Strain Name:
C57BL/6J-MtgxR5416Btlr/Mmmh
Stock Number:
042985-MU
Citation ID:
RRID:MMRRC_042985-MU
Other Names:
R5416 (G1), C57BL/6J-MtgxR5416Btlr
Major Collection:

Strain Information

Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Nrg4
Name: neuregulin 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 83961
Homologene: 12921
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNA-PKcs, slip, DNAPDcs, XRCC7, DNA-PK, DOXNPH, dxnph
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Clptm1
Name: cleft lip and palate associated transmembrane protein 1
Synonyms: N14, HS9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56457
HGNC: HGNC:2087
Homologene: 37464
Sorbs1
Name: sorbin and SH3 domain containing 1
Synonyms: c-Cbl-associated protein, CAP, Sh3d5, 9530001P15Rik, 2310065E01Rik, Ponsin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20411
VEGA: 19
Homologene: 83252
Rnf216
Name: ring finger protein 216
Synonyms: UIP83, F830018F18Rik, 2810055G22Rik, Ubce7ip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 108086
Homologene: 19442
Dhx40
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 40
Synonyms: ARG147, DDX40, 2410016C14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67487
Homologene: 57000
Adrm1
Name: adhesion regulating molecule 1 26S proteasome ubiquitin receptor
Synonyms: ARM-1, 2510006J17Rik, Gp110, 1110063P18Rik, Rpn13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56436
Homologene: 10513
Sez6l2
Name: seizure related 6 homolog like 2
Synonyms: Psk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233878
Homologene: 8237
Ppp6r1
Name: protein phosphatase 6, regulatory subunit 1
Synonyms: 2010309P17Rik, B430201G11Rik, Pp6r1, Saps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243819
Homologene: 86982
Ccdc187
Name: coiled-coil domain containing 187
Synonyms: 4932418E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329366
Homologene: 77630
Cndp1
Name: carnosine dipeptidase 1 (metallopeptidase M20 family)
Synonyms: Cn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 338403
Homologene: 57178
Ptprs
Name: protein tyrosine phosphatase, receptor type, S
Synonyms: PTP-NU3, PTPsigma, RPTPsigma, Ptpt9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 19280
HGNC: HGNC:9681
Homologene: 20626
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: LR11, mSorLA, 2900010L19Rik, Sorla
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20660
Homologene: 2336
Pwp2
Name: PWP2 periodic tryptophan protein homolog (yeast)
Synonyms: Pwp2, 6530411D08Rik, Pwp2h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 110816
VEGA: 10
HGNC: HGNC:9711
Homologene: 3702
Edrf1
Name: erythroid differentiation regulatory factor 1
Synonyms: 2700050L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 214764
Homologene: 27985
Gpr107
Name: G protein-coupled receptor 107
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 277463
Homologene: 81077
C87436
Name: expressed sequence C87436
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232196
Homologene: 9897
Asxl3
Name: ASXL transcriptional regulator 3
Synonyms: LOC381127, D930044O18Rik, D430002O22Rik, C230079D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 211961
Homologene: 19371
Tmem204
Name: transmembrane protein 204
Synonyms: Clp24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 407831
Homologene: 36419
Pfdn2
Name: prefoldin 2
Synonyms: ESTM27, W48336
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18637
HGNC: HGNC:8867
Homologene: 7887
Ttll5
Name: tubulin tyrosine ligase-like family, member 5
Synonyms: 4930556H18Rik, 1700048H13Rik, 2310009M18Rik, D630041K24Rik, STAMP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 320244
Homologene: 9013
Ccr1
Name: chemokine (C-C motif) receptor 1
Synonyms: Cmkbr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12768
VEGA: 9
HGNC: HGNC:1602
Homologene: 20344
Col24a1
Name: collagen, type XXIV, alpha 1
Synonyms: 5430404K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71355
Homologene: 65061
Prkg2
Name: protein kinase, cGMP-dependent, type II
Synonyms: cGK-II, Prkgr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19092
HGNC: HGNC:9416
Homologene: 4556
Fat2
Name: FAT atypical cadherin 2
Synonyms: LOC245827, mKIAA0811, Fath2, EMI2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Srp72
Name: signal recognition particle 72
Synonyms: 72kDa, 5730576P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66661
Homologene: 38254
Fhad1
Name: forkhead-associated (FHA) phosphopeptide binding domain 1
Synonyms: 2900090M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329977
Homologene: 77947
Adcy3
Name: adenylate cyclase 3
Synonyms: AC3, ACIII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104111
HGNC: HGNC:234
Homologene: 2978
Nwd1
Name: NACHT and WD repeat domain containing 1
Synonyms: A230063L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 319555
Homologene: 72261
Or6d14
Name: olfactory receptor family 6 subfamily D member 14
Synonyms: GA_x54KRFPKN04-58190962-58191900, MOR119-1, Olfr214
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258754
Homologene: 133694
Specc1
Name: sperm antigen with calponin homology and coiled-coil domains 1
Synonyms: 2810012G08Rik, B230396K10Rik, Cytsb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 432572
Homologene: 45157
Hsd3b5
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5
Synonyms: 3(beta)HSDV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 15496
Homologene: 104115
Chadl
Name: chondroadherin-like
Synonyms: D930017K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 214685
Homologene: 130044
Zfp575
Name: zinc finger protein 575
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101544
Homologene: 45485
Gm13941
Name: predicted gene 13941
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Abcb5
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 5
Synonyms: 9230106F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 77706
HGNC: HGNC:46
Homologene: 83488
Evpl
Name: envoplakin
Synonyms: 210kDa protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14027
HGNC: HGNC:3503
Homologene: 1506
Itgb7
Name: integrin beta 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16421
HGNC: HGNC:6162
Homologene: 20247
Serpina1f
Name: serine (or cysteine) peptidase inhibitor, clade A, member 1F
Synonyms: epserin, 0610012A11Rik, Serpina2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 68348
HGNC: HGNC:8985
Homologene: 87037
Ctsj
Name: cathepsin J
Synonyms: rat gene/Cathepsin L-related protein, CatRLP, CATP, Cat P, Ctsp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 26898
VEGA: 13
HGNC: HGNC:2537
Homologene: 137246
Pcdhb8
Name: protocadherin beta 8
Synonyms: Pcdhb5C, PcdhbH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93879
HGNC: HGNC:8690
Homologene: 89038
Cacna1e
Name: calcium channel, voltage-dependent, R type, alpha 1E subunit
Synonyms: Cav2.3, Cchra1, alpha1E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12290
HGNC: HGNC:1392
Homologene: 20185
Clcnkb
Name: chloride channel, voltage-sensitive Kb
Synonyms: Clcnk1l, Clck2, ClC-K2, Clcnk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56365
HGNC: HGNC:2027
Homologene: 107317
Psg26
Name: pregnancy-specific beta-1-glycoprotein 26
Synonyms: cea14, EG574429
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 574429
Homologene: 110989
Plxnc1
Name: plexin C1
Synonyms: vespr, CD232, 2510048K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 54712
HGNC: HGNC:9106
Homologene: 4211
Ube4a
Name: ubiquitination factor E4A
Synonyms: UFD2b, 9930123J21Rik, 4732444G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 140630
Homologene: 3517
Slc28a3
Name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
Synonyms: Cnt3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 114304
Homologene: 32533
Fam83d
Name: family with sequence similarity 83, member D
Synonyms: 2310007D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71878
Homologene: 23715
Cdh18
Name: cadherin 18
Synonyms: B230220E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 320865
HGNC: HGNC:1757
Homologene: 55858
Phkg2
Name: phosphorylase kinase, gamma 2 (testis)
Synonyms: 1500017I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68961
HGNC: HGNC:8931
Homologene: 47915
Gpr161
Name: G protein-coupled receptor 161
Synonyms: LOC240888, vl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240888
Homologene: 17824
Epha1
Name: Eph receptor A1
Synonyms: Esk, 5730453L17Rik, Eph
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13835
HGNC: HGNC:3385
Homologene: 3835
Acsl6
Name: acyl-CoA synthetase long-chain family member 6
Synonyms: Lacsl, A330035H04Rik, Facl6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216739
Homologene: 100939
Tnfrsf13b
Name: tumor necrosis factor receptor superfamily, member 13b
Synonyms: Taci, 1200009E08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 57916
Homologene: 49320
Fuca1
Name: fucosidase, alpha-L- 1, tissue
Synonyms: Afuc, 0610006A03Rik, 9530055J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 71665
HGNC: HGNC:4006
Homologene: 20078
Cybb
Name: cytochrome b-245, beta polypeptide
Synonyms: gp91phox, gp91phox, Nox2, Cgd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 13058
HGNC: HGNC:2578
Homologene: 68054
Ubqln3
Name: ubiquilin 3
Synonyms: 4933400K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244178
Homologene: 9700
Comtd1
Name: catechol-O-methyltransferase domain containing 1
Synonyms: 1810030M08Rik, MT773
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 69156
Homologene: 41703
Igkv4-80
Name: immunoglobulin kappa variable 4-80
Synonyms: Gm16729
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 545848
Or56b2j
Name: olfactory receptor family 56 subfamily B member 2J
Synonyms: GA_x6K02T2PBJ9-7331927-7332961, MOR40-12, Olfr663
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 257914
Homologene: 133594
Gm13229
Name: predicted gene 13229
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 115489971
Homologene: 137330
Gm6612
Name: predicted gene 6612
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 625672
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 154,465,779 bp
  • T to A, chromosome 1 at 165,321,461 bp
  • C to T, chromosome 1 at 171,357,909 bp
  • G to A, chromosome 2 at 26,276,092 bp
  • T to A, chromosome 2 at 31,185,548 bp
  • A to T, chromosome 2 at 111,094,734 bp
  • T to C, chromosome 2 at 158,785,632 bp
  • C to T, chromosome 2 at 180,176,137 bp
  • A to G, chromosome 3 at 98,619,150 bp
  • A to T, chromosome 3 at 145,315,025 bp
  • A to G, chromosome 4 at 135,922,980 bp
  • T to C, chromosome 4 at 141,413,900 bp
  • G to A, chromosome 4 at 141,918,802 bp
  • C to A, chromosome 4 at 145,469,792 bp
  • A to G, chromosome 5 at 76,997,472 bp
  • A to T, chromosome 5 at 98,943,467 bp
  • G to T, chromosome 5 at 143,015,771 bp
  • A to T, chromosome 6 at 42,365,871 bp
  • A to C, chromosome 6 at 69,016,665 bp
  • A to G, chromosome 6 at 86,465,850 bp
  • A to T, chromosome 6 at 116,557,205 bp
  • A to T, chromosome 7 at 4,639,748 bp
  • T to C, chromosome 7 at 18,482,600 bp
  • C to A, chromosome 7 at 19,633,816 bp
  • C to T, chromosome 7 at 24,586,722 bp
  • C to T, chromosome 7 at 104,141,672 bp
  • C to T, chromosome 7 at 104,703,716 bp
  • T to A, chromosome 7 at 126,961,886 bp
  • A to G, chromosome 7 at 127,582,935 bp
  • T to C, chromosome 7 at 133,641,402 bp
  • A to G, chromosome 8 at 72,666,694 bp
  • A to T, chromosome 9 at 42,002,636 bp
  • G to A, chromosome 9 at 44,941,178 bp
  • A to T, chromosome 9 at 55,258,590 bp
  • G to T, chromosome 9 at 123,964,376 bp
  • G to T, chromosome 10 at 78,183,001 bp
  • G to A, chromosome 10 at 94,837,554 bp
  • C to A, chromosome 11 at 21,997,037 bp
  • A to G, chromosome 11 at 54,337,171 bp
  • T to C, chromosome 11 at 55,303,688 bp
  • T to C, chromosome 11 at 61,147,023 bp
  • T to C, chromosome 11 at 62,118,909 bp
  • T to C, chromosome 11 at 86,797,691 bp
  • C to A, chromosome 11 at 116,234,259 bp
  • G to A, chromosome 12 at 4,209,308 bp
  • G to A, chromosome 12 at 86,012,828 bp
  • T to A, chromosome 12 at 103,693,944 bp
  • T to A, chromosome 12 at 118,907,596 bp
  • A to T, chromosome 13 at 58,576,793 bp
  • G to T, chromosome 13 at 61,004,523 bp
  • T to C, chromosome 14 at 21,847,241 bp
  • A to G, chromosome 15 at 23,226,723 bp
  • T to A, chromosome 15 at 80,952,183 bp
  • T to C, chromosome 15 at 81,693,899 bp
  • A to T, chromosome 15 at 102,217,309 bp
  • T to C, chromosome 16 at 15,805,950 bp
  • T to C, chromosome 17 at 25,058,326 bp
  • T to C, chromosome 17 at 56,435,724 bp
  • T to A, chromosome 18 at 22,524,494 bp
  • A to G, chromosome 18 at 37,356,955 bp
  • G to A, chromosome 18 at 84,636,090 bp
  • A to G, chromosome 19 at 40,376,989 bp
  • C to G, chromosome X at 9,450,750 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5416 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042985-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.