Strain Name:
C57BL/6J-MtgxR5383Btlr/Mmmh
Stock Number:
042958-MU
Citation ID:
RRID:MMRRC_042958-MU
Other Names:
R5383 (G1), C57BL/6J-MtgxR5383Btlr
Major Collection:

Gene Information

Pkd1
Name: polycystin 1, transient receptor poteintial channel interacting
Synonyms: polycystin-1, PC1, PC-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Acvr1c
Name: activin A receptor, type IC
Synonyms: Alk-7, ALK7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269275
Homologene: 26724
Otx1
Name: orthodenticle homeobox 1
Synonyms: jv, A730044F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Tfap2b
Name: transcription factor AP-2 beta
Synonyms: Tcfap2b, E130018K07Rik, AP-2(beta)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21419
Homologene: 20688
Pkp4
Name: plakophilin 4
Synonyms: p0071, 5031422I09Rik, Armrp, 9430019K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227937
HGNC: HGNC:9026
Homologene: 2689
Sptan1
Name: spectrin alpha, non-erythrocytic 1
Synonyms: alpha-fodrin, alphaII-spectrin, Spna2, Spna-2, 2610027H02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20740
Homologene: 2353
Abl2
Name: v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)
Synonyms: Arg, Abll
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11352
HGNC: HGNC:77
Homologene: 5278
Ano6
Name: anoctamin 6
Synonyms: F730003B03Rik, Tmem16f, 2900059G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105722
VEGA: 15
Homologene: 27888
Specc1l
Name: sperm antigen with calponin homology and coiled-coil domains 1-like
Synonyms: 4930470P14Rik, Specc1l, 9530057A13Rik, Cytsa, 4932439K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 74392
VEGA: 10
Homologene: 15610
Tdrd3
Name: tudor domain containing 3
Synonyms: 4732418C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219249
Homologene: 12771
Dmbx1
Name: diencephalon/mesencephalon homeobox 1
Synonyms: Dmbx1, Mbx, Otx3, Atx, Cdmx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 140477
Homologene: 15639
Trim23
Name: tripartite motif-containing 23
Synonyms: Arfd1, 6330516O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 81003
HGNC: HGNC:660
Homologene: 1251
Taf2
Name: TATA-box binding protein associated factor 2
Synonyms: CIF150, TAFII150, 150kDa, TAF2B, 4732460C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 319944
VEGA: 15
Homologene: 31137
Cyfip2
Name: cytoplasmic FMR1 interacting protein 2
Synonyms: 6430511D02Rik, 1500004I01Rik, Pir121
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76884
Homologene: 7936
Rpf1
Name: ribosome production factor 1 homolog
Synonyms: 2310066N05Rik, 2210420E24Rik, Bxdc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 70285
Homologene: 68728
Tmem43
Name: transmembrane protein 43
Synonyms: LUMA, 1200015A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74122
Homologene: 11532
Cdhr1
Name: cadherin-related family member 1
Synonyms: Pcdh21, Prcad
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 170677
VEGA: 14
Homologene: 13215
Dennd1b
Name: DENN/MADD domain containing 1B
Synonyms: 4930467M19Rik, 6820401H01Rik, F730008N07Rik, 4632404N19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329260
Homologene: 11739
Ddi2
Name: DNA-damage inducible protein 2
Synonyms: 1700027M01Rik, 1110056G13Rik, 9130022E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68817
Homologene: 121661
Muc2
Name: mucin 2
Synonyms: 2010015E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17831
HGNC: HGNC:7512
Homologene: 136755
Zfp451
Name: zinc finger protein 451
Synonyms: 4930515K21Rik, Kiaa0576-hp, 4933435G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98403
Homologene: 9188
Lsm14a
Name: LSM14A mRNA processing body assembly factor
Synonyms: Tral, 2700023B17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67070
Homologene: 40537
Dmpk
Name: dystrophia myotonica-protein kinase
Synonyms: DM, Dm15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13400
HGNC: HGNC:2933
Homologene: 3247
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: b2b1279Clo, Dnahc11, b2b598Clo, lrd, b2b1727Clo, b2b1203Clo, b2b1289Clo, avc4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Dpysl3
Name: dihydropyrimidinase-like 3
Synonyms: CRMP-4, Ulip1, TUC4, Ulip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 22240
HGNC: HGNC:3015
Homologene: 20361
Olfr1484
Name: olfactory receptor 1484
Synonyms: MOR202-37, GA_x6K02T2RE5P-3917859-3918806
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258288
Homologene: 110492
Zfp637
Name: zinc finger protein 637
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232337
Homologene: 5069
Cdh5
Name: cadherin 5
Synonyms: CD144, VEC, VECD, 7B4/cadherin-5, VE-cadherin, VEcad, VE-Cad
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12562
HGNC: HGNC:1764
Homologene: 1359
Cacna1d
Name: calcium channel, voltage-dependent, L type, alpha 1D subunit
Synonyms: Cchl1a2, 8430418G19Rik, D-LTCC, Cchl1a, C79217, Cav1.3alpha1, Cacnl1a2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12289
VEGA: 14
HGNC: HGNC:1391
Homologene: 578
1700010I14Rik
Name: RIKEN cDNA 1700010I14 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66931
Homologene: 49841
D130043K22Rik
Name: RIKEN cDNA D130043K22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 210108
Homologene: 8878
Scap
Name: SREBF chaperone
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235623
Homologene: 8160
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217843
Homologene: 41397
Impg2
Name: interphotoreceptor matrix proteoglycan 2
Synonyms: Spacrcan, PG10.2, IPM200
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224224
Homologene: 9439
Phf8-ps
Name: PHD finger protein 8, pseudogene
Synonyms: 4921501E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74042
VEGA: 17
Homologene: 66275
Ptprt
Name: protein tyrosine phosphatase, receptor type, T
Synonyms: RPTPrho
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19281
HGNC: HGNC:9682
Homologene: 56924
Pitrm1
Name: pitrilysin metallepetidase 1
Synonyms: 2310012C15Rik, MP-1, Ntup1, PreP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69617
VEGA: 13
Homologene: 5742
Olfr741
Name: olfactory receptor 741
Synonyms: MOR106-15, GA_x6K02T2PMLR-6197851-6198786, MOR106-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258233
C1s1
Name: complement component 1, s subcomponent 1
Synonyms: C1s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 50908
HGNC: HGNC:1247
Homologene: 1314
Adck1
Name: aarF domain containing kinase 1
Synonyms: 2610005A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 72113
VEGA: 12
Homologene: 6493
Ppp4r4
Name: protein phosphatase 4, regulatory subunit 4
Synonyms: 8430415E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 74521
Homologene: 12571
Ctdnep1
Name: CTD nuclear envelope phosphatase 1
Synonyms: 2610507E10Rik, Dullard
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67181
Homologene: 9100
AW551984
Name: expressed sequence AW551984
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244810
Ttbk1
Name: tau tubulin kinase 1
Synonyms: C330008L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106763
VEGA: 17
Homologene: 50342
Itprid1
Name: ITPR interacting domain containing 1
Synonyms: D530004J12Rik, Ccdc129
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232016
Homologene: 52344
Kcnh1
Name: potassium voltage-gated channel, subfamily H (eag-related), member 1
Synonyms: ether a go-go, Kv10.1, Eag1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16510
HGNC: HGNC:6250
Homologene: 68242
Zfp563
Name: zinc finger protein 563
Synonyms: Zfp413, zinc finger protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240068
Homologene: 77346
Srrm4
Name: serine/arginine repetitive matrix 4
Synonyms: B230202K19Rik, flopsy, bv, nSR100, 1500001A10Rik, fp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68955
Homologene: 49869
Zfp618
Name: zinc finger protein 618
Synonyms: Nedd10, 2810031P15Rik, D430033D05Rik, 2810040O04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72701
Homologene: 18975
Disc1
Name: disrupted in schizophrenia 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244667
HGNC: HGNC:2888
Homologene: 10257
Aadac
Name: arylacetamide deacetylase
Synonyms: Aada, 5033417E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67758
HGNC: HGNC:17
Homologene: 37436
Hook3
Name: hook microtubule tethering protein 3
Synonyms: E330005F07Rik, 5830454D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 320191
Homologene: 13022
Inf2
Name: inverted formin, FH2 and WH2 domain containing
Synonyms: EG629699, 2610204M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 70435
VEGA: 12
Homologene: 82406
Olfr1246
Name: olfactory receptor 1246
Synonyms: GA_x6K02T2Q125-51034790-51033846, MOR231-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258788
Homologene: 74246
Sp110
Name: Sp110 nuclear body protein
Synonyms: 5031415C07Rik, Ifi75, 5830484A20Rik, 52kDa, Ipr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 109032
HGNC: HGNC:5401
Homologene: 82192
Fam98a
Name: family with sequence similarity 98, member A
Synonyms: 2810405J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72722
Homologene: 41042
Olfr780
Name: olfactory receptor 780
Synonyms: GA_x6K02T2PULF-11002360-11003298, MOR114-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258281
Homologene: 133586
Cdk5rap1
Name: CDK5 regulatory subunit associated protein 1
Synonyms: 2310066P17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66971
Homologene: 9502
Smpd2
Name: sphingomyelin phosphodiesterase 2, neutral
Synonyms: nSMase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 20598
Homologene: 31129
Nim1k
Name: NIM1 serine/threonine protein kinase
Synonyms: Nim1, E130304F04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 245269
VEGA: 13
Homologene: 25286
Igkv4-80
Name: immunoglobulin kappa variable 4-80
Synonyms: Gm16729
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 545848
Gm28036
Name: predicted gene, 28036
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Trav9-1
Name: T cell receptor alpha variable 9-1
Synonyms: Gm13947
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 627324
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 19,226,498 bp
  • A to C, chromosome 1 at 33,813,806 bp
  • TC to TCC, chromosome 1 at 85,591,569 bp
  • A to G, chromosome 1 at 139,167,671 bp
  • G to A, chromosome 1 at 156,642,232 bp
  • G to A, chromosome 1 at 192,505,691 bp
  • T to A, chromosome 2 at 30,011,328 bp
  • T to C, chromosome 2 at 58,287,735 bp
  • T to A, chromosome 2 at 59,310,273 bp
  • T to C, chromosome 2 at 89,591,113 bp
  • A to T, chromosome 2 at 154,350,835 bp
  • G to T, chromosome 2 at 156,103,365 bp
  • T to A, chromosome 2 at 161,698,049 bp
  • T to C, chromosome 3 at 60,036,075 bp
  • T to C, chromosome 3 at 146,519,391 bp
  • G to A, chromosome 4 at 63,095,492 bp
  • A to G, chromosome 4 at 115,918,145 bp
  • A to G, chromosome 4 at 141,684,852 bp
  • T to C, chromosome 5 at 116,471,260 bp
  • T to A, chromosome 6 at 55,978,290 bp
  • A to C, chromosome 6 at 69,016,665 bp
  • G to A, chromosome 6 at 91,473,890 bp
  • G to T, chromosome 6 at 117,843,309 bp
  • T to C, chromosome 6 at 124,534,401 bp
  • C to G, chromosome 7 at 19,088,019 bp
  • C to T, chromosome 7 at 34,389,364 bp
  • T to C, chromosome 7 at 141,753,719 bp
  • C to A, chromosome 8 at 26,118,989 bp
  • A to G, chromosome 8 at 104,137,847 bp
  • A to G, chromosome 8 at 125,135,457 bp
  • T to A, chromosome 9 at 39,590,698 bp
  • G to T, chromosome 9 at 110,374,529 bp
  • C to T, chromosome 10 at 41,488,702 bp
  • T to A, chromosome 10 at 75,246,705 bp
  • A to G, chromosome 10 at 129,322,336 bp
  • C to A, chromosome 11 at 21,997,037 bp
  • T to C, chromosome 11 at 46,278,091 bp
  • T to A, chromosome 11 at 69,984,396 bp
  • T to C, chromosome 12 at 88,455,603 bp
  • A to G, chromosome 12 at 103,104,627 bp
  • T to C, chromosome 12 at 103,584,168 bp
  • T to A, chromosome 12 at 112,600,145 bp
  • T to C, chromosome 12 at 118,085,697 bp
  • T to A, chromosome 13 at 6,577,432 bp
  • G to A, chromosome 13 at 24,857,414 bp
  • T to G, chromosome 13 at 104,198,697 bp
  • C to T, chromosome 13 at 119,727,799 bp
  • T to A, chromosome 14 at 30,045,279 bp
  • C to T, chromosome 14 at 37,089,007 bp
  • T to A, chromosome 14 at 50,486,052 bp
  • T to A, chromosome 14 at 53,488,376 bp
  • C to T, chromosome 14 at 87,480,791 bp
  • A to G, chromosome 15 at 55,049,419 bp
  • A to G, chromosome 15 at 95,916,037 bp
  • A to G, chromosome 16 at 56,243,626 bp
  • A to T, chromosome 17 at 8,992,700 bp
  • T to C, chromosome 17 at 24,574,375 bp
  • T to C, chromosome 17 at 33,065,257 bp
  • T to A, chromosome 17 at 33,104,707 bp
  • T to C, chromosome 17 at 46,467,416 bp
  • C to T, chromosome 17 at 75,538,581 bp
  • A to T, chromosome 18 at 43,438,038 bp
  • T to A, chromosome 19 at 13,586,075 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5383 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042958-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.