Strain Name:
C57BL/6J-MtgxR5240Btlr/Mmmh
Stock Number:
042811-MU
Citation ID:
RRID:MMRRC_042811-MU
Other Names:
R5240 (G1), C57BL/6J-MtgxR5240Btlr
Major Collection:

Strain Information

Ptch2
Name: patched 2
Synonyms: ptc2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19207
HGNC: HGNC:9586
Homologene: 37842
Vcan
Name: versican
Synonyms: PG-M, hdf, heart defect, 5430420N07Rik, DPEAAE, Cspg2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Nae1
Name: NEDD8 activating enzyme E1 subunit 1
Synonyms: Appbp1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234664
HGNC: HGNC:621
Homologene: 68370
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Prrc2b
Name: proline-rich coiled-coil 2B
Synonyms: 5830434P21Rik, Bat2l
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227723
Homologene: 106649
Sipa1l1
Name: signal-induced proliferation-associated 1 like 1
Synonyms: 4931426N11Rik, Spar
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217692
VEGA: 12
Homologene: 9189
Rbpj
Name: recombination signal binding protein for immunoglobulin kappa J region
Synonyms: CBF1, Igkrsbp, RBP-J kappa, RBPjk, Igkjrb, Rbpsuh
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19664
HGNC: HGNC:5724
Homologene: 7511
Prkd2
Name: protein kinase D2
Synonyms: PKD2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101540
Homologene: 9516
Prim2
Name: DNA primase, p58 subunit
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19076
HGNC: HGNC:9370
Homologene: 731
Trip12
Name: thyroid hormone receptor interactor 12
Synonyms: Gtl6, 1110036I07Rik, 6720416K24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14897
Homologene: 44226
Nsmce4a
Name: NSE4 homolog A, SMC5-SMC6 complex component
Synonyms: 2410003A14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67872
Homologene: 9745
Zfp619
Name: zinc finger protein 619
Synonyms: 3000002G13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70227
Homologene: 133818
Nfe2l2
Name: nuclear factor, erythroid derived 2, like 2
Synonyms: Nrf2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18024
HGNC: HGNC:7782
Homologene: 2412
Cdc42bpg
Name: CDC42 binding protein kinase gamma
Synonyms: MRCKgamma
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240505
Homologene: 28384
Znhit1
Name: zinc finger, HIT domain containing 1
Synonyms: 2700001K05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70103
Homologene: 4630
Chchd10
Name: coiled-coil-helix-coiled-coil-helix domain containing 10
Synonyms: 1620401E04Rik, Ndg2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103172
VEGA: 10
Homologene: 27885
Ipo9
Name: importin 9
Synonyms: 0710008K06Rik, Imp9
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226432
Homologene: 5874
Unc5b
Name: unc-5 netrin receptor B
Synonyms: 6330415E02Rik, Unc5h2, D10Bwg0792e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 107449
VEGA: 10
Homologene: 32538
Dennd1b
Name: DENN domain containing 1B
Synonyms: F730008N07Rik, 4632404N19Rik, 4930467M19Rik, 6820401H01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329260
Homologene: 11739
Chn2
Name: chimerin 2
Synonyms: 1700026N20Rik, 4930557O16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69993
HGNC: HGNC:1944
Homologene: 31213
Fgfr3
Name: fibroblast growth factor receptor 3
Synonyms: HBGFR, Fgfr-3, sam3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14184
HGNC: HGNC:3690
Homologene: 55437
Fchsd1
Name: FCH and double SH3 domains 1
Synonyms: A030002D08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319262
Homologene: 14127
Osbp
Name: oxysterol binding protein
Synonyms: 1110018F06Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 76303
VEGA: 19
HGNC: HGNC:8503
Homologene: 97668
Dgke
Name: diacylglycerol kinase, epsilon
Synonyms: DAGK6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56077
HGNC: HGNC:2852
Homologene: 2705
Sugp2
Name: SURP and G patch domain containing 2
Synonyms: Sfrs14, Srsf14
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234373
Homologene: 8923
Gipc2
Name: GIPC PDZ domain containing family, member 2
Synonyms: 2200002N01Rik, Semcap2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 54120
Homologene: 22994
Kcnv1
Name: potassium channel, subfamily V, member 1
Synonyms: 2700023A03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67498
VEGA: 15
Homologene: 22811
Smarcc2
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
Synonyms: 5930405J04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 68094
VEGA: 10
Homologene: 2312
Exosc9
Name: exosome component 9
Synonyms: PM/Scl-75, RRP45, p6, p5, Pmscl1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 50911
HGNC: HGNC:9137
Homologene: 3693
Pigo
Name: phosphatidylinositol glycan anchor biosynthesis, class O
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56703
Homologene: 31761
Vav1
Name: vav 1 oncogene
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22324
Homologene: 3961
Pcdhb4
Name: protocadherin beta 4
Synonyms: Pcdhb5A, PcdhbD
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93875
HGNC: HGNC:8690
Homologene: 62176
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Ifit2
Name: interferon-induced protein with tetratricopeptide repeats 2
Synonyms: Ifi54
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15958
HGNC: HGNC:5409
Homologene: 1187
D130043K22Rik
Name: RIKEN cDNA D130043K22 gene
Synonyms: Kiaa0319
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210108
Homologene: 8878
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217843
Homologene: 41397
Pls1
Name: plastin 1 (I-isoform)
Synonyms: I-fimbrin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102502
HGNC: HGNC:9090
Homologene: 68270
Ripk4
Name: receptor-interacting serine-threonine kinase 4
Synonyms: PKK, DIk, RIP4, ANKK2, Ankrd3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72388
HGNC: HGNC:496
Homologene: 10772
Aadacl2fm2
Name: AADACL2 family member 2
Synonyms: Gm5538
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 433597
Homologene: 79018
Mplkip
Name: M-phase specific PLK1 intereacting protein
Synonyms: C330007M08Rik, 2810021B07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66308
VEGA: 13
Homologene: 32633
Or5p70
Name: olfactory receptor family 5 subfamily P member 70
Synonyms: GA_x6K02T2PBJ9-10725148-10726140, MOR204-37, Olfr495
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258361
Homologene: 133600
Tkt
Name: transketolase
Synonyms: p68
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21881
Homologene: 68154
Sdr42e1
Name: short chain dehydrogenase/reductase family 42E, member 1
Synonyms: 4632417N05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74032
Homologene: 23654
Tmem163
Name: transmembrane protein 163
Synonyms: 2610024A01Rik, SV31
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72160
Homologene: 12798
Ddx31
Name: DEAD/H box helicase 31
Synonyms: 5830444G11Rik, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 31
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227674
Homologene: 6389
Vmn2r4
Name: vomeronasal 2, receptor 4
Synonyms: EG637053
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 637053
Homologene: 129754
Stom
Name: stomatin
Synonyms: stomatin, protein 7.2b, Epb7.2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13830
HGNC: HGNC:3383
Homologene: 81681
Zfp672
Name: zinc finger protein 672
Synonyms: 4930488P06Rik, 4930511N19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319475
Homologene: 23493
Or3a1d
Name: olfactory receptor family 3 subfamily A member 1D
Synonyms: GA_x6K02T2P1NL-4481525-4480578, MOR255-3, Olfr411
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258704
Homologene: 74999
Iffo1
Name: intermediate filament family orphan 1
Synonyms: 4733401N06Rik, Iffo, A930037G23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320678
Homologene: 18706
Tbrg4
Name: transforming growth factor beta regulated gene 4
Synonyms: TB-12, Cpr2, 2310042P22Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21379
Homologene: 31259
Haus6
Name: HAUS augmin-like complex, subunit 6
Synonyms: D4Ertd27e, 6230416J20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230376
Homologene: 9760
Clec2l
Name: C-type lectin domain family 2, member L
Synonyms: LOC381758
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 665180
VEGA: 6
Homologene: 35527
Or1e1f
Name: olfactory receptor family 1 subfamily E member 1F
Synonyms: GA_x6K02T2P1NL-4121434-4122381, MOR135-28, Olfr397
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258343
Homologene: 138309
Eif2b5
Name: eukaryotic translation initiation factor 2B, subunit 5 epsilon
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224045
HGNC: HGNC:3261
Homologene: 2903
Cpeb3
Name: cytoplasmic polyadenylation element binding protein 3
Synonyms: 4831444O18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 208922
Homologene: 40992
Gm11787
Name: predicted gene 11787
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 666513
Homez
Name: homeodomain leucine zipper-encoding gene
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239099
Homologene: 10828
Dusp29
Name: dual specificity phosphatase 29
Synonyms: EG435391, Dupd1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 435391
VEGA: 14
Homologene: 51120
Pde6g
Name: phosphodiesterase 6G, cGMP-specific, rod, gamma
Synonyms: Pdeg
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18588
HGNC: HGNC:8789
Homologene: 1955
Gm4877
Name: predicted gene 4877
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232745
Pycr2
Name: pyrroline-5-carboxylate reductase family, member 2
Synonyms: 1810018M05Rik, P5cr2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 69051
Homologene: 8343
Pth
Name: parathyroid hormone
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19226
HGNC: HGNC:9606
Homologene: 266
Pcdhgb2
Name: protocadherin gamma subfamily B, 2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93700
HGNC: HGNC:8709
Homologene: 49571
Cfap73
Name: cilia and flagella associated protein 73
Synonyms: Gm5988, Ccdc42b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 546886
Homologene: 53205
Kdm6bos
Name: KDM1 lysine (K)-specific demethylase 6B, opposite strand
Synonyms: 1700064E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
E130116L18Rik
Name: RIKEN cDNA E130116L18 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 20,275,641 bp
  • A to G, chromosome 1 at 33,480,316 bp
  • T to A, chromosome 1 at 34,208,558 bp
  • A to G, chromosome 1 at 84,794,133 bp
  • G to A, chromosome 1 at 127,491,552 bp
  • A to C, chromosome 1 at 135,389,606 bp
  • A to G, chromosome 1 at 139,062,877 bp
  • A to C, chromosome 1 at 180,907,623 bp
  • A to G, chromosome 2 at 28,846,030 bp
  • C to T, chromosome 2 at 32,206,396 bp
  • T to A, chromosome 2 at 35,336,877 bp
  • A to T, chromosome 2 at 75,676,009 bp
  • T to C, chromosome 3 at 36,554,118 bp
  • A to C, chromosome 3 at 59,752,028 bp
  • A to C, chromosome 3 at 64,406,937 bp
  • A to T, chromosome 3 at 152,102,662 bp
  • A to C, chromosome 4 at 3,511,810 bp
  • C to A, chromosome 4 at 43,020,675 bp
  • A to G, chromosome 4 at 86,583,178 bp
  • C to A, chromosome 4 at 117,106,138 bp
  • G to T, chromosome 5 at 25,223,020 bp
  • A to T, chromosome 5 at 33,730,038 bp
  • A to T, chromosome 5 at 53,649,440 bp
  • C to T, chromosome 5 at 120,629,707 bp
  • T to A, chromosome 5 at 136,982,381 bp
  • C to T, chromosome 6 at 38,673,452 bp
  • T to C, chromosome 6 at 42,519,685 bp
  • T to C, chromosome 6 at 54,220,695 bp
  • T to C, chromosome 6 at 125,152,460 bp
  • T to A, chromosome 7 at 16,855,786 bp
  • A to G, chromosome 7 at 39,537,218 bp
  • A to T, chromosome 7 at 108,395,702 bp
  • A to T, chromosome 7 at 113,385,844 bp
  • G to A, chromosome 7 at 130,537,024 bp
  • G to T, chromosome 8 at 70,243,275 bp
  • T to C, chromosome 8 at 104,523,144 bp
  • T to C, chromosome 8 at 117,663,282 bp
  • A to T, chromosome 9 at 95,776,622 bp
  • A to G, chromosome 10 at 60,774,640 bp
  • A to T, chromosome 10 at 75,937,449 bp
  • T to C, chromosome 10 at 128,481,006 bp
  • A to T, chromosome 11 at 6,617,516 bp
  • A to G, chromosome 11 at 58,329,701 bp
  • A to C, chromosome 11 at 69,401,904 bp
  • T to C, chromosome 11 at 73,964,806 bp
  • T to A, chromosome 11 at 74,347,242 bp
  • T to A, chromosome 11 at 89,050,685 bp
  • A to G, chromosome 11 at 120,448,086 bp
  • A to G, chromosome 12 at 82,341,588 bp
  • T to A, chromosome 12 at 103,070,751 bp
  • T to C, chromosome 13 at 17,695,719 bp
  • A to G, chromosome 13 at 24,877,977 bp
  • T to G, chromosome 13 at 89,692,532 bp
  • G to A, chromosome 14 at 21,677,023 bp
  • G to T, chromosome 14 at 30,565,678 bp
  • G to A, chromosome 14 at 54,858,074 bp
  • C to T, chromosome 15 at 45,113,244 bp
  • G to A, chromosome 16 at 20,501,398 bp
  • C to A, chromosome 16 at 97,743,767 bp
  • G to A, chromosome 17 at 57,297,122 bp
  • A to G, chromosome 18 at 37,309,926 bp
  • A to C, chromosome 18 at 37,691,050 bp
  • C to T, chromosome 18 at 37,959,873 bp
  • T to G, chromosome 19 at 6,315,899 bp
  • T to A, chromosome 19 at 11,978,290 bp
  • T to A, chromosome 19 at 34,574,396 bp
  • T to A, chromosome 19 at 37,174,515 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5240 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042811-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.