Strain Name:
C57BL/6J-MtgxR5425Btlr/Mmmh
Stock Number:
042991-MU
Citation ID:
RRID:MMRRC_042991-MU
Other Names:
R5425 (G1), C57BL/6J-MtgxR5425Btlr
Major Collection:

Gene Information

Pdpk1
Name: 3-phosphoinositide dependent protein kinase 1
Synonyms: Pkb kinase, Pdk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 18607
HGNC: HGNC:8816
Homologene: 37643
Pzp
Name: PZP, alpha-2-macroglobulin like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 11287
Homologene: 104112
Faah
Name: fatty acid amide hydrolase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 14073
HGNC: HGNC:3553
Homologene: 68184
Dst
Name: dystonin
Synonyms: A830042E19Rik, 2310001O04Rik, Macf2, bullous pemphigoid antigen 1, BPAG1-n, BPAG1, athetoid, Bpag, ah, bullous pemphigoid antigen 1, Bpag1, nmf339, nmf203
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Paip1
Name: polyadenylate binding protein-interacting protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218693
Homologene: 4709
Dab2ip
Name: disabled 2 interacting protein
Synonyms: 2310011D08Rik, AIP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 69601
Homologene: 13058
Uhrf1bp1
Name: UHRF1 (ICBP90) binding protein 1
Synonyms: F830021D11Rik, 1110020K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224648
Homologene: 9816
Opa1
Name: OPA1, mitochondrial dynamin like GTPase
Synonyms: 1200011N24Rik, optic atrophy 1, lilr3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 74143
HGNC: HGNC:8140
Homologene: 14618
Ywhag
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
Synonyms: D7Bwg1348e, 14-3-3 gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 22628
Homologene: 22725
Gab1
Name: growth factor receptor bound protein 2-associated protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 14388
HGNC: HGNC:4066
Homologene: 1542
Tmem126b
Name: transmembrane protein 126B
Synonyms: 1110001A23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 68472
Homologene: 10222
Gm14403
Name: predicted gene 14403
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 433520
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, 2310038E12Rik, Fath
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Cwc22
Name: CWC22 spliceosome-associated protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 80744
Homologene: 6048
Aldh1a2
Name: aldehyde dehydrogenase family 1, subfamily A2
Synonyms: Aldh1a7, Raldh2, retinaldehyde dehydrogenase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 19378
Homologene: 68368
Cfap74
Name: cilia and flagella associated protein 74
Synonyms: 2010015L04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 544678
Homologene: 129584
Snx13
Name: sorting nexin 13
Synonyms: RGS-PX1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217463
VEGA: 12
Homologene: 41011
Tnfrsf1b
Name: tumor necrosis factor receptor superfamily, member 1b
Synonyms: TNF-R-II, TNFRII, Tnfr2, TNFBR, CD120b, TNFalpha-R2, TNFR80, TNF-R75, TNF-R2, p75, TNF-alphaR2, p75 TNFR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 21938
Homologene: 829
Wdr17
Name: WD repeat domain 17
Synonyms: 3010002I12Rik, B230207L18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 244484
Homologene: 12460
Csf1
Name: colony stimulating factor 1 (macrophage)
Synonyms: M-CSF, CSF-1, colony-stimulating factor-1, Csfm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 12977
HGNC: HGNC:2432
Homologene: 7282
Carmil3
Name: capping protein regulator and myosin 1 linker 3
Synonyms: Lrrc16b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 268747
VEGA: 14
Homologene: 74564
Gm9457
Name: predicted gene 9457
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 669393
Homologene: 131643
Mrgprb1
Name: MAS-related GPR, member B1
Synonyms: MrgB1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233231
Homologene: 24986
Perm1
Name: PPARGC1 and ESRR induced regulator, muscle 1
Synonyms: 2310042D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 74183
Homologene: 135954
Cd101
Name: CD101 antigen
Synonyms: Igsf2, LOC381460
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 630146
HGNC: HGNC:5949
Homologene: 3142
Ttc41
Name: tetratricopeptide repeat domain 41
Synonyms: BC030307, Gnn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 103220
VEGA: 10
Homologene: 52968
Gm8909
Name: predicted gene 8909
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 667977
HGNC: HGNC:4931
Homologene: 128352
Tshz2
Name: teashirt zinc finger family member 2
Synonyms: Zfp218, Tsh2, Mtsh2, teashirt2, Sdccag33l, 2900073F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228911
Homologene: 35258
Ccnd2
Name: cyclin D2
Synonyms: Vin1, cD2, 2600016F06Rik, Vin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12444
HGNC: HGNC:1583
Homologene: 37525
Tcaf3
Name: TRPM8 channel-associated factor 3
Synonyms: Fam115e, Eapa2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 403088
Homologene: 74374
Sprr2e
Name: small proline-rich protein 2E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 20759
Mcrs1
Name: microspherule protein 1
Synonyms: ICP22BP, MSP58, C78274, P78
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 51812
VEGA: 15
HGNC: HGNC:6960
Homologene: 4622
Dipk2a
Name: divergent protein kinase domain 2A
Synonyms: 1190002N15Rik, GoPro49
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 68861
Homologene: 18315
Rassf8
Name: Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
Synonyms: mHoj-1, 5133400D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 71323
Homologene: 5219
Arhgap9
Name: Rho GTPase activating protein 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216445
VEGA: 10
Homologene: 13041
Atxn7l1
Name: ataxin 7-like 1
Synonyms: Atxn7l4, 2810423G08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 380753
Homologene: 53366
Cfap43
Name: cilia and flagella associated protein 43
Synonyms: 4930428C11Rik, Wdr96, D19Ertd652e, 4930463G05Rik, 4632415N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 100048534
Homologene: 36425
Irx6
Name: Iroquois homeobox 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 64379
Homologene: 41481
Ankmy1
Name: ankyrin repeat and MYND domain containing 1
Synonyms: 4930483I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 241158
Homologene: 9561
Ces1g
Name: carboxylesterase 1G
Synonyms: Ces-1, Ses-1, Ces1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 12623
HGNC: HGNC:1863
Homologene: 137354
Repin1
Name: replication initiator 1
Synonyms: Zfp464, AP4, E430037F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 58887
Homologene: 22810
Ace
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Synonyms: CD143
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 11421
HGNC: HGNC:2707
Homologene: 37351
Ffar1
Name: free fatty acid receptor 1
Synonyms: Gpr40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233081
HGNC: HGNC:4498
Homologene: 3876
Sirpb1b
Name: signal-regulatory protein beta 1B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 668101
Homologene: 82993
Nck2
Name: non-catalytic region of tyrosine kinase adaptor protein 2
Synonyms: 4833426I10Rik, Grb4, NCKbeta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 17974
HGNC: HGNC:7665
Homologene: 20794
Fez1
Name: fasciculation and elongation protein zeta 1 (zygin I)
Synonyms: UNC-76, UNC76
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235180
HGNC: HGNC:3659
Homologene: 21063
Aldh3a1
Name: aldehyde dehydrogenase family 3, subfamily A1
Synonyms: Ahd4, Ahd-4, Aldh3, Aldh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 11670
HGNC: HGNC:405
Homologene: 20175
Dus4l
Name: dihydrouridine synthase 4-like (S. cerevisiae)
Synonyms: 2310069P03Rik, 2700089B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 71916
VEGA: 12
Homologene: 6535
Psg25
Name: pregnancy-specific glycoprotein 25
Synonyms: cea13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 114868
Homologene: 110989
Spesp1
Name: sperm equatorial segment protein 1
Synonyms: 4921508E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 66712
VEGA: 9
Homologene: 49838
Crnn
Name: cornulin
Synonyms: LOC381457
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 381457
HGNC: HGNC:1230
Homologene: 9416
Tmem17
Name: transmembrane protein 17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 103765
Homologene: 17795
Acyp2
Name: acylphosphatase 2, muscle type
Synonyms: 2310004B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 75572
HGNC: HGNC:180
Homologene: 41776
Aida
Name: axin interactor, dorsalization associated
Synonyms: 2610208M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 108909
Homologene: 11268
Haghl
Name: hydroxyacylglutathione hydrolase-like
Synonyms: 2810014I23Rik, 1500017E18Rik, C330022E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 68977
Homologene: 57062
Diras2
Name: DIRAS family, GTP-binding RAS-like 2
Synonyms: 2900052J15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 68203
VEGA: 13
Homologene: 56777
Gm7935
Name: predicted pseudogene 7935
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 666113
VEGA: 15
Gm4956
Name: predicted gene 4956
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 241041
Castor1
Name: cytosolic arginine sensor for mTORC1 subunit 1
Synonyms: 2410008K03Rik, Gatsl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 71962
Homologene: 81920
Sox6os
Name: SRY (sex determining region Y)-box 6, opposite strand
Synonyms: 1110006G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 68469
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 21,294,966 bp
  • T to C, chromosome 1 at 34,179,750 bp
  • T to G, chromosome 1 at 43,554,392 bp
  • G to T, chromosome 1 at 92,870,957 bp
  • T to A, chromosome 1 at 183,322,346 bp
  • T to G, chromosome 2 at 35,709,991 bp
  • T to C, chromosome 2 at 77,931,467 bp
  • A to T, chromosome 2 at 169,884,024 bp
  • AAACCCTA to AA, chromosome 2 at 177,509,655 bp
  • A to C, chromosome 3 at 15,548,669 bp
  • G to A, chromosome 3 at 92,353,063 bp
  • A to G, chromosome 3 at 93,149,149 bp
  • T to A, chromosome 3 at 101,018,686 bp
  • A to G, chromosome 3 at 107,748,896 bp
  • A to T, chromosome 4 at 116,000,796 bp
  • T to C, chromosome 4 at 145,229,108 bp
  • A to G, chromosome 4 at 155,455,692 bp
  • A to G, chromosome 4 at 156,218,295 bp
  • G to T, chromosome 5 at 135,911,265 bp
  • G to A, chromosome 6 at 42,596,763 bp
  • A to G, chromosome 6 at 48,596,431 bp
  • A to G, chromosome 6 at 127,150,617 bp
  • G to A, chromosome 6 at 128,489,048 bp
  • A to T, chromosome 6 at 145,815,542 bp
  • A to T, chromosome 7 at 18,524,784 bp
  • A to C, chromosome 7 at 30,860,779 bp
  • T to A, chromosome 7 at 48,447,971 bp
  • A to G, chromosome 7 at 90,470,947 bp
  • C to T, chromosome 7 at 116,032,468 bp
  • C to A, chromosome 8 at 4,813,035 bp
  • T to C, chromosome 8 at 45,025,885 bp
  • C to T, chromosome 8 at 54,681,399 bp
  • T to C, chromosome 8 at 80,800,389 bp
  • T to C, chromosome 8 at 92,677,517 bp
  • T to A, chromosome 8 at 93,325,800 bp
  • T to A, chromosome 9 at 36,878,588 bp
  • A to G, chromosome 9 at 62,282,049 bp
  • G to A, chromosome 9 at 71,253,004 bp
  • T to C, chromosome 9 at 94,537,692 bp
  • A to T, chromosome 10 at 86,776,630 bp
  • C to A, chromosome 10 at 127,326,418 bp
  • T to A, chromosome 11 at 4,221,689 bp
  • G to T, chromosome 11 at 22,518,624 bp
  • C to T, chromosome 11 at 30,506,354 bp
  • T to C, chromosome 11 at 61,213,581 bp
  • A to G, chromosome 11 at 105,973,428 bp
  • A to T, chromosome 12 at 31,640,808 bp
  • T to C, chromosome 12 at 33,367,120 bp
  • C to T, chromosome 12 at 35,100,644 bp
  • A to G, chromosome 13 at 52,508,047 bp
  • C to T, chromosome 13 at 119,430,166 bp
  • A to G, chromosome 14 at 55,493,877 bp
  • C to T, chromosome 15 at 74,081,337 bp
  • C to A, chromosome 15 at 99,243,688 bp
  • T to C, chromosome 16 at 29,628,759 bp
  • A to T, chromosome 17 at 24,098,121 bp
  • A to G, chromosome 17 at 25,784,506 bp
  • G to A, chromosome 17 at 27,887,515 bp
  • A to C, chromosome 17 at 36,168,485 bp
  • C to T, chromosome 19 at 47,896,932 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5425 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042991-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.