Strain Name:
C57BL/6J-MtgxR5410Btlr/Mmmh
Stock Number:
042979-MU
Citation ID:
RRID:MMRRC_042979-MU
Other Names:
R5410 (G1), C57BL/6J-MtgxR5410Btlr
Major Collection:

Gene Information

Adamts20
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20
Synonyms: ADAMTS-20, bt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223838
Homologene: 11808
Cdon
Name: cell adhesion molecule-related/down-regulated by oncogenes
Synonyms: CDO, CAM-related/down-regulated by oncogenes
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 57810
Homologene: 22996
Rc3h1
Name: RING CCCH (C3H) domains 1
Synonyms: roquin, 5730557L09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381305
Homologene: 19036
Pomt1
Name: protein-O-mannosyltransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99011
HGNC: HGNC:9202
Homologene: 68548
Rai14
Name: retinoic acid induced 14
Synonyms: 1700020L11Rik, Ankycorbin, Norpeg, 1700008J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 75646
VEGA: 15
Homologene: 9199
Il17rd
Name: interleukin 17 receptor D
Synonyms: Sef, Sef-S, 2810004A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 171463
VEGA: 14
Homologene: 9717
Ptpn3
Name: protein tyrosine phosphatase, non-receptor type 3
Synonyms: PTPCL, 9530011I20Rik, PTP-H1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 545622
HGNC: HGNC:9655
Homologene: 74451
Kif5b
Name: kinesin family member 5B
Synonyms: Khc, kinesin heavy chain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16573
HGNC: HGNC:6324
Homologene: 55829
Exoc2
Name: exocyst complex component 2
Synonyms: Sec5, 2410030I24Rik, Sec5l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66482
Homologene: 10122
Hif1a
Name: hypoxia inducible factor 1, alpha subunit
Synonyms: MOP1, HIF-1alpha, HIF1alpha, bHLHe78
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 15251
HGNC: HGNC:4910
Homologene: 1171
Ep300
Name: E1A binding protein p300
Synonyms: p300, KAT3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 328572
HGNC: HGNC:3373
Homologene: 1094
Lmbr1l
Name: limb region 1 like
Synonyms: 1110013E13Rik, D15Ertd735e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 74775
Homologene: 10011
Prr14l
Name: proline rich 14-like
Synonyms: 6030436E02Rik, C330019G07Rik, Prl14l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 215476
Homologene: 65866
Arhgap17
Name: Rho GTPase activating protein 17
Synonyms: WBP15, Nadrin, Rich1, 5730403H17Rik, Nadrin2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70497
Homologene: 9984
Pdia5
Name: protein disulfide isomerase associated 5
Synonyms: 2700053F16Rik, Pdir
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 72599
VEGA: 16
Homologene: 4957
AU040320
Name: expressed sequence AU040320
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100317
Homologene: 11764
Mecom
Name: MDS1 and EVI1 complex locus
Synonyms: ZNFPR1B1, Prdm3, MDS1-EVI1, Evi-1, D630039M04Rik, Jbo, Evi1, Mds1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14013
HGNC: HGNC:3498
Homologene: 21086
Rfx8
Name: regulatory factor X 8
Synonyms: 4933400N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 619289
Homologene: 82436
Tab2
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 2
Synonyms: Tak1 binding protein 2, 1110030N06Rik, A530078N03Rik, Map3k7ip2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 68652
Homologene: 9019
Rasgrp3
Name: RAS, guanyl releasing protein 3
Synonyms: LOC240168
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240168
VEGA: 17
Homologene: 15019
Cntn3
Name: contactin 3
Synonyms: Pang
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 18488
HGNC: HGNC:2173
Homologene: 7461
Zscan10
Name: zinc finger and SCAN domain containing 10
Synonyms: Zscan10, Zfp206
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 332221
Homologene: 13122
Tbx19
Name: T-box 19
Synonyms: Tpit, D1Ertd754e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 83993
Homologene: 3779
Madd
Name: MAP-kinase activating death domain
Synonyms: 9630059K23Rik, Rab3 GEP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228355
HGNC: HGNC:6766
Homologene: 14249
Bpifb9a
Name: BPI fold containing family B, member 9A
Synonyms: vomeromodulin, 4833413D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71425
Homologene: 128535
Shank1
Name: SH3 and multiple ankyrin repeat domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243961
Homologene: 22949
Arfgef3
Name: ARFGEF family member 3
Synonyms: B930094H20Rik, D10Bwg1379e, BIG3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215821
VEGA: 10
Homologene: 41366
Csmd2
Name: CUB and Sushi multiple domains 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329942
Homologene: 89034
Trim34a
Name: tripartite motif-containing 34A
Synonyms: Trim34-1, Trim34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 94094
Homologene: 128238
Vmn1r63
Name: vomeronasal 1 receptor 63
Synonyms: V1R1, V1rd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 81017
Homologene: 41799
Dennd3
Name: DENN/MADD domain containing 3
Synonyms: E030003N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105841
Homologene: 28254
Tmprss11f
Name: transmembrane protease, serine 11f
Synonyms: 4732406D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243083
Homologene: 65356
Phldb2
Name: pleckstrin homology like domain, family B, member 2
Synonyms: LL5beta, LL5b, C820004H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 208177
Homologene: 17100
Ces1e
Name: carboxylesterase 1E
Synonyms: Es-22, Eg, egasyn, Es22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13897
HGNC: HGNC:1863
Homologene: 115660
Olfr272
Name: olfactory receptor 272
Synonyms: GA_x6K02T2N78B-7084885-7085844, MOR262-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 258836
Homologene: 17409
Adam24
Name: a disintegrin and metallopeptidase domain 24 (testase 1)
Synonyms: Dtgn5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13526
HGNC: HGNC:203
Homologene: 137232
Galnt1
Name: polypeptide N-acetylgalactosaminyltransferase 1
Synonyms: ppGaNTase-T1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 14423
HGNC: HGNC:4123
Homologene: 8469
Ptprr
Name: protein tyrosine phosphatase, receptor type, R
Synonyms: PTPBR7, PTP-SL, RPTPRR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19279
HGNC: HGNC:9680
Homologene: 2135
Slc16a14
Name: solute carrier family 16 (monocarboxylic acid transporters), member 14
Synonyms: 1110004H10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71781
Homologene: 34318
Zfyve16
Name: zinc finger, FYVE domain containing 16
Synonyms: B130024H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218441
Homologene: 8826
Slc41a2
Name: solute carrier family 41, member 2
Synonyms: A230035L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 338365
Homologene: 9870
Iqca1l
Name: IQ motif containing with AAA domain 1 like
Synonyms: 4931409K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231045
Homologene: 18602
Clip2
Name: CAP-GLY domain containing linker protein 2
Synonyms: CLIP-115, WSCR4, Cyln2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269713
HGNC: HGNC:2586
Homologene: 20718
Klhl29
Name: kelch-like 29
Synonyms: A230106N14Rik, Kbtbd9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 208439
VEGA: 12
Homologene: 66272
9230019H11Rik
Name: RIKEN cDNA 9230019H11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215728
VEGA: 10
Zfp938
Name: zinc finger protein 938
Synonyms: B230315N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237411
Homologene: 135924
Olfr67
Name: olfactory receptor 67
Synonyms: 3'[b]1, MOR31-1, GA_x6K02T2PBJ9-6515150-6514170
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18368
Homologene: 85930
Otud4
Name: OTU domain containing 4
Synonyms: 4930431L18Rik, D8Ertd69e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 73945
Homologene: 35370
Cyp2c68
Name: cytochrome P450, family 2, subfamily c, polypeptide 68
Synonyms: 9030012A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 433247
Homologene: 74936
Olfr20
Name: olfactory receptor 20
Synonyms: MTPCR55, MTPCR06, Olfr21, MOR135-11, GA_x6K02T2P1NL-3514066-3515010
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258925
Homologene: 128054
Tox2
Name: TOX high mobility group box family member 2
Synonyms: RxHMG1, LOC269389
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269389
Homologene: 13155
Trim72
Name: tripartite motif-containing 72
Synonyms: MG53, mitsugumin 53
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434246
Homologene: 66924
Cenps
Name: centromere protein S
Synonyms: 2810407L01Rik, 2610040C18Rik, Apitd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69928
Homologene: 66004
Ifi211
Name: interferon activated gene 211
Synonyms: Mnda, Ifi205b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381308
HGNC: HGNC:5395
Homologene: 115929
Olfr1305
Name: olfactory receptor 1305
Synonyms: GA_x6K02T2Q125-72930843-72929905, MOR245-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258396
Homologene: 74056
Trbv17
Name: T cell receptor beta, variable 17
Synonyms: Gm16779, Tcrb-V9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100124681
5830462I19Rik
Name: RIKEN cDNA 5830462I19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Rdh5
Name: retinol dehydrogenase 5
Synonyms: cRDH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19682
HGNC: HGNC:9940
Homologene: 2179
Ascl5
Name: achaete-scute family bHLH transcription factor 5
Synonyms: LOC226439, bHLHa47, Ascl5-ps, AmeloD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226439
Homologene: 136628
Gm12880
Name: predicted gene 12880
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100504652
Homologene: 111034
Rpl31-ps10
Name: ribosomal protein L31, pseudogene 10
Synonyms: Gm13004
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 665533
Gm4795
Name: predicted pseudogene 4795
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215974
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 39,710,156 bp
  • T to A, chromosome 1 at 84,907,424 bp
  • A to T, chromosome 1 at 136,051,188 bp
  • G to T, chromosome 1 at 160,964,963 bp
  • T to A, chromosome 1 at 165,160,372 bp
  • T to C, chromosome 1 at 173,906,263 bp
  • T to A, chromosome 2 at 32,243,718 bp
  • C to T, chromosome 2 at 91,154,514 bp
  • C to T, chromosome 2 at 111,873,292 bp
  • A to T, chromosome 2 at 154,270,235 bp
  • A to G, chromosome 2 at 163,320,373 bp
  • C to A, chromosome 3 at 29,997,721 bp
  • C to A, chromosome 4 at 52,910,991 bp
  • T to C, chromosome 4 at 57,205,019 bp
  • T to G, chromosome 4 at 121,479,448 bp
  • A to T, chromosome 4 at 126,823,716 bp
  • C to A, chromosome 4 at 128,548,819 bp
  • T to A, chromosome 4 at 137,395,577 bp
  • C to A, chromosome 4 at 149,130,201 bp
  • G to A, chromosome 5 at 24,552,078 bp
  • C to A, chromosome 5 at 32,827,777 bp
  • A to T, chromosome 5 at 86,530,106 bp
  • G to A, chromosome 5 at 134,522,791 bp
  • T to C, chromosome 6 at 41,163,538 bp
  • T to A, chromosome 6 at 102,278,353 bp
  • C to T, chromosome 7 at 5,803,190 bp
  • T to A, chromosome 7 at 44,351,822 bp
  • A to T, chromosome 7 at 103,787,374 bp
  • A to G, chromosome 7 at 104,335,775 bp
  • A to G, chromosome 7 at 123,297,493 bp
  • A to G, chromosome 7 at 128,009,923 bp
  • A to G, chromosome 8 at 40,681,064 bp
  • T to A, chromosome 8 at 79,672,997 bp
  • T to A, chromosome 8 at 93,210,442 bp
  • G to T, chromosome 9 at 35,470,035 bp
  • A to G, chromosome 9 at 110,374,182 bp
  • G to A, chromosome 10 at 3,126,473 bp
  • T to C, chromosome 10 at 7,919,821 bp
  • T to G, chromosome 10 at 18,611,237 bp
  • A to G, chromosome 10 at 45,006,840 bp
  • A to C, chromosome 10 at 82,225,258 bp
  • A to G, chromosome 10 at 83,281,368 bp
  • T to C, chromosome 10 at 116,188,330 bp
  • T to A, chromosome 10 at 128,918,291 bp
  • C to T, chromosome 11 at 73,353,806 bp
  • G to T, chromosome 12 at 5,091,366 bp
  • T to A, chromosome 12 at 73,928,323 bp
  • A to G, chromosome 13 at 30,864,856 bp
  • A to G, chromosome 13 at 92,521,231 bp
  • T to C, chromosome 14 at 27,095,911 bp
  • A to G, chromosome 15 at 10,574,938 bp
  • C to T, chromosome 15 at 73,547,448 bp
  • T to C, chromosome 15 at 81,648,854 bp
  • T to A, chromosome 15 at 94,281,957 bp
  • T to C, chromosome 15 at 98,909,262 bp
  • A to G, chromosome 16 at 35,453,536 bp
  • T to A, chromosome 16 at 45,825,612 bp
  • T to C, chromosome 17 at 23,610,421 bp
  • T to C, chromosome 17 at 75,497,047 bp
  • A to G, chromosome 18 at 6,209,178 bp
  • A to G, chromosome 18 at 24,267,547 bp
  • T to C, chromosome 19 at 39,699,284 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5410 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042979-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.