Strain Name:
C57BL/6J-MtgxR5458Btlr/Mmmh
Stock Number:
043021-MU
Citation ID:
RRID:MMRRC_043021-MU
Other Names:
R5458 (G1), C57BL/6J-MtgxR5458Btlr
Major Collection:

Gene Information

Wsb1
Name: WD repeat and SOCS box-containing 1
Synonyms: 1110056B13Rik, 2700038M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 78889
Homologene: 9218
Srpk1
Name: serine/arginine-rich protein specific kinase 1
Synonyms: SR protein-specific kinase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 20815
Homologene: 110962
Chd1
Name: chromodomain helicase DNA binding protein 1
Synonyms: 4930525N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 12648
HGNC: HGNC:1915
Homologene: 68174
Trappc12
Name: trafficking protein particle complex 12
Synonyms: CGI-87, D930014A20Rik, Ttc15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217449
VEGA: 12
Homologene: 34805
Akap13
Name: A kinase (PRKA) anchor protein 13
Synonyms: 1700026G02Rik, 5830460E08Rik, 5730522G15Rik, AKAP-Lbc, PROTO-LBC, PROTO-LB, Ht31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 75547
HGNC: HGNC:371
Homologene: 4903
Atp2c1
Name: ATPase, Ca++-sequestering
Synonyms: ATP2C1A, 1700121J11Rik, SPCA, PMR1, D930003G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235574
Homologene: 56672
Phip
Name: pleckstrin homology domain interacting protein
Synonyms: Wdr11, 2810004D21Rik, 4632404O06Rik, Ndrp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 83946
Homologene: 41209
Brca1
Name: breast cancer 1, early onset
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 12189
HGNC: HGNC:1100
Homologene: 5276
Chek1
Name: checkpoint kinase 1
Synonyms: Chk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 12649
HGNC: HGNC:1925
Homologene: 975
Ankrd27
Name: ankyrin repeat domain 27 (VPS9 domain)
Synonyms: Varp, D330003H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 245886
Homologene: 12956
Clock
Name: circadian locomotor output cycles kaput
Synonyms: KAT13D, bHLHe8, 5330400M04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 12753
HGNC: HGNC:2082
Homologene: 3603
Vps50
Name: VPS50 EARP/GARPII complex subunit
Synonyms: 1700034M03Rik, Ccdc132, 8430415E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 73288
Homologene: 11498
Acsl5
Name: acyl-CoA synthetase long-chain family member 5
Synonyms: 1700030F05Rik, Facl5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 433256
VEGA: 19
Homologene: 69208
Lclat1
Name: lysocardiolipin acyltransferase 1
Synonyms: AGPAT8, Lycat, ALCAT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 225010
Homologene: 33167
Bcr
Name: breakpoint cluster region
Synonyms: 5133400C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 110279
VEGA: 10
HGNC: HGNC:1014
Homologene: 3192
Rdh11
Name: retinol dehydrogenase 11
Synonyms: Psdr1, Mdt1, 2610319N22Rik, Arsdr1, M42C60
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 17252
Homologene: 100724
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, 2310038E12Rik, Fath
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Scmh1
Name: sex comb on midleg homolog 1
Synonyms: Scml3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 29871
Homologene: 32146
Ino80
Name: INO80 complex subunit
Synonyms: 4632409L19Rik, 2310079N15Rik, Inoc1, INO80
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 68142
Homologene: 75070
Trim33
Name: tripartite motif-containing 33
Synonyms: 8030451N04Rik, ectodermin, Ecto, Tif1g
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 94093
Homologene: 9296
Dhx29
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 29
Synonyms: E130202M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218629
VEGA: 13
Homologene: 10387
Pcdh15
Name: protocadherin 15
Synonyms: roda, nmf19, Ush1f, Gm9815
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 11994
Homologene: 23401
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Wdr95
Name: WD40 repeat domain 95
Synonyms: 4930434E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 381693
Homologene: 124480
Nlgn2
Name: neuroligin 2
Synonyms: NL2, NLG2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216856
Homologene: 69317
Nkpd1
Name: NTPase, KAP family P-loop domain containing 1
Synonyms: 2310015G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 69547
Homologene: 18876
Myo3a
Name: myosin IIIA
Synonyms: 9030416P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 667663
HGNC: HGNC:7601
Homologene: 49486
Ankhd1
Name: ankyrin repeat and KH domain containing 1
Synonyms: 9130019P20Rik, 1110004O12Rik, 4933432B13Rik, A530027J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 108857
Homologene: 87006
Skint2
Name: selection and upkeep of intraepithelial T cells 2
Synonyms: B7S3, OTTMUSG00000008540
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 329919
Homologene: 136741
Unc13a
Name: unc-13 homolog A
Synonyms: Munc13-1, 2410078G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 382018
Homologene: 11279
Acrbp
Name: proacrosin binding protein
Synonyms: OY-TES-1, sp32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 54137
Homologene: 9641
Wdr66
Name: WD repeat domain 66
Synonyms: 4930415N18Rik, 4933428F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 269701
Homologene: 16964
Spata16
Name: spermatogenesis associated 16
Synonyms: Nyd-sp12, 4921511F01Rik, spermatogenesis-related protein, 4930503K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 70862
Homologene: 49974
Tcaf1
Name: TRPM8 channel-associated factor 1
Synonyms: A230020K05Rik, 3321401G04Rik, Fam115a, 2810407D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 77574
Homologene: 8815
Rin3
Name: Ras and Rab interactor 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217835
Homologene: 11748
Ppfibp1
Name: PTPRF interacting protein, binding protein 1 (liprin beta 1)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 67533
HGNC: HGNC:9249
Homologene: 2685
B4galnt3
Name: beta-1,4-N-acetyl-galactosaminyl transferase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 330406
Homologene: 18328
Pop5
Name: processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae)
Synonyms: 1500019J17Rik, Rnasep3, 2700077E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 117109
Homologene: 41076
Vrk2
Name: vaccinia related kinase 2
Synonyms: 2810003O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 69922
Homologene: 55966
Atp6v0a2
Name: ATPase, H+ transporting, lysosomal V0 subunit A2
Synonyms: TJ6s, ATP6a2, Atp6n2, 8430408C20Rik, Tj6, V-ATPase a2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 21871
Homologene: 56523
Fggy
Name: FGGY carbohydrate kinase domain containing
Synonyms: 2310009E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 75578
Homologene: 49535
Ankfn1
Name: ankyrin-repeat and fibronectin type III domain containing 1
Synonyms: LOC382543, 4932411E22Rik, nmf9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 382543
Homologene: 34996
Pdzd7
Name: PDZ domain containing 7
Synonyms: Pdzk7, EG435601
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 100503041
Homologene: 129509
Uqcrc1
Name: ubiquinol-cytochrome c reductase core protein 1
Synonyms: 1110032G10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 22273
Homologene: 2525
Ano3
Name: anoctamin 3
Synonyms: Tmem16c, B230324K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228432
Homologene: 57147
Pax5
Name: paired box 5
Synonyms: Pax-5, EBB-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 18507
HGNC: HGNC:8619
Homologene: 56419
Olfr284
Name: olfactory receptor 284
Synonyms: MOR160-4, GA_x6K02T2NBG7-5395976-5396893
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 258278
Homologene: 74250
Bco2
Name: beta-carotene oxygenase 2
Synonyms: beta-diox-II, Bcdo2, B-diox-II, CMO2, Bcmo2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 170752
Homologene: 12912
Atp8b2
Name: ATPase, class I, type 8B, member 2
Synonyms: Id
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 54667
Homologene: 23226
Gnas
Name: GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
Synonyms: XLalphas, neuroendocrine-specific Golgi protein p55 isoform 1, P2, Nespl, Gs alpha, Galphas, Nesp, Gnas1, P1, SCG6, Gnasxl, Nesp55, Oedsml, Gsa, G alpha s, Gs-alpha, P3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14683
HGNC: HGNC:4392
Homologene: 55534
Ephb4
Name: Eph receptor B4
Synonyms: Tyro11, Htk, Myk1, b2b2412Clo, MDK2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 13846
HGNC: HGNC:3395
Homologene: 20939
Aspg
Name: asparaginase
Synonyms: A530050D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 104816
VEGA: 12
Homologene: 113390
Fv1
Name: Friend virus susceptibility 1
Synonyms: Rv-1, Fv-1, Rv1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 14349
Gm5965
Name: predicted gene 5965
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 546672
VEGA: 16
Gm3436
Name: predicted pseudogene 3436
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 100041622
VEGA: 9
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 2 at 22,245,550 bp
  • G to A, chromosome 2 at 110,781,413 bp
  • T to C, chromosome 2 at 119,412,429 bp
  • A to G, chromosome 2 at 174,298,331 bp
  • A to T, chromosome 3 at 26,777,537 bp
  • T to C, chromosome 3 at 89,946,022 bp
  • T to A, chromosome 3 at 103,330,180 bp
  • T to C, chromosome 4 at 44,679,526 bp
  • A to G, chromosome 4 at 95,926,743 bp
  • A to G, chromosome 4 at 112,624,180 bp
  • C to T, chromosome 4 at 120,505,281 bp
  • A to G, chromosome 4 at 147,870,269 bp
  • T to C, chromosome 5 at 76,266,882 bp
  • C to T, chromosome 5 at 115,240,437 bp
  • A to G, chromosome 5 at 123,254,445 bp
  • C to T, chromosome 5 at 124,721,779 bp
  • T to C, chromosome 5 at 137,369,852 bp
  • C to T, chromosome 5 at 149,564,414 bp
  • T to C, chromosome 6 at 3,565,674 bp
  • T to C, chromosome 6 at 42,686,542 bp
  • T to A, chromosome 6 at 73,086,185 bp
  • A to G, chromosome 6 at 120,210,385 bp
  • A to G, chromosome 6 at 125,050,050 bp
  • A to T, chromosome 6 at 147,012,435 bp
  • C to A, chromosome 7 at 19,524,276 bp
  • A to G, chromosome 7 at 35,591,811 bp
  • T to A, chromosome 7 at 75,586,301 bp
  • T to C, chromosome 8 at 45,013,053 bp
  • C to T, chromosome 8 at 71,664,245 bp
  • A to G, chromosome 9 at 36,714,429 bp
  • T to C, chromosome 9 at 50,545,344 bp
  • T to C, chromosome 9 at 70,852,582 bp
  • G to T, chromosome 9 at 82,926,500 bp
  • A to T, chromosome 9 at 105,414,725 bp
  • G to A, chromosome 9 at 108,946,942 bp
  • T to A, chromosome 10 at 74,504,779 bp
  • T to C, chromosome 10 at 75,154,960 bp
  • A to G, chromosome 11 at 26,498,919 bp
  • G to T, chromosome 11 at 69,827,900 bp
  • T to C, chromosome 11 at 79,248,436 bp
  • C to T, chromosome 11 at 89,434,810 bp
  • T to C, chromosome 11 at 101,517,285 bp
  • A to G, chromosome 12 at 28,746,390 bp
  • C to T, chromosome 12 at 79,188,505 bp
  • A to G, chromosome 12 at 102,373,716 bp
  • T to C, chromosome 12 at 112,120,002 bp
  • T to C, chromosome 13 at 112,966,621 bp
  • G to A, chromosome 15 at 98,340,365 bp
  • A to T, chromosome 16 at 88,778,507 bp
  • A to G, chromosome 17 at 15,738,549 bp
  • T to C, chromosome 17 at 28,599,472 bp
  • T to C, chromosome 17 at 73,239,919 bp
  • T to C, chromosome 18 at 36,648,485 bp
  • T to C, chromosome 19 at 45,027,791 bp
  • A to G, chromosome 19 at 55,294,230 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5458 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043021-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.