Strain Name:
C57BL/6J-MtgxR5263Btlr/Mmmh
Stock Number:
042831-MU
Citation ID:
RRID:MMRRC_042831-MU
Other Names:
R5263 (G1), C57BL/6J-MtgxR5263Btlr
Major Collection:

Gene Information

Gfap
Name: glial fibrillary acidic protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14580
HGNC: HGNC:4235
Homologene: 1554
Sort1
Name: sortilin 1
Synonyms: sortilin, Ntsr3, neurotensin receptor 3, Ntr3, 2900053A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20661
Homologene: 136097
Faah
Name: fatty acid amide hydrolase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14073
HGNC: HGNC:3553
Homologene: 68184
Mllt10
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10
Synonyms: B130021D15Rik, Af10, D630001B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17354
Homologene: 20973
Cop1
Name: COP1, E3 ubiquitin ligase
Synonyms: Cop1, Rfwd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 26374
Homologene: 115565
Trpm7
Name: transient receptor potential cation channel, subfamily M, member 7
Synonyms: 4833414K03Rik, CHAK, LTRPC7, CHAK1, TRP-PLIK, 2310022G15Rik, 5033407O22Rik, Ltpr7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 58800
Homologene: 9774
Ascc3
Name: activating signal cointegrator 1 complex subunit 3
Synonyms: B630009I04Rik, Helic1, ASC1p200
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 77987
VEGA: 10
Homologene: 4973
Arid2
Name: AT rich interactive domain 2 (ARID, RFX-like)
Synonyms: 4432409D24Rik, zipzap/p200, 1700124K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 77044
Homologene: 14601
Polr3a
Name: polymerase (RNA) III (DNA directed) polypeptide A
Synonyms: RPC1, RPC155, 9330175N20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218832
VEGA: 14
Homologene: 5124
Cct3
Name: chaperonin containing Tcp1, subunit 3 (gamma)
Synonyms: Cctg, TriC-P5, Tcp1-rs3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12462
HGNC: HGNC:1616
Homologene: 4373
Sltm
Name: SAFB-like, transcription modulator
Synonyms: 5730455C01Rik, 9130215G10Rik, 5730555F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66660
VEGA: 9
Homologene: 11696
Aqr
Name: aquarius
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11834
Homologene: 7629
Eif4g1
Name: eukaryotic translation initiation factor 4, gamma 1
Synonyms: E030015G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 208643
HGNC: HGNC:3296
Homologene: 110725
Zranb1
Name: zinc finger, RAN-binding domain containing 1
Synonyms: 9330160G10Rik, D7Wsu87e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 360216
Homologene: 9728
Ntng1
Name: netrin G1
Synonyms: A930010C08Rik, Lmnt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80883
Homologene: 8949
Dhx29
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 29
Synonyms: E130202M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218629
VEGA: 13
Homologene: 10387
Sucnr1
Name: succinate receptor 1
Synonyms: Gpr91
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 84112
HGNC: HGNC:4542
Homologene: 41865
Rhob
Name: ras homolog family member B
Synonyms: Arhb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 11852
VEGA: 12
HGNC: HGNC:668
Homologene: 68377
Izumo1r
Name: IZUMO1 receptor, JUNO
Synonyms: Folbp3, 0910001L11Rik, Juno, Folr4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 64931
Homologene: 11283
Zfpm2
Name: zinc finger protein, multitype 2
Synonyms: FOG-2, B330005D23Rik, FOG2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22762
VEGA: 15
Homologene: 8008
Mmrn2
Name: multimerin 2
Synonyms: ENDOGLYX1, EndoGlyx-1, Emilin3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105450
VEGA: 14
Homologene: 11697
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20192
Homologene: 68151
Gprc6a
Name: G protein-coupled receptor, family C, group 6, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 210198
VEGA: 10
Homologene: 17529
Pld4
Name: phospholipase D family, member 4
Synonyms: thss
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104759
VEGA: 12
Homologene: 16350
Cgnl1
Name: cingulin-like 1
Synonyms: 9930020M10Rik, 4933421H10Rik, Jacop
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68178
Homologene: 41901
Arhgef4
Name: Rho guanine nucleotide exchange factor (GEF) 4
Synonyms: Asef, 9330140K16Rik, C230030N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226970
HGNC: HGNC:684
Homologene: 49414
Vmn2r13
Name: vomeronasal 2, receptor 13
Synonyms: Gm4867
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231589
Homologene: 129606
Pla2g3
Name: phospholipase A2, group III
Synonyms: 9130003P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237625
Homologene: 9251
Adh4
Name: alcohol dehydrogenase 4 (class II), pi polypeptide
Synonyms: mouse class II type ADH, Adh2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 26876
HGNC: HGNC:252
Homologene: 20162
Prkd1
Name: protein kinase D1
Synonyms: Pkcm, PKD1, Prkcm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 18760
VEGA: 12
HGNC: HGNC:9407
Homologene: 55680
Cd209f
Name: CD209f antigen
Synonyms: SIGNR8, 1810029C22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 69142
Homologene: 114519
Dync1i1
Name: dynein cytoplasmic 1 intermediate chain 1
Synonyms: IC74, Dncic1, DIC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13426
HGNC: HGNC:2963
Homologene: 68398
Mrgprb5
Name: MAS-related GPR, member B5
Synonyms: MrgB5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 404239
Homologene: 115575
Sema6c
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
Synonyms: Semay, Sema Y
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20360
Homologene: 7931
Agmo
Name: alkylglycerol monooxygenase
Synonyms: A530016O06Rik, Tmem195
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319660
Homologene: 45620
Zfp971
Name: zinc finger protein 971
Synonyms: Etohi1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 626848
Homologene: 134324
Dcaf5
Name: DDB1 and CUL4 associated factor 5
Synonyms: 9430020B07Rik, BCRG2, BCRP2, Wdr22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 320808
VEGA: 12
Homologene: 18564
Tgtp2
Name: T cell specific GTPase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 100039796
Homologene: 129991
Gm10563
Name: predicted gene 10563
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Mettl4
Name: methyltransferase like 4
Synonyms: 2410198H06Rik, HsT661, A730091E08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 76781
VEGA: 17
Homologene: 35305
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 34,724,997 bp
  • G to A, chromosome 1 at 159,324,937 bp
  • A to G, chromosome 2 at 18,159,491 bp
  • T to C, chromosome 2 at 41,960,679 bp
  • A to G, chromosome 2 at 112,718,002 bp
  • A to G, chromosome 2 at 114,116,578 bp
  • A to G, chromosome 2 at 126,821,217 bp
  • T to A, chromosome 2 at 178,033,762 bp
  • A to G, chromosome 3 at 60,086,769 bp
  • T to C, chromosome 3 at 88,321,365 bp
  • T to C, chromosome 3 at 95,173,152 bp
  • A to G, chromosome 3 at 108,356,682 bp
  • T to C, chromosome 3 at 109,934,872 bp
  • G to T, chromosome 3 at 138,428,055 bp
  • A to T, chromosome 4 at 115,998,773 bp
  • CTTT to CTTTATTT, chromosome 4 at 155,614,483 bp
  • A to T, chromosome 5 at 109,173,975 bp
  • G to A, chromosome 6 at 5,969,446 bp
  • A to G, chromosome 7 at 48,168,189 bp
  • CTGATGATGATG to CTGATGATGATGATG, chromosome 7 at 132,982,827 bp
  • T to C, chromosome 8 at 4,104,506 bp
  • A to G, chromosome 9 at 14,901,680 bp
  • T to C, chromosome 9 at 70,584,799 bp
  • G to A, chromosome 9 at 71,632,654 bp
  • A to C, chromosome 10 at 50,716,661 bp
  • C to A, chromosome 10 at 51,626,804 bp
  • C to T, chromosome 11 at 3,493,102 bp
  • T to A, chromosome 11 at 49,059,263 bp
  • C to T, chromosome 11 at 102,896,930 bp
  • C to T, chromosome 11 at 115,984,157 bp
  • A to T, chromosome 12 at 8,499,232 bp
  • T to C, chromosome 12 at 37,357,681 bp
  • A to G, chromosome 12 at 50,388,306 bp
  • A to G, chromosome 12 at 80,348,346 bp
  • T to C, chromosome 12 at 112,765,031 bp
  • T to C, chromosome 13 at 112,948,221 bp
  • T to C, chromosome 14 at 24,454,941 bp
  • A to G, chromosome 14 at 34,399,584 bp
  • T to A, chromosome 15 at 41,099,395 bp
  • T to A, chromosome 15 at 96,392,314 bp
  • G to T, chromosome 16 at 20,692,462 bp
  • G to A, chromosome 17 at 94,740,509 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5263 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042831-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.