Strain Name:
C57BL/6J-MtgxR5272Btlr/Mmmh
Stock Number:
042836-MU
Citation ID:
RRID:MMRRC_042836-MU
Other Names:
R5272 (G1), C57BL/6J-MtgxR5272Btlr
Major Collection:

Gene Information

Cyp19a1
Name: cytochrome P450, family 19, subfamily a, polypeptide 1
Synonyms: Int-5, Int5, Cyp19, Ar, ArKO, aromatase, p450arom
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 13075
VEGA: 9
HGNC: HGNC:2594
Homologene: 30955
Fryl
Name: FRY like transcription coactivator
Synonyms: 2510002A14Rik, 9030227G01Rik, 2310004H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72313
Homologene: 103956
Ticrr
Name: TOPBP1-interacting checkpoint and replication regulator
Synonyms: 5730590G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 77011
Homologene: 67120
Ttc27
Name: tetratricopeptide repeat domain 27
Synonyms: 2610511O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74196
VEGA: 17
Homologene: 41191
Ercc6
Name: excision repair cross-complementing rodent repair deficiency, complementation group 6
Synonyms: CS group B correcting gene, CSB, C130058G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 319955
VEGA: 14
HGNC: HGNC:3438
Homologene: 133552
Fnbp4
Name: formin binding protein 4
Synonyms: FBP30
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 55935
Homologene: 9087
Gpi1
Name: glucose-6-phosphate isomerase 1
Synonyms: Gpi1-s, Gpi1-t, autocrine motility factor, neuroleukin, Gpi-1, Org, Gpi-1t, MF, maturation factor, Gpi-1r, Gpi-1s, NK, Gpi1-r, NK/GPI, AMF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14751
HGNC: HGNC:4458
Homologene: 145
Dis3l2
Name: DIS3 like 3'-5' exoribonuclease 2
Synonyms: 4930429A22Rik, 8030493P09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208718
Homologene: 62417
Ddx55
Name: DEAD box helicase 55
Synonyms: 2810021H22Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 55
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67848
Homologene: 12196
C77080
Name: expressed sequence C77080
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 97130
Homologene: 45837
Tesmin
Name: testis expressed metallothionein like
Synonyms: Mtl5, tesmin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 17771
HGNC: HGNC:7446
Homologene: 31275
Panx1
Name: pannexin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 55991
HGNC: HGNC:8599
Homologene: 49416
Nectin3
Name: nectin cell adhesion molecule 3
Synonyms: 4921513D19Rik, 3000002N23Rik, nectin-3, Pvrl3, 2610301B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 58998
Homologene: 9162
Trf
Name: transferrin
Synonyms: HP, Tfn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22041
Homologene: 68153
Tgif1
Name: TGFB-induced factor homeobox 1
Synonyms: Tgif
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 21815
Homologene: 7574
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: l7Rn3, Doc4, Odz4, Ten-m4, ELM2, l(7)-3Rn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 23966
Homologene: 8034
Galr1
Name: galanin receptor 1
Synonyms: Galnr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 14427
VEGA: 18
HGNC: HGNC:4132
Homologene: 74396
Fibcd1
Name: fibrinogen C domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 98970
Homologene: 122246
Mia3
Name: melanoma inhibitory activity 3
Synonyms: 9130229H14Rik, B230399H06Rik, LOC385255, Tango, A930039G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 338366
Homologene: 85165
Tpst2
Name: protein-tyrosine sulfotransferase 2
Synonyms: grt, D5Ucla3, grm, Tango13b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22022
Homologene: 2666
Zfp148
Name: zinc finger protein 148
Synonyms: BERF-1, 2210405J08Rik, ZBP-89, BFCOL1, beta enolase repressor factor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 22661
VEGA: 16
Homologene: 8003
Actl6a
Name: actin-like 6A
Synonyms: 2810432C06Rik, Actl6, ARP4, Baf53a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56456
Homologene: 55811
Cep152
Name: centrosomal protein 152
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99100
Homologene: 37159
Vit
Name: vitrin
Synonyms: akhirin, 1700052E02Rik, AKH, 1700110E08Rik, 2810429K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74199
VEGA: 17
Homologene: 24942
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94109
Homologene: 69536
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: b2b1537Clo, b2b1565Clo, b2b1154Clo, b2b1134Clo, b2b3491Clo, Mdnah5, Dnahc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: Dnahc6, A730004I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Pcdhb4
Name: protocadherin beta 4
Synonyms: Pcdhb5A, PcdhbD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93875
Homologene: 62176
Dgkg
Name: diacylglycerol kinase, gamma
Synonyms: 2900055E17Rik, E430001K23Rik, Dagk3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 110197
HGNC: HGNC:2853
Homologene: 1029
Trim45
Name: tripartite motif-containing 45
Synonyms: 4921530N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229644
Homologene: 11865
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20192
Homologene: 68151
Arsb
Name: arylsulfatase B
Synonyms: As-1, As-1s, 1110007C02Rik, As-1r, Asr-1, As1, As1-r, As1-t, As1-s, Ast-1, As-1t
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 11881
VEGA: 13
HGNC: HGNC:714
Homologene: 73870
Ugt1a6b
Name: UDP glucuronosyltransferase 1 family, polypeptide A6B
Synonyms: A9'
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 394435
Homologene: 85959
Arhgap26
Name: Rho GTPase activating protein 26
Synonyms: 4933432P15Rik, 2610010G17Rik, 1810044B20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 71302
Homologene: 36349
Ptprr
Name: protein tyrosine phosphatase, receptor type, R
Synonyms: PTPBR7, PTP-SL, RPTPRR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19279
HGNC: HGNC:9680
Homologene: 2135
Kcnh8
Name: potassium voltage-gated channel, subfamily H (eag-related), member 8
Synonyms: ELK1, C130090D05Rik, Kv12.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 211468
Homologene: 14332
Krt23
Name: keratin 23
Synonyms: K23, Krt1-23, CK23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 94179
HGNC: HGNC:6438
Homologene: 9172
Plbd1
Name: phospholipase B domain containing 1
Synonyms: 1100001H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66857
Homologene: 11745
Crx
Name: cone-rod homeobox
Synonyms: Crx1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12951
HGNC: HGNC:2383
Homologene: 467
Olfr284
Name: olfactory receptor 284
Synonyms: GA_x6K02T2NBG7-5395976-5396893, MOR160-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 258278
Homologene: 74250
Tmc7
Name: transmembrane channel-like gene family 7
Synonyms: C630024K23Rik, 1700030H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 209760
Homologene: 36424
Gm7251
Name: predicted pseudogene 7251
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 638833
Gm11677
Name: predicted gene 11677
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 629967
Gm20713
Name: predicted gene 20713
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Gm16401
Name: predicted gene 16401
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Smlr1
Name: small leucine-rich protein 1
Synonyms: 2010003K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 100504474
Homologene: 133233
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 86,973,404 bp
  • C to T, chromosome 1 at 88,107,227 bp
  • G to A, chromosome 1 at 183,328,270 bp
  • A to T, chromosome 2 at 31,816,623 bp
  • G to T, chromosome 2 at 31,816,624 bp
  • G to A, chromosome 2 at 90,753,115 bp
  • T to C, chromosome 2 at 112,653,213 bp
  • G to A, chromosome 2 at 125,611,030 bp
  • A to G, chromosome 3 at 32,718,610 bp
  • T to C, chromosome 3 at 100,929,919 bp
  • T to C, chromosome 4 at 129,224,212 bp
  • A to T, chromosome 5 at 44,101,511 bp
  • A to T, chromosome 5 at 73,065,136 bp
  • T to A, chromosome 5 at 112,307,952 bp
  • A to T, chromosome 5 at 124,558,029 bp
  • A to G, chromosome 6 at 73,127,861 bp
  • A to G, chromosome 6 at 136,640,158 bp
  • C to T, chromosome 7 at 15,868,285 bp
  • T to C, chromosome 7 at 34,220,690 bp
  • C to A, chromosome 7 at 79,669,605 bp
  • T to A, chromosome 7 at 96,874,203 bp
  • A to G, chromosome 7 at 118,561,053 bp
  • T to A, chromosome 8 at 16,199,944 bp
  • C to T, chromosome 9 at 15,044,856 bp
  • A to T, chromosome 9 at 54,176,614 bp
  • A to T, chromosome 9 at 103,227,978 bp
  • T to C, chromosome 10 at 25,536,027 bp
  • A to T, chromosome 10 at 116,229,491 bp
  • A to T, chromosome 11 at 99,478,273 bp
  • C to T, chromosome 11 at 111,724,711 bp
  • G to C, chromosome 13 at 49,805,381 bp
  • A to T, chromosome 13 at 93,794,162 bp
  • A to T, chromosome 14 at 32,519,028 bp
  • C to A, chromosome 14 at 115,788,235 bp
  • T to C, chromosome 15 at 28,350,665 bp
  • G to A, chromosome 15 at 98,340,365 bp
  • C to A, chromosome 16 at 22,588,294 bp
  • T to A, chromosome 16 at 33,496,224 bp
  • A to G, chromosome 16 at 46,448,476 bp
  • A to G, chromosome 17 at 52,905,015 bp
  • A to G, chromosome 17 at 70,846,254 bp
  • G to A, chromosome 17 at 74,742,977 bp
  • A to G, chromosome 17 at 78,586,835 bp
  • A to G, chromosome 18 at 37,307,766 bp
  • T to A, chromosome 18 at 38,642,571 bp
  • T to A, chromosome 18 at 82,405,636 bp
  • C to A, chromosome 19 at 3,406,992 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5272 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042836-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.