Strain Name:
C57BL/6J-MtgxR5363Btlr/Mmmh
Stock Number:
042941-MU
Citation ID:
RRID:MMRRC_042941-MU
Other Names:
R5363 (G1), C57BL/6J-MtgxR5363Btlr
Major Collection:

Gene Information

Pkd1
Name: polycystin 1, transient receptor poteintial channel interacting
Synonyms: polycystin-1, PC1, PC-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Ap4e1
Name: adaptor-related protein complex AP-4, epsilon 1
Synonyms: 2310033A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 108011
HGNC: HGNC:573
Homologene: 22397
Dicer1
Name: dicer 1, ribonuclease type III
Synonyms: 1110006F08Rik, D12Ertd7e, Dicer1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 192119
VEGA: 12
Homologene: 13251
Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Ntmt1
Name: N-terminal Xaa-Pro-Lys N-methyltransferase 1
Synonyms: 2610205E22Rik, Mettl11a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66617
Homologene: 5439
Apod
Name: apolipoprotein D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 11815
HGNC: HGNC:612
Homologene: 1246
Lactb2
Name: lactamase, beta 2
Synonyms: E430032H21Rik, Cgi-83
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 212442
Homologene: 9349
Rock2
Name: Rho-associated coiled-coil containing protein kinase 2
Synonyms: Rock-II, B230113H15Rik, Rho-kinase, ROKalpha, Rock2m
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 19878
VEGA: 12
Homologene: 21010
Anapc1
Name: anaphase promoting complex subunit 1
Synonyms: tsg24, Apc1, 2610021O03Rik, Mcpr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17222
Homologene: 7414
Abca1
Name: ATP-binding cassette, sub-family A (ABC1), member 1
Synonyms: ABC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11303
HGNC: HGNC:29
Homologene: 21130
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 195018
Homologene: 9027
Afg3l2
Name: AFG3-like AAA ATPase 2
Synonyms: 2310036I02Rik, par, Emv66
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 69597
VEGA: 18
HGNC: HGNC:315
Homologene: 4947
Trappc10
Name: trafficking protein particle complex 10
Synonyms: LOC380642, B230307C21Rik, Tmem1, b2b2613Clo, b2b2416Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216131
VEGA: 10
Homologene: 37751
Hsph1
Name: heat shock 105kDa/110kDa protein 1
Synonyms: hsp-E7I, HSP110, Hsp105, hsp110/105
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15505
Homologene: 21322
Thbs1
Name: thrombospondin 1
Synonyms: TSP1, TSP-1, Thbs-1, tbsp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 21825
Homologene: 31142
Bcan
Name: brevican
Synonyms: Cspg7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12032
Homologene: 7244
Syt14
Name: synaptotagmin XIV
Synonyms: B230320I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329324
Homologene: 17719
Prune2
Name: prune homolog 2
Synonyms: 6330414G02Rik, A330102H22Rik, A230083H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 353211
VEGA: 19
Homologene: 18939
Rasa1
Name: RAS p21 protein activator 1
Synonyms: p120-rasGAP, Gap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218397
HGNC: HGNC:9871
Homologene: 2168
Tenm3
Name: teneurin transmembrane protein 3
Synonyms: Ten-m3, 2610100B16Rik, Odz3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 23965
Homologene: 22673
Cpsf3
Name: cleavage and polyadenylation specificity factor 3
Synonyms: 73 kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 54451
VEGA: 12
HGNC: HGNC:2326
Homologene: 6499
Cwc22
Name: CWC22 spliceosome-associated protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 80744
Homologene: 6048
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269700
Homologene: 28297
Ccl2
Name: chemokine (C-C motif) ligand 2
Synonyms: monocyte chemotactic protein, MCP-1, monocyte chemoattractant protein-1, Sigje, Scya2, MCP1, HC11, SMC-CF, MCAF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20296
Homologene: 2241
Ltbr
Name: lymphotoxin B receptor
Synonyms: TNFRrp, TNF receptor-related protein, LT-beta receptor, LT beta-R, Tnfbr, Ltar, TNF-R-III, TNFCR, TNFR2-RP, LTbetaR, Tnfrsf3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17000
HGNC: HGNC:6718
Homologene: 1753
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268379
Homologene: 27991
Ciita
Name: class II transactivator
Synonyms: C2ta, Gm9475
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12265
VEGA: 16
HGNC: HGNC:7067
Homologene: 207
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26875
Homologene: 69111
Elf3
Name: E74-like factor 3
Synonyms: jen, ESX, ESE-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13710
HGNC: HGNC:3318
Homologene: 3265
Tet3
Name: tet methylcytosine dioxygenase 3
Synonyms: D230004J03Rik, B430006D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 194388
Homologene: 35360
Clspn
Name: claspin
Synonyms: E130314M08Rik, C85083
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269582
Homologene: 11138
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329628
Homologene: 14377
Bche
Name: butyrylcholinesterase
Synonyms: C730038G20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12038
HGNC: HGNC:983
Homologene: 20065
Rnpepl1
Name: arginyl aminopeptidase (aminopeptidase B)-like 1
Synonyms: 1110014H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 108657
Homologene: 36367
Zxdc
Name: ZXD family zinc finger C
Synonyms: B930086F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 80292
Homologene: 82340
Cstdc1
Name: cystatin domain containing 1
Synonyms: cystatin SC, 8030411F24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 78609
Homologene: 128710
Cdh4
Name: cadherin 4
Synonyms: Rcad, R-cadherin, R-Cadh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12561
HGNC: HGNC:1763
Homologene: 48044
Trp63
Name: transformation related protein 63
Synonyms: KET protein, p63, p73L, Trp53rp1, TAp63, p51/p63, deltaNp63
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 22061
Homologene: 31189
Zyg11a
Name: zyg-11 family member A, cell cycle regulator
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230590
Homologene: 66294
Rin3
Name: Ras and Rab interactor 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217835
Homologene: 11748
Notch4
Name: notch 4
Synonyms: Int-3, Int3, N4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18132
HGNC: HGNC:7884
Homologene: 3351
Sun1
Name: Sad1 and UNC84 domain containing 1
Synonyms: 4632417G13Rik, 5730434D03Rik, Unc84a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 77053
Homologene: 11544
Olfr763
Name: olfactory receptor 763
Synonyms: GA_x6K02T2PULF-10696986-10697915, MOR269-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258861
Homologene: 85121
Slc34a1
Name: solute carrier family 34 (sodium phosphate), member 1
Synonyms: renal Na+/Pi transporter, Na/Pi cotransporter, Slc17a2, Npt2, NaPi-IIa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20505
VEGA: 13
Homologene: 20663
Arrdc5
Name: arrestin domain containing 5
Synonyms: 1700013E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 76920
VEGA: 17
Homologene: 66277
Fkbpl
Name: FK506 binding protein-like
Synonyms: Ppiase-X, NG7, DIR1, WISp39, WAF-1/CIP1 stabilizing protein 39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56299
Homologene: 10529
Insyn2b
Name: inhibitory synaptic factor family member 2B
Synonyms: Gm6041, Fam196b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 574403
VEGA: 11
Homologene: 107175
Gm8775
Name: predicted gene 8775
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 100417855
Slco2a1
Name: solute carrier organic anion transporter family, member 2a1
Synonyms: Pgt, 2310021C19Rik, mPgt, Slc21a2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 24059
Homologene: 38077
Zfy2
Name: zinc finger protein 2, Y-linked
Synonyms: Zfy-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 22768
Homologene: 56456
Zfp446
Name: zinc finger protein 446
Synonyms: A630035I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269870
Homologene: 9910
Btbd6
Name: BTB (POZ) domain containing 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 399566
VEGA: 12
Homologene: 41967
Myg1
Name: melanocyte proliferating gene 1
Synonyms: Gamm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 60315
Homologene: 5853
Tmem41b
Name: transmembrane protein 41B
Synonyms: 1500031M19Rik, D7Ertd70e, 1500015G02Rik, D7Ertd743e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233724
Homologene: 42740
R3hdm4
Name: R3H domain containing 4
Synonyms: C030046I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 109284
VEGA: 10
Homologene: 16343
Adck5
Name: aarF domain containing kinase 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 268822
Homologene: 34378
Spink11
Name: serine peptidase inhibitor, Kazal type 11
Synonyms: 9230112K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 433181
Homologene: 128818
Cyp2a22
Name: cytochrome P450, family 2, subfamily a, polypeptide 22
Synonyms: EG233005
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233005
Homologene: 69128
Olfr1167
Name: olfactory receptor 1167
Synonyms: GA_x6K02T2Q125-49641892-49640942, MOR174-16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258291
Homologene: 138307
B430218F22Rik
Name: RIKEN cDNA B430218F22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
AC146980.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 13,630,132 bp
  • G to A, chromosome 1 at 92,918,026 bp
  • A to G, chromosome 1 at 135,257,249 bp
  • T to A, chromosome 1 at 192,930,663 bp
  • A to G, chromosome 2 at 30,820,648 bp
  • ATCTCTCTCTCTCTCTCT to ATCTCTCTCTCTCTCT, chromosome 2 at 77,929,459 bp
  • A to T, chromosome 2 at 88,149,802 bp
  • A to T, chromosome 2 at 118,122,666 bp
  • G to A, chromosome 2 at 127,037,864 bp
  • A to G, chromosome 2 at 128,650,194 bp
  • G to T, chromosome 2 at 148,783,378 bp
  • A to G, chromosome 2 at 179,886,763 bp
  • A to G, chromosome 3 at 4,212,006 bp
  • A to G, chromosome 3 at 38,888,005 bp
  • T to A, chromosome 3 at 40,801,984 bp
  • A to G, chromosome 3 at 73,700,639 bp
  • A to G, chromosome 3 at 87,995,487 bp
  • A to G, chromosome 4 at 53,132,963 bp
  • A to G, chromosome 4 at 108,189,622 bp
  • A to G, chromosome 4 at 126,561,786 bp
  • A to G, chromosome 5 at 14,669,410 bp
  • T to C, chromosome 5 at 121,310,603 bp
  • A to G, chromosome 5 at 139,234,743 bp
  • G to T, chromosome 5 at 149,631,459 bp
  • A to T, chromosome 6 at 83,376,764 bp
  • A to G, chromosome 6 at 90,382,146 bp
  • G to A, chromosome 6 at 125,312,794 bp
  • G to A, chromosome 7 at 12,978,057 bp
  • T to A, chromosome 7 at 26,936,433 bp
  • G to A, chromosome 7 at 109,976,701 bp
  • T to C, chromosome 8 at 48,287,831 bp
  • A to T, chromosome 9 at 103,070,263 bp
  • A to G, chromosome 10 at 78,188,840 bp
  • C to T, chromosome 10 at 79,912,458 bp
  • C to A, chromosome 10 at 129,011,914 bp
  • T to C, chromosome 11 at 9,277,035 bp
  • C to A, chromosome 11 at 21,997,037 bp
  • G to A, chromosome 11 at 34,402,788 bp
  • T to A, chromosome 11 at 72,924,747 bp
  • T to A, chromosome 11 at 82,037,148 bp
  • T to C, chromosome 12 at 16,965,654 bp
  • T to A, chromosome 12 at 21,308,985 bp
  • G to A, chromosome 12 at 102,325,834 bp
  • A to G, chromosome 12 at 104,703,151 bp
  • A to G, chromosome 12 at 112,978,136 bp
  • A to G, chromosome 13 at 55,403,268 bp
  • T to C, chromosome 13 at 55,412,290 bp
  • G to T, chromosome 13 at 85,288,555 bp
  • A to G, chromosome 13 at 118,387,162 bp
  • A to G, chromosome 15 at 76,589,244 bp
  • T to C, chromosome 15 at 102,337,824 bp
  • C to T, chromosome 16 at 10,512,167 bp
  • C to A, chromosome 16 at 25,863,718 bp
  • T to C, chromosome 16 at 31,311,091 bp
  • T to A, chromosome 17 at 24,565,073 bp
  • C to T, chromosome 17 at 34,587,123 bp
  • G to A, chromosome 17 at 34,645,329 bp
  • C to T, chromosome 17 at 56,300,138 bp
  • T to C, chromosome 18 at 44,195,686 bp
  • G to T, chromosome 18 at 67,421,259 bp
  • A to T, chromosome 19 at 17,118,266 bp
  • C to T, chromosome Y at 2,106,555 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5363 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042941-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.