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Strain Name:
C57BL/6J-MtgxR5497Btlr/Mmmh
Stock Number:
043058-MU
Citation ID:
RRID:MMRRC_043058-MU
Other Names:
R5497 (G1), C57BL/6J-MtgxR5497Btlr
Major Collection:

Strain Information

Hdac5
Name: histone deacetylase 5
Synonyms: mHDA1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15184
Homologene: 3995
Tbcel
Name: tubulin folding cofactor E-like
Synonyms: E130107N23Rik, Lrrc35
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 272589
Homologene: 16120
Lrp5
Name: low density lipoprotein receptor-related protein 5
Synonyms: LR3, LRP7
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16973
Homologene: 1746
Atp2a2
Name: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Synonyms: sarco/endoplasmic reticulum Ca2+-ATPase 2, SERCA2, 9530097L16Rik, D5Wsu150e, SERCA2B, Serca2a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11938
HGNC: HGNC:812
Homologene: 80167
Snx6
Name: sorting nexin 6
Synonyms: 2610032J07Rik, 2010006G21Rik, 2810425K19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 72183
VEGA: 12
Homologene: 12304
Map2k4
Name: mitogen-activated protein kinase kinase 4
Synonyms: MKK4, JNKK1, Serk1, Sek1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 26398
HGNC: HGNC:6844
Homologene: 48159
Micos10
Name: mitochondrial contact site and cristae organizing system subunit 10
Synonyms: 2310028O11Rik, Minos1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 433771
Homologene: 55024
Ralgapb
Name: Ral GTPase activating protein, beta subunit (non-catalytic)
Synonyms: B230339M05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228850
Homologene: 10666
Eif3e
Name: eukaryotic translation initiation factor 3, subunit E
Synonyms: eIF3-p48, eIF3-p46, Int6, 48kDa, Eif3s6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16341
VEGA: 15
HGNC: HGNC:3277
Homologene: 1205
Heatr1
Name: HEAT repeat containing 1
Synonyms: B130016L12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 217995
VEGA: 13
Homologene: 34562
Pcmtd1
Name: protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1
Synonyms: 8430411F12Rik, A030012M09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319263
Homologene: 14180
Apaf1
Name: apoptotic peptidase activating factor 1
Synonyms: Apaf1l, 6230400I06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11783
HGNC: HGNC:576
Homologene: 7626
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Galnt5
Name: polypeptide N-acetylgalactosaminyltransferase 5
Synonyms: ppGaNTase-T5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241391
HGNC: HGNC:4127
Homologene: 8733
Cic
Name: capicua transcriptional repressor
Synonyms: 1200010B10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71722
Homologene: 87637
Dmbt1
Name: deleted in malignant brain tumors 1
Synonyms: CRP-[b], CRP-[a], ebnerin, hensin, vomeroglandin, Crpd, MUCLIN, gp300
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12945
HGNC: HGNC:2926
Homologene: 68990
Gja8
Name: gap junction protein, alpha 8
Synonyms: Cnx50, connexin 50, alpha 8 connexin, Cx50, Aey5, Lop10, dcm
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14616
HGNC: HGNC:4281
Homologene: 3857
Rnd2
Name: Rho family GTPase 2
Synonyms: Arhn, Rohn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11858
Homologene: 21123
Ifnar1
Name: interferon (alpha and beta) receptor 1
Synonyms: Ifrc, Ifar, IFN-alpha/betaR
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15975
HGNC: HGNC:5432
Homologene: 524
Rph3a
Name: rabphilin 3A
Synonyms: 2900002P20Rik, Doc2 family
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19894
Homologene: 7921
Zfp980
Name: zinc finger protein 980
Synonyms: Gm13242
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100041379
Homologene: 133076
Hjurp
Name: Holliday junction recognition protein
Synonyms: C330011F01Rik, A730008H23Rik, 6430706D22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381280
Homologene: 10184
Nptx2
Name: neuronal pentraxin 2
Synonyms: np2, narp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 53324
HGNC: HGNC:7953
Homologene: 1892
Map3k7
Name: mitogen-activated protein kinase kinase kinase 7
Synonyms: Tak1, transforming growth factor-beta-activated kinase 1, TGF-beta activated kinase 1, TAK1, transforming growth factor beta-activated kinase 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26409
HGNC: HGNC:6859
Homologene: 118818
Tm9sf3
Name: transmembrane 9 superfamily member 3
Synonyms: 2810031D16Rik, 1810073M23Rik, Smbp
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107358
VEGA: 19
Homologene: 10588
Vps51
Name: VPS51 GARP complex subunit
Synonyms: 3110057M17Rik, 1110014N23Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68505
HGNC: HGNC:1172
Homologene: 34675
Asap3
Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
Synonyms: UPLC1, 9430088F20Rik, Ddefl1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230837
Homologene: 41190
Tlr3
Name: toll-like receptor 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 142980
Homologene: 20696
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Adarb1
Name: adenosine deaminase, RNA-specific, B1
Synonyms: RED1, ADAR2, D10Bwg0447e, 1700057H01Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 110532
HGNC: HGNC:226
Homologene: 8280
Primpol
Name: primase and polymerase (DNA-directed)
Synonyms: Ccdc111
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 408022
Homologene: 14065
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Cpa1
Name: carboxypeptidase A1, pancreatic
Synonyms: 0910001L12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 109697
HGNC: HGNC:2296
Homologene: 55609
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, syne-2, D12Ertd777e, 6820443O06Rik, Nesp2g, diminished cone electroretinogram, dice, Cpfl8
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Abca4
Name: ATP-binding cassette, sub-family A member 4
Synonyms: Rim protein, RmP, Abc10, D430003I15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11304
HGNC: HGNC:34
Homologene: 298
Fhip2a
Name: FHF complex subunit HOOK interacting protein 2A
Synonyms: Fam160b1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226252
VEGA: 19
Homologene: 28133
Cfap58
Name: cilia and flagella associated protein 58
Synonyms: LOC381229, Ccdc147
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 381229
VEGA: 19
Homologene: 77312
Vmn2r61
Name: vomeronasal 2, receptor 61
Synonyms: Casr-rs2, EG637873, Gprc2a-rs2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637873
Homologene: 129683
Gucy2g
Name: guanylate cyclase 2g
Synonyms: 2410077I05Rik, GC-G
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73707
Homologene: 44544
Gxylt2
Name: glucoside xylosyltransferase 2
Synonyms: LOC232313, Glt8d4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232313
Homologene: 16823
Abca9
Name: ATP-binding cassette, sub-family A member 9
Synonyms: D630040K07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217262
HGNC: HGNC:39
Homologene: 33332
Capn8
Name: calpain 8
Synonyms: nCL-2', nCL-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 170725
HGNC: HGNC:1485
Homologene: 15643
Or2aj4
Name: olfactory receptor family 2 subfamily AJ member 4
Synonyms: GA_x54KRFPKG5P-16014972-16014031, MOR273-3P, Olfr169
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258158
Homologene: 128058
Klhl32
Name: kelch-like 32
Synonyms: LOC384000, D4Ertd389e, 6430524H05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 212390
Homologene: 14173
Cebpe
Name: CCAAT/enhancer binding protein epsilon
Synonyms: C/EBPepsilon, C/EBPe, CRP1, LOC239097
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110794
VEGA: 14
HGNC: HGNC:1836
Homologene: 1367
Shank2
Name: SH3 and multiple ankyrin repeat domains 2
Synonyms: ProSAP1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210274
Homologene: 105965
4933427D14Rik
Name: RIKEN cDNA 4933427D14 gene
Synonyms: Gm43951
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74477
Homologene: 8874
Ces1c
Name: carboxylesterase 1C
Synonyms: Es-N, Es-4, Es-1, Ee-1, Es1, Ces-N
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13884
HGNC: HGNC:1863
Homologene: 117484
Atp6v0a1
Name: ATPase, H+ transporting, lysosomal V0 subunit A1
Synonyms: V-ATPase a1, Vpp1, Vpp-1, Atp6n1, Atp6n1a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11975
HGNC: HGNC:865
Homologene: 3795
Retreg2
Name: reticulophagy regulator family member 2
Synonyms: MGC47289, Fam134a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227298
Homologene: 11507
Klc3
Name: kinesin light chain 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232943
Homologene: 14899
Srm
Name: spermidine synthase
Synonyms: SpdSy, SpdST
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20810
Homologene: 40514
Ebf4
Name: early B cell factor 4
Synonyms: Olf-1/EBF-like 4, O/E-4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228598
Homologene: 65064
Atg16l2
Name: autophagy related 16 like 2
Synonyms: 2410118P20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73683
Homologene: 18981
Usp31
Name: ubiquitin specific peptidase 31
Synonyms: 6330567E21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76179
Homologene: 44504
Acsm2
Name: acyl-CoA synthetase medium-chain family member 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233799
Homologene: 70404
H2-Ob
Name: histocompatibility 2, O region beta locus
Synonyms: Ob, H-2I, H2-IAb2, H2-Ab, H-2Ob, H2-Ab2, A-beta2, A-beta-2, vic1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15002
HGNC: HGNC:4937
Homologene: 1602
Hsd3b7
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101502
Homologene: 41617
Tas2r105
Name: taste receptor, type 2, member 105
Synonyms: Tas2r5, T2R05, T2R9, mGR05, mt2r5, T2r5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 57252
Homologene: 69307
Cacng8
Name: calcium channel, voltage-dependent, gamma subunit 8
Synonyms: TARP gamma 8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81905
Homologene: 12894
Isoc2b
Name: isochorismatase domain containing 2b
Synonyms: 0610042E07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67441
Homologene: 85975
Gon7
Name: GON7 subunit of KEOPS complex
Synonyms: AK010878
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 100233175
Homologene: 53430
Aspdh
Name: aspartate dehydrogenase domain containing
Synonyms: 0610012D14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68352
Homologene: 41692
Nutf2-ps1
Name: nuclear transport factor 2, pseudogene 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 100043462
VEGA: 19
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 7,155,046 bp
  • T to A, chromosome 1 at 20,377,404 bp
  • G to A, chromosome 1 at 75,144,989 bp
  • G to A, chromosome 1 at 88,266,320 bp
  • G to A, chromosome 1 at 182,620,180 bp
  • T to C, chromosome 2 at 58,025,328 bp
  • T to C, chromosome 2 at 130,369,390 bp
  • T to C, chromosome 2 at 158,482,399 bp
  • A to G, chromosome 3 at 96,920,197 bp
  • T to C, chromosome 3 at 122,087,372 bp
  • T to C, chromosome 4 at 24,800,817 bp
  • T to C, chromosome 4 at 31,991,719 bp
  • A to G, chromosome 4 at 136,239,222 bp
  • A to G, chromosome 4 at 139,105,893 bp
  • A to G, chromosome 4 at 145,701,447 bp
  • G to T, chromosome 4 at 148,594,109 bp
  • T to A, chromosome 5 at 120,942,190 bp
  • C to T, chromosome 5 at 122,458,169 bp
  • A to T, chromosome 5 at 144,556,189 bp
  • A to G, chromosome 6 at 30,640,730 bp
  • A to G, chromosome 6 at 100,787,329 bp
  • G to A, chromosome 6 at 131,686,842 bp
  • A to G, chromosome 7 at 3,415,553 bp
  • C to T, chromosome 7 at 4,850,783 bp
  • T to C, chromosome 7 at 19,394,670 bp
  • A to G, chromosome 7 at 25,289,279 bp
  • T to A, chromosome 7 at 42,275,482 bp
  • T to C, chromosome 7 at 44,466,187 bp
  • G to A, chromosome 7 at 101,291,537 bp
  • A to T, chromosome 7 at 119,573,320 bp
  • A to T, chromosome 7 at 121,651,601 bp
  • A to G, chromosome 7 at 127,801,888 bp
  • A to T, chromosome 7 at 131,063,403 bp
  • A to G, chromosome 7 at 141,807,643 bp
  • A to G, chromosome 7 at 144,409,534 bp
  • A to G, chromosome 8 at 16,085,181 bp
  • C to T, chromosome 8 at 45,398,814 bp
  • A to T, chromosome 8 at 46,592,622 bp
  • A to C, chromosome 8 at 93,130,715 bp
  • T to A, chromosome 9 at 42,451,745 bp
  • T to C, chromosome 10 at 77,325,889 bp
  • G to A, chromosome 10 at 90,999,656 bp
  • A to G, chromosome 11 at 65,735,205 bp
  • A to T, chromosome 11 at 72,165,534 bp
  • G to A, chromosome 11 at 101,029,185 bp
  • C to T, chromosome 11 at 101,468,999 bp
  • A to G, chromosome 11 at 102,197,096 bp
  • G to A, chromosome 11 at 110,130,692 bp
  • A to G, chromosome 12 at 54,757,061 bp
  • A to G, chromosome 12 at 75,880,389 bp
  • A to G, chromosome 12 at 102,754,104 bp
  • A to T, chromosome 13 at 11,705,701 bp
  • T to A, chromosome 13 at 12,421,064 bp
  • A to G, chromosome 14 at 54,710,595 bp
  • T to C, chromosome 15 at 43,270,970 bp
  • C to T, chromosome 16 at 19,566,330 bp
  • T to G, chromosome 16 at 91,505,364 bp
  • A to G, chromosome 17 at 34,241,170 bp
  • C to A, chromosome 19 at 3,602,319 bp
  • T to G, chromosome 19 at 6,071,033 bp
  • T to C, chromosome 19 at 41,215,116 bp
  • T to G, chromosome 19 at 48,029,109 bp
  • A to T, chromosome 19 at 53,588,834 bp
  • C to T, chromosome 19 at 55,198,701 bp
  • G to C, chromosome 19 at 57,381,151 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5497 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043058-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.