Strain Name:
C57BL/6J-MtgxR5239Btlr/Mmmh
Stock Number:
042810-MU
Citation ID:
RRID:MMRRC_042810-MU
Other Names:
R5239 (G1), C57BL/6J-MtgxR5239Btlr
Major Collection:

Strain Information

Zfp143
Name: zinc finger protein 143
Synonyms: Zfp80-rs1, D7Ertd805e, KRAB14, Staf, Zfp79, pHZ-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20841
Homologene: 56444
Lasp1
Name: LIM and SH3 protein 1
Synonyms: Def-4, SH3P6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16796
HGNC: HGNC:6513
Homologene: 4480
Lemd2
Name: LEM domain containing 2
Synonyms: NET25, Lem2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224640
VEGA: 17
Homologene: 17136
Tnrc6a
Name: trinucleotide repeat containing 6a
Synonyms: 3110054G10Rik, CAGH26, D130023A07Rik, 2010321I05Rik, Tnrc6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233833
Homologene: 41399
Snd1
Name: staphylococcal nuclease and tudor domain containing 1
Synonyms: Tudor-SN, p100 co-activator
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56463
Homologene: 8665
Ago1
Name: argonaute RISC catalytic subunit 1
Synonyms: argonaute 1, Eif2c1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 236511
HGNC: HGNC:3262
Homologene: 81826
Tsc22d1
Name: TSC22 domain family, member 1
Synonyms: TSC-22, Egr5, Tgfb1i4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21807
Homologene: 7573
Eif3l
Name: eukaryotic translation initiation factor 3, subunit L
Synonyms: Eif3eip, D15N1e, Eif3s6ip, 0610011H21Rik, HSP-66Y, PAF67
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223691
VEGA: 15
Homologene: 9380
Polr1a
Name: polymerase (RNA) I polypeptide A
Synonyms: 3010014K16Rik, 2900087K15Rik, mRPA1, 194kDa, RPA194, Rpo1-4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20019
Homologene: 7033
Bub1
Name: BUB1, mitotic checkpoint serine/threonine kinase
Synonyms: Bub1a, D2Xrf87
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12235
HGNC: HGNC:1148
Homologene: 37910
Smoc2
Name: SPARC related modular calcium binding 2
Synonyms: 1700056C05Rik, Smoc2l, 5430426J21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 64074
VEGA: 17
Homologene: 11150
Rag1
Name: recombination activating 1
Synonyms: Rag-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19373
HGNC: HGNC:9831
Homologene: 387
Galnt9
Name: polypeptide N-acetylgalactosaminyltransferase 9
Synonyms: GalNAc-T9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231605
HGNC: HGNC:4131
Homologene: 72793
Cpsf2
Name: cleavage and polyadenylation specific factor 2
Synonyms: 2610024B04Rik, 100kDa, Cpsf
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 51786
VEGA: 12
HGNC: HGNC:2325
Homologene: 6460
Arhgef1
Name: Rho guanine nucleotide exchange factor 1
Synonyms: Lbcl2, Lsc
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16801
HGNC: HGNC:681
Homologene: 3454
Baz1a
Name: bromodomain adjacent to zinc finger domain 1A
Synonyms: Gtl5, Acf1, Wcrf180
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217578
HGNC: HGNC:960
Homologene: 45654
Pwwp3a
Name: PWWP domain containing 3A, DNA repair factor
Synonyms: 9430059D04Rik, Mum1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 68114
Homologene: 11349
Hibch
Name: 3-hydroxyisobutyryl-Coenzyme A hydrolase
Synonyms: HIBYL-COA-H, 2610509I15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227095
HGNC: HGNC:4908
Homologene: 5607
Wnt9b
Name: wingless-type MMTV integration site family, member 9B
Synonyms: clf, clf1, Wnt15, Wnt14b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22412
Homologene: 2551
Kel
Name: Kell blood group
Synonyms: CD238
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 23925
HGNC: HGNC:6308
Homologene: 362
Nbas
Name: neuroblastoma amplified sequence
Synonyms: 4933425L03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71169
VEGA: 12
Homologene: 41073
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: skrr, calcium release channel isoform 1, Ryr
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20190
Homologene: 68069
Cpne5
Name: copine V
Synonyms: A830083G22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240058
HGNC: HGNC:2318
Homologene: 23266
Ttn
Name: titin
Synonyms: 2310036G12Rik, 2310057K23Rik, D330041I19Rik, mdm, connectin, D830007G01Rik, 1100001C23Rik, shru, 2310074I15Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Tmem26
Name: transmembrane protein 26
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327766
VEGA: 10
Homologene: 14428
Wdr87-ps
Name: WD repeat domain 87, pseudogene
Synonyms: 4932431P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 114675
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 4632412F08Rik, 5330435L01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237979
Homologene: 10406
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Otog
Name: otogelin
Synonyms: Otgn
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18419
HGNC: HGNC:8516
Homologene: 8421
Myh2
Name: myosin, heavy polypeptide 2, skeletal muscle, adult
Synonyms: MHC2A, Myhs-f, Myhsf1, MyHC-IIa, Myhs-f1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17882
HGNC: HGNC:7572
Homologene: 23019
Myh1
Name: myosin, heavy polypeptide 1, skeletal muscle, adult
Synonyms: MyHC-IId/x, A530084A17Rik, Myhs-f2, Myhsf2, MYHC-IIX, myosin heavy chain 2X, IId/x, IId, Myhs-f
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17879
HGNC: HGNC:7567
Homologene: 133718
Myo1f
Name: myosin IF
Synonyms: C330006B10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17916
HGNC: HGNC:7600
Homologene: 56276
Grik5
Name: glutamate receptor, ionotropic, kainate 5 (gamma 2)
Synonyms: GluRgamma2, KA2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14809
HGNC: HGNC:4583
Homologene: 1578
Il1rl2
Name: interleukin 1 receptor-like 2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 107527
HGNC: HGNC:5999
Homologene: 2860
Pcnx2
Name: pecanex homolog 2
Synonyms: Pcnxl2, E330039K12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
4930568D16Rik
Name: RIKEN cDNA 4930568D16 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75859
Homologene: 86865
Pkn1
Name: protein kinase N1
Synonyms: F730027O18Rik, PRK1, PAK1, Stk3, Prkcl1, Pkn
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320795
HGNC: HGNC:9405
Homologene: 48130
Nrxn1
Name: neurexin I
Synonyms: neurexin I beta, neurexin I alpha, neurexin I alpha, neurexin I beta, 1700062G21Rik, alpha-latrotoxin receptor (calcium-dependent), A230068P09Rik, 9330127H16Rik, neurexin I beta, neurexin I alpha
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18189
HGNC: HGNC:8008
Homologene: 21005
Drc1
Name: dynein regulatory complex subunit 1
Synonyms: Gm1060, LOC381738, Ccdc164, b2b1654Clo
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381738
Homologene: 35977
Gm1110
Name: predicted gene 1110
Synonyms: LOC382064
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382064
VEGA: 9
Homologene: 78608
Myom3
Name: myomesin family, member 3
Synonyms: 8430427K15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242702
Homologene: 19432
Or5p68
Name: olfactory receptor family 5 subfamily P member 68
Synonyms: Olfr493, GA_x6K02T2PBJ9-10676998-10676054, MOR204-35
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258307
Homologene: 17188
Atp8b4
Name: ATPase, class I, type 8B, member 4
Synonyms: Im
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241633
Homologene: 133162
Pkdcc
Name: protein kinase domain containing, cytoplasmic
Synonyms: ESTM17, Vlk, Adtk1, MAd1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106522
Homologene: 18932
Or9g4b
Name: olfactory receptor family 9 subfamily G member 4B
Synonyms: GA_x6K02T2Q125-47264151-47265089, MOR213-3, Olfr1015
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258564
Homologene: 115499
Brinp2
Name: bone morphogenic protein/retinoic acid inducible neural-specific 2
Synonyms: 6430517E21Rik, Fam5b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240843
Homologene: 10905
Epha1
Name: Eph receptor A1
Synonyms: 5730453L17Rik, Eph, Esk
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13835
HGNC: HGNC:3385
Homologene: 3835
Hyou1
Name: hypoxia up-regulated 1
Synonyms: Orp150, 140 kDa, Cab140, Grp170, CBP-140
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12282
Homologene: 4658
Or2y1
Name: olfactory receptor family 2 subfamily Y member 1
Synonyms: MOR256-41P, Olfr1549-ps1, MOR256-42P, GA_x6K02T2QP88-5941817-5940888, Olfr1385, MOR256-42P
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258027
Homologene: 86692
Adam3
Name: ADAM metallopeptidase domain 3
Synonyms: ADAM3, tMDC, Cyrn1, Taz83, Taz83
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11497
HGNC: HGNC:209
Homologene: 69052
Clip4
Name: CAP-GLY domain containing linker protein family, member 4
Synonyms: 1700074B05Rik, 1700024K14Rik, 5830409B12Rik, 4833417L20Rik, Rsnl2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78785
VEGA: 17
Homologene: 11662
Npdc1
Name: neural proliferation, differentiation and control 1
Synonyms: NPDC-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18146
HGNC: HGNC:7899
Homologene: 32050
Or8g54
Name: olfactory receptor family 8 subfamily G member 54
Synonyms: MOR171-7, GA_x6K02T2PVTD-33492981-33493916, Olfr969
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258823
VEGA: 9
Homologene: 121532
Nr2e3
Name: nuclear receptor subfamily 2, group E, member 3
Synonyms: Pnr, photoreceptor-specific nuclear receptor, RNR
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23958
HGNC: HGNC:7974
Homologene: 84397
Cish
Name: cytokine inducible SH2-containing protein
Synonyms: cytokine-inducible SH2 protein, F23, Cis, CIS1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12700
HGNC: HGNC:1984
Homologene: 7667
Ddx51
Name: DEAD box helicase 51
Synonyms: 2310061O04Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69663
Homologene: 6850
Vpreb1a
Name: V-set pre-B cell surrogate light chain 1A
Synonyms: Vpreb1, CD179a, Vpreb-1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22362
Homologene: 84741
Vmn1r122
Name: vomeronasal 1 receptor 122
Synonyms: Gm5729
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 435951
Homologene: 104166
Alyreffm2
Name: Aly/REF export factor family member 2
Synonyms: Gm6489
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 624262
RP24-121I11.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 31,287,270 bp
  • T to C, chromosome 1 at 40,365,095 bp
  • T to C, chromosome 1 at 52,865,608 bp
  • T to C, chromosome 1 at 158,251,338 bp
  • A to G, chromosome 2 at 25,400,818 bp
  • T to C, chromosome 2 at 35,354,836 bp
  • A to T, chromosome 2 at 76,811,243 bp
  • T to G, chromosome 2 at 85,785,658 bp
  • G to T, chromosome 2 at 101,642,955 bp
  • T to C, chromosome 2 at 126,392,861 bp
  • T to A, chromosome 2 at 127,821,696 bp
  • G to T, chromosome 4 at 126,441,215 bp
  • G to A, chromosome 4 at 135,800,992 bp
  • G to A, chromosome 5 at 25,661,121 bp
  • A to T, chromosome 5 at 30,363,123 bp
  • T to A, chromosome 5 at 110,544,769 bp
  • C to A, chromosome 5 at 110,653,648 bp
  • T to C, chromosome 6 at 28,545,525 bp
  • A to T, chromosome 6 at 41,688,114 bp
  • C to A, chromosome 6 at 42,365,010 bp
  • A to G, chromosome 6 at 71,913,037 bp
  • T to C, chromosome 7 at 21,134,098 bp
  • C to T, chromosome 7 at 24,923,825 bp
  • A to T, chromosome 7 at 25,065,470 bp
  • T to C, chromosome 7 at 29,036,128 bp
  • A to T, chromosome 7 at 29,532,022 bp
  • T to A, chromosome 7 at 46,287,435 bp
  • T to A, chromosome 7 at 108,346,646 bp
  • A to G, chromosome 7 at 110,094,352 bp
  • A to G, chromosome 7 at 123,186,619 bp
  • T to A, chromosome 8 at 24,694,191 bp
  • A to G, chromosome 8 at 83,684,182 bp
  • A to T, chromosome 8 at 125,861,082 bp
  • A to G, chromosome 9 at 26,893,570 bp
  • T to A, chromosome 9 at 39,796,196 bp
  • T to A, chromosome 9 at 44,385,263 bp
  • G to T, chromosome 9 at 59,949,776 bp
  • T to A, chromosome 9 at 107,299,912 bp
  • T to A, chromosome 10 at 68,751,266 bp
  • C to T, chromosome 10 at 80,228,421 bp
  • A to G, chromosome 11 at 49,494,728 bp
  • G to A, chromosome 11 at 67,192,443 bp
  • A to T, chromosome 11 at 67,215,225 bp
  • A to G, chromosome 11 at 97,799,860 bp
  • A to T, chromosome 11 at 103,731,228 bp
  • C to A, chromosome 11 at 113,868,033 bp
  • C to A, chromosome 12 at 13,441,518 bp
  • A to G, chromosome 12 at 54,898,344 bp
  • T to A, chromosome 12 at 101,987,273 bp
  • T to A, chromosome 14 at 76,418,412 bp
  • T to A, chromosome 15 at 79,089,795 bp
  • A to T, chromosome 16 at 16,868,728 bp
  • A to T, chromosome 16 at 37,094,575 bp
  • A to G, chromosome 17 at 14,368,965 bp
  • C to A, chromosome 17 at 27,203,799 bp
  • T to G, chromosome 17 at 29,237,618 bp
  • T to C, chromosome 17 at 33,601,735 bp
  • T to A, chromosome 17 at 71,799,077 bp
  • C to A, chromosome 17 at 83,215,984 bp
  • T to C, chromosome 17 at 90,704,109 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5239 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042810-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.