Strain Name:
C57BL/6J-MtgxR5504Btlr/Mmmh
Stock Number:
043065-MU
Citation ID:
RRID:MMRRC_043065-MU
Other Names:
R5504 (G1), C57BL/6J-MtgxR5504Btlr
Major Collection:

Strain Information

Sema6d
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
Synonyms: 1110067B02Rik, Sema6D-6, Sema6D-5, Sema6D-4, Sema6D-2, Sema6D-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214968
Homologene: 16195
Colgalt2
Name: collagen beta(1-O)galactosyltransferase 2
Synonyms: Glt25d2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269132
Homologene: 22865
Nrcam
Name: neuronal cell adhesion molecule
Synonyms: Bravo, C030017F07Rik, C130076O07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319504
VEGA: 12
HGNC: HGNC:7994
Homologene: 21041
Rgs14
Name: regulator of G-protein signaling 14
Synonyms: Rap1/rap2 interacting protein
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 51791
HGNC: HGNC:9996
Homologene: 4735
Dock5
Name: dedicator of cytokinesis 5
Synonyms: lr2, 1110060D06Rik, rlc
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 68813
VEGA: 14
Homologene: 57016
Synj2
Name: synaptojanin 2
Synonyms: SJ2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20975
Homologene: 117703
Hdlbp
Name: high density lipoprotein (HDL) binding protein
Synonyms: D1Ertd101e, 1110005P14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 110611
HGNC: HGNC:4857
Homologene: 38035
Cabin1
Name: calcineurin binding protein 1
Synonyms: Ppp3in, Cain, A330070M20Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 104248
VEGA: 10
Homologene: 49307
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: apollon, Bruce, A430032G04Rik, D630005A10Rik, A430040A19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12211
Homologene: 7248
Atp2c1
Name: ATPase, Ca++-sequestering
Synonyms: SPCA, ATP2C1A, PMR1, 1700121J11Rik, D930003G21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235574
Homologene: 56672
Akap9
Name: A kinase anchor protein 9
Synonyms: AKAP450, 5730481H23Rik, G1-448-15, repro12, mei2-5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100986
HGNC: HGNC:379
Homologene: 134583
Heatr1
Name: HEAT repeat containing 1
Synonyms: B130016L12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 217995
VEGA: 13
Homologene: 34562
Hmgn2
Name: high mobility group nucleosomal binding domain 2
Synonyms: Hmg17, HMG-17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15331
HGNC: HGNC:4986
Homologene: 128537
Gabpa
Name: GA repeat binding protein, alpha
Synonyms: GABPalpha
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14390
HGNC: HGNC:4071
Homologene: 1543
Rif1
Name: replication timing regulatory factor 1
Synonyms: 5730435J01Rik, 6530403D07Rik, D2Ertd145e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 51869
Homologene: 41231
Nek1
Name: NIMA (never in mitosis gene a)-related expressed kinase 1
Synonyms: kat, kidney, anemia and testis, D8Ertd790e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18004
HGNC: HGNC:7744
Homologene: 14376
Zfp866
Name: zinc finger protein 866
Synonyms: 9830167H18Rik, D330038O06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330788
Angel2
Name: angel homolog 2
Synonyms: 5730410O10Rik, 2610307I21Rik, D1Ertd654e, D1Ertd396e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 52477
Homologene: 16932
Tmeff1
Name: transmembrane protein with EGF-like and two follistatin-like domains 1
Synonyms: tomoregulin-like, M7365
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230157
Homologene: 130458
Bsx
Name: brain specific homeobox
Synonyms: Bsx1b, Bsx1a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244813
Homologene: 65347
Dennd1b
Name: DENN domain containing 1B
Synonyms: F730008N07Rik, 4632404N19Rik, 4930467M19Rik, 6820401H01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329260
Homologene: 11739
Angptl2
Name: angiopoietin-like 2
Synonyms: Arp2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26360
HGNC: HGNC:490
Homologene: 22695
Src
Name: Rous sarcoma oncogene
Synonyms: pp60c-src
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20779
Homologene: 21120
Npat
Name: nuclear protein in the AT region
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244879
HGNC: HGNC:7896
Homologene: 1888
Pcnx4
Name: pecanex homolog 4
Synonyms: 1810048J11Rik, Pcnxl4
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67708
VEGA: 12
Homologene: 23366
Fhad1
Name: forkhead-associated phosphopeptide binding domain 1
Synonyms: 2900090M10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329977
Homologene: 77947
Gvin3
Name: GTPase, very large interferon inducible, family member 3
Synonyms: Gm1966
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434223
Homologene: 32708
Pear1
Name: platelet endothelial aggregation receptor 1
Synonyms: 3110045G13Rik, Jedi-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 73182
Homologene: 12492
Rp1
Name: retinitis pigmentosa 1 (human)
Synonyms: oxygen-regulated protein 1, Orp1, mG145, Dcdc3, Rp1h
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19888
Homologene: 4564
Ppp2r1b
Name: protein phosphatase 2, regulatory subunit A, beta
Synonyms: 2410091N08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73699
HGNC: HGNC:9303
Homologene: 70244
Or56a4
Name: olfactory receptor family 56 subfamily A member 4
Synonyms: GA_x6K02T2PBJ9-7786441-7785503, MOR40-8P, Olfr684
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244187
Homologene: 133596
Adam34l
Name: a disintegrin and metallopeptidase domain 34 like
Synonyms: Gm5346
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 384813
Homologene: 78104
Myom2
Name: myomesin 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17930
HGNC: HGNC:7614
Homologene: 2953
Pxdn
Name: peroxidasin
Synonyms: 2310075M15Rik, VPO1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 69675
Homologene: 33907
Serpina3i
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3I
Synonyms: 2B2, antitrypsin, alpha-1 antiproteinase, Gm6930
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 628900
HGNC: HGNC:16
Homologene: 115927
Dhx30
Name: DExH-box helicase 30
Synonyms: Ddx30, 2810477H02Rik, C130058C04Rik, helG, DEAH (Asp-Glu-Ala-His) box polypeptide 30
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72831
Homologene: 15779
Cmklr1
Name: chemerin chemokine-like receptor 1
Synonyms: Gpcr27, ChemR23
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14747
HGNC: HGNC:2121
Homologene: 129967
Pappa2
Name: pappalysin 2
Synonyms: placenta-specific 3, pregnancy-associated plasma preproprotein-A2, pregnancy-associated plasma protein-E, PAPP-A2, PLAC3, Pappe
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23850
Homologene: 10661
Cfhr4
Name: complement factor H-related 4
Synonyms: Gm4788
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 214403
HGNC: HGNC:4883
Mctp1
Name: multiple C2 domains, transmembrane 1
Synonyms: 2810465F10Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 78771
Homologene: 75211
Rad21l
Name: RAD21-like (S. pombe)
Synonyms: Gm14160
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668929
Homologene: 82650
Piwil2
Name: piwi-like RNA-mediated gene silencing 2
Synonyms: Miwi like, mili
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 57746
VEGA: 14
Homologene: 23071
Gm20547
Name: predicted gene 20547
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Or2a7
Name: olfactory receptor family 2 subfamily A member 7
Synonyms: MOR261-6, GA_x6K02T2P3E9-4384160-4383228, Olfr13
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18310
Homologene: 27232
Slc13a1
Name: solute carrier family 13 (sodium/sulfate symporters), member 1
Synonyms: NaSi-1, Nas1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 55961
Homologene: 31893
Lgals3bp
Name: lectin, galactoside-binding, soluble, 3 binding protein
Synonyms: CyCAP, MAC-2BP, 90K, Ppicap, Tango10b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19039
HGNC: HGNC:6564
Homologene: 4067
Slco6d1
Name: solute carrier organic anion transporter family, member 6d1
Synonyms: 4921511I05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70866
Homologene: 86643
Vmn2r45
Name: vomeronasal 2, receptor 45
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042810
Homologene: 113703
Zfp945
Name: zinc finger protein 945
Synonyms: C730040L01Rik, A630033E08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240041
Homologene: 133214
Or4c114
Name: olfactory receptor family 4 subfamily C member 114
Synonyms: GA_x6K02T2Q125-50555603-50554668, MOR233-6, Olfr1219
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258901
Homologene: 27292
Ccdc185
Name: coiled-coil domain containing 185
Synonyms: 4922505E12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 433386
Homologene: 17631
Dnajb12
Name: DnaJ heat shock protein family (Hsp40) member B12
Synonyms: mDj10
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 56709
Homologene: 9749
Amy2a1
Name: amylase 2a1
Synonyms: mAmy2-6, Amy2-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100043207
Hecw1
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Synonyms: NEDL1, E130207I19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 94253
VEGA: 13
Homologene: 9004
Asb18
Name: ankyrin repeat and SOCS box-containing 18
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208372
Homologene: 16382
Ankrd40
Name: ankyrin repeat domain 40
Synonyms: 5530600A18Rik, Gcap15, 1110011C06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71452
Homologene: 12393
Mpi
Name: mannose phosphate isomerase
Synonyms: Mpi-1, 1110002E17Rik, Mpi1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110119
HGNC: HGNC:7216
Homologene: 1825
Gm4775
Name: predicted gene 4775
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 212084
VEGA: 14
Dlg2
Name: discs large MAGUK scaffold protein 2
Synonyms: PSD93, Chapsyn-110, B330007M19Rik, A330103J02Rik, LOC382816, Dlgh2, B230218P12Rik, Gm21505
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23859
HGNC: HGNC:2901
Homologene: 1046
Asphd1
Name: aspartate beta-hydroxylase domain containing 1
Synonyms: A830007L07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233879
Kncn
Name: kinocilin
Synonyms: L5, Kino
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 654462
Homologene: 88613
Capza3
Name: capping actin protein of muscle Z-line subunit alpha 3
Synonyms: Gsg3, Tex8, cp alpha3, Cappa3, 510-4, repro32
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12344
Homologene: 7253
Vmn2r125
Name: vomeronasal 2, receptor 125
Synonyms: Gm20782
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 670059
VEGA: 4
Gm13857
Name: predicted gene 13857
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 102635489
Rgs13
Name: regulator of G-protein signaling 13
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 246709
HGNC: HGNC:9995
Homologene: 14774
Gm17654
Name: predicted gene, 17654
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 108168156
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 4,349,890 bp
  • T to A, chromosome 1 at 89,993,024 bp
  • T to C, chromosome 1 at 93,438,373 bp
  • A to G, chromosome 1 at 98,421,339 bp
  • A to T, chromosome 1 at 139,090,508 bp
  • A to T, chromosome 1 at 139,701,820 bp
  • A to T, chromosome 1 at 144,139,620 bp
  • G to A, chromosome 1 at 152,400,303 bp
  • A to G, chromosome 1 at 158,848,045 bp
  • G to T, chromosome 1 at 182,747,627 bp
  • A to G, chromosome 1 at 190,943,886 bp
  • T to C, chromosome 2 at 33,229,038 bp
  • A to C, chromosome 2 at 52,116,376 bp
  • C to T, chromosome 2 at 89,074,680 bp
  • T to A, chromosome 2 at 124,658,021 bp
  • A to T, chromosome 2 at 151,668,437 bp
  • T to C, chromosome 2 at 157,464,721 bp
  • G to A, chromosome 3 at 87,752,695 bp
  • T to G, chromosome 3 at 113,531,669 bp
  • T to C, chromosome 4 at 48,650,396 bp
  • T to A, chromosome 4 at 115,884,865 bp
  • A to T, chromosome 4 at 133,966,803 bp
  • A to G, chromosome 4 at 141,985,535 bp
  • A to G, chromosome 4 at 156,351,161 bp
  • T to A, chromosome 5 at 4,064,803 bp
  • C to G, chromosome 5 at 113,614,929 bp
  • A to T, chromosome 6 at 24,150,744 bp
  • A to G, chromosome 6 at 34,419,518 bp
  • T to A, chromosome 6 at 43,174,638 bp
  • A to T, chromosome 6 at 140,042,439 bp
  • T to C, chromosome 7 at 8,483,177 bp
  • C to T, chromosome 7 at 92,442,657 bp
  • T to C, chromosome 7 at 105,157,176 bp
  • T to A, chromosome 7 at 106,602,744 bp
  • T to C, chromosome 7 at 126,946,178 bp
  • G to A, chromosome 8 at 15,128,879 bp
  • C to T, chromosome 8 at 43,625,282 bp
  • C to T, chromosome 8 at 61,020,078 bp
  • A to T, chromosome 8 at 69,765,691 bp
  • A to T, chromosome 9 at 40,874,164 bp
  • T to G, chromosome 9 at 50,858,887 bp
  • T to A, chromosome 9 at 53,570,264 bp
  • T to C, chromosome 9 at 57,545,217 bp
  • C to T, chromosome 9 at 105,453,681 bp
  • A to G, chromosome 9 at 110,085,210 bp
  • GC to G, chromosome 10 at 59,892,752 bp
  • A to G, chromosome 10 at 75,653,009 bp
  • A to G, chromosome 11 at 94,328,327 bp
  • G to T, chromosome 11 at 118,393,985 bp
  • C to A, chromosome 12 at 30,002,801 bp
  • T to G, chromosome 12 at 44,564,132 bp
  • T to C, chromosome 12 at 72,574,448 bp
  • T to A, chromosome 12 at 104,266,603 bp
  • T to A, chromosome 13 at 12,406,619 bp
  • A to G, chromosome 13 at 14,340,902 bp
  • G to A, chromosome 13 at 55,383,238 bp
  • C to G, chromosome 13 at 76,825,731 bp
  • A to T, chromosome 14 at 43,578,037 bp
  • T to C, chromosome 14 at 67,803,086 bp
  • T to A, chromosome 14 at 70,389,899 bp
  • T to C, chromosome 14 at 106,100,955 bp
  • T to C, chromosome 16 at 84,852,558 bp
  • T to C, chromosome 17 at 6,036,475 bp
  • T to A, chromosome 17 at 22,852,138 bp
  • C to T, chromosome 17 at 34,857,240 bp
  • C to T, chromosome 17 at 74,655,213 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5504 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043065-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.