Strain Name:
C57BL/6J-MtgxR5414Btlr/Mmmh
Stock Number:
042983-MU
Citation ID:
RRID:MMRRC_042983-MU
Other Names:
R5414 (G1), C57BL/6J-MtgxR5414Btlr
Major Collection:

Gene Information

Xrcc1
Name: X-ray repair complementing defective repair in Chinese hamster cells 1
Synonyms: Xrcc-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 22594
Homologene: 31368
Myo1e
Name: myosin IE
Synonyms: 9130023P14Rik, 2310020N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 71602
VEGA: 9
HGNC: HGNC:7599
Homologene: 55864
Bcat1
Name: branched chain aminotransferase 1, cytosolic
Synonyms: Bcat-1, Eca39, BCATc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12035
HGNC: HGNC:976
Homologene: 20320
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Phr1, C130061D10Rik, Pam
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 105689
Homologene: 9005
Washc4
Name: WASH complex subunit 4
Synonyms: A230046K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 319277
VEGA: 10
Homologene: 123926
Ppp6r3
Name: protein phosphatase 6, regulatory subunit 3
Synonyms: Saps3, 9130026N02Rik, D19Bwg1430e, 4930528G08Rik, Pp6r3, Pptcs3, D19Ertd703e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 52036
VEGA: 19
HGNC: HGNC:1173
Homologene: 115911
Atr
Name: ataxia telangiectasia and Rad3 related
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 245000
HGNC: HGNC:882
Homologene: 96916
Nploc4
Name: NPL4 homolog, ubiquitin recognition factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217365
Homologene: 5403
Focad
Name: focadhesin
Synonyms: BC057079
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230393
Homologene: 9842
Coro1c
Name: coronin, actin binding protein 1C
Synonyms: CRN2, coronin 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 23790
HGNC: HGNC:2254
Homologene: 56537
Thra
Name: thyroid hormone receptor alpha
Synonyms: T3Ralpha, 6430529J03Rik, T3R[a], Erba, TR alpha 1, Thra1, Nr1a1, Thra2, Rvr, c-erbAalpha, TR alpha 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 21833
Homologene: 37747
Cdan1
Name: congenital dyserythropoietic anemia, type I (human)
Synonyms: 1500015A01Rik, CDA1, CDA-I, codanin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 68968
HGNC: HGNC:1713
Homologene: 16324
Cnih1
Name: cornichon family AMPA receptor auxiliary protein 1
Synonyms: Cnih
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 12793
Homologene: 4219
Tenm3
Name: teneurin transmembrane protein 3
Synonyms: Ten-m3, Odz3, 2610100B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 23965
Homologene: 22673
Ibtk
Name: inhibitor of Bruton agammaglobulinemia tyrosine kinase
Synonyms: 5430411K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 108837
Homologene: 34661
Pgs1
Name: phosphatidylglycerophosphate synthase 1
Synonyms: 2610019F11Rik, 4933424M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 74451
Homologene: 5467
Scamp5
Name: secretory carrier membrane protein 5
Synonyms: Sc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 56807
VEGA: 9
Homologene: 56880
Ddx11
Name: DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
Synonyms: KRG2, CHL1, CHLR1, 4732462I11Rik, essa15a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 320209
VEGA: 17
HGNC: HGNC:2736
Homologene: 68973
Cd34
Name: CD34 antigen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12490
HGNC: HGNC:1662
Homologene: 1343
Atp2b2
Name: ATPase, Ca++ transporting, plasma membrane 2
Synonyms: PMCA2, Gena300, Tmy, wms, jog, D6Abb2e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 11941
HGNC: HGNC:815
Homologene: 56150
Akr1c18
Name: aldo-keto reductase family 1, member C18
Synonyms: 20alpha-hydroxysteroid dehydrogenase, 20alpha-HSD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 105349
HGNC: HGNC:386
Homologene: 128661
Gcgr
Name: glucagon receptor
Synonyms: GR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 14527
HGNC: HGNC:4192
Homologene: 131
C1rl
Name: complement component 1, r subcomponent-like
Synonyms: C1rl1, C1r-LP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232371
Homologene: 9559
Pdk4
Name: pyruvate dehydrogenase kinase, isoenzyme 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 27273
HGNC: HGNC:8812
Homologene: 129720
Pgm5
Name: phosphoglucomutase 5
Synonyms: aciculin, 9530034F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 226041
HGNC: HGNC:8908
Homologene: 74881
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: 1110021D17Rik, 4833413O10Rik, Polydom, D430029O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 64817
Homologene: 23386
Sis
Name: sucrase isomaltase (alpha-glucosidase)
Synonyms: sucrase-isomaltase, 2010204N08Rik, Si-s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 69983
Homologene: 37424
Zfp629
Name: zinc finger protein 629
Synonyms: 9330199A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 320683
Homologene: 65318
Fbn2
Name: fibrillin 2
Synonyms: Sne, Fib-2, sy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Vmn2r3
Name: vomeronasal 2, receptor 3
Synonyms: EG637004
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 637004
HGNC: null
Homologene: null
Hfm1
Name: HFM1, ATP-dependent DNA helicase homolog
Synonyms: A330009G12Rik, LOC381663, Sec63d1, Mer3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 330149
Homologene: 87103
Kcnh4
Name: potassium voltage-gated channel, subfamily H (eag-related), member 4
Synonyms: BEC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 380728
HGNC: HGNC:6253
Homologene: 8180
Galnt16
Name: polypeptide N-acetylgalactosaminyltransferase 16
Synonyms: Galntl1, 5730405L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 108760
VEGA: 12
Homologene: 18907
Trim30a
Name: tripartite motif-containing 30A
Synonyms: Trim30, Rpt1, Rpt-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20128
HGNC: null
Homologene: 114426
Ros1
Name: Ros1 proto-oncogene
Synonyms: c-ros, Ros-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 19886
Homologene: 2207
Nos1ap
Name: nitric oxide synthase 1 (neuronal) adaptor protein
Synonyms: 6330408P19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 70729
Homologene: 135990
Abca5
Name: ATP-binding cassette, sub-family A (ABC1), member 5
Synonyms: ABC13, B930033A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217265
HGNC: HGNC:35
Homologene: 10263
Rin3
Name: Ras and Rab interactor 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217835
Homologene: 11748
Pdzrn3
Name: PDZ domain containing RING finger 3
Synonyms: 1110020C07Rik, LNX3, Semcap3, semaphorin cytoplasmic domain-associated protein 3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 55983
Homologene: 10328
Celsr3
Name: cadherin, EGF LAG seven-pass G-type receptor 3
Synonyms: flamingo, Fmi1, Adgrc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 107934
HGNC: HGNC:3230
Homologene: 1077
Akt3
Name: thymoma viral proto-oncogene 3
Synonyms: D930002M15Rik, Nmf350, PKB gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 23797
HGNC: HGNC:393
Homologene: 55904
Gm6327
Name: predicted gene 6327
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: null
HGNC: null
Homologene: null
Gm10288
Name: predicted gene 10288
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 100040540
HGNC: null
Homologene: null
Acan
Name: aggrecan
Synonyms: Agc1, b2b183Clo, Cspg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 11595
HGNC: HGNC:319
Homologene: 137204
Clec2h
Name: C-type lectin domain family 2, member h
Synonyms: Clrf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 94071
HGNC: null
Homologene: 131164
Olfr1271
Name: olfactory receptor 1271
Synonyms: MOR227-5, GA_x6K02T2Q125-51620802-51619885
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258789
HGNC: null
Homologene: null
Prag1
Name: PEAK1 related kinase activating pseudokinase 1
Synonyms: NACK, D8Ertd82e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 244418
Homologene: 18256
Gbp2b
Name: guanylate binding protein 2b
Synonyms: Mpa-1, Mag-1, Gbp1, Mpa1, Gbp-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 14468
HGNC: HGNC:4184
Homologene: 137233
Ifit1bl1
Name: interferon induced protein with tetratricpeptide repeats 1B like 1
Synonyms: Gm14446
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 667373
Homologene: 78213
Gm10192
Name: predicted gene 10192
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: null
VEGA: null
HGNC: null
Homologene: null
Krt33b
Name: keratin 33B
Synonyms: Ha4, mHa3, Krt1-3, Ha3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 16671
Homologene: 74433
Gm21761
Name: predicted gene, 21761
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 106029237
HGNC: null
Homologene: null
Gm17106
Name: predicted gene 17106
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: null
HGNC: null
Homologene: null
Gm4181
Name: predicted gene 4181
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: null
HGNC: null
Homologene: null
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 170,349,399 bp
  • A to G, chromosome 1 at 177,050,251 bp
  • A to G, chromosome 1 at 194,947,911 bp
  • T to C, chromosome 2 at 90,265,702 bp
  • A to G, chromosome 2 at 120,729,584 bp
  • T to A, chromosome 3 at 64,259,557 bp
  • C to A, chromosome 3 at 72,952,493 bp
  • T to C, chromosome 3 at 142,599,091 bp
  • T to C, chromosome 3 at 146,838,962 bp
  • T to C, chromosome 4 at 58,206,322 bp
  • C to T, chromosome 4 at 88,410,702 bp
  • T to C, chromosome 4 at 97,183,109 bp
  • A to G, chromosome 5 at 106,902,076 bp
  • A to G, chromosome 5 at 113,848,546 bp
  • T to C, chromosome 6 at 5,485,499 bp
  • C to T, chromosome 6 at 101,153,311 bp
  • G to A, chromosome 6 at 113,842,141 bp
  • C to T, chromosome 6 at 124,508,468 bp
  • G to T, chromosome 6 at 128,674,786 bp
  • A to G, chromosome 6 at 145,015,447 bp
  • A to G, chromosome 7 at 24,570,218 bp
  • A to G, chromosome 7 at 79,100,988 bp
  • A to C, chromosome 7 at 104,411,141 bp
  • T to C, chromosome 7 at 127,611,282 bp
  • C to G, chromosome 8 at 36,139,622 bp
  • A to C, chromosome 8 at 48,236,355 bp
  • A to G, chromosome 9 at 57,447,224 bp
  • C to A, chromosome 9 at 70,322,358 bp
  • T to C, chromosome 9 at 85,726,689 bp
  • A to G, chromosome 9 at 95,870,704 bp
  • A to G, chromosome 9 at 108,840,042 bp
  • T to C, chromosome 10 at 52,155,093 bp
  • A to G, chromosome 10 at 83,556,103 bp
  • A to G, chromosome 11 at 98,760,957 bp
  • T to C, chromosome 11 at 100,029,786 bp
  • T to C, chromosome 11 at 100,746,896 bp
  • A to G, chromosome 11 at 110,314,622 bp
  • T to G, chromosome 11 at 118,014,676 bp
  • A to T, chromosome 11 at 120,413,643 bp
  • C to T, chromosome 11 at 120,536,082 bp
  • A to T, chromosome 12 at 80,584,048 bp
  • C to T, chromosome 12 at 102,389,857 bp
  • T to A, chromosome 13 at 4,136,735 bp
  • A to C, chromosome 13 at 119,912,336 bp
  • T to C, chromosome 14 at 46,778,983 bp
  • C to T, chromosome 14 at 51,635,590 bp
  • A to T, chromosome 14 at 103,306,261 bp
  • T to A, chromosome 16 at 12,760,358 bp
  • T to A, chromosome 16 at 32,985,965 bp
  • A to G, chromosome 17 at 66,148,768 bp
  • C to A, chromosome 18 at 58,093,405 bp
  • A to G, chromosome 19 at 3,507,330 bp
  • A to G, chromosome 19 at 24,709,325 bp
  • T to A, chromosome 19 at 34,593,924 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5414 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042983-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.