Strain Name:
C57BL/6J-MtgxR5233Btlr/Mmmh
Stock Number:
042805-MU
Citation ID:
RRID:MMRRC_042805-MU
Other Names:
R5233 (G1), C57BL/6J-MtgxR5233Btlr
Major Collection:

Strain Information

Rnf10
Name: ring finger protein 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 50849
Homologene: 40990
Odf2l
Name: outer dense fiber of sperm tails 2-like
Synonyms: 4733401D09Rik, 9630045K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 52184
Homologene: 12011
Csrnp3
Name: cysteine-serine-rich nuclear protein 3
Synonyms: mbu1, A330102K23Rik, CSRNP-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 77771
Homologene: 11803
Hspa4
Name: heat shock protein 4
Synonyms: APG-2, Hsp70RY, Hsp110, 70kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15525
HGNC: HGNC:5237
Homologene: 1624
Xrcc5
Name: X-ray repair complementing defective repair in Chinese hamster cells 5
Synonyms: Ku80, Ku86
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22596
VEGA: 1
Homologene: 40681
Nup98
Name: nucleoporin 98
Synonyms: Nup96
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269966
HGNC: HGNC:8068
Homologene: 35472
Fry
Name: FRY microtubule binding protein
Synonyms: cg003, 9330186A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 320365
Homologene: 113770
Mcph1
Name: microcephaly, primary autosomal recessive 1
Synonyms: 5430437K10Rik, BRIT1, D030046N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244329
HGNC: HGNC:6954
Homologene: 32586
Cttnbp2nl
Name: CTTNBP2 N-terminal like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80281
Homologene: 36371
Zfp292
Name: zinc finger protein 292
Synonyms: Zn-16, Zn-15, Krox-10, Zfp-15, 9430062L07Rik, 5730450D02Rik, Zfp15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 30046
Homologene: 8493
Gcfc2
Name: GC-rich sequence DNA binding factor 2
Synonyms: AW146020
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330361
HGNC: HGNC:1317
Homologene: 2411
Myo9a
Name: myosin IXa
Synonyms: 4732465J09Rik, C130068I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270163
HGNC: HGNC:7608
Homologene: 21371
Cep135
Name: centrosomal protein 135
Synonyms: LOC381644, Cep4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381644
Homologene: 45709
Krt33a
Name: keratin 33A
Synonyms: 2310015J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71888
HGNC: HGNC:6450
Homologene: 74433
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Got2
Name: glutamatic-oxaloacetic transaminase 2, mitochondrial
Synonyms: mAspAT, mitochondrial aspartate aminotransferase, FABP-pm, plasma membrane fatty acid binding protein, Kyat4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14719
HGNC: HGNC:4433
Homologene: 1572
Arhgef17
Name: Rho guanine nucleotide exchange factor (GEF) 17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 207212
Homologene: 129601
Nxf1
Name: nuclear RNA export factor 1
Synonyms: Tip associated protein, TAP, Mex67, Mvb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 53319
HGNC: HGNC:8071
Homologene: 38176
Zfp142
Name: zinc finger protein 142
Synonyms: 9330177B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 77264
Homologene: 3723
Serpind1
Name: serine (or cysteine) peptidase inhibitor, clade D, member 1
Synonyms: HC II, Hcf2, HCII, heparin cofactor II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 15160
HGNC: HGNC:4838
Homologene: 36018
Dclk3
Name: doublecortin-like kinase 3
Synonyms: Click-I, -II related, Dcamkl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 245038
Homologene: 70580
Cd22
Name: CD22 antigen
Synonyms: Lyb-8, Lyb8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12483
HGNC: HGNC:1643
Homologene: 31052
Capg
Name: capping protein (actin filament), gelsolin-like
Synonyms: mbh1, gCap39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12332
HGNC: HGNC:1474
Homologene: 37523
Mov10l1
Name: Mov10 like RISC complex RNA helicase 1
Synonyms: CHAMP, Csm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 83456
HGNC: HGNC:7201
Homologene: 56835
Rorc
Name: RAR-related orphan receptor gamma
Synonyms: thymus orphan receptor, Thor, RORgamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 19885
Homologene: 21051
Scin
Name: scinderin
Synonyms: adseverin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20259
Homologene: 36296
Ciita
Name: class II transactivator
Synonyms: C2ta, Gm9475
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12265
VEGA: 16
HGNC: HGNC:7067
Homologene: 207
Insc
Name: INSC spindle orientation adaptor protein
Synonyms: Inscuteable, 3830422K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233752
Homologene: 78662
Nell1
Name: NEL-like 1
Synonyms: B230343H07Rik, l7R6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 338352
HGNC: HGNC:7750
Homologene: 4486
Tet3
Name: tet methylcytosine dioxygenase 3
Synonyms: D230004J03Rik, B430006D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 194388
Homologene: 35360
Ndst4
Name: N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
Synonyms: 4930439H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 64580
Homologene: 11208
Aadat
Name: aminoadipate aminotransferase
Synonyms: mKat-2, Kat2, KATII, Kyat2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 23923
Homologene: 56540
Pcdh10
Name: protocadherin 10
Synonyms: 6430703F07Rik, 6430521D13Rik, OL-pc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18526
Homologene: 74967
Coq2
Name: coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
Synonyms: 2310002F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71883
Homologene: 69192
Itgad
Name: integrin, alpha D
Synonyms: Cd11d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381924
HGNC: HGNC:6146
Homologene: 56919
Rfx6
Name: regulatory factor X, 6
Synonyms: 4930572O07Rik, Rfxdc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320995
Homologene: 18318
Nup210
Name: nucleoporin 210
Synonyms: gp210, gp190, Pom210
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 54563
Homologene: 41286
Col15a1
Name: collagen, type XV, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12819
HGNC: HGNC:2192
Homologene: 1396
Fyn
Name: Fyn proto-oncogene
Synonyms: Src Kinase p59
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14360
HGNC: HGNC:4037
Homologene: 48068
Mmp15
Name: matrix metallopeptidase 15
Synonyms: MT2-MMP, Membrane type 2-MMP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17388
HGNC: HGNC:7161
Homologene: 20549
Fam171a1
Name: family with sequence similarity 171, member A1
Synonyms: 9630050M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269233
Homologene: 19521
Fbxw17
Name: F-box and WD-40 domain protein 17
Synonyms: 1110064L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 109082
Homologene: 82571
Gm5087
Name: predicted gene 5087
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 328354
Tas2r117
Name: taste receptor, type 2, member 117
Synonyms: Tas2r17, mGR17, T2R17, mt2r54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 353166
Homologene: 130073
Acsl6
Name: acyl-CoA synthetase long-chain family member 6
Synonyms: Lacsl, A330035H04Rik, Facl6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216739
Homologene: 100939
Dtx3l
Name: deltex 3-like, E3 ubiquitin ligase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 209200
Homologene: 51375
Csn3
Name: casein kappa
Synonyms: CSN10, Csnk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12994
HGNC: HGNC:2446
Homologene: 3818
Vmn1r212
Name: vomeronasal 1 receptor 212
Synonyms: V1rh18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171275
Homologene: 110880
Pou3f3
Name: POU domain, class 3, transcription factor 3
Synonyms: Otf8, Brn1, Brn-1, urehr2, HST011
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18993
HGNC: HGNC:9216
Homologene: 68509
Slc7a9
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 9
Synonyms: CSNU3, bo, +AT, bo, + amino acid transporter
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 30962
Homologene: 56668
9030619P08Rik
Name: RIKEN cDNA 9030619P08 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105892
Vmn2r42
Name: vomeronasal 2, receptor 42
Synonyms: V2r4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22310
Homologene: 113703
Or8b38
Name: olfactory receptor family 8 subfamily B member 38
Synonyms: GA_x6K02T2PVTD-31740639-31741568, MOR162-12, Olfr885
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 257885
Homologene: 79400
Ear-ps2
Name: eosinophil-associated, ribonuclease A family, pseudogene 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 93743
Trbc1
Name: T cell receptor beta, constant region 1
Synonyms: Gm16802, Tcrb-C1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100125262
Gm12144
Name: predicted gene 12144
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 42,698,278 bp
  • T to A, chromosome 1 at 72,340,050 bp
  • T to C, chromosome 1 at 74,585,449 bp
  • G to C, chromosome 2 at 3,178,353 bp
  • A to G, chromosome 2 at 66,022,340 bp
  • C to A, chromosome 3 at 45,384,191 bp
  • T to A, chromosome 3 at 94,397,325 bp
  • A to G, chromosome 3 at 105,005,041 bp
  • A to G, chromosome 3 at 125,710,117 bp
  • T to A, chromosome 3 at 145,136,705 bp
  • A to T, chromosome 4 at 34,809,755 bp
  • T to C, chromosome 4 at 47,296,112 bp
  • AGTCTGCCTTTGG to A, chromosome 5 at 76,591,843 bp
  • C to T, chromosome 5 at 87,929,835 bp
  • G to A, chromosome 5 at 100,657,832 bp
  • A to T, chromosome 5 at 115,248,997 bp
  • A to G, chromosome 5 at 150,469,720 bp
  • T to A, chromosome 6 at 41,538,449 bp
  • C to T, chromosome 6 at 72,555,526 bp
  • T to C, chromosome 6 at 81,953,290 bp
  • T to A, chromosome 6 at 83,386,063 bp
  • T to A, chromosome 6 at 85,656,371 bp
  • C to T, chromosome 6 at 91,026,969 bp
  • T to C, chromosome 6 at 132,803,622 bp
  • T to A, chromosome 7 at 8,194,838 bp
  • A to G, chromosome 7 at 30,877,534 bp
  • A to G, chromosome 7 at 35,454,637 bp
  • T to C, chromosome 7 at 50,176,314 bp
  • A to T, chromosome 7 at 100,881,369 bp
  • A to T, chromosome 7 at 102,195,822 bp
  • G to A, chromosome 7 at 114,834,757 bp
  • A to G, chromosome 7 at 128,193,428 bp
  • T to C, chromosome 8 at 18,671,238 bp
  • A to G, chromosome 8 at 60,526,622 bp
  • T to C, chromosome 8 at 95,371,068 bp
  • T to A, chromosome 8 at 95,875,849 bp
  • A to G, chromosome 9 at 38,062,150 bp
  • T to A, chromosome 9 at 59,910,617 bp
  • A to G, chromosome 9 at 111,468,681 bp
  • T to C, chromosome 10 at 39,529,940 bp
  • T to A, chromosome 10 at 51,712,091 bp
  • A to G, chromosome 11 at 43,230,560 bp
  • C to T, chromosome 11 at 53,286,975 bp
  • G to A, chromosome 11 at 54,325,606 bp
  • A to G, chromosome 11 at 100,014,135 bp
  • T to A, chromosome 12 at 40,077,559 bp
  • C to A, chromosome 13 at 22,883,134 bp
  • T to C, chromosome 13 at 50,432,354 bp
  • C to T, chromosome 14 at 13,158,788 bp
  • G to A, chromosome 14 at 44,047,060 bp
  • T to A, chromosome 15 at 75,429,952 bp
  • T to C, chromosome 15 at 88,983,032 bp
  • A to T, chromosome 16 at 10,509,401 bp
  • A to G, chromosome 16 at 17,336,894 bp
  • A to T, chromosome 16 at 35,933,238 bp
  • T to C, chromosome 19 at 8,763,929 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5233 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042805-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.