224826
VEGA: 17
Homologene: 26151
Fgd2
Name: FYVE, RhoGEF and PH domain containing 2
Synonyms: tcs-2, Tcd-2, tcs2, Tcd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 26382
HGNC: HGNC:3664
Homologene: 8438
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 77505
Homologene: 131117
Primpol
Name: primase and polymerase (DNA-directed)
Synonyms: Ccdc111
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 408022
Homologene: 14065
Slc45a2
Name: solute carrier family 45, member 2
Synonyms: Dbr, bls, Aim1, Aim-1, dominant brown, blanc-sale, Matp, Oca4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22293
Homologene: 9412
Piezo2
Name: piezo-type mechanosensitive ion channel component 2
Synonyms: 9430028L06Rik, 9030411M15Rik, Fam38b2, Piezo2, Fam38b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 667742
Homologene: 49695
Col5a3
Name: collagen, type V, alpha 3
Synonyms: Pro-alpha3(V)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 53867
Homologene: 9253
Olfr905
Name: olfactory receptor 905
Synonyms: GA_x6K02T2PVTD-32165709-32166641, MOR167-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258800
VEGA: 9
Homologene: 110524
Abcg4
Name: ATP binding cassette subfamily G member 4
Synonyms: 6430517O04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 192663
Homologene: 75179
Sptbn5
Name: spectrin beta, non-erythrocytic 5
Synonyms: EG640524, Spnb5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 640524
Homologene: 41150
Zfp652
Name: zinc finger protein 652
Synonyms: 9530033F24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268469
Homologene: 54768
Olfr771
Name: olfactory receptor 771
Synonyms: GA_x6K02T2PULF-10846420-10845467, MOR114-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258540
Homologene: 74047
Arhgef5
Name: Rho guanine nucleotide exchange factor (GEF) 5
Synonyms: 2210412D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 54324
Homologene: 66300
Olfr221
Name: olfactory receptor 221
Synonyms: GA_x6K02SYYB8M-929-258, MOR205-1, GA_x6K02T2RJGY-959918-960853, MOR205-2, Olfr1514
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258420
Homologene: 45823
Adgb
Name: androglobin
Synonyms: 9130014G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215772
Homologene: 100289
4932415D10Rik
Name: RIKEN cDNA 4932415D10 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Abca14
Name: ATP-binding cassette, sub-family A (ABC1), member 14
Synonyms: 1700110B15Rik, 4930539G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67928
Homologene: 86128
Ces1d
Name: carboxylesterase 1D
Synonyms: TGH, Ces3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 104158
HGNC: HGNC:1863
Homologene: 35606
Pkd1l2
Name: polycystic kidney disease 1 like 2
Synonyms: 1700126L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 76645
Homologene: 124481
Gjc3
Name: gap junction protein, gamma 3
Synonyms: connexin 29, Cx29, Gje1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 118446
Homologene: 15399
Mylk
Name: myosin, light polypeptide kinase
Synonyms: telokin, Mlck, MLCK210, MLCK108, 9530072E15Rik, A930019C19Rik, nmMlck
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 107589
HGNC: HGNC:7590
Homologene: 14202
Mamdc4
Name: MAM domain containing 4
Synonyms: LOC381352
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 381352
Homologene: 17102
Adprhl1
Name: ADP-ribosylhydrolase like 1
Synonyms: Arh2, D330008N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234072
Homologene: 16311
Ptprr
Name: protein tyrosine phosphatase, receptor type, R
Synonyms: PTPBR7, PTP-SL, RPTPRR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19279
HGNC: HGNC:9680
Homologene: 2135
Pth2r
Name: parathyroid hormone 2 receptor
Synonyms: Pthr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 213527
HGNC: HGNC:9609
Homologene: 3701
Pde8b
Name: phosphodiesterase 8B
Synonyms: B230331L10Rik, C030047E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218461
HGNC: HGNC:8794
Homologene: 2758
Rexo5
Name: RNA exonuclease 5
Synonyms: 2610020H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434234
Homologene: 12803
Pcdhb17
Name: protocadherin beta 17
Synonyms: Pcdhb16, PcdhbQ
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93888
Homologene: 81881
Mapk8ip2
Name: mitogen-activated protein kinase 8 interacting protein 2
Synonyms: JNK-interacting protein, Jip2, 3230402N03Rik, IB2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 60597
HGNC: HGNC:6883
Homologene: 8201
Arhgap24
Name: Rho GTPase activating protein 24
Synonyms: 0610025G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231532
Homologene: 32754
Chmp2a
Name: charged multivesicular body protein 2A
Synonyms: 1500016L11Rik, chromatin modifying protein 2A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68953
Homologene: 6382
Reep5
Name: receptor accessory protein 5
Synonyms: DP1/TB2, TB2/DP1, Dp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13476
VEGA: 18
Homologene: 68479
Samd14
Name: sterile alpha motif domain containing 14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217125
Homologene: 17130
Btbd18
Name: BTB (POZ) domain containing 18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 100270744
Homologene: 122125
Olfr105-ps
Name: olfactory receptor 105, pseudogene
Synonyms: MOR250-7, GA_x6K02T2PSCP-1843460-1844386, Olfr105
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 257893
Slfn14
Name: schlafen 14
Synonyms: LOC237890, Slfn14-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237890
Homologene: 19082
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 65,388,697 bp
  • T to A, chromosome 2 at 14,146,347 bp
  • G to T, chromosome 2 at 25,566,923 bp
  • A to G, chromosome 2 at 84,668,099 bp
  • T to C, chromosome 2 at 101,644,215 bp
  • T to A, chromosome 2 at 120,072,002 bp
  • T to C, chromosome 4 at 46,387,740 bp
  • G to A, chromosome 4 at 116,724,698 bp
  • A to T, chromosome 4 at 133,865,818 bp
  • T to C, chromosome 5 at 48,176,196 bp
  • T to A, chromosome 5 at 102,892,149 bp
  • C to T, chromosome 5 at 137,957,271 bp
  • A to T, chromosome 6 at 43,273,700 bp
  • T to A, chromosome 6 at 113,253,775 bp
  • C to A, chromosome 7 at 13,032,674 bp
  • T to G, chromosome 7 at 105,696,460 bp
  • T to A, chromosome 7 at 119,834,299 bp
  • T to C, chromosome 7 at 120,232,907 bp
  • T to A, chromosome 8 at 13,242,563 bp
  • T to C, chromosome 8 at 46,590,260 bp
  • A to T, chromosome 8 at 93,175,188 bp
  • G to A, chromosome 8 at 117,056,442 bp
  • C to T, chromosome 9 at 20,778,643 bp
  • T to A, chromosome 9 at 38,473,521 bp
  • A to G, chromosome 9 at 44,275,375 bp
  • T to C, chromosome 9 at 70,125,160 bp
  • C to A, chromosome 10 at 10,398,937 bp
  • T to G, chromosome 10 at 74,991,991 bp
  • T to C, chromosome 10 at 82,283,818 bp
  • A to T, chromosome 10 at 116,162,609 bp
  • T to C, chromosome 10 at 127,045,334 bp
  • A to C, chromosome 10 at 129,160,932 bp
  • C to T, chromosome 11 at 52,376,452 bp
  • A to G, chromosome 11 at 83,279,633 bp
  • T to A, chromosome 11 at 95,014,390 bp
  • G to C, chromosome 11 at 95,763,665 bp
  • T to C, chromosome 11 at 109,239,594 bp
  • T to C, chromosome 12 at 28,737,794 bp
  • T to C, chromosome 12 at 110,874,060 bp
  • A to G, chromosome 13 at 92,344,954 bp
  • T to C, chromosome 13 at 95,049,987 bp
  • T to C, chromosome 13 at 96,666,512 bp
  • T to C, chromosome 14 at 52,035,953 bp
  • C to T, chromosome 15 at 11,027,785 bp
  • A to G, chromosome 15 at 11,848,603 bp
  • A to T, chromosome 15 at 89,459,287 bp
  • T to C, chromosome 16 at 34,922,625 bp
  • G to A, chromosome 17 at 26,508,093 bp
  • T to A, chromosome 17 at 29,368,376 bp
  • T to C, chromosome 17 at 37,382,830 bp
  • C to A, chromosome 17 at 46,968,424 bp
  • A to T, chromosome 17 at 51,809,207 bp
  • A to C, chromosome 17 at 74,670,374 bp
  • A to T, chromosome 18 at 34,357,240 bp
  • T to C, chromosome 18 at 37,487,461 bp
  • T to C, chromosome 18 at 63,032,929 bp
  • T to A, chromosome 18 at 77,951,282 bp
  • G to A, chromosome 19 at 11,416,438 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5209 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042784-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.