Strain Name:
C57BL/6J-MtgxR5390Btlr/Mmmh
Stock Number:
042962-MU
Citation ID:
RRID:MMRRC_042962-MU
Other Names:
R5390 (G1), C57BL/6J-MtgxR5390Btlr
Major Collection:

Gene Information

Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, Acf7, trabeculin alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 11426
Homologene: 136191
Hmgn3
Name: high mobility group nucleosomal binding domain 3
Synonyms: 1110002A15Rik, HMGN3a, HMGN3b, 6330514M13Rik, TRIP7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 94353
Ufc1
Name: ubiquitin-fold modifier conjugating enzyme 1
Synonyms: ESTM29, 1110021H02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 66155
Homologene: 9500
Anxa4
Name: annexin A4
Synonyms: AIV, Anx4, Xanx-4, annexin IV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 11746
HGNC: HGNC:542
Homologene: 68164
Net1
Name: neuroepithelial cell transforming gene 1
Synonyms: Net1 homolog, mNET1, 9530071N24Rik, 0610025H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 56349
VEGA: 13
Homologene: 4283
Glcci1
Name: glucocorticoid induced transcript 1
Synonyms: GIG18, A130036A18Rik, 2310047L21Rik, Tssn1, Fam117c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 170772
Homologene: 15773
Senp7
Name: SUMO1/sentrin specific peptidase 7
Synonyms: 2900036C23Rik, 6030449K19Rik, 2410152H17Rik, 2810413I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 66315
Homologene: 10778
Ddx19a
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 19a
Synonyms: Ddx19, DBP5, Eif4a-rs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 13680
Homologene: 5240
Usp34
Name: ubiquitin specific peptidase 34
Synonyms: Murr2, A530081C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17847
Homologene: 40978
Stk3
Name: serine/threonine kinase 3
Synonyms: Mst2, MST, 0610042I06Rik, mess1, Ste20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 56274
Homologene: 48420
Rag1
Name: recombination activating 1
Synonyms: Rag-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 19373
HGNC: HGNC:9831
Homologene: 387
Grm4
Name: glutamate receptor, metabotropic 4
Synonyms: Gprc1d, mGluR4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 268934
HGNC: HGNC:4596
Homologene: 20230
Clec4g
Name: C-type lectin domain family 4, member g
Synonyms: 4930572L20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 75863
Homologene: 18879
Ms4a4d
Name: membrane-spanning 4-domains, subfamily A, member 4D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 66607
Homologene: 113790
Pwp2
Name: PWP2 periodic tryptophan protein homolog (yeast)
Synonyms: 6530411D08Rik, Pwp2, Pwp2h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 110816
VEGA: 10
HGNC: HGNC:9711
Homologene: 3702
Kctd10
Name: potassium channel tetramerisation domain containing 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 330171
Homologene: 32652
Zfp653
Name: zinc finger protein 653
Synonyms: E430039K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 319601
VEGA: 9
Homologene: 16346
Cachd1
Name: cache domain containing 1
Synonyms: B430218L07Rik, Vwcd1, 1190007F10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 320508
Homologene: 10854
Gpx3
Name: glutathione peroxidase 3
Synonyms: GPx, EGPx, extracellular GPx, plasma GPx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 14778
HGNC: HGNC:4555
Homologene: 20480
Fbxw9
Name: F-box and WD-40 domain protein 9
Synonyms: Fbw9, 1110017H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 68628
Homologene: 23598
Pigo
Name: phosphatidylinositol glycan anchor biosynthesis, class O
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 56703
Homologene: 31761
Slc45a2
Name: solute carrier family 45, member 2
Synonyms: Oca4, bls, Matp, Aim1, Dbr, blanc-sale, Aim-1, dominant brown
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 22293
Homologene: 9412
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: 4930545D19Rik, hy-3, hy3, 1700034M11Rik, hyrh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 244653
Homologene: 52118
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Ttc30a2
Name: tetratricopeptide repeat domain 30A2
Synonyms: OTTMUSG00000015167
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 620631
Homologene: 44342
Hrc
Name: histidine rich calcium binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 15464
HGNC: HGNC:5178
Homologene: 137234
Nlrp2
Name: NLR family, pyrin domain containing 2
Synonyms: Nalp2, PYPAF2, E330007A02Rik, Pan1, Nbs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 232827
Homologene: 56789
Pcyox1l
Name: prenylcysteine oxidase 1 like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 240334
Homologene: 23429
Sorbs2
Name: sorbin and SH3 domain containing 2
Synonyms: 2010203O03Rik, 9430041O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234214
Homologene: 83295
Megf8
Name: multiple EGF-like-domains 8
Synonyms: Egfl4, b2b1702Clo, m687Ddg, b2b288Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 269878
HGNC: HGNC:3233
Homologene: 15988
Pla2r1
Name: phospholipase A2 receptor 1
Synonyms: M-type receptor, Pla2g1br, PLA2-I receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 18779
HGNC: HGNC:9042
Homologene: 32016
Pstpip1
Name: proline-serine-threonine phosphatase-interacting protein 1
Synonyms: def-2, CD2BP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 19200
HGNC: HGNC:9580
Homologene: 37867
Eml6
Name: echinoderm microtubule associated protein like 6
Synonyms: 2900083P10Rik, C230094A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237711
Homologene: 104282
H2-M10.4
Name: histocompatibility 2, M region locus 10.4
Synonyms: 15H
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224753
Homologene: 117973
Gpnmb
Name: glycoprotein (transmembrane) nmb
Synonyms: Osteoactivin, Dchil, DC-HIL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 93695
HGNC: HGNC:4462
Homologene: 1880
Hsd17b6
Name: hydroxysteroid (17-beta) dehydrogenase 6
Synonyms: 17betaHSD9, Hsd17b9, Rdh8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 27400
VEGA: 10
Homologene: 20811
Pla2g6
Name: phospholipase A2, group VI
Synonyms: iPLA2, iPLA2beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 53357
HGNC: HGNC:9039
Homologene: 2635
Ltv1
Name: LTV1 ribosome biogenesis factor
Synonyms: 2610020N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 353258
VEGA: 10
Homologene: 6338
Atg16l2
Name: autophagy related 16-like 2 (S. cerevisiae)
Synonyms: 2410118P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 73683
Homologene: 18981
Olfr1437
Name: olfactory receptor 1437
Synonyms: GA_x6K02T2RE5P-2658227-2657289, MOR214-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258117
Homologene: 83129
Ints5
Name: integrator complex subunit 5
Synonyms: 1110055N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 109077
Homologene: 35303
Vnn3
Name: vanin 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 26464
Homologene: 48295
Cyp21a1
Name: cytochrome P450, family 21, subfamily a, polypeptide 1
Synonyms: 21OH, 21-OH, Oh21-1, Cyp21, 21OHA, Oh21-1, 21-hydroxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 13079
Homologene: 68063
Olfr3
Name: olfactory receptor 3
Synonyms: Y71, MOR136-14, GA_x6K02T2NLDC-33507606-33506665
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 18328
HGNC: HGNC:8208
Homologene: 66579
Fam161b
Name: family with sequence similarity 161, member B
Synonyms: 9830169C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217705
Homologene: 17581
5830454E08Rik
Name: RIKEN cDNA 5830454E08 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 76100
VEGA: 9
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 171,290,173 bp
  • C to T, chromosome 2 at 36,812,432 bp
  • A to T, chromosome 2 at 60,420,362 bp
  • A to T, chromosome 2 at 75,977,286 bp
  • T to C, chromosome 2 at 76,710,051 bp
  • T to C, chromosome 2 at 101,642,734 bp
  • A to G, chromosome 4 at 43,019,645 bp
  • T to A, chromosome 4 at 100,981,006 bp
  • A to G, chromosome 4 at 123,471,753 bp
  • A to G, chromosome 5 at 114,365,703 bp
  • A to T, chromosome 6 at 8,537,835 bp
  • A to T, chromosome 6 at 49,047,841 bp
  • G to A, chromosome 6 at 86,753,883 bp
  • T to C, chromosome 7 at 5,300,909 bp
  • G to A, chromosome 7 at 25,340,289 bp
  • T to A, chromosome 7 at 45,335,485 bp
  • C to T, chromosome 7 at 101,290,344 bp
  • C to A, chromosome 8 at 3,718,441 bp
  • A to G, chromosome 8 at 45,819,741 bp
  • A to G, chromosome 8 at 85,060,178 bp
  • A to T, chromosome 8 at 110,595,467 bp
  • G to A, chromosome 8 at 110,980,631 bp
  • C to A, chromosome 9 at 22,057,803 bp
  • A to G, chromosome 9 at 56,128,744 bp
  • A to G, chromosome 9 at 83,112,295 bp
  • T to C, chromosome 9 at 120,577,706 bp
  • G to A, chromosome 10 at 13,182,359 bp
  • T to A, chromosome 10 at 23,851,585 bp
  • T to C, chromosome 10 at 78,177,771 bp
  • T to A, chromosome 10 at 127,991,439 bp
  • T to A, chromosome 11 at 23,444,202 bp
  • T to C, chromosome 11 at 29,760,096 bp
  • A to T, chromosome 11 at 54,909,549 bp
  • C to T, chromosome 12 at 84,348,634 bp
  • C to T, chromosome 13 at 3,893,379 bp
  • C to T, chromosome 15 at 11,027,785 bp
  • T to A, chromosome 15 at 35,114,560 bp
  • A to T, chromosome 15 at 79,289,693 bp
  • A to G, chromosome 16 at 56,169,916 bp
  • C to T, chromosome 17 at 27,434,738 bp
  • T to A, chromosome 17 at 34,802,264 bp
  • T to A, chromosome 17 at 36,460,641 bp
  • T to C, chromosome 18 at 61,699,362 bp
  • T to A, chromosome 19 at 8,896,567 bp
  • T to C, chromosome 19 at 11,548,640 bp
  • T to A, chromosome 19 at 12,322,141 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5390 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042962-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.