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Strain Name:
C57BL/6J-MtgxR5488Btlr/Mmmh
Stock Number:
043049-MU
Citation ID:
RRID:MMRRC_043049-MU
Other Names:
R5488 (G1), C57BL/6J-MtgxR5488Btlr
Major Collection:

Strain Information

Cdk17
Name: cyclin dependent kinase 17
Synonyms: 6430598J10Rik, Pctk2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237459
VEGA: 10
HGNC: HGNC:8750
Homologene: 55666
D630045J12Rik
Name: RIKEN cDNA D630045J12 gene
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330286
Homologene: 19782
Gprc5a
Name: G protein-coupled receptor, family C, group 5, member A
Synonyms: Gprc5a, Raig1, Rai3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232431
HGNC: HGNC:9836
Homologene: 2961
Pdzd2
Name: PDZ domain containing 2
Synonyms: 4930537L06Rik, LOC223364, A930022H17Rik, Pdzk3, Gm21706
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68070
Homologene: 23393
Kat6b
Name: K(lysine) acetyltransferase 6B
Synonyms: qkf, querkopf, Morf, B130044K16Rik, monocytic leukemia, Myst4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 54169
Homologene: 136480
Miga1
Name: mitoguardin 1
Synonyms: C030011O14Rik, Mita1, Fam73a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 215708
Homologene: 18369
Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Synonyms: trithorax Drosophila, HTRX1, ALL-1, All1, Cxxc7, Mll, Mll1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214162
HGNC: HGNC:7132
Homologene: 4338
Sart3
Name: squamous cell carcinoma antigen recognized by T cells 3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 53890
Homologene: 40977
Zmym2
Name: zinc finger, MYM-type 2
Synonyms: SCLL, RAMP, MYM, FIM, Zfp198
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 76007
VEGA: 14
Homologene: 12631
Kctd3
Name: potassium channel tetramerisation domain containing 3
Synonyms: NY-REN-45, E330032J19Rik, 4930438A20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226823
Homologene: 9395
Mark4
Name: MAP/microtubule affinity regulating kinase 4
Synonyms: Markl1, 2410090P21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232944
Homologene: 57146
Mcm10
Name: minichromosome maintenance 10 replication initiation factor
Synonyms: C330019M07Rik, 2410041F14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70024
Homologene: 41275
Mmp20
Name: matrix metallopeptidase 20 (enamelysin)
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 30800
VEGA: 9
HGNC: HGNC:7167
Homologene: 21001
Wdr5
Name: WD repeat domain 5
Synonyms: Big-3, 2410008O07Rik, Bmp2-induced gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 140858
Homologene: 59931
Chd8
Name: chromodomain helicase DNA binding protein 8
Synonyms: 5830451P18Rik, Duplin
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67772
Homologene: 72405
Slc6a11
Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 11
Synonyms: GAT4, D930045G19Rik, E130202I16Rik, Gabt4, Gat3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243616
Homologene: 129935
Cripto
Name: cripto, EGF-CFC family member
Synonyms: CR1, Tdgf1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21667
Homologene: 2416
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: 1810042B05Rik, Coh1, C330002D13Rik, 2310042E16Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Tardbp
Name: TAR DNA binding protein
Synonyms: 1190002A23Rik, Tdp43, TDP-43
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230908
Homologene: 7221
Nrip3
Name: nuclear receptor interacting protein 3
Synonyms: ICRFP703N2430Q5.2, D7H11orf14, ICRFP703B1614Q5.2, A330103B05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78593
HGNC: HGNC:1167
Homologene: 10764
Farsa
Name: phenylalanyl-tRNA synthetase, alpha subunit
Synonyms: 0610012A19Rik, Farsla
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66590
HGNC: HGNC:3592
Homologene: 3280
Kdelr2
Name: KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
Synonyms: 1110007A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66913
HGNC: HGNC:6305
Homologene: 129146
Rab40c
Name: Rab40C, member RAS oncogene family
Synonyms: RAR3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224624
Homologene: 10907
Robo4
Name: roundabout guidance receptor 4
Synonyms: 1200012D01Rik, Magic roundabout
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74144
Homologene: 10397
Rec8
Name: REC8 meiotic recombination protein
Synonyms: mrec, Rec8L1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 56739
Homologene: 3768
Itga2
Name: integrin alpha 2
Synonyms: VLA-2 receptor, alpha 2 subunit, CD49B, DX5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16398
VEGA: 13
HGNC: HGNC:6137
Homologene: 1662
Vwa3b
Name: von Willebrand factor A domain containing 3B
Synonyms: A230074B11Rik, 4921511C04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70853
Homologene: 27053
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, syne-2, D12Ertd777e, 6820443O06Rik, Nesp2g, Cpfl8, diminished cone electroretinogram, dice
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Cdcp3
Name: CUB domain containing protein 3
Synonyms: 5430419D17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71395
Homologene: 138430
Gvin3
Name: GTPase, very large interferon inducible, family member 3
Synonyms: Gm1966
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434223
Homologene: 32708
Col9a3
Name: collagen, type IX, alpha 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12841
HGNC: HGNC:2219
Homologene: 20438
Pcdh10
Name: protocadherin 10
Synonyms: 6430703F07Rik, 6430521D13Rik, OL-pc, Olpc
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18526
Homologene: 74967
Tdpoz1
Name: TD and POZ domain containing 1
Synonyms: 2cpoz56, Spopl1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 207213
Homologene: 128308
Col4a1
Name: collagen, type IV, alpha 1
Synonyms: Col4a-1, Del(8)Bru44H, Del(8)44H, Bru, Svc, Raw, alpha1(IV) collagen
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12826
HGNC: HGNC:2202
Homologene: 20437
Or52s1b
Name: olfactory receptor family 52 subfamily S member 1B
Synonyms: GA_x6K02T2PBJ9-5889409-5888465, MOR24-1P, Olfr591
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258139
Homologene: 79429
Abca5
Name: ATP-binding cassette, sub-family A member 5
Synonyms: ABC13, B930033A02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217265
HGNC: HGNC:35
Homologene: 10263
Abca14
Name: ATP-binding cassette, sub-family A member 14
Synonyms: 1700110B15Rik, 4930539G24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67928
Homologene: 86128
Fam83b
Name: family with sequence similarity 83, member B
Synonyms: C530008M07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208994
Homologene: 19478
Lao1
Name: L-amino acid oxidase 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100470
Homologene: 44223
Eif4a3l1
Name: eukaryotic translation initiation factor 4A3 like 1
Synonyms: Gm8994, B020013A22Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 668137
Foxred1
Name: FAD-dependent oxidoreductase domain containing 1
Synonyms: TEG-23, Tex23
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235169
Homologene: 9712
Gm9116
Name: predicted gene 9116
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 668344
Ano2
Name: anoctamin 2
Synonyms: Tmem16b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243634
HGNC: HGNC:1183
Homologene: 23221
Pkn3
Name: protein kinase N3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 263803
Homologene: 50980
Nlrp5
Name: NLR family, pyrin domain containing 5
Synonyms: Op1, Mater, Nalp5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23968
Homologene: 65105
Cd48
Name: CD48 antigen
Synonyms: BLAST-1, Sgp-60, Bcm-1, BCM1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12506
HGNC: HGNC:1683
Homologene: 1347
Fam13a
Name: family with sequence similarity 13, member A
Synonyms: D430015B01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58909
Homologene: 135847
Tmem117
Name: transmembrane protein 117
Synonyms: B930062P21Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320709
VEGA: 15
Homologene: 12992
Cyp2c69
Name: cytochrome P450, family 2, subfamily c, polypeptide 69
Synonyms: AI098658
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 100043108
VEGA: 19
Homologene: 74936
Oas1c
Name: 2'-5' oligoadenylate synthetase 1C
Synonyms: Oasl5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 114643
HGNC: HGNC:8086
Homologene: 110815
Or12d2
Name: olfactory receptor family 12 subfamily D member 2
Synonyms: MOR250-4, GA_x6K02T2PSCP-1775063-1774137, Olfr102
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258218
Homologene: 133728
Pfkfb3
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Synonyms: E330010H22Rik, uPFK-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 170768
HGNC: HGNC:8874
Homologene: 88708
Smpd2
Name: sphingomyelin phosphodiesterase 2, neutral
Synonyms: nSMase
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20598
Homologene: 31129
Gm26672
Name: predicted gene, 26672
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Mettl21e
Name: methyltransferase like 21E
Synonyms: LOC381340, 4832428D23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 403183
Homologene: 19006
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 37,114,578 bp
  • T to C, chromosome 1 at 44,218,116 bp
  • G to A, chromosome 1 at 171,695,705 bp
  • A to G, chromosome 1 at 188,981,366 bp
  • A to G, chromosome 2 at 4,992,118 bp
  • T to C, chromosome 2 at 11,484,669 bp
  • A to T, chromosome 2 at 13,575,581 bp
  • T to G, chromosome 2 at 27,525,153 bp
  • T to C, chromosome 2 at 30,088,584 bp
  • T to C, chromosome 2 at 114,133,073 bp
  • T to A, chromosome 2 at 158,217,021 bp
  • G to A, chromosome 2 at 180,616,525 bp
  • G to A, chromosome 3 at 45,381,368 bp
  • T to A, chromosome 3 at 93,670,667 bp
  • A to G, chromosome 3 at 93,910,293 bp
  • CACAACAACAACAACAACA to CACAACAACAACAACA, chromosome 3 at 152,333,446 bp
  • A to G, chromosome 4 at 118,967,369 bp
  • A to G, chromosome 4 at 148,618,640 bp
  • A to G, chromosome 5 at 113,771,380 bp
  • G to A, chromosome 5 at 120,808,012 bp
  • T to A, chromosome 5 at 143,404,029 bp
  • A to T, chromosome 6 at 38,196,847 bp
  • A to T, chromosome 6 at 59,024,318 bp
  • A to G, chromosome 6 at 114,243,894 bp
  • G to T, chromosome 6 at 126,039,253 bp
  • T to C, chromosome 6 at 135,078,870 bp
  • C to G, chromosome 6 at 136,329,557 bp
  • G to T, chromosome 7 at 19,429,607 bp
  • A to T, chromosome 7 at 23,417,934 bp
  • T to C, chromosome 7 at 103,173,451 bp
  • T to A, chromosome 7 at 106,601,590 bp
  • T to C, chromosome 7 at 109,761,838 bp
  • T to A, chromosome 7 at 120,252,250 bp
  • A to G, chromosome 7 at 131,246,595 bp
  • A to T, chromosome 8 at 11,312,550 bp
  • C to T, chromosome 8 at 84,868,028 bp
  • A to G, chromosome 9 at 7,643,957 bp
  • A to T, chromosome 9 at 35,209,970 bp
  • CGG to CG, chromosome 9 at 37,411,490 bp
  • A to T, chromosome 9 at 44,841,038 bp
  • T to C, chromosome 9 at 76,545,599 bp
  • A to T, chromosome 9 at 88,582,176 bp
  • G to A, chromosome 9 at 110,943,197 bp
  • G to A, chromosome 10 at 41,488,005 bp
  • A to G, chromosome 10 at 93,232,412 bp
  • A to G, chromosome 11 at 110,292,183 bp
  • A to G, chromosome 12 at 75,888,172 bp
  • A to T, chromosome 13 at 114,843,435 bp
  • A to G, chromosome 14 at 21,669,264 bp
  • A to T, chromosome 14 at 52,213,048 bp
  • A to T, chromosome 14 at 55,622,826 bp
  • A to G, chromosome 14 at 56,956,255 bp
  • G to A, chromosome 15 at 12,382,676 bp
  • A to T, chromosome 15 at 35,770,542 bp
  • ACCC to ACC, chromosome 15 at 95,094,817 bp
  • G to A, chromosome 17 at 25,890,669 bp
  • T to C, chromosome 17 at 37,313,668 bp
  • A to T, chromosome 18 at 37,752,180 bp
  • T to G, chromosome 19 at 39,851,159 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5488 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043049-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.