Strain Name:
C57BL/6J-MtgxR5266Btlr/Mmmh
Stock Number:
042858-MU
Citation ID:
RRID:MMRRC_042858-MU
Other Names:
R5266 (G1), C57BL/6J-MtgxR5266Btlr
Major Collection:

Gene Information

Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Crym
Name: crystallin, mu
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12971
HGNC: HGNC:2418
Homologene: 1424
Cux1
Name: cut-like homeobox 1
Synonyms: Cux, CDP, Cux-1, Cutl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13047
HGNC: HGNC:2557
Opa1
Name: OPA1, mitochondrial dynamin like GTPase
Synonyms: 1200011N24Rik, lilr3, optic atrophy 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74143
HGNC: HGNC:8140
Homologene: 14618
Map3k11
Name: mitogen-activated protein kinase kinase kinase 11
Synonyms: Mlk3, 2610017K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 26403
VEGA: 19
HGNC: HGNC:6850
Homologene: 37618
Tead1
Name: TEA domain family member 1
Synonyms: mTEF-1, TEF-1, TEAD-1, Tcf13, Gtrgeo5, B230114H05Rik, 2610024B07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 21676
Homologene: 2418
Zfp985
Name: zinc finger protein 985
Synonyms: Gm13154
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 433804
Homologene: 133076
Azin1
Name: antizyme inhibitor 1
Synonyms: ODC antizyme inhibitor, Oazi, 1700085L02Rik, Oazin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 54375
Homologene: 22933
Bdp1
Name: B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
Synonyms: TFIIIB150, TFIIIB90, TAF3B1, TFC5, Tfnr, G630013P12Rik, B130055N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 544971
Homologene: 34582
Scube2
Name: signal peptide, CUB domain, EGF-like 2
Synonyms: ICRFP703N2430Q5.1, ICRFP703B1614Q5.1, 4932442O19Rik, Cegf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56788
Homologene: 36383
Gprc5c
Name: G protein-coupled receptor, family C, group 5, member C
Synonyms: 1110028I06Rik, 3200002M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70355
Homologene: 11099
Pnkp
Name: polynucleotide kinase 3'- phosphatase
Synonyms: PNK, 1810009G08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 59047
HGNC: HGNC:9154
Homologene: 5247
Erbb3
Name: erb-b2 receptor tyrosine kinase 3
Synonyms: Erbb-3, Erbb3r, HER3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 13867
HGNC: HGNC:3431
Homologene: 20457
Gask1b
Name: golgi associated kinase 1B
Synonyms: 2210419I08Rik, Ened, 1110032E23Rik, Fam198b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68659
Homologene: 9590
Ppp4r3b
Name: protein phosphatase 4 regulatory subunit 3B
Synonyms: Smek2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 104570
Homologene: 68886
Tecpr2
Name: tectonin beta-propeller repeat containing 2
Synonyms: 4930573I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104859
VEGA: 12
Homologene: 8897
Zfp975
Name: zinc finger protein 975
Synonyms: Gm5595
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434179
Homologene: 134004
Mfng
Name: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Synonyms: manic fringe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 17305
HGNC: HGNC:7038
Homologene: 1803
Atp2a3
Name: ATPase, Ca++ transporting, ubiquitous
Synonyms: Serca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 53313
HGNC: HGNC:813
Homologene: 69131
Asic4
Name: acid-sensing (proton-gated) ion channel family member 4
Synonyms: Accn4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241118
Homologene: 11166
Zfpm2
Name: zinc finger protein, multitype 2
Synonyms: FOG-2, FOG2, B330005D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22762
VEGA: 15
Homologene: 8008
Zfp420
Name: zinc finger protein 420
Synonyms: B230312I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233058
Homologene: 129731
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hy-3, hy3, 1700034M11Rik, 4930545D19Rik, hyrh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244653
Homologene: 52118
Olfr651
Name: olfactory receptor 651
Synonyms: GA_x6K02T2PBJ9-7179540-7180481, MOR31-11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258809
Homologene: 64922
Vnn1
Name: vanin 1
Synonyms: pantetheinase, V-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22361
Homologene: 32130
Ttc39a
Name: tetratricopeptide repeat domain 39A
Synonyms: 4922503N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230603
Homologene: 17739
Ikzf3
Name: IKAROS family zinc finger 3
Synonyms: Aiolos, 5830411O07Rik, Zfpn1a3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22780
Homologene: 8269
Ppargc1b
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 beta
Synonyms: PGC-1beta/ERRL1, 4631412G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 170826
Homologene: 15776
Myo7b
Name: myosin VIIB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17922
HGNC: HGNC:7607
Homologene: 81947
Elac1
Name: elaC ribonuclease Z 1
Synonyms: 8430417G19Rik, 2610018O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 114615
Homologene: 10272
Wdr41
Name: WD repeat domain 41
Synonyms: MSTP048, B830029I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218460
Homologene: 23087
Catsperg2
Name: cation channel sperm associated auxiliary subunit gamma 2
Synonyms: 1700067C01Rik, CATSPERG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76718
Homologene: 10915
Chl1
Name: cell adhesion molecule L1-like
Synonyms: CALL, A530023M13Rik, close homolog of L1, LICAM2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12661
HGNC: HGNC:1939
Homologene: 21314
Ndst2
Name: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
Synonyms: glucosaminyl N-deacetylase/N-sulphotransferase-2, Mndns, [Heparan sulfate]-glucosamine N-sulfotransferase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 17423
VEGA: 14
HGNC: HGNC:7681
Homologene: 20803
Pla2g4a
Name: phospholipase A2, group IVA (cytosolic, calcium-dependent)
Synonyms: cPLA2, Type IV PLA2, cytosolic PLA2, cPLA2alpha, cytosolic phospholipase A2, Pla2g4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18783
HGNC: HGNC:9035
Homologene: 32059
4930503L19Rik
Name: RIKEN cDNA 4930503L19 gene
Synonyms: Las2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 269033
Homologene: 52120
Slc25a35
Name: solute carrier family 25, member 35
Synonyms: 1810012H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71998
Homologene: 6343
Sipa1l2
Name: signal-induced proliferation-associated 1 like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244668
Homologene: 18956
Pkp3
Name: plakophilin 3
Synonyms: 2310056L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56460
HGNC: HGNC:9025
Homologene: 5200
Mrm1
Name: mitochondrial rRNA methyltransferase 1
Synonyms: A530065E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217038
Homologene: 40307
Pon3
Name: paraoxonase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 269823
HGNC: HGNC:9206
Homologene: 37371
Sry
Name: sex determining region of Chr Y
Synonyms: Tdf, Tdy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 21674
Rbm20
Name: RNA binding motif protein 20
Synonyms: 2010003H22Rik, 1110018J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 73713
Homologene: 28386
Rexo5
Name: RNA exonuclease 5
Synonyms: 2610020H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434234
Homologene: 12803
Stk36
Name: serine/threonine kinase 36
Synonyms: 1700112N14Rik, Fused
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269209
Homologene: 49432
Padi4
Name: peptidyl arginine deiminase, type IV
Synonyms: PAD type IV, Pdi4, Pad4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18602
Homologene: 7883
Cyp3a44
Name: cytochrome P450, family 3, subfamily a, polypeptide 44
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 337924
HGNC: HGNC:2638
Homologene: 133568
Tha1
Name: threonine aldolase 1
Synonyms: GLY1, 1300017K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71776
Homologene: 57081
Olfr1173
Name: olfactory receptor 1173
Synonyms: GA_x6K02T2Q125-49759783-49758845, MOR174-20_p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 404329
Homologene: 128091
Pcdh1
Name: protocadherin 1
Synonyms: 2010005A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 75599
HGNC: HGNC:8655
Homologene: 12613
Slbp
Name: stem-loop binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20492
Homologene: 31389
Tbc1d22b
Name: TBC1 domain family, member 22B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 381085
Homologene: 23043
Vmn1r128
Name: vomeronasal 1 receptor 128
Synonyms: Gm8509
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 667199
Homologene: 104166
Dnase1l1
Name: deoxyribonuclease 1-like 1
Synonyms: G4.8, Dnl1ll, 2310005K03Rik, Dnase1ll
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 69537
HGNC: HGNC:2957
Homologene: 4896
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 74,611,158 bp
  • G to A, chromosome 1 at 75,450,923 bp
  • T to C, chromosome 1 at 149,865,167 bp
  • T to C, chromosome 2 at 88,274,221 bp
  • T to A, chromosome 3 at 79,936,603 bp
  • A to T, chromosome 4 at 109,422,504 bp
  • A to G, chromosome 4 at 140,746,131 bp
  • A to T, chromosome 4 at 147,582,832 bp
  • A to T, chromosome 5 at 33,643,866 bp
  • A to G, chromosome 5 at 136,312,694 bp
  • T to C, chromosome 5 at 145,794,397 bp
  • T to C, chromosome 6 at 5,240,860 bp
  • A to G, chromosome 6 at 103,700,543 bp
  • A to T, chromosome 7 at 21,349,403 bp
  • G to A, chromosome 7 at 29,717,066 bp
  • C to T, chromosome 7 at 29,875,124 bp
  • T to G, chromosome 7 at 42,662,230 bp
  • C to T, chromosome 7 at 44,862,403 bp
  • A to T, chromosome 7 at 104,553,819 bp
  • C to T, chromosome 7 at 109,809,230 bp
  • A to G, chromosome 7 at 112,759,466 bp
  • C to A, chromosome 7 at 119,844,437 bp
  • A to G, chromosome 7 at 120,199,294 bp
  • A to G, chromosome 7 at 141,083,277 bp
  • A to G, chromosome 8 at 110,334,784 bp
  • T to C, chromosome 8 at 125,492,126 bp
  • G to A, chromosome 10 at 23,903,405 bp
  • T to G, chromosome 10 at 92,815,902 bp
  • G to A, chromosome 10 at 128,569,636 bp
  • T to C, chromosome 11 at 29,173,309 bp
  • T to C, chromosome 11 at 68,968,929 bp
  • A to G, chromosome 11 at 72,975,397 bp
  • A to T, chromosome 11 at 84,819,260 bp
  • A to T, chromosome 11 at 98,490,580 bp
  • G to T, chromosome 11 at 114,864,267 bp
  • A to C, chromosome 11 at 117,869,676 bp
  • G to C, chromosome 12 at 110,915,402 bp
  • T to C, chromosome 13 at 13,660,970 bp
  • T to C, chromosome 13 at 94,995,251 bp
  • T to C, chromosome 13 at 100,067,535 bp
  • G to A, chromosome 14 at 20,724,487 bp
  • T to C, chromosome 15 at 38,491,551 bp
  • T to C, chromosome 15 at 41,099,469 bp
  • C to T, chromosome 15 at 78,764,388 bp
  • T to A, chromosome 16 at 29,618,130 bp
  • C to T, chromosome 17 at 29,578,900 bp
  • A to G, chromosome 18 at 31,998,734 bp
  • A to G, chromosome 18 at 38,192,199 bp
  • A to T, chromosome 18 at 61,315,805 bp
  • T to C, chromosome 18 at 70,458,384 bp
  • A to G, chromosome 18 at 73,742,669 bp
  • T to A, chromosome 19 at 5,700,594 bp
  • A to G, chromosome 19 at 53,813,387 bp
  • C to T, chromosome X at 74,277,038 bp
  • C to G, chromosome Y at 2,662,975 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5266 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042858-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.