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Strain Name:
C57BL/6J-MtgxR5262Btlr/Mmmh
Stock Number:
042857-MU
Citation ID:
RRID:MMRRC_042857-MU
Other Names:
R5262 (G1), C57BL/6J-MtgxR5262Btlr
Major Collection:

Strain Information

Iqgap1
Name: IQ motif containing GTPase activating protein 1
Synonyms: D7Ertd237e, D7Ertd257e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 29875
HGNC: HGNC:6110
Homologene: 74514
Wwp1
Name: WW domain containing E3 ubiquitin protein ligase 1
Synonyms: SDRP1, Tiul1, AIP5, 8030445B08Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 107568
Homologene: 21385
Shroom3
Name: shroom family member 3
Synonyms: D5Ertd287e, Shrm, Shrm3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27428
Homologene: 9263
Nfkb1
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Synonyms: NF kappaB1, p50 subunit of NF kappaB, p50/p105, p50, nuclear factor kappaB p50, NF-kappaB, NF-kappaB p50
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18033
HGNC: HGNC:7794
Homologene: 2971
Ppp2r5e
Name: protein phosphatase 2, regulatory subunit B', epsilon
Synonyms: protein phosphatase 2A subunit beta, 4633401M22Rik, B56beta
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 26932
VEGA: 12
HGNC: HGNC:9313
Homologene: 55962
Virma
Name: vir like m6A methyltransferase associated
Synonyms: 1110037F02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66185
Homologene: 41043
Cct6a
Name: chaperonin containing TCP1 subunit 6A
Synonyms: Cctz-1, chaperonin containing TCP-1, Cct6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12466
HGNC: HGNC:1620
Homologene: 1336
Trappc8
Name: trafficking protein particle complex 8
Synonyms: 5033403J15Rik, D030074E01Rik, Trs85
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75964
VEGA: 18
Homologene: 40993
Ints8
Name: integrator complex subunit 8
Synonyms: D130008D20Rik, 2810013E07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72656
Homologene: 9888
Snx16
Name: sorting nexin 16
Synonyms: 4930522N22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74718
Homologene: 11169
Ptn
Name: pleiotrophin
Synonyms: heparin-binding growth factor 8, HBGF-8, heparin-binding growth-associated molecule, HB-GAM, Osf-1, Osf1, HBNF
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19242
HGNC: HGNC:9630
Homologene: 2117
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Dcdc2a
Name: doublecortin domain containing 2a
Synonyms: RU2, Dcdc2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 195208
Homologene: 9483
Zranb1
Name: zinc finger, RAN-binding domain containing 1
Synonyms: D7Wsu87e, 9330160G10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 360216
Homologene: 9728
Tap2
Name: transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Synonyms: MTP2, PSF2, Tap-2, Ham2, Ham-2, HAM2, Abcb3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21355
HGNC: HGNC:44
Homologene: 37323
Pdgfa
Name: platelet derived growth factor, alpha
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18590
HGNC: HGNC:8799
Homologene: 32055
Usp8
Name: ubiquitin specific peptidase 8
Synonyms: Ubpy
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 84092
Homologene: 3782
Rbp3
Name: retinol binding protein 3, interstitial
Synonyms: Irbp, Rbp-3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19661
VEGA: 14
HGNC: HGNC:9921
Homologene: 9261
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Nlrp4a
Name: NLR family, pyrin domain containing 4A
Synonyms: Nalp-eta, E330028A19Rik, Nalp4a
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243880
Homologene: 79696
Cfap53
Name: cilia and flagella associated protein 53
Synonyms: 4933415I03Rik, Ccdc11
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 74453
Homologene: 27056
Trim58
Name: tripartite motif-containing 58
Synonyms: LOC216781, LOC386443
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216781
Homologene: 9135
Dpyd
Name: dihydropyrimidine dehydrogenase
Synonyms: DPD, E330028L06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99586
HGNC: HGNC:3012
Homologene: 85
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: D11Ertd686e, Dnahc9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Lrp4
Name: low density lipoprotein receptor-related protein 4
Synonyms: 6430526J12Rik, mdig, Megf7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228357
HGNC: HGNC:6696
Homologene: 17964
Vmn1r48
Name: vomeronasal 1 receptor 48
Synonyms: V1ra3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113845
Homologene: 137651
Kmt2b
Name: lysine (K)-specific methyltransferase 2B
Synonyms: 2610014H22Rik, Mll2, Wbp7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75410
Homologene: 22838
Defb26
Name: defensin beta 26
Synonyms: EG654457
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 654457
Homologene: 86850
Corin
Name: corin, serine peptidase
Synonyms: Lrp4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 53419
Homologene: 4804
Ifi47
Name: interferon gamma inducible protein 47
Synonyms: 47kDa, IRG-47, Iigp4, Igrd
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15953
Homologene: 49169
Nrap
Name: nebulin-related anchoring protein
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18175
HGNC: HGNC:7988
Homologene: 4499
Vrk2
Name: vaccinia related kinase 2
Synonyms: 2810003O05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69922
Homologene: 55966
Ago4
Name: argonaute RISC catalytic subunit 4
Synonyms: 5730550L01Rik, argonaute 4, Eif2c4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76850
Homologene: 41184
Ces1e
Name: carboxylesterase 1E
Synonyms: Es-22, Eg, egasyn, Es22
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13897
HGNC: HGNC:1863
Homologene: 115660
Hrh4
Name: histamine receptor H4
Synonyms: H4R
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225192
VEGA: 18
Homologene: 11002
Lilrb4a
Name: leukocyte immunoglobulin-like receptor, subfamily B, member 4A
Synonyms: CD85K, ILT3, HM18, Gp49b, Lilrb4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14728
VEGA: 10
HGNC: HGNC:6608
Homologene: 86756
Ankrd13b
Name: ankyrin repeat domain 13b
Synonyms: B930093C12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268445
Homologene: 27367
Slc16a14
Name: solute carrier family 16 (monocarboxylic acid transporters), member 14
Synonyms: 1110004H10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71781
Homologene: 34318
Gstm1
Name: glutathione S-transferase, mu 1
Synonyms: Gstb-1, Gstb1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14862
Homologene: 115474
Rtp3
Name: receptor transporter protein 3
Synonyms: Tmem7
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235636
Homologene: 135957
Maip1
Name: matrix AAA peptidase interacting protein 1
Synonyms: 9430016H08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68115
Homologene: 11565
Fars2
Name: phenylalanine-tRNA synthetase 2, mitochondrial
Synonyms: 2810431B21Rik, 6720478K01Rik, Fars1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69955
VEGA: 13
Homologene: 4788
Zbtb24
Name: zinc finger and BTB domain containing 24
Synonyms: ZNF450
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268294
VEGA: 10
Homologene: 8870
Gtf2h2
Name: general transcription factor II H, polypeptide 2
Synonyms: Btf2p44, basal transcription factor 2, p44 subunit, 44kDa, p44
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 23894
Homologene: 1159
Igsf5
Name: immunoglobulin superfamily, member 5
Synonyms: 2010003D20Rik, Igsf5, Jam4
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72058
HGNC: HGNC:5952
Homologene: 12437
Duoxa1
Name: dual oxidase maturation factor 1
Synonyms: Nip1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 213696
Homologene: 16043
Cyp2d34
Name: cytochrome P450, family 2, subfamily d, polypeptide 34
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223706
VEGA: 15
Homologene: 86099
Elovl1
Name: ELOVL fatty acid elongase 1
Synonyms: Ssc1, elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 54325
Homologene: 41322
Rcor2
Name: REST corepressor 2
Synonyms: CoREST, 1A13
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 104383
Homologene: 14280
Ankdd1b
Name: ankyrin repeat and death domain containing 1B
Synonyms: 9330128J19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 271144
Homologene: 19566
Snx21
Name: sorting nexin family member 21
Synonyms: 5730407K14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 101113
Homologene: 43132
Pou1f1
Name: POU domain, class 1, transcription factor 1
Synonyms: GHF-1, Pit-1, Hmp1, Pit1, Pit1-rs1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 18736
HGNC: HGNC:9210
Homologene: 259
Gtf2e1
Name: general transcription factor II E, polypeptide 1 (alpha subunit)
Synonyms: TFIIE-A, FE, 2610024P03Rik, 56kDa
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74197
HGNC: HGNC:4650
Homologene: 38062
Gm15401
Name: predicted gene 15401
Synonyms: ENSMUSG00000072999
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100038714
Gm11906
Name: predicted gene 11906
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
U2af1l4
Name: U2 small nuclear RNA auxiliary factor 1-like 4
Synonyms: auxiliary factor 26, U2af26
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233073
Homologene: 134014
Sgo2b
Name: shugoshin 2B
Synonyms: Gm4975, Sgol2b
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244495
Homologene: 51867
Scgb2b11
Name: secretoglobin, family 2B, member 11
Synonyms: Gm4687, Abpbg11
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043842
Homologene: 83171
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 57,406,972 bp
  • A to G, chromosome 1 at 84,912,891 bp
  • C to T, chromosome 2 at 91,477,105 bp
  • T to A, chromosome 2 at 122,304,705 bp
  • A to G, chromosome 2 at 126,751,111 bp
  • A to T, chromosome 2 at 152,507,958 bp
  • T to C, chromosome 2 at 164,791,821 bp
  • C to T, chromosome 3 at 10,437,832 bp
  • T to A, chromosome 3 at 108,016,363 bp
  • C to A, chromosome 3 at 118,797,422 bp
  • A to T, chromosome 3 at 135,612,412 bp
  • A to G, chromosome 4 at 11,211,916 bp
  • A to T, chromosome 4 at 11,539,926 bp
  • A to G, chromosome 4 at 19,631,057 bp
  • G to T, chromosome 4 at 25,251,294 bp
  • G to A, chromosome 4 at 118,430,927 bp
  • T to A, chromosome 4 at 126,496,764 bp
  • A to G, chromosome 5 at 72,304,955 bp
  • A to G, chromosome 5 at 92,964,573 bp
  • A to C, chromosome 5 at 124,785,156 bp
  • T to A, chromosome 5 at 129,793,622 bp
  • A to G, chromosome 5 at 138,993,294 bp
  • T to A, chromosome 6 at 36,744,484 bp
  • T to C, chromosome 6 at 72,636,466 bp
  • A to T, chromosome 6 at 90,036,034 bp
  • T to C, chromosome 7 at 26,459,811 bp
  • C to T, chromosome 7 at 30,564,213 bp
  • A to G, chromosome 7 at 30,569,794 bp
  • T to C, chromosome 7 at 32,209,351 bp
  • T to G, chromosome 7 at 80,726,742 bp
  • T to C, chromosome 7 at 83,650,899 bp
  • CTGATGATGATG to CTGATGATGATGATG, chromosome 7 at 132,982,827 bp
  • T to A, chromosome 7 at 141,651,110 bp
  • C to A, chromosome 8 at 63,943,137 bp
  • A to G, chromosome 8 at 93,223,958 bp
  • A to T, chromosome 9 at 110,986,127 bp
  • C to T, chromosome 10 at 41,464,560 bp
  • T to C, chromosome 10 at 51,493,207 bp
  • T to A, chromosome 11 at 26,591,697 bp
  • A to G, chromosome 11 at 49,095,732 bp
  • T to C, chromosome 11 at 58,651,668 bp
  • C to T, chromosome 11 at 66,112,333 bp
  • T to C, chromosome 11 at 77,473,634 bp
  • A to G, chromosome 11 at 82,956,670 bp
  • G to A, chromosome 12 at 75,593,271 bp
  • T to C, chromosome 13 at 11,772,437 bp
  • A to T, chromosome 13 at 25,110,100 bp
  • T to A, chromosome 13 at 36,342,018 bp
  • C to A, chromosome 13 at 96,420,773 bp
  • A to G, chromosome 13 at 100,481,848 bp
  • G to T, chromosome 14 at 33,954,850 bp
  • A to T, chromosome 15 at 82,618,371 bp
  • T to C, chromosome 16 at 37,535,931 bp
  • G to T, chromosome 16 at 65,531,982 bp
  • G to T, chromosome 16 at 96,391,037 bp
  • A to G, chromosome 17 at 34,214,016 bp
  • G to T, chromosome 18 at 13,015,813 bp
  • C to T, chromosome 18 at 20,818,190 bp
  • A to C, chromosome 18 at 74,329,459 bp
  • G to T, chromosome 19 at 7,274,061 bp
  • A to T, chromosome 19 at 56,320,223 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5262 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042857-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.