Strain Name:
C57BL/6J-MtgxR5359Btlr/Mmmh
Stock Number:
042938-MU
Citation ID:
RRID:MMRRC_042938-MU
Other Names:
R5359 (G1), C57BL/6J-MtgxR5359Btlr
Major Collection:

Gene Information

Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: Cycn, Lda, A730019I05Rik, Obt, GENA 47, Mt, Todo, Gena 52, Whi, WBE1, GENA 60, Dz, Edy, Cyn, Flo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320790
Homologene: 19067
Dspp
Name: dentin sialophosphoprotein
Synonyms: Dsp, Dmp3, Dpp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 666279
HGNC: HGNC:3054
Dap3
Name: death associated protein 3
Synonyms: 4921514D13Rik, DAP-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 65111
HGNC: HGNC:2673
Homologene: 3404
Iqgap1
Name: IQ motif containing GTPase activating protein 1
Synonyms: D7Ertd257e, D7Ertd237e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 29875
HGNC: HGNC:6110
Homologene: 74514
Plekha7
Name: pleckstrin homology domain containing, family A member 7
Synonyms: A430081P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233765
Homologene: 52172
Dock9
Name: dedicator of cytokinesis 9
Synonyms: Zizimin1, B230309H04Rik, D14Wsu89e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105445
Homologene: 41026
Erp44
Name: endoplasmic reticulum protein 44
Synonyms: Txndc4, 1110001E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76299
Homologene: 12638
Clic4
Name: chloride intracellular channel 4 (mitochondrial)
Synonyms: mtCLIC, D0Jmb3, mc3s5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 29876
Homologene: 8490
Arap2
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Synonyms: Centd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 212285
Homologene: 9064
Zgrf1
Name: zinc finger, GRF-type containing 1
Synonyms: 4930422G04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71643
Homologene: 34708
Mllt3
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3
Synonyms: 3830408D16Rik, 2610012I03Rik, Af9, 2210011H10Rik, D4Ertd321e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 70122
HGNC: HGNC:7136
Homologene: 37933
Pyroxd1
Name: pyridine nucleotide-disulphide oxidoreductase domain 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232491
Homologene: 11758
Pole
Name: polymerase (DNA directed), epsilon
Synonyms: pol-epsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18973
HGNC: HGNC:9177
Homologene: 4539
Chpf
Name: chondroitin polymerizing factor
Synonyms: 1700028N03Rik, D1Bwg1363e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74241
Homologene: 11574
Bcr
Name: BCR activator of RhoGEF and GTPase
Synonyms: breakpoint cluster region, 5133400C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 110279
VEGA: 10
HGNC: HGNC:1014
Homologene: 3192
Cdk2
Name: cyclin-dependent kinase 2
Synonyms: A630093N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12566
VEGA: 10
HGNC: HGNC:1771
Homologene: 74409
Timm50
Name: translocase of inner mitochondrial membrane 50
Synonyms: TIM50L, 2810403L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66525
Homologene: 57031
Gm14411
Name: predicted gene 14411
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 628239
Hibadh
Name: 3-hydroxyisobutyrate dehydrogenase
Synonyms: 6430402H10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 58875
HGNC: HGNC:4907
Homologene: 15088
Elane
Name: elastase, neutrophil expressed
Synonyms: F430011M15Rik, Ela2, NE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 50701
VEGA: 10
HGNC: HGNC:3309
Homologene: 20455
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hyrh, 1700034M11Rik, 4930545D19Rik, hy3, hy-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244653
Homologene: 52118
Ttn
Name: titin
Synonyms: 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, mdm, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru, connectin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Rasef
Name: RAS and EF hand domain containing
Synonyms: RAB45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242505
Homologene: 28424
Pik3c2g
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 18705
HGNC: HGNC:8973
Homologene: 3362
Plcz1
Name: phospholipase C, zeta 1
Synonyms: 1700041H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 114875
Homologene: 23815
Casc1
Name: cancer susceptibility candidate 1
Synonyms: Las1, A230084G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320662
Homologene: 41242
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20192
Homologene: 68151
Dennd5a
Name: DENN/MADD domain containing 5A
Synonyms: Rab6ip1, ORF37, 1500012B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19347
Homologene: 14584
Kcnj6
Name: potassium inwardly-rectifying channel, subfamily J, member 6
Synonyms: Kir3.2, GIRK2, KCNJ7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 16522
VEGA: 16
HGNC: HGNC:6267
Homologene: 1688
Rsph4a
Name: radial spoke head 4 homolog A (Chlamydomonas)
Synonyms: Rshl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 212892
Homologene: 71779
Dhx30
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 30
Synonyms: helG, 2810477H02Rik, Ddx30, C130058C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72831
Homologene: 15779
Zdhhc14
Name: zinc finger, DHHC domain containing 14
Synonyms: B530001K09Rik, New1cp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224454
VEGA: 17
Homologene: 62301
Fkbpl
Name: FK506 binding protein-like
Synonyms: WAF-1/CIP1 stabilizing protein 39, WISp39, DIR1, NG7, Ppiase-X
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56299
Homologene: 10529
Insyn2b
Name: inhibitory synaptic factor family member 2B
Synonyms: Gm6041, Fam196b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 574403
VEGA: 11
Homologene: 107175
Slc30a1
Name: solute carrier family 30 (zinc transporter), member 1
Synonyms: Znt1, C130040I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22782
Homologene: 6681
Or2w1b
Name: olfactory receptor family 2 subfamily W member 1B
Synonyms: MOR256-31, Olfr1369, GA_x6K02T2QHY8-12126170-12125935
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 404504
Thumpd2
Name: THUMP domain containing 2
Synonyms: 2810025A12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72167
VEGA: 17
Homologene: 11898
Ap5b1
Name: adaptor-related protein complex 5, beta 1 subunit
Synonyms: Gm962
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 381201
VEGA: 19
Homologene: 16299
Gm1968
Name: predicted gene 1968
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 328657
VEGA: 16
Cav2
Name: caveolin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12390
HGNC: HGNC:1528
Homologene: 942
Pex11b
Name: peroxisomal biogenesis factor 11 beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18632
HGNC: HGNC:8853
Homologene: 2852
Rgs13
Name: regulator of G-protein signaling 13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 246709
HGNC: HGNC:9995
Homologene: 14774
Spcs1
Name: signal peptidase complex subunit 1 homolog (S. cerevisiae)
Synonyms: 1810004F21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 69019
Homologene: 40915
Gm10015
Name: predicted gene 10015
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 100502680
Homologene: 138713
Rps15a-ps2
Name: ribosomal protein S15A, pseudogene 2
Synonyms: Gm5623
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 434460
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 75,477,416 bp
  • T to A, chromosome 1 at 144,139,584 bp
  • T to A, chromosome 1 at 191,909,753 bp
  • G to A, chromosome 2 at 76,895,803 bp
  • A to T, chromosome 2 at 112,775,841 bp
  • A to T, chromosome 2 at 177,125,820 bp
  • A to T, chromosome 3 at 88,930,989 bp
  • G to A, chromosome 3 at 96,643,913 bp
  • T to A, chromosome 3 at 127,601,165 bp
  • G to A, chromosome 4 at 8,752,653 bp
  • A to T, chromosome 4 at 48,211,704 bp
  • A to G, chromosome 4 at 73,771,328 bp
  • A to G, chromosome 4 at 87,840,927 bp
  • G to A, chromosome 4 at 135,217,135 bp
  • A to T, chromosome 5 at 62,683,419 bp
  • T to A, chromosome 5 at 104,175,886 bp
  • A to G, chromosome 5 at 110,332,488 bp
  • A to T, chromosome 6 at 17,287,065 bp
  • G to A, chromosome 6 at 52,557,812 bp
  • A to G, chromosome 6 at 139,622,123 bp
  • T to C, chromosome 6 at 140,028,452 bp
  • T to G, chromosome 6 at 142,361,991 bp
  • T to G, chromosome 6 at 145,196,892 bp
  • A to G, chromosome 7 at 28,308,167 bp
  • T to C, chromosome 7 at 80,766,959 bp
  • T to C, chromosome 7 at 109,897,962 bp
  • T to C, chromosome 7 at 116,164,238 bp
  • T to G, chromosome 8 at 61,364,282 bp
  • T to A, chromosome 8 at 110,538,372 bp
  • T to C, chromosome 9 at 110,093,135 bp
  • A to G, chromosome 10 at 33,908,236 bp
  • T to A, chromosome 10 at 75,166,085 bp
  • A to G, chromosome 10 at 79,887,036 bp
  • T to C, chromosome 10 at 128,703,988 bp
  • G to A, chromosome 11 at 34,402,788 bp
  • A to C, chromosome 13 at 21,116,267 bp
  • T to C, chromosome 14 at 31,000,117 bp
  • A to G, chromosome 14 at 121,653,060 bp
  • A to T, chromosome 16 at 29,958,799 bp
  • G to C, chromosome 16 at 94,832,453 bp
  • A to G, chromosome 17 at 5,493,546 bp
  • G to A, chromosome 17 at 34,645,329 bp
  • C to T, chromosome 17 at 81,026,777 bp
  • T to A, chromosome 19 at 5,569,098 bp
  • A to G, chromosome 19 at 28,742,547 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5359 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042938-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.