Strain Name:
C57BL/6J-MtgxR5340Btlr/Mmmh
Stock Number:
042919-MU
Citation ID:
RRID:MMRRC_042919-MU
Other Names:
R5340 (G1), C57BL/6J-MtgxR5340Btlr
Major Collection:

Gene Information

Ctbp2
Name: C-terminal binding protein 2
Synonyms: Gtrgeo6, D7Ertd45e, Ribeye
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13017
HGNC: HGNC:2495
Homologene: 75187
Eri3
Name: exoribonuclease 3
Synonyms: Prnpip1, PINT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 140546
Homologene: 15403
Csrnp3
Name: cysteine-serine-rich nuclear protein 3
Synonyms: mbu1, A330102K23Rik, CSRNP-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 77771
Homologene: 11803
Baz2a
Name: bromodomain adjacent to zinc finger domain, 2A
Synonyms: Tip5, C030005G16Rik, Walp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 116848
VEGA: 10
HGNC: HGNC:962
Homologene: 8393
Tmem245
Name: transmembrane protein 245
Synonyms: A630051L19Rik, D730040F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242474
HGNC: HGNC:1363
Homologene: 41841
Ipo9
Name: importin 9
Synonyms: Imp9, 0710008K06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226432
Homologene: 5874
Flii
Name: flightless I actin binding protein
Synonyms: 3632430F08Rik, Fliih
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14248
HGNC: HGNC:3750
Homologene: 11092
Mta2
Name: metastasis-associated gene family, member 2
Synonyms: mmta2, Mta1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 23942
HGNC: HGNC:7411
Homologene: 3480
Zfp667
Name: zinc finger protein 667
Synonyms: A830025F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384763
Homologene: 23343
Zfp940
Name: zinc finger protein 940
Synonyms: BC027344
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233057
Homologene: 138421
Pak2
Name: p21 (RAC1) activated kinase 2
Synonyms: PAK-2, D16Ertd269e, A130002K10Rik, 5330420P17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224105
HGNC: HGNC:8591
Homologene: 99711
Atp4a
Name: ATPase, H+/K+ exchanging, gastric, alpha polypeptide
Synonyms: H+K+-transporting alpha 1, H+/K+-ATPase alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11944
HGNC: HGNC:819
Homologene: 68081
Zcchc7
Name: zinc finger, CCHC domain containing 7
Synonyms: 4930572I07Rik, D4Wsu132e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 319885
Homologene: 22217
H2bl1
Name: H2B.L histone variant 1
Synonyms: SubH2Bv, 1700024P04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69382
Homologene: 105972
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20192
Homologene: 68151
Astn1
Name: astrotactin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11899
HGNC: HGNC:773
Homologene: 7233
Gzmm
Name: granzyme M (lymphocyte met-ase 1)
Synonyms: Lmet1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16904
HGNC: HGNC:4712
Homologene: 21099
Sh3pxd2a
Name: SH3 and PX domains 2A
Synonyms: Sh3md1, Fish, 2310014D11Rik, Tks5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 14218
VEGA: 19
Homologene: 7317
Mblac1
Name: metallo-beta-lactamase domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 330216
Homologene: 45596
BC034090
Name: cDNA sequence BC034090
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 207792
Homologene: 19490
Olfr736
Name: olfactory receptor 736
Synonyms: GA_x6K02T2PMLR-6089963-6090901, MOR106-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258660
Homologene: 64902
Vmn2r56
Name: vomeronasal 2, receptor 56
Synonyms: EG629079
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 629079
Homologene: 104040
Tcaf1
Name: TRPM8 channel-associated factor 1
Synonyms: A230020K05Rik, 3321401G04Rik, Fam115a, 2810407D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 77574
Homologene: 8815
Masp1
Name: mannan-binding lectin serine peptidase 1
Synonyms: Crarf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17174
VEGA: 16
HGNC: HGNC:6901
Homologene: 88793
Pla2g4b
Name: phospholipase A2, group IVB (cytosolic)
Synonyms: A030011C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 211429
HGNC: HGNC:9036
Homologene: 3730
Sned1
Name: sushi, nidogen and EGF-like domains 1
Synonyms: 6720455I24Rik, Snep, D430044C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208777
Homologene: 14708
Fmo1
Name: flavin containing monooxygenase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14261
HGNC: HGNC:3769
Homologene: 55520
Zfp709
Name: zinc finger protein 709
Synonyms: GIOT-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 236193
Homologene: 136795
Otulinl
Name: OTU deubiquitinase with linear linkage specificity like
Synonyms: Fam105a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223433
VEGA: 15
Homologene: 41302
Ttll11
Name: tubulin tyrosine ligase-like family, member 11
Synonyms: 4933424A20Rik, D2Ertd624e, 4932702F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74410
Homologene: 77534
Olfr1263
Name: olfactory receptor 1263
Synonyms: MOR234-2, GA_x6K02T2Q125-51447049-51447969
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258790
Homologene: 45043
Gm10334
Name: predicted gene 10334
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100040233
Homologene: 88408
Tmem232
Name: transmembrane protein 232
Synonyms: LOC381107, E130009J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 381107
VEGA: 17
Homologene: 54378
Dync2li1
Name: dynein cytoplasmic 2 light intermediate chain 1
Synonyms: D2lic, LIC3, mD2LIC, CGI-60, 4933404O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 213575
VEGA: 17
Homologene: 9336
Fbxw5
Name: F-box and WD-40 domain protein 5
Synonyms: Fbw5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 30839
Homologene: 8496
Mical1
Name: microtubule associated monooxygenase, calponin and LIM domain containing 1
Synonyms: Nical
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 171580
Homologene: 11246
Ccdc136
Name: coiled-coil domain containing 136
Synonyms: 4921511K06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232664
Homologene: 23378
Gm2128
Name: predicted gene 2128
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100039269
Homologene: 45597
Bnip1
Name: BCL2/adenovirus E1B interacting protein 1
Synonyms: 2010005M06Rik, 5930429G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224630
HGNC: HGNC:1082
Homologene: 930
Aqp7
Name: aquaporin 7
Synonyms: AQP7L, AQPap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11832
HGNC: HGNC:640
Homologene: 48000
Phc3
Name: polyhomeotic 3
Synonyms: E030046K01Rik, EDR3, HPH3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 241915
Homologene: 69390
Rogdi
Name: rogdi homolog
Synonyms: 0610011C19Rik, Lzf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 66049
Homologene: 11605
Scrn3
Name: secernin 3
Synonyms: 4833415E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74616
Homologene: 11601
Mroh9
Name: maestro heat-like repeat family member 9
Synonyms: 4921528O07Rik, Armc11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 78258
Homologene: 123521
RP23-235E15.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Igkv4-55
Name: immunoglobulin kappa variable 4-55
Synonyms: LOC385253, Gm1524
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 385253
Gm15612
Name: predicted gene 15612
Synonyms: ENSMUSG00000072920
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100038356
Gm11735
Name: predicted gene 11735
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 634720
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 93,282,757 bp
  • A to G, chromosome 1 at 135,385,432 bp
  • T to C, chromosome 1 at 155,226,414 bp
  • G to C, chromosome 1 at 158,510,980 bp
  • A to T, chromosome 1 at 162,829,982 bp
  • C to T, chromosome 1 at 163,080,587 bp
  • A to G, chromosome 2 at 25,504,555 bp
  • G to T, chromosome 2 at 35,902,789 bp
  • A to G, chromosome 2 at 66,022,437 bp
  • A to T, chromosome 2 at 73,335,810 bp
  • T to C, chromosome 2 at 90,015,362 bp
  • T to C, chromosome 2 at 112,834,125 bp
  • T to C, chromosome 2 at 120,041,448 bp
  • A to T, chromosome 3 at 30,907,467 bp
  • A to G, chromosome 3 at 119,709,808 bp
  • T to C, chromosome 4 at 41,034,347 bp
  • T to A, chromosome 4 at 44,762,245 bp
  • T to C, chromosome 4 at 56,910,202 bp
  • A to T, chromosome 4 at 117,673,794 bp
  • A to T, chromosome 5 at 138,194,578 bp
  • A to G, chromosome 6 at 29,411,860 bp
  • T to C, chromosome 6 at 41,445,373 bp
  • A to G, chromosome 6 at 42,678,989 bp
  • A to G, chromosome 6 at 69,607,505 bp
  • A to G, chromosome 6 at 73,212,620 bp
  • A to C, chromosome 6 at 88,845,164 bp
  • A to G, chromosome 7 at 6,305,253 bp
  • A to C, chromosome 7 at 12,715,872 bp
  • A to G, chromosome 7 at 29,844,841 bp
  • A to G, chromosome 7 at 30,720,806 bp
  • A to G, chromosome 7 at 41,157,667 bp
  • G to T, chromosome 7 at 133,013,963 bp
  • T to A, chromosome 8 at 71,889,752 bp
  • T to A, chromosome 10 at 41,483,431 bp
  • C to A, chromosome 10 at 79,695,073 bp
  • C to T, chromosome 10 at 128,115,042 bp
  • T to A, chromosome 11 at 60,717,268 bp
  • C to T, chromosome 11 at 116,742,554 bp
  • C to T, chromosome 13 at 98,984,443 bp
  • T to C, chromosome 14 at 50,393,220 bp
  • T to C, chromosome 15 at 27,658,089 bp
  • C to A, chromosome 16 at 5,013,361 bp
  • T to C, chromosome 16 at 23,458,108 bp
  • G to T, chromosome 16 at 32,034,946 bp
  • T to C, chromosome 17 at 26,786,790 bp
  • C to T, chromosome 17 at 65,402,998 bp
  • A to G, chromosome 17 at 84,649,702 bp
  • T to C, chromosome 19 at 8,942,356 bp
  • T to C, chromosome 19 at 47,268,231 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5340 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042919-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.