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Strain Name:
C57BL/6J-MtgxR5361Btlr/Mmmh
Stock Number:
042940-MU
Citation ID:
RRID:MMRRC_042940-MU
Other Names:
R5361 (G1), C57BL/6J-MtgxR5361Btlr
Major Collection:

Strain Information

Dnmt3a
Name: DNA methyltransferase 3A
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13435
HGNC: HGNC:2978
Homologene: 7294
Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Slc6a1
Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 1
Synonyms: XT-1, Gabt, Xtrp1, Gat1, Gabt1, GAT-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232333
Homologene: 2290
Thbs4
Name: thrombospondin 4
Synonyms: TSP-4, TSP4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21828
Homologene: 20691
Dop1b
Name: DOP1 leucine zipper like protein B
Synonyms: 0610038M01Rik, 2610510B01Rik, Dopey2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70028
VEGA: 16
HGNC: HGNC:1291
Homologene: 21068
Dtx4
Name: deltex 4, E3 ubiquitin ligase
Synonyms: RNF155
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 207521
VEGA: 19
Homologene: 27781
Trpm7
Name: transient receptor potential cation channel, subfamily M, member 7
Synonyms: 5033407O22Rik, 4833414K03Rik, CHAK1, CHAK, TRP-PLIK, Ltpr7, 2310022G15Rik, LTRPC7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 58800
Homologene: 9774
Med4
Name: mediator complex subunit 4
Synonyms: HSPC126, p36 TRAP/SMCC/PC2 subunit, DRIP36, 2410046H15Rik, MED4, TRAP36, Vdrip
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67381
VEGA: 14
Homologene: 8568
Nploc4
Name: NPL4 homolog, ubiquitin recognition factor
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217365
Homologene: 5403
Tbl1xr1
Name: transducin (beta)-like 1X-linked receptor 1
Synonyms: Ira1, TBLR1, DC42, C21, C230089I12Rik, A630076E03Rik, 8030499H02Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 81004
Homologene: 69382
Nefl
Name: neurofilament, light polypeptide
Synonyms: NF-L, CMT2E, NF68, Nfl
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18039
HGNC: HGNC:7739
Homologene: 4487
Dennd10
Name: DENN domain containing 10
Synonyms: 1810055E12Rik, Fam45a
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67894
Homologene: 10217
Afg3l2
Name: AFG3-like AAA ATPase 2
Synonyms: 2310036I02Rik, par, Emv66
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 69597
VEGA: 18
HGNC: HGNC:315
Homologene: 4947
Hsph1
Name: heat shock 105kDa/110kDa protein 1
Synonyms: hsp-E7I, HSP110, Hsp105, hsp110/105
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15505
Homologene: 21322
Zswim7
Name: zinc finger SWIM-type containing 7
Synonyms: 2410012H22Rik, SWS1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69747
Homologene: 15565
Xpot
Name: exportin, tRNA (nuclear export receptor for tRNAs)
Synonyms: EXPORTIN-T, C79645, 1110004L07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73192
VEGA: 10
Homologene: 38291
Mrpl15
Name: mitochondrial ribosomal protein L15
Synonyms: MRP-L7, Rpml7, HSPC145
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 27395
Homologene: 32210
Rps17
Name: ribosomal protein S17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20068
Homologene: 110867
Gm14496
Name: predicted gene 14496
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 672125
Homologene: 129606
Htt
Name: huntingtin
Synonyms: huntingtin, HD, htt, IT15, C430023I11Rik, Hdh
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15194
HGNC: HGNC:4851
Homologene: 1593
Tmbim6
Name: transmembrane BAX inhibitor motif containing 6
Synonyms: Tegt, Bax inhibitor 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110213
Homologene: 2419
Ddx20
Name: DEAD box helicase 20
Synonyms: GEMIN3, dp103, DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 53975
HGNC: HGNC:2743
Homologene: 5214
1700017B05Rik
Name: RIKEN cDNA 1700017B05 gene
Synonyms: D9Ertd278e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74211
VEGA: 9
Homologene: 19283
Smcr8
Name: Smith-Magenis syndrome chromosome region, candidate 8 homolog (human)
Synonyms: D030073L15Rik, 2310076G09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237782
Homologene: 16989
Cdh23
Name: cadherin related 23 (otocadherin)
Synonyms: 4930542A03Rik, USH1D, mdfw, ahl, nmf112, nmf181, nmf252, bob, sals
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22295
Homologene: 11142
Ltbr
Name: lymphotoxin B receptor
Synonyms: TNFRrp, TNF receptor-related protein, LT-beta receptor, LT beta-R, Tnfbr, Ltar, TNF-R-III, TNFCR, TNFR2-RP, LTbetaR, Tnfrsf3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17000
HGNC: HGNC:6718
Homologene: 1753
Aldob
Name: aldolase B, fructose-bisphosphate
Synonyms: Aldo-2, Aldo2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230163
HGNC: HGNC:417
Homologene: 20060
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: Zfh-4, C130041O22Rik, Zfh4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80892
Homologene: 23477
Col7a1
Name: collagen, type VII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12836
HGNC: HGNC:2214
Homologene: 73
Cul9
Name: cullin 9
Synonyms: 1810035I07Rik, Parc
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78309
Homologene: 56696
Ahnak
Name: AHNAK nucleoprotein
Synonyms: DY6, 2310047C17Rik, 1110004P15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
C4b
Name: complement C4B (Chido blood group)
Synonyms: Ss, C4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12268
Homologene: 36030
Dnm3
Name: dynamin 3
Synonyms: B230343F03Rik, 9630020E24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 103967
Homologene: 22906
Slc7a4
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 4
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224022
Homologene: 20883
Grm5
Name: glutamate receptor, metabotropic 5
Synonyms: mGluR5, Gprc1e, 6430542K11Rik, Glu5R
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108071
HGNC: HGNC:4597
Homologene: 37354
Zfp712
Name: zinc finger protein 712
Synonyms: 4921504N20Rik, mszf31, mszf89
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 78251
VEGA: 13
Homologene: 136296
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243369
Homologene: 45453
Lhcgr
Name: luteinizing hormone/choriogonadotropin receptor
Synonyms: Lhr, Gpcr19-rs1, LH-R
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16867
VEGA: 17
HGNC: HGNC:6585
Homologene: 37276
Trim10
Name: tripartite motif-containing 10
Synonyms: Herf1, Rnf9
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19824
Homologene: 4932
Vmn2r9
Name: vomeronasal 2, receptor 9
Synonyms: EG435864
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 435864
Homologene: 129606
Dsg1c
Name: desmoglein 1 gamma
Synonyms: Dsg6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 211924
HGNC: HGNC:3048
Serpinb3c
Name: serine (or cysteine) peptidase inhibitor, clade B, member 3C
Synonyms: 1110001H02Rik, 1110013A16Rik, ovalbumin, Serpinb4, Scca2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381286
Homologene: 131278
Hsdl2
Name: hydroxysteroid dehydrogenase like 2
Synonyms: 2610207I16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72479
Itih2
Name: inter-alpha trypsin inhibitor, heavy chain 2
Synonyms: Intin2, Itih-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16425
HGNC: HGNC:6167
Homologene: 1668
Pcdhb12
Name: protocadherin beta 12
Synonyms: Pcdhb5F, PcdhbL, Pcdh3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93883
HGNC: HGNC:8690
Homologene: 87126
Elovl4
Name: ELOVL fatty acid elongase 4
Synonyms: elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83603
Homologene: 41488
Fkbpl
Name: FK506 binding protein-like
Synonyms: Ppiase-X, NG7, DIR1, WISp39, WAF-1/CIP1 stabilizing protein 39
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56299
Homologene: 10529
Insyn2b
Name: inhibitory synaptic factor family member 2B
Synonyms: Gm6041, Fam196b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 574403
VEGA: 11
Homologene: 107175
Prss3
Name: serine protease 3
Synonyms: Tb, TRY4, MTG, mesotrypsin, Try3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22073
Homologene: 88408
Dbndd1
Name: dysbindin domain containing 1
Synonyms: D8Ertd590e, 2810427I04Rik, dysbindin (dystrobrevin binding protein 1) domain containing 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72185
Homologene: 11433
Synpo
Name: synaptopodin
Synonyms: 9330140I15Rik, 9030217H17Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 104027
Homologene: 5274
Slc26a3
Name: solute carrier family 26, member 3
Synonyms: Dra, 9030623B18Rik, 9130013M11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13487
HGNC: HGNC:3018
Homologene: 55435
Prr27
Name: proline rich 27
Synonyms: 4930432K09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73779
Homologene: 136277
Fbxo40
Name: F-box protein 40
Synonyms: 9830003A13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207215
Homologene: 9459
Or1o4
Name: olfactory receptor family 1 subfamily O member 4
Synonyms: MOR156-1, GA_x6K02T2PSCP-1720261-1719344, Olfr99
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258508
Homologene: 74030
Gpr156
Name: G protein-coupled receptor 156
Synonyms: Gababl
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239845
VEGA: 16
Homologene: 17683
Or6c66
Name: olfactory receptor family 6 subfamily C member 66
Synonyms: GA_x6K02T2PULF-11304679-11303744, MOR108-1, Olfr798
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258549
Homologene: 133881
Pstpip2
Name: proline-serine-threonine phosphatase-interacting protein 2
Synonyms: cmo
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 19201
VEGA: 18
HGNC: HGNC:9581
Homologene: 69150
Pcdha3
Name: protocadherin alpha 3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 192163
HGNC: HGNC:8669
Homologene: 129613
Pcdhga10
Name: protocadherin gamma subfamily A, 10
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93722
HGNC: HGNC:8697
Homologene: 49567
Rpl31-ps9
Name: ribosomal protein L31, pseudogene 9
Synonyms: Gm10191
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100042740
Gm5561
Name: predicted gene 5561
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 433941
Rps15a-ps7
Name: ribosomal protein S15A, pseudogene 7
Synonyms: Gm14166
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 100043843
Pigyl
Name: phosphatidylinositol glycan anchor biosynthesis, class Y-like
Synonyms: 1810008A14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66268
Homologene: 134660
Ccdc166
Name: coiled-coil domain containing 166
Synonyms: 2410075B13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223648
Homologene: 109421
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 4,782,673 bp
  • A to T, chromosome 1 at 107,276,931 bp
  • A to C, chromosome 1 at 129,801,558 bp
  • A to G, chromosome 1 at 162,010,902 bp
  • T to C, chromosome 1 at 179,520,662 bp
  • T to A, chromosome 2 at 10,096,461 bp
  • A to T, chromosome 2 at 126,829,241 bp
  • A to T, chromosome 2 at 152,185,447 bp
  • T to C, chromosome 2 at 175,131,578 bp
  • T to G, chromosome 2 at 182,000,354 bp
  • G to A, chromosome 3 at 5,399,207 bp
  • T to A, chromosome 3 at 22,192,069 bp
  • T to A, chromosome 3 at 105,683,509 bp
  • T to A, chromosome 4 at 49,539,831 bp
  • A to G, chromosome 4 at 59,592,301 bp
  • T to C, chromosome 5 at 34,907,584 bp
  • T to C, chromosome 5 at 87,843,344 bp
  • T to A, chromosome 5 at 108,848,063 bp
  • G to T, chromosome 5 at 149,631,459 bp
  • C to T, chromosome 6 at 41,373,846 bp
  • T to A, chromosome 6 at 48,466,313 bp
  • A to T, chromosome 6 at 70,699,027 bp
  • A to T, chromosome 6 at 114,302,532 bp
  • G to A, chromosome 6 at 125,312,794 bp
  • T to C, chromosome 7 at 81,342,755 bp
  • A to T, chromosome 7 at 88,074,496 bp
  • T to A, chromosome 8 at 123,506,745 bp
  • T to A, chromosome 9 at 22,157,996 bp
  • T to A, chromosome 9 at 57,257,185 bp
  • A to G, chromosome 9 at 83,790,101 bp
  • A to G, chromosome 9 at 108,963,224 bp
  • A to G, chromosome 10 at 60,657,265 bp
  • T to A, chromosome 10 at 121,600,860 bp
  • A to T, chromosome 10 at 129,625,732 bp
  • C to A, chromosome 11 at 21,997,037 bp
  • G to A, chromosome 11 at 34,402,788 bp
  • T to G, chromosome 11 at 60,778,292 bp
  • A to T, chromosome 11 at 62,267,547 bp
  • T to A, chromosome 11 at 120,384,563 bp
  • T to C, chromosome 12 at 3,895,643 bp
  • T to C, chromosome 12 at 31,450,981 bp
  • A to G, chromosome 13 at 67,041,015 bp
  • C to T, chromosome 13 at 92,776,993 bp
  • T to C, chromosome 14 at 68,084,639 bp
  • C to A, chromosome 14 at 73,510,113 bp
  • A to G, chromosome 15 at 75,981,020 bp
  • G to A, chromosome 15 at 99,405,752 bp
  • T to C, chromosome 16 at 17,575,052 bp
  • T to A, chromosome 16 at 36,969,552 bp
  • A to G, chromosome 16 at 38,005,725 bp
  • C to A, chromosome 16 at 93,770,504 bp
  • G to A, chromosome 17 at 34,645,329 bp
  • T to A, chromosome 17 at 34,741,238 bp
  • T to G, chromosome 17 at 36,875,436 bp
  • A to G, chromosome 17 at 37,279,610 bp
  • TTCCTCCTCCTCCTCCTCCTCCTC to TTCCTCCTCCTCCTCCTCCTC, chromosome 17 at 46,500,849 bp
  • T to A, chromosome 17 at 88,742,853 bp
  • T to C, chromosome 18 at 20,283,646 bp
  • T to G, chromosome 18 at 36,946,699 bp
  • T to A, chromosome 18 at 37,437,046 bp
  • T to C, chromosome 18 at 37,747,450 bp
  • C to A, chromosome 18 at 60,596,159 bp
  • G to T, chromosome 18 at 67,421,259 bp
  • A to G, chromosome 18 at 77,870,378 bp
  • T to A, chromosome 19 at 9,015,341 bp
  • A to G, chromosome 19 at 12,485,262 bp
  • A to G, chromosome 19 at 60,825,886 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5361 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042940-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.