Strain Name:
C57BL/6J-MtgxR5490Btlr/Mmmh
Stock Number:
043051-MU
Citation ID:
RRID:MMRRC_043051-MU
Other Names:
R5490 (G1), C57BL/6J-MtgxR5490Btlr
Major Collection:

Gene Information

Aatf
Name: apoptosis antagonizing transcription factor
Synonyms: 4933415H02Rik, Trb, 5830465M17Rik, Che-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 56321
Homologene: 40811
Prpf6
Name: pre-mRNA splicing factor 6
Synonyms: 1190003A07Rik, U5-102K, ANT-1, 2610031L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68879
Homologene: 5368
Pepd
Name: peptidase D
Synonyms: Pep-4, peptidase D, Pep4, dal
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18624
HGNC: HGNC:8840
Homologene: 239
Stam2
Name: signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Synonyms: Hbp, 1200004O12Rik, 5730456G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56324
Homologene: 68490
Cdca2
Name: cell division cycle associated 2
Synonyms: 2610311M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 108912
Homologene: 18444
Zc3h4
Name: zinc finger CCCH-type containing 4
Synonyms: LOC330474, Bwq1, Kiaa1064-hp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330474
Homologene: 87150
Relch
Name: RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
Synonyms: 2310035C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227446
Homologene: 10834
Lima1
Name: LIM domain and actin binding 1
Synonyms: 1110021C24Rik, 3526402A12Rik, epithelial protein lost in neoplasm, EPLIN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 65970
Homologene: 9484
Smg1
Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Synonyms: C130002K18Rik, 5430435M13Rik, 2610207I05Rik, SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233789
Homologene: 56697
Gapvd1
Name: GTPase activating protein and VPS9 domains 1
Synonyms: 2010005B09Rik, 4432404J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66691
Homologene: 32637
Nubp1
Name: nucleotide binding protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 26425
HGNC: HGNC:8041
Homologene: 1857
Tceanc2
Name: transcription elongation factor A (SII) N-terminal and central domain containing 2
Synonyms: 2210010B22Rik, 6330404A07Rik, 2210012G02Rik, Tdeanc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66526
Homologene: 11984
Btnl9
Name: butyrophilin-like 9
Synonyms: D330012D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237754
Homologene: 68540
Rbm43
Name: RNA binding motif protein 43
Synonyms: 0610033I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71684
Homologene: 12715
Map2
Name: microtubule-associated protein 2
Synonyms: MAP-2, G1-397-34, Mtap2, repro4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
1810013L24Rik
Name: RIKEN cDNA 1810013L24 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 69053
VEGA: 16
Homologene: 105712
Tecpr2
Name: tectonin beta-propeller repeat containing 2
Synonyms: 4930573I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104859
VEGA: 12
Homologene: 8897
Cblb
Name: Casitas B-lineage lymphoma b
Synonyms: Cbl-b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 208650
VEGA: 16
HGNC: HGNC:1542
Homologene: 15856
Eea1
Name: early endosome antigen 1
Synonyms: B230358H09Rik, ZFYVE2, A430109M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216238
VEGA: 10
HGNC: HGNC:3185
Homologene: 37822
Robo4
Name: roundabout guidance receptor 4
Synonyms: 1200012D01Rik, Magic roundabout
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74144
Homologene: 10397
Mgat4f
Name: MGAT4 family, member F
Synonyms: 4933406M09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240755
Homologene: 128441
Olfr568
Name: olfactory receptor 568
Synonyms: GA_x6K02T2PBJ9-5588278-5589228, MOR14-3, MOR14-11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259095
Homologene: 81595
Kif5c
Name: kinesin family member 5C
Synonyms: Khc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16574
HGNC: HGNC:6325
Homologene: 56234
Madd
Name: MAP-kinase activating death domain
Synonyms: 9630059K23Rik, Rab3 GEP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228355
HGNC: HGNC:6766
Homologene: 14249
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243369
Homologene: 45453
Yipf2
Name: Yip1 domain family, member 2
Synonyms: 1300010K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74766
VEGA: 9
Homologene: 23430
Gpr87
Name: G protein-coupled receptor 87
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 84111
HGNC: HGNC:4538
Homologene: 13021
Ppp1r36
Name: protein phosphatase 1, regulatory subunit 36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 210762
VEGA: 12
Homologene: 52094
Nup210
Name: nucleoporin 210
Synonyms: gp210, gp190, Pom210
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 54563
Homologene: 41286
Tmem241
Name: transmembrane protein 241
Synonyms: 6030446N20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 338363
Homologene: 87267
Mpeg1
Name: macrophage expressed gene 1
Synonyms: Mpg-1, MPS1, Perforin-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 17476
VEGA: 19
Homologene: 11216
Mamdc4
Name: MAM domain containing 4
Synonyms: LOC381352
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 381352
Homologene: 17102
Klk14
Name: kallikrein related-peptidase 14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 317653
HGNC: HGNC:6362
Homologene: 69348
Hmgxb3
Name: HMG box domain containing 3
Synonyms: 2510002C16Rik, A630042L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 106894
VEGA: 18
Homologene: 44229
Abcc1
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Synonyms: MRP, Mdrap, Mrp1, Abcc1b, Abcc1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17250
HGNC: HGNC:51
Homologene: 133779
Olfr348
Name: olfactory receptor 348
Synonyms: GA_x6K02T2NLDC-33481050-33481991, MOR136-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258946
HGNC: HGNC:8209
Homologene: 105219
Zfp184
Name: zinc finger protein 184 (Kruppel-like)
Synonyms: 4930500C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 193452
Homologene: 113602
Glyat
Name: glycine-N-acyltransferase
Synonyms: A330009E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107146
Homologene: 64840
Syne3
Name: spectrin repeat containing, nuclear envelope family member 3
Synonyms: nesprin-3beta, nesprin-3alpha, nesprin-3, 4831426I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 212073
VEGA: 12
Homologene: 17625
Rassf5
Name: Ras association (RalGDS/AF-6) domain family member 5
Synonyms: 1300019G20Rik, Nore1B, Nore1A, Rapl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 54354
Homologene: 10296
Zhx1
Name: zinc fingers and homeoboxes 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22770
Homologene: 5225
Asic2
Name: acid-sensing (proton-gated) ion channel 2
Synonyms: Mdeg, BNaC1a, BNC1, Accn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11418
HGNC: HGNC:99
Homologene: 137202
Chfr
Name: checkpoint with forkhead and ring finger domains
Synonyms: RNF116, 5730484M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231600
Homologene: 10078
Olfr1009
Name: olfactory receptor 1009
Synonyms: GA_x6K02T2Q125-47195323-47196267, MOR175-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258565
Homologene: 17297
Mapre3
Name: microtubule-associated protein, RP/EB family, member 3
Synonyms: EB3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100732
HGNC: HGNC:6892
Homologene: 56565
Star
Name: steroidogenic acute regulatory protein
Synonyms: D8Ertd419e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20845
Homologene: 297
Slc35a3
Name: solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
Synonyms: 2310050P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229782
Homologene: 40826
Nkx2-3
Name: NK2 homeobox 3
Synonyms: Nkx2.3, tinman, Nkx-2.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18089
HGNC: HGNC:7836
Homologene: 17061
Sds
Name: serine dehydratase
Synonyms: SDH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231691
Homologene: 38235
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 66,413,133 bp
  • T to A, chromosome 1 at 105,719,501 bp
  • T to A, chromosome 1 at 131,181,195 bp
  • A to G, chromosome 1 at 134,389,928 bp
  • T to C, chromosome 2 at 25,565,878 bp
  • T to C, chromosome 2 at 34,693,433 bp
  • T to A, chromosome 2 at 36,787,181 bp
  • T to C, chromosome 2 at 49,758,858 bp
  • T to A, chromosome 2 at 51,925,595 bp
  • T to C, chromosome 2 at 52,720,917 bp
  • G to T, chromosome 2 at 85,722,322 bp
  • G to T, chromosome 2 at 91,170,635 bp
  • T to G, chromosome 2 at 181,608,165 bp
  • T to C, chromosome 3 at 59,179,326 bp
  • A to T, chromosome 3 at 116,681,190 bp
  • A to T, chromosome 4 at 107,165,649 bp
  • G to A, chromosome 5 at 30,861,897 bp
  • A to G, chromosome 5 at 110,153,129 bp
  • C to A, chromosome 5 at 120,483,650 bp
  • T to C, chromosome 6 at 48,493,280 bp
  • C to T, chromosome 6 at 91,085,988 bp
  • T to A, chromosome 7 at 16,429,005 bp
  • A to G, chromosome 7 at 34,942,690 bp
  • G to A, chromosome 7 at 43,692,077 bp
  • T to C, chromosome 7 at 102,877,893 bp
  • G to A, chromosome 7 at 118,139,436 bp
  • A to G, chromosome 8 at 25,809,917 bp
  • G to A, chromosome 9 at 21,592,191 bp
  • CGG to CG, chromosome 9 at 37,411,490 bp
  • A to G, chromosome 10 at 96,026,054 bp
  • T to C, chromosome 11 at 49,169,568 bp
  • T to C, chromosome 11 at 80,889,820 bp
  • C to T, chromosome 11 at 84,510,273 bp
  • T to A, chromosome 12 at 76,437,986 bp
  • G to T, chromosome 12 at 76,437,987 bp
  • A to G, chromosome 12 at 104,955,672 bp
  • T to C, chromosome 12 at 110,914,684 bp
  • T to A, chromosome 13 at 21,958,577 bp
  • T to C, chromosome 14 at 67,680,284 bp
  • T to C, chromosome 15 at 58,053,299 bp
  • T to C, chromosome 15 at 99,783,700 bp
  • T to A, chromosome 16 at 8,855,857 bp
  • T to G, chromosome 16 at 10,420,929 bp
  • G to T, chromosome 16 at 14,410,917 bp
  • A to G, chromosome 16 at 52,174,370 bp
  • C to T, chromosome 18 at 12,043,263 bp
  • A to G, chromosome 18 at 61,162,977 bp
  • T to C, chromosome 19 at 12,461,693 bp
  • C to T, chromosome 19 at 12,650,281 bp
  • A to T, chromosome 19 at 43,612,654 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5490 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043051-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.